DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ct and cux1

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_031752620.1	Gene:	cux1 / 100488175	XenbaseID:	XB-GENE-853070	Length:	1527	Species:	Xenopus tropicalis

Alignment Length:	1900	Identity:	454/1900 - (23%)
Similarity:	729/1900 - (38%)	Gaps:	519/1900 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 TTSNANHTNSNNSHQDEEELDDEEEDEEEDEDEDDEEENASMQSNADDMELDAQQETRTEPSATT 320
            ||:.......:.|.|..::|.|:..:.:::..||..::.|.:..:. ..|:||..:...|..|..
Frog    26 TTATVLANRQDESEQSRKKLIDQSREFKKNTPEDLRKQVAPLLKSF-QAEIDALSKRSKEAEAAF 89

  Fly   321 QQQHQQQ-DTEDLEENKDAG-EASLNVSNNHNTTDSN----NSCSRKNNNGGNESEQHVASSAED 379
            ...:::. |..|.....|.| :..|.|...|:....|    .:....|........|.|...|..
Frog    90 LNVYKRLIDVPDPVPALDLGQQLQLKVQRMHDIETENQKLRETLDEYNKEFAEVKNQEVTIKALK 154

  Fly   380 DDCANNNTNTSNNNNTSNTATSNTNNNNNNNSSSGNSEKRKKKNN---------NNNNGQPAVLL 435
            :..  .....:..|...|.|........|:     .:||.:|...         .....:...|.
Frog   155 EKI--REYEQTLKNQAENLALEKEQKLQND-----FAEKERKLQETQMFTSSKLEETEQKVQFLQ 212

  Fly   436 AAKDK------EIKALLDELQRLRAQE-QTHLVQIQRLEEHLEVKRQHIIRLEARLDKQQ---IN 490
            .|.||      ::||..||....:|.| :..:..::|..:..||.::     ||...|:|   :|
Frog   213 TALDKSQAALFDLKAKYDEDTSAKADEIEMIMTDLERANQRAEVAQR-----EAEALKEQLATLN 272

  Fly   491 EALAEATALSAAASTNNNNNSQSSDNNKKLNTAAERPMDASSNADLPESTKAPVPAEDDEEDEDQ 555
            ::|...:....|..|..:..:.|..:.:...||.||.:     |.|.|..:. :.|...:..|:.
Frog   273 KSLQHVSQSQKAPDTEQSTEAVSHSSMEVELTAKEREI-----AQLVEDVQR-LQASLTKLRENS 331

  Fly   556 AMLVDSEEAEDKPEDSHHDDDEDEDEDREAVNATTTDSNELKIKKEQHSPLDLNVLSPNSAIAAA 620
            |..:...|.:...::|    ...:.|::..|.|   |..|  ||||      ||:|   .::..|
Frog   332 ATQISQLEQQLNTKNS----SLKQLEEKLKVQA---DYEE--IKKE------LNIL---KSMEFA 378

  Fly   621 AAAAAAAACANDPNKFQALLIERTKALAAE-ALKNGASDALSEDAHHQQQQHHQQQHQHQQQHHQ 684
            .:..:....|:.|  .:.||:|:.::|.:| |.....:..||..|..:.:...:.|
Frog   379 PSEGSGVQDASKP--LEVLLLEKNRSLQSENATLRITNSELSGSARRKGKDQPEIQ--------- 432

  Fly   685 QQHLHQQHHHHLQQQPNSGSNSNPASNDHHHGHHLHGHGLLHPSSAHHLHHQTTESNSNSSTPTA 749
                                  .||:              |..|....|.....|.
Frog   433 ----------------------RPAT--------------LPASPPSQLLRNAGEQ--------- 452

  Fly   750 AGNNNGSNN-SSSNTN----ANSTAQLAASLAST----LNG--TKSLMQEDSNGLAAVAMAAHAQ 803
            |.|.||::. |.:..|    ::|.|..:..||||    ||.  .:.|||  |....|:..|....
Frog   453 ASNTNGTHQFSPTGLNQDFFSSSIASPSLPLASTGKFALNSLLQRQLMQ--SFYSKAMQEAGSTS 515

