DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and LDB3

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	656	Identity:	125/656 - (19%)
Similarity:	198/656 - (30%)	Gaps:	225/656 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   922 SELLSKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSLIPKKDSGLPQYAGRGAGGAGGD--- 983
            |..|:.|.||....:.|:|.           |..:.:..:.|...:...|.       :.||
Human     4 SVTLTGPGPWGFRLQGGKDF-----------NMPLTISRITPGSKAAQSQL-------SQGDLVV 50

  Fly   984 --DSMSEDRIAHILSEASSLMKQSS----------------------------VAQHREQERRSH 1018
              |.::.|.:.|:  ||.:.:|.:|                            |..|::......
Human    51 AIDGVNTDTMTHL--EAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPVIPHQKDPALDT 113

  Fly  1019 GGE---DSHSNEDSKSPPQSCT-------SPFF---KVENQLKQHQHLNPEQAAAQQREREREQR 1070
            .|.   .|.|.|...||....|       ||.|   ...:.|.:.....|.:|:.:.:......|
Human   114 NGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGAR 178

  Fly  1071 EREQQQRLRHDDQDKMAR----LYQELIARTPRETAFPSFLFSPSLFGGAA--GMPGAA--SNAF 1127
            :....:.|....|.:...    ||.   |.|.||.|   .::..||.|.|:  |:||.|  ...|
Human   179 DLLGPKALPGSSQPRQYNNPIGLYS---AETLREMA---QMYQMSLRGKASGVGLPGGADYQERF 237

  Fly  1128 --PAMADENMRHVFEREIAKLQQ-----HQQQQQ--------------AAQAQAQFPNFSSLMAL 1171
              .|:.|..:......|:..|..     |.|...              |.|||||..:||..:.:
Human   238 NPSALKDSALSTHKPIEVKGLGGKATIIHAQYNTPISMYSQDAIMDAIAGQAQAQGSDFSGSLPI 302

  Fly  1172 QQQVLNGAQDL-------------------------------SLAAAAAKDIKLNGQRSSLEHSA 1205
            :...::.|..:                               .||.....:...:....:|..|.
Human   303 KDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSR 367

  Fly  1206 GSSSCSKDGERDDAYPSSLHGRKSEGGGTPAP----------------PAPPS--GPGTGAGAPP 1252
            ..:|.........:.|:: |...|||...|||                |.|.|  .|..||...|
Human   368 PQASSYSPAVAASSAPAT-HTSYSEGPAAPAPKPRVVTTASIRPSVYQPVPASTYSPSPGANYSP 431

  Fly  1253 TAAPPTGGASSNSAAPSP-LSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPVTPHHST 1316
            |...|: .|.:.:.:|:| .:.|.:|....|....:..:.:|....|          |...:...
Human   432 TPYTPS-PAPAYTPSPAPAYTPSPVPTYTPSPAPAYTPSPAPNYNPA----------PSVAYSGG 485

  Fly  1317 PQRPTKAVLPP-ITQQQFDMFNNLNTEDIVRRVKEALSQYSISQRLF----------GESVLGLS 1370
            |..|  |..|| :|...|.           ::.....|..|||::..          |..|..|:
Human   486 PAEP--ASRPPWVTDDSFS-----------QKFAPGKSTTSISKQTLPRGGPAYTPAGPQVPPLA 537

  Fly  1371 QGSVSD------------------------LLARPKPWHMLTQKGREPF--------IRMKMFLE 1403
            :|:|..                        |:|..:.||      .|.|        :....|:|
Human   538 RGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAMGRSWH------PEEFTCAYCKTSLADVCFVE 596

  Fly  1404 DENAVH 1409
            ::|.|:
Human   597 EQNNVY 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	8/32 (25%)
		CUT	1335..1411	CDD:280527	19/117 (16%)
		CUT	1616..1690	CDD:280527
		Homeobox	1749..1801	CDD:278475
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492	18/95 (19%)
		DUF4045	<77..180	CDD:330572	16/102 (16%)
		ZM	189..214	CDD:128974	8/30 (27%)
		DUF4749	263..353	CDD:318205	13/89 (15%)
		Atrophin-1	<387..554	CDD:331285	40/190 (21%)
		LIM1_ZASP_Cypher	556..607	CDD:188838	10/53 (19%)
		LIM2_Enigma_like	615..666	CDD:188748
		LIM3_Enigma_like	674..727	CDD:188749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910