Protein Alignment rg and Wdfy3

DIOPT Version :10

• Sequence 1: NP_001284879.1
• Gene: rg / 44531
• FlyBaseID: FBgn0266098
• Length: 3785
• Species: Drosophila melanogaster
• Sequence 2: XP_006535283.1
• Gene: Wdfy3 / 72145
• MGIID: 1096875
• Length: 3527
• Species: Mus musculus
• Alignment Length: 3660
• Identity: 735/3660 - (20%)
• Similarity: 1232/3660 - (33%)
• Gaps: 1247/3660 - (34%)

  Fly   573 SVSSLNSMVGSADTEEVNQLKAVLYDGKLSNAIVFMYNPVATDGQLCLQSSPKG----NVSYFVH 633
            ::..|.|:|.|..|..|::||..   |..:.|      |....|....|.:.||    |:..|..
Mouse   331 ALKDLVSLVTSLTTYGVSELKPA---GVTTGA------PFLLPGFAVPQPAGKGHSVRNIQAFAV 386

  Fly   634 TPHALMLQDVKAVVTHSIHCTLNSIGGIQV-----LFPLFSQ--LDMAHEGLGDIKRDPTLCSKL 691
            ..:|.:    ||.........|::|..|.:     .|.|.||  |....|.:..:........::
Mouse   387 LQNAFL----KAKTNFLAQIILDAITNIYMADNANYFILESQHTLSQFAEKISKLPEVQNKYFEM 447

  Fly   692 LGFICELVETSQTVQQHMIQNRGFLVISFMLQRSSREHLTLEVLGSFLNLTKYLVTCLSANSDLL 756
            |.|:        ....:.|..:..:.:|.:|:.||..|.::..:.:.|..|::         |.:
Mouse   448 LEFV--------VFSLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRH---------DYI 495

  Fly   757 LKQLFCFSFLTWQLLDHVLFNPALWIYTPANVQARLYSYLATEFLSDTQIYSNV----------- 810
            .|.:|....|. :::.::|...|..:..||.         |.....|::..|:|
Mouse   496 FKDVFREVGLL-EVMVNLLHKYAALLKDPAQ---------ALNEQGDSRNNSSVEDQKHLALLVM 550

  Fly   811 RRVSTVLQTVHTLKYYYWVVNPRAKSGIIPKGLDGPRPAQKDIL--AIRAYILLFLKQLIMIGNG 873
            ..::.:||..:|            .:||. :...|.|.|...:.  ..|.:.|:.::||::..||
Mouse   551 EALTVLLQGSNT------------NAGIF-REFGGARCAHNIVKYPQCRQHALMTIQQLVLSPNG 602

  Fly   874 VKEDELQSILNYLTTMH-----EDENLHDVLQMLISLMSEHPSSMVPAFDVKHGVRSIFKLLAAE 933
              ||::.::|.   .||     |.:...|:|:.|:|::.|           .|..|::|:
Mouse   603 --EDDMGTLLG---LMHSAPPTELQLKTDILRALLSVLRE-----------SHRSRTVFR----- 646

  Fly   934 SQLIRLQALKLLGFFLSRSTHKRKYDVMSPHNLYTLLAERLLLYEESLSLPTYNVLYEIMTEHIS 998
                     |:.||                    ..:...|:..|.|||.|..|     ..|.:|
Mouse   647 ---------KVGGF--------------------VYITSLLVAMERSLSSPPKN-----GWEKVS 677

  Fly   999 Q----QILYT---------RHPEPESHYRLENPMILKVVATLIRQSKQTESLIDVKKLFLQDMTL 1050
            |    ::|:|         |:....||:              .:...|.|.|.|..:.      |
Mouse   678 QSQVLELLHTVFCTLTAALRYEPANSHF--------------FKTEIQYEKLADAVRF------L 722

  Fly  1051 LCNSNRENRRTVLQMSVWQEWLIAMAYIHPKSSEEQKISDMVYSLFRMLLHHAIKHEYGGWRVWV 1115
            .|.|:...              |:...:.|.:::.          |:.||      |.|.  |.|
Mouse   723 GCFSDLRK--------------ISAVNVFPSNTQP----------FQRLL------EEGA--VSV 755

