DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ct and onecut2

DIOPT Version :9

Sequence 1:	NP_524764.1	Gene:	ct / 44540	FlyBaseID:	FBgn0004198	Length:	2175	Species:	Drosophila melanogaster
Sequence 2:	XP_001920308.3	Gene:	onecut2 / 100000073	ZFINID:	ZDB-GENE-120215-73	Length:	461	Species:	Danio rerio

Alignment Length:	728	Identity:	148/728 - (20%)
Similarity:	219/728 - (30%)	Gaps:	303/728 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1123 ASNAFPAMADE----NMRHVFEREIAKLQ---QHQQQQQAAQAQAQFPNFSSLMALQQQVLNGAQ 1180
            |.||:..:|.:    .|......:|..|.   .|:|...::.:.....|..:.:.:.       |
Zfish     4 AYNAYRCLAKDLDAYAMNPEMTMDIGSLHAGVSHEQDLMSSHSPHHSRNPGAALRIH-------Q 61

  Fly  1181 DLSLAAAAAKDIKLNGQRSSLEHSAGSSSCSKDGERDDAYPSSLHGRKSEGGGTPAPPAPPSGPG 1245
            |||:|.:          ||::..|..|   ..||                |||         |.|
Zfish    62 DLSVAPS----------RSAMVSSMAS---ILDG----------------GGG---------GGG 88

  Fly  1246 TGAGAPPTAAPPTGGASSNSAAPSPLSNSILPPALSSQGEEFAATASPLQRMASITNSLITQPPV 1310
            .|...|..:.|      .:.|...|...|  ||.:|..    ..|.:|||.:          ||:
Zfish    89 GGEYRPELSLP------LHHAMSMPCDTS--PPGMSGT----YTTLTPLQPL----------PPI 131

  Fly  1311 TP-----------HHSTPQRPTKAVLPPIT----QQQFDMFNNLNTEDIVRRVKEALSQYSISQR 1360
            :.           ||...||.:..|....|    ::.....|||            .|.|.....
Zfish   132 STVSDKFHHPHHHHHHHHQRLSGNVSGSFTLMRDERTLPAMNNL------------YSPYHKDMS 184

  Fly  1361 LFGESVLGLSQGSVSDLLARPKPWHMLTQKGREPFIRMKMFLEDENAVHKLVASQYKIAPEKLMR 1425
            ..|:|:..|..|..|...|:|    .|...|.:                |:::|.:......|.|
Zfish   185 GMGQSLSPLGNGLGSIHSAQP----TLHNYGHD----------------KMLSSNFDAHTAMLSR 229

  Fly  1426 TGSYSGSPQMPQGLASKMQAASLPMQKMMSELKLQEPAQAQHLMQQMQAAAMSAAMQQQQVAQAQ 1490
                 |...:.:||..       |...||..|
Zfish   230 -----GDQHLSRGLGG-------PAAGMMPHL--------------------------------- 249

  Fly  1491 QQAQQAQQAQQHLQQQAQQHLQQQQHLAQQQHPHQQHHQAAAAAAALHHQSMLLTSPGLPPQHAI 1555
                                        ...|.|                      ||.||.|..
Zfish   250 ----------------------------NGMHAH----------------------PGHPPSHGP 264

  Fly  1556 SL------PPSAGGAQPGGPGGNQGSSNPSNSEKKPMLMPVHGTNAMRSLHQHMSPTVYEMAALT 1614
            .|      |.|:..:..|.||..|                                        .
Zfish   265 VLASNRDRPLSSSSSSCGAPGSGQ----------------------------------------L 289

  Fly  1615 QDLDTHDITTKIKEALLANNIGQKIFGEAVLGLSQGSVSELLSKPKPWHMLSIKGREPFIRMQLW 1679
            ::::|.::..:|...|...:|.|.||.:.||..|||::|:||..||||..|. .|||.|.||..|
Zfish   290 EEINTKEVAQRITAELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLK-SGRETFRRMWKW 353

  Fly  1680 LSDANNVERLQLLKNERREASKRRRSTGPNQQDNSSDTSSNDTNDFYTSSPGPGSVGSGVGGAPP 1744
            |.:. ..:|:..|   |..|.||:      :||.|.|.|:.
Zfish   354 LQEP-EFQRMSAL---RLAACKRK------EQDPSKDRSNT------------------------ 384

  Fly  1745 SKKQRVLFSEEQKEALRLAFALDPYPNVGTIEFLANELGLATRTITNWFHNHRMR-LKQQVPHGP 1808
            .||.|::|::.|:..|...|..:..|:......::.:|||...|::|:|.|.|.| |.:.:..|
Zfish   385 PKKSRLVFTDLQRRTLLAIFKENKRPSKEMQMTISQQLGLELSTVSNFFMNARRRSLDKWLDEG- 448

  Fly  1809 AGQDNPIPSREST 1821
                :|..|..||
Zfish   449 ----SPNNSSSST 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ct	NP_524764.1	CUT	886..955	CDD:280527
		CUT	1335..1411	CDD:280527	14/75 (19%)
		CUT	1616..1690	CDD:280527	29/73 (40%)
		Homeobox	1749..1801	CDD:278475	15/52 (29%)
onecut2	XP_001920308.3	CUT	290..362	CDD:280527	28/73 (38%)
onecut2	XP_001920308.3	HOX	385..440	CDD:197696	16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910