DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rg and BPH1

DIOPT Version :9

Sequence 1:	NP_001284879.1	Gene:	rg / 44531	FlyBaseID:	FBgn0266098	Length:	3785	Species:	Drosophila melanogaster
Sequence 2:	NP_009961.2	Gene:	BPH1 / 850398	SGDID:	S000000628	Length:	2167	Species:	Saccharomyces cerevisiae

Alignment Length:	976	Identity:	267/976 - (27%)
Similarity:	414/976 - (42%)	Gaps:	230/976 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2895 VQKSP----YWKLDAWEDDARRRKRMVQNPRGSSHPQATLKAALENGGPEDAIL----QTRD--- 2948
            :|.:|    .|..|..||....::|::........|...     |....:|.|.    |.|:
Yeast  1277 IQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLIN-----EEDANQDTITGGNRQRRESGS 1336

  Fly  2949 ----EFHTQIAVSRTHPSGQHNGELLDDAELLIEDRELDLDLTGPVNIST--KARLIAPGLVAPG 3007
                ||...:....:.|.|..|           |:|::...|....:|:|  ...||....:..|
Yeast  1337 ILSYEFIEHMETLESEPVGDLN-----------ENRKILRLLKDNDSIATIWNCSLIIGLEIKEG 1390

  Fly  3008 TVSITSTEMFF-----------------EVDEEHPEF--QKIDGEVLK----YCDHLHGKWYFSE 3049
            .:...|..::|                 ||.:|..:.  ..|:|..:|    :..|....|...:
Yeast  1391 ILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLD 1455

  Fly  3050 VRAIFSRRYLLQNVALEIFLASRTSILFAFPDQ-------HTVKKVIKALP-------------- 3093
            :..:..|.:||::||:|:....|.|..|:|.::       ..:.|:.|.||
Yeast  1456 ITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEIND 1520

  Fly  3094 -------RVGVGIKYGIPQTRRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYND 3151
                   |.|:| |..|.....:...:...|:....:::||.|.|||||.||:.:|.:|||::||
Yeast  1521 RGNSIVARNGIG-KASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFND 1584

  Fly  3152 LNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYE---SWDSDTIPPFHY 3213
            |.|||:||||:.:|||..|||..|..|||||||:||.:..|:..|.||||   |.::....||||
Yeast  1585 LTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSAPFHY 1649

  Fly  3214 GTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNC-QRDTSDVKELIPEWY 3277
            |||||:|....::|:|::||...||.||||.|...||||||:..:|.:. ..:|:||:||.||::
Yeast  1650 GTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFF 1714

  Fly  3278 FLPEMFYNSSGYRLGHREDGALVDDIELPPWAK-SPEEFVRINRMALESEFVSCQLHQWIDLIFG 3341
            ||||...|.:.|..|..:.|..|||:.|||||. .|:.|::.||.||||.:||..||:|||||||
Yeast  1715 FLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFG 1779

  Fly  3342 YKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMH 3406
            |||:|..|:::.|||..|:|.|:|:||.:.|...|.|:...|.||||||.|:..||||.:.:
Yeast  1780 YKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIA--- 1841

  Fly  3407 LSPMMFSAMPEDLCQMLKFYQNSPVIHISANTYPQLSLPSVVTVTAGHQFAVNRWNCNYTASVQS 3471
                         |.         |..::...:.::.:..:...|.   |.:|..|.:....:..
Yeast  1842 -------------CN---------VQQLTTEVWRKVPMKPIFEKTI---FNLNEKNRSVDYVIHD 1881

  Fly  3472 PSYAESPQSPGSNQPLTIDPVLAVHGTNNNSNAASRRHLGDNFSQMLKIRSNCFVTTVDSRFLIA 3536
            |||.:|....|...|                                    |.|..|.:|  |:
Yeast  1882 PSYFDSLYWRGFAFP------------------------------------NLFFRTEES--LV- 1907

  Fly  3537 CGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCY-----IASGSADCTVLLWHWN 3596
                  |.|:......||...:|..    |.||:    |||..|     ..:|..:..:.:|.:.
Yeast  1908 ------SLRIVHKNWLKIGLDIFKK----THMAQ----ITSFAYWKLGEFITGDKNGLIKVWKYR 1958

  Fly  3597 ARTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTFGDLLRSLDPPAE 3661
            ....|:.|..:   .:.|:.||                                  |..|.....
Yeast  1959 KDKHSVSGNLE---NKKTMFGH----------------------------------LCELKEMRC 1986

  Fly  3662 FHS-PELITMSREGFI----VINYDKGNVAAYTINGKKLRHETHNDNLQCMLLSRDGEYLMTAGD 3721
            :|. ..|:|:...|.:    :||::.  |...|.:.:|:....|..::  |:|:::.. :.....
Yeast  1987 YHDYNTLLTLDISGLVYVWDMINFEL--VRQITNDAQKVAISQHAGSI--MVLTKNNA-ISIFNL 2046

  Fly  3722 RGIVEVWRTFNLAPL------YAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHIDFNRWHHE 3780
            .|.:...:.|..|.:      :.|...:||.|......:.:.||.|...|:|.::.: |..:|:|
Yeast  2047 NGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYEL-FLNFHNE 2110

  Fly  3781 Y 3781
            :
Yeast  2111 W 2111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rg	NP_001284879.1	LamG	210..358	CDD:304605
		DUF4704	634..918	CDD:292415
		MARCKS	1434..1751	CDD:280269
		DUF1088	2791..2972	CDD:284000	18/91 (20%)
		PH_BEACH	2996..3093	CDD:291510	25/126 (20%)
		Beach	3125..3401	CDD:280327	146/280 (52%)
		WD40 repeat	3524..3560	CDD:293791	8/35 (23%)
		WD40	<3526..3729	CDD:295369	37/212 (17%)
		WD40	<3530..3773	CDD:225201	47/258 (18%)
		WD40 repeat	3566..3617	CDD:293791	12/55 (22%)
		WD40 repeat	3622..3657	CDD:293791	1/34 (3%)
		WD40 repeat	3669..3699	CDD:293791	7/33 (21%)
		WD40 repeat	3704..3739	CDD:293791	5/40 (13%)
BPH1	NP_009961.2	PH_BEACH	1371..1500	CDD:275391	25/128 (20%)
		Beach	1558..1839	CDD:214982	146/280 (52%)
		WD40 repeat	1933..1976	CDD:293791	8/45 (18%)
		WD40 repeat	1981..2017	CDD:293791	8/37 (22%)
		WD40 repeat	2021..2055	CDD:293791	5/36 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13743
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010