DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and Cux2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_011246473.2	Gene:	Cux2 / 13048	MGIID:	107321	Length:	1595	Species:	Mus musculus

Alignment Length:	2182	Identity:	472/2182 - (21%)
Similarity:	708/2182 - (32%)	Gaps:	850/2182 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 AAAITLQQQNGSNLLANTNTPSPSPPLLSAEQQQQLQ------SSLQQSGGVGGACLNPKLFFN- 184
            |||....::....||.....|..|..|.....:::|.      |:.|:..|     |:||.|..
Mouse    85 AAAQPSSRRRRRRLLHRLLQPGRSVLLPGRSLRKELSSVASELSAPQEESG-----LSPKHFIEL 144

  Fly   185 -----------------------HAQQMMMMEAAAAAAAAALQQQQQQ-QSPLHSPANEVA---- 221
                                   .|:.:.:.:.:..|.||.|...:|. ::|...|:.|||
Mouse   145 RREFKKDVPEGIRAMVAPVLKSFQAEVVALSKRSREAEAAFLSVYKQLIEAPDPVPSFEVARTLD 209

  Fly   222 ----IPTEQPAATVATGAAAAAAAAATPIATGNVKSGSTTSNANHTNSNNSH----QDEEELDDE 278
                .|:..|:.........|......|.:......|  |....||.:|.:|    :|....|..
Mouse   210 DRLQRPSFDPSGQRLQDVHIAWKRCPEPPSAREQNEG--TCPTGHTPANGNHLPGPEDTLVTDTL 272

  Fly   279 EEDEEEDEDEDDEEENASMQSNADDMELDAQQETRTEPSATTQQQHQQQDTEDLEENKDAGEASL 343
            .:..|.:..:..:|.:.::.:...    :|:::.:...||....|     ||.||..:
Mouse   273 LQKNEAERQKGLQEVHITLAARLG----EAEEKIKVLHSALKATQ-----TELLELRR------- 321

  Fly   344 NVSNNHNTTDSNNSCSRKNNNGGNESEQHVASSAEDDDCANNNTNTSNNNNTSNTATSNTNNNNN 408
                                    :.::..||.|  |:.....||....|..:..|.....:...
Mouse   322 ------------------------KYDEEAASKA--DEVGLIMTNLEKANQRAEAAQREVESLRE 360

  Fly   409 NNSSSGNSEKRKKKNNNNNNGQPA-----------VLLAAKDKEIKALLDELQRLRAQ----EQT 458
            ..:|..:|.:....:....:|:..           ..||:||:||..||.:.|:||..    |:.
Mouse   361 QLASVNSSIRLACCSPQGPSGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEV 425

  Fly   459 HLVQIQRLEEHLEVKRQHIIRLEARLDKQ-QINEALAEATALSAAASTNNNNNSQSSDNNKKLNT 522
            ...||..||..|..|.:.|.:|:.:|:.| ...|...|.:.|.|                .||
Mouse   426 SANQIADLERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRA----------------MKL-- 472

  Fly   523 AAERPMDASSNADLPESTKAPVPAEDD----EED---EDQAMLVDSEEAEDKPEDSHHDDDEDED 580
                   |||...||::...|    ||    .:|   ..|..|::.......||       ||..
Mouse   473 -------ASSTCSLPQTLAKP----DDPLLVAKDVFFPTQKFLLEKPALLASPE-------EDPS 519

  Fly   581 EDREAVNATTTDSNELKIKKEQHSPLDL-------NVLSPNSAIAAAAAAAAAAACANDPNKFQA 638
            ||         ||.:..:..|...|..|       :.|||:.|
Mouse   520 ED---------DSIKGSLGTEPPYPPQLPPPPGPEDPLSPSPA---------------------- 553

  Fly   639 LLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQQQHLHQQHHHHLQQQPNSG 703
                                                                        ||
Mouse   554 ------------------------------------------------------------QP--- 555