  Fly   804 HAAALGPGFLPGLPAFQFAAAQVAAGGDGRGHYRFADSELQLP--------PGASMAGRLGESLI 860
            ...:.||          |:...::           :.|.||.|        |..|.:...|.  :
Frog   516 MIFSAGP----------FSTNSIS-----------SQSPLQQPSPDVNGMAPSPSQSESAGS--V 557

  Fly   861 PKGDPMEAKLQEMLRYNMDKYANQALDTLHISRRVRELLSVHNIGQRLFAKYILGLSQGTVSELL 925
            .:|:.                    :||..|:|:|:|.|..||||||:|..|:||||||:|||:|
Frog   558 SEGED--------------------IDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEIL 602

  Fly   926 SKPKPWDKLTEKGRDSYRKMHAWACDDNAVMLLKSL------------------IPKKDSGLPQY 972
            ::||||:|||.:|::.:.||..:..|:..::.|:|:                  :||:.:|   .
Frog   603 ARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRENPGQNLNRLFQEVPKRRNG---S 664

  Fly   973 AGRGAGGAGGDDSMSEDRIAHILSEASSLMKQSSVAQHREQERRSHGGEDSHSNEDSKSPPQSCT 1037
            .|.........::.|:|.|..||.:|...::....|:..:....|:.|     |.|
Frog   665 EGNITTRIRSSETGSDDAIKSILEQAKRELQVQKTAEPAQPTSASNSG-----NSD--------- 715

  Fly  1038 SPFFKVENQLKQHQHLNPEQAAAQQREREREQREREQQQRLRHDDQDKMARLYQELIARTPRETA 1102
                            :..::..||..||.|.::...:..|      |.|.|.|..:.
Frog   716 ----------------DAIRSILQQARREMEAQQAVFEPVL------KSASLSQADLT------- 751

  Fly  1103 FPSFLFSPSLFGGAAGMPGAASNAFPAMADENM---RH--VFEREIAKLQQHQQQQQAAQAQAQF 1162
                :.||.|      :|.:|.::..:.:...:   :|  |.:..|:.||
Frog   752 ----IISPKL------IPTSAVSSLSSYSPVTLSLKKHTSVLDSGISTLQ--------------- 791

  Fly  1163 PNFSSLMALQQQ--VLNGAQDLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLH 1225
             |.|.:....|:  ||    ||...|.:.     :|....::...|.||..|    |..:.:..|
Frog   792 -NLSGVKKESQETPVL----DLHSIADST-----HGMIRHVKSELGRSSVWK----DHWWNTVQH 842

  Fly  1226 GRKSEGGGTPAPPAPPSGPGTGAGAPPTAAPPT-GGASSNSAAPSPLSNSILPPALSSQGEEFAA 1289
            .|::                 ...:..|....| .|....|.......|.:..|:.|...:|:..
Frog   843 DRRN-----------------AVSSEDTKTEETVCGKEKLSTQNRTERNQLQGPSSSEYWKEWPN 890

  Fly  1290 TASPLQRMASIT---NSLITQPPVTPHHSTP----QRPTKAVLPPITQQQFD--MFNNLNTEDIV 1345
            ..||..:.:.|:   .|....|..:|..|:|    .:|||..:||:|.:|::  |:..::|.::.
Frog   891 AESPYSQSSEISMTGASRSETPQNSPLPSSPVVSMSKPTKPSVPPLTPEQYEMYMYQEVDTIELT 955

  Fly  1346 RRVKEALSQYSISQRLFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDE---NA 1407
            |:|||.|::..|.||:|||.|||||||||||:|:|||||..||||||||||||:::|..|   :.
Frog   956 RQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQSV 1020

  Fly  1408 VHKLVASQYKIAPEKLMRTGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQM 1472
            :|
Frog  1021 LH--------------------------------------------------------------- 1022

  Fly  1473 QAAAMSAAMQQQQVAQAQQQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAAL 1537
                          :|.|||.|..|.|      .|||...|:...:.:..|......:.|..:.:
Frog  1023 --------------SQGQQQGQALQSA------TAQQDSLQEGFPSSESTPKTSASCSPAPESPM 1067

