DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and HMEN_ANOGA

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_317438.3	Gene:	HMEN_ANOGA / 1277926	VectorBaseID:	AGAP008023	Length:	594	Species:	Anopheles gambiae

Alignment Length:	764	Identity:	136/764 - (17%)
Similarity:	226/764 - (29%)	Gaps:	294/764 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   553 EDQAMLVDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAI 617
            ||:.    |.::...|...||..        ::..:|||      :.....||:      |....
Mosquito     4 EDRC----SPQSAPSPPHHHHSS--------QSPTSTTT------VTMATASPV------PACTT 44

  Fly   618 AAAAAAAAAAACANDPNKFQALLIERTKALAAEALKNGASDALSEDAHHQQQQHHQQQHQHQQQH 682
            .....:.:.|:.|:.|.:.:..|:.....|..:      .:.|..|.....|..|..||.|   |
Mosquito    45 TTTTTSTSGASAASSPTRDEMSLVVPISPLHIK------QEPLGSDGPMPAQPPHHHQHPH---H 100

  Fly   683 HQQQHLHQQHHHHLQQQPNSGSNSNPAS---------ND-------------------------- 712
            ||..| |..|.||.|||| |...|.|||         :|
Mosquito   101 HQLPH-HPHHQHHPQQQP-SPQTSPPASISFSITNILSDRFGKATAEQQQQPHPQPPAIREPISP 163

  Fly   713 ------------HHHGHHLHGHGLLHPSSAHHLHHQ----------------------------- 736
                        .|..|..|...||||:....|||.
Mosquito   164 GPIHPAVLLPYPQHVLHPAHHPALLHPAYHTGLHHYYQPSPSHPQPIVPQPQRASLERRDSLFRP 228

  Fly   737 --------------------------------TTESNSNSSTPTAAGN-NNGSNNSSSNTNANST 768
                                            :|:.::::.:|...|: .:.|:.||:.|...:|
Mosquito   229 YDISKSPRLCSSNGSSSATPLPLHPYHTDSDCSTQDSTSAPSPATYGDIASPSSASSAMTTPVTT 293

  Fly   769 AQLAASL------ASTLNGTKSLMQEDSNGLAAVAMAAHAQHAAALGPGFLPGLPAFQFAAAQVA 827
            :....|:      ||.|:...:|:    ||.:|.| :....|...:.|..:||      .|.::|
Mosquito   294 SSPTGSVYDYSRKASALDHRAALL----NGFSAAA-SYPKLHEEIINPPQVPG------EADRIA 347

  Fly   828 -AGGDGRGHYRFADSELQLPPGASMAGRLGESLIPKGDPMEAKLQEMLRYNMDKYANQALDTLHI 891
             .||.|.|.:                |..|.|..|              :||....:.......|
Mosquito   348 NEGGTGCGGH----------------GCCGGSATP--------------HNMPPLGSLCKTVSQI 382

  Fly   892 SRRVRELLSVHNIGQRLFAKYILGLSQGTVSELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVM 956
            .:.|....|::..|..  |........|..:.....|||..|
Mosquito   383 GQHVAGTGSLNGSGSA--ANGASNGGSGAPATAKPTPKPIPK----------------------- 422

  Fly   957 LLKSLIPKKDSGLPQYAGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGE 1021
                  |...|.....:.:.||....||:.||.......||..|.:..:.|...|..:|.|.|
Mosquito   423 ------PAPSSETNGSSSQDAGMESSDDAKSETSSTKDGSENGSNLWPAWVYCTRYSDRPSSG-- 479

  Fly  1022 DSHSNEDSKSPPQSCTSPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKM 1086
                             |.::...|        |::....:.:|.|......|.|||:::..:
Mosquito   480 -----------------PRYRRTKQ--------PKEKGDSEEKRPRTAFSNAQLQRLKNEFNE-- 517

  Fly  1087 ARLYQELIARTPRETAFPSFLFSPSLFGGAAGMPGAASNAFPAMADENMRHVFEREIAKLQQHQQ 1151
                ...:....|:|.                      :|...:.:..::..|:.:.||:::...
Mosquito   518 ----NRYLTEKRRQTL----------------------SAELGLNEAQIKIWFQNKRAKIKKSSS 556

  Fly  1152 QQQ--AAQAQAQ-FPNFSSLMALQQQVLNGAQDLSLAAAAAKDIKLNGQ 1197
            ::.  |.|..|| ..|.|::...:::     ::|        ::::|||
Mosquito   557 EKNPLALQLMAQGLYNHSTVPLTKEE-----EEL--------EMRMNGQ 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	10/68 (15%)
		CUT	1335..1411	CDD:280527
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
HMEN_ANOGA	XP_317438.3	Homeobox	499..552	CDD:278475	11/80 (14%)
HMEN_ANOGA	XP_317438.3	Engrail_1_C_sig	554..583	CDD:287495	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910