  Fly   704 SNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTAAGNNNGSNNSSSNTNANST 768
                                ||.||    |......:.|.|..|:.|.....:.:|
Mouse   556 --------------------LLGPS----LGPDGPRTFSLSPFPSLAPGERLAGDS--------- 587

  Fly   769 AQLAASLASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVAAGGDGR 833
                 .|:..:.|..:...|..|.|             |..|.|..|.......||.|..
Mouse   588 -----LLSKHMMGPAAFKGETGNLL-------------AFPPTFYGGAKPPSAPAASVPC----- 629

  Fly   834 GHYRFADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVREL 898
                      ..|.||..|       :....|.|                :.|||..|:.:|:|.
Mouse   630 ----------PEPTGAPEA-------VDGAGPEE----------------EQLDTAEIAFQVKEQ 661

  Fly   899 LSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSL-- 961
            |..||||||:|..|:||||||:|||:|::||||.|||.||::.:.||..:..|:..|:.|:::
Mouse   662 LLKHNIGQRVFGHYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQV 726

  Fly   962 ----------IPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERR 1016
                      :|...|..|:......|        |:|.|..||.:|            :::...
Mouse   727 RQRGPTAATFVPLPGSITPRIRTPETG--------SDDAIKSILEQA------------KKEIES 771

  Fly  1017 SHGGEDSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHD 1081
            ..|||       ||:.|.|.:.|.....:.       ..|.|.....|:.|.:.:.:||..|..:
Mouse   772 QKGGE-------SKNSPASVSIPNGTASSS-------TSEDAIKNILEQARREMQAQQQALLEME 822

  Fly  1082 DQDKMARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAKL 1146
            .              .||..:.|               |.......||.|.:|
Mouse   823 S--------------GPRGRSVP---------------PSPPERPSPATASQN------------ 846

  Fly  1147 QQHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQD-----------LSLAAAAAKDIKLNGQRSS 1200
                               .:|..::|:...|...           ||.||...:.|:      .
Mouse   847 -------------------GALTCVKQEDGGGGSGSSSTVQAPLAVLSPAAFVQRIIR------K 886

  Fly  1201 LEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPTGGASSNS 1265
            ::...|      |....|.:.:|..|..|....:.:|..  |...:.:|.|...|.|.|..:
Mouse   887 VKSEIG------DAGYFDHHWASDRGLLSRPYASVSPSL--SSSSSYSGQPNGRAWPRGDEA--- 940

  Fly  1266 AAPSPLSNSILPPALSSQGEEFAATASPLQRMASIT----NSLITQPPVTPHHSTPQRPTKAVLP 1326
                    :|.|...::.||:.|.....|:..|...    ..|...|...|      |..|..:|
Mouse   941 --------TIAPEDEAAMGEDEAPRVGELKAEAGAPEVGGGRLPYYPAYVP------RTLKPTVP 991

  Fly  1327 PITQQQFD--MFNNLNTEDIVRRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQ 1389
            |:|.:|::  |:..::|.::.|:|||.|::..|.||:|||.|||||||||||:|:|||||..|||
Mouse   992 PLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQ 1056

  Fly  1390 KGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMM 1454
            |||||||||:::|.|
Mouse  1057 KGREPFIRMQLWLSD-------------------------------------------------- 1071

  Fly  1455 SELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQ 1519
                                          |:.|.|.||                  ..||..|.
Mouse  1072 ------------------------------QLGQGQGQA------------------PTQQPSAS 1088

  Fly  1520 QQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQH-----------AISLPPSAGGAQPGGPGGNQ 1573
            |..|.:.                 .:||..||..           .:||..|....||.|...:.
Mouse  1089 QASPTEP-----------------TSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQPEGRASSS 1136

  Fly  1574 GSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQK 1638
            ....|.:|.:                   .:..:.||.|::.:|||:.||.::||.|..||:||:
Mouse  1137 LGGKPFSSSQ-------------------AAGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQR 1182