  Fly  1538 HHQSMLLTSPGLPPQHAISLPPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQH 1602
            .....:.:...|..|...::..|.       .|..|.||..:...:.|..:|..|         |
Frog  1068 SSSESIKSLTELVQQPCPTIDTSK-------EGETQESSETTCDSQPPTPLPFPG---------H 1116

  Fly  1603 MSPTVYEMAALTQDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSI 1667
            .:.::.|:.|::.:|||:.||.::||.|..||:||::|||::|||:|||||:||::|||||.||:
Frog  1117 SALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGESILGLTQGSVSDLLARPKPWHKLSL 1181

  Fly  1668 KGREPFIRMQLWLSDANNVERLQLLKN-ERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPG 1731
            ||||||:||||||:|.|||::|..:|. |::...|||.|:..:.|.....:|..|.:.
Frog  1182 KGREPFVRMQLWLNDPNNVDKLMDMKRMEKKAYMKRRHSSVSDSQPCEPLSSGIDYSQ------- 1239

  Fly  1732 PGSVGSGVGGAPPS-----KKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITN 1791
                     ||.|.     ||.||:.:.|:||||:.|:...|||:..|||.||.:|.|.|.|:.|
Frog  1240 ---------GASPQPQHHLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVIN 1295

  Fly  1792 WFHNHRMRLKQQ--VPHGPAGQDNPIPSRESTSATPFDPVQFRILLQQRLLELHKERMGMSGAPI 1854
            ||||:|.|::::  :....||....|.|.:|.|||                   ..|
Frog  1296 WFHNYRSRIRRELFIEEIQAGSHGQIGSSDSPSAT-------------------SSR-------- 1333

  Fly  1855 PYPPYFAAAAILGRSLAGIPGAAAAAGAAAAA--------AAVGASGGDELQALNQAFKEQMSGL 1911
                  ||.:..|.|..|:...:.:.|...||        .::.:.||....|..::  |.....
Frog  1334 ------AAHSSEGDSCDGVDMESTSEGKHGAALDPDEYSSVSMKSQGGQTDSAFEES--EDARST 1390

  Fly  1912 DLSMPTLKRERSDDYQDDLELEG-----GGHNLS-DNESLEGQEPEDKTTDYEKVLHKSALAAAA 1970
            :::..|..|..|.|..||   ||     |..:|| .|.|.||.......|  ||:...||.:...
Frog  1391 EITGSTRPRAESPDNTDD---EGQKMLLGQSSLSGSNCSGEGLSTAKSAT--EKLSSTSAASGTV 1450

  Fly  1971 AYMSNAVRSSRRKPAAPQWVNPAGAVTNPSAVVAAVAAAAAAAADNERIINGVCVMQASEYGRDD 2035
            :...:..||...|                   :::|.:.::...::.:.:.......:|:..||:
Frog  1451 SAKESTHRSESEK-------------------LSSVPSTSSQKGNSIQSLFSFSETSSSKNTRDN 1496

  Fly  2036 TDSNKPTDGGNDSDH 2050
            |...|.....|...|
Frog  1497 TLRKKKAANLNSIIH 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527	36/68 (53%)
		CUT	1335..1411	CDD:280527	45/78 (58%)
		CUT	1616..1690	CDD:280527	48/73 (66%)
		Homeobox	1749..1801	CDD:278475	27/51 (53%)
cux1	XP_031752620.1	SMC_prok_B	111..>364	CDD:274008	53/277 (19%)
		CUT	559..635	CDD:396794	37/95 (39%)
		CUT	945..1013	CDD:396794	42/67 (63%)
		CUT	1127..1204	CDD:396794	48/76 (63%)
		Homeobox	1252..1306	CDD:395001	27/53 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5848
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2328
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001636
OrthoInspector	1	1.000	-	-		otm48247
Panther	1	1.100	-	-	O	PTHR14043
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R168
SonicParanoid	1	1.000	-	-		X2130
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090