  Fly  1639 IFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLWLSDANNVERLQLLKNERREASKRR 1703
            :|||::|||:|||||:|||:|||||.||:||||||:||||||||.:|||:|:.:|...::|..:|
Mouse  1183 LFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLSDPHNVEKLRDMKKLEKKAYLKR 1247

  Fly  1704 R----STGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPPSKKQRVLFSEEQKEALRLAF 1764
            |    .||          |.:::...::..|.|......: ....:||.||:.:..:|||||.|:
Mouse  1248 RYGLIGTG----------SDSESPAAHSECPSPCLQPQEL-SLMQAKKPRVVLAPAEKEALRKAY 1301

  Fly  1765 ALDPYPNVGTIEFLANELGLATRTITNWFHNHRMRLKQQ-VPHGPAGQDNPIPSRESTSATPFDP 1828
            .|:|||:..|||.|:.:|.|.|.|:.|||||:|.|:::: :..|.  ||:|          .|||
Mouse  1302 QLEPYPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGT--QDDP----------DFDP 1354

  Fly  1829 VQFRILLQQRLLELHKERMGMSGAPIPYPPYFAAAAILGRSLAGIPGAAAAAGAAAAAAAVGASG 1893
                                                                           ||
Mouse  1355 ---------------------------------------------------------------SG 1356

  Fly  1894 GDELQALNQAFKEQMSGLDLSMPTLKRERSDDYQDDLELEGGGHNLSDNESLEGQEPEDKTTDYE 1958
            |..:.......:|       ..|......::|.:..:            :|||.||||
Mouse  1357 GPNVLTPGHTHRE-------PTPQSPDSETEDQKPPM------------KSLELQEPE------- 1395

  Fly  1959 KVLHKSALAAAAAYMSNAVRSSRRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNERIINGV 2023
                 ..|..||                            |...:..:........|.:
Mouse  1396 -----GPLQRAA----------------------------PDRALVKIKQEEGLEVDGD------ 1421

  Fly  2024 CVMQASEYGRDDTDSNKPTDGGNDSDHEHAQLEIDQRFMEPEVHIKQEEDDDEEQSGSVNLD--- 2085
              .|..:.|..|...:.|.:     :|.|.....|...:.|...:          ||:.|.|
Mouse  1422 --SQPQDVGDPDRGQDGPKE-----EHTHPLGNSDLSELAPGPFL----------SGTPNPDCPS 1469

  Fly  2086 ---NEDNATSEQKLKVINEEKLRMVRVRRLSSTGGGSSEEMPAPLAPPPPPPAASSSIVSGESTT 2147
               .::..|.||    ::.|.|      ...||    ||.....|..||..|    |::|....|
Mouse  1470 LHNPQEKGTGEQ----VHSEPL------SFKST----SESSCCSLEGPPNSP----SVISSPDLT 1516

  Fly  2148 SSSSSSNTSSS-------------TPAVTTAAATAAA 2171
            :..|.:.:||:             .|:.:....||||
Mouse  1517 TCVSPAPSSSAPISPSLPGAPPAKVPSTSPTGDTAAA 1553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	37/68 (54%)
		CUT	1335..1411	CDD:280527	44/75 (59%)
		CUT	1616..1690	CDD:280527	50/73 (68%)
		Homeobox	1749..1801	CDD:278475	27/51 (53%)
Cux2	XP_011246473.2	Smc	<279..473	CDD:224117	48/260 (18%)
		CUT	645..718	CDD:367059	38/88 (43%)
		CUT	1002..1075	CDD:367059	45/152 (30%)
		CUT	1157..1230	CDD:367059	47/72 (65%)
		Homeobox	1285..1339	CDD:365835	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831330
Domainoid	1	1.000	117	1.000	Domainoid score	I5886
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2178
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm43114
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R168
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.020