  Fly  1116 DTLA--IVH-SKVSYEEFKLQFAQMYEHYERQRTDNITDPALRQARPISTISGWEREELHQQQNG 1177
            |:::  :.| ||:....:|:.......|.|:      ..|.|....  |..|.|....|.::::.
Mouse   756 DSVSPTLRHCSKLFIYLYKVATDSFDSHAEQ------IPPCLTSES--SLPSPWGTPALSRKRHA 812

  Fly  1178 GSAAAV-----ATNQTAAVKGSVSIASLEDVPPVVEEEVEELELEEVEIQEGPITE---ETEQKS 1234
            ....:.     |.|.| .:|..|:.:.|:....|:......|.:.::....|.:|:   ..:.:.
Mouse   813 FHCVSTPPVYPAKNVT-DLKLQVTSSPLQSSDAVIIHPGAMLAMLDLLASVGSVTQPEHALDLQL 876

  Fly  1235 VIANI--SDVY---NEQLKTDATCNGNL----------EDVKEEEPVQQQIGDLEKQP-EPSTPL 1283
            .:|||  |.|:   |:|:..:|..:..|          ||.....|:|:....|..|. ||.
Mouse   877 AVANILQSLVHTERNQQVMCEAGLHARLLQRCGAALADEDHSLHPPLQRMFERLASQALEPM--- 938

  Fly  1284 GALRETLQLGDDMDVEELELATAKDALNAEQHVSRVLQASEAALNDCKMAVDDVLQESSSVLKDE 1348
             .|||.|:|...::                           ....|.|:.....:.:.||:..:.
Mouse   939 -VLREFLRLASPLN---------------------------CGAWDKKLLKQYRVHKPSSLSFEP 975

  Fly  1349 EIELAVNEVVQGVLNNEKKTQSQDNKDNKEQPGEQDVNVSLLNSKNLLNNNNNNNNNSPSPTPTT 1413
            |:..:|...::|:        ..||..:..:.....::.||:.|
Mouse   976 EMRSSVITSLEGL--------GSDNVFSSHEDNHYRISKSLVKS--------------------- 1011

  Fly  1414 ATATAETEAETEVNANEIVSSTEAPKAETE-TSVAP---EVET----------PETAKPSPIVPS 1464
              |...|...|.|..  :||.|........ :||.|   |.:|          |..|..:  .|:
Mouse  1012 --AEGSTVPLTRVKC--LVSMTTPHDIRLHGSSVTPAFVEFDTSLEGFGCLFLPSLAPHN--APT 1070

  Fly  1465 PVLATNQKTEDA-ANKLNNNEKL--------------AEISASPEPPIVVETPEADLLQLSDSET 1514
            ....|...|:.| .:.:.:.|:.              .|..:||        |....::|.....
Mouse  1071 NNTVTTGLTDGAVVSGMGSGERFFPPPSGLSYSCWFCIEHFSSP--------PNNHPVRLLTVVR 1127

  Fly  1515 KPNKETEAEDSVALAVRDIVEQLIDKVIDATEAESASETKTETNNNEIPKKEKQTSEEPEDVETA 1579
            :.|  :..:..|.||:          |:.|.:......||.|...|.:       .:..|:....
Mouse  1128 RAN--SSEQHYVCLAI----------VLSAKDRSLIVSTKEELLQNYV-------DDFSEESSFY 1173

  Fly  1580 ETLAAAAKEIVQEVV------EAALVMVQEESTQEKPEKGANSEEEKNEIGKEEILLQLEEKPAS 1638
            |.|...|:....|:|      ..||:|                  .:..:......|.|:.:..|
Mouse  1174 EILPCCARFRCGELVVEGQWHHLALLM------------------SRGMLKNSTAALYLDGQLVS 1220

  Fly  1639 T----EVQETKIEGDLKKPEDPKGHSSVEPK----------TPN-----------------LEEP 1672
            |    .|..|           |.|..|..|.          ||.                 |||.
Mouse  1221 TVKLHYVHST-----------PGGSGSANPPVLSTVYAYVGTPPAQRQIASLVWRLGPTHFLEEV 1274

  Fly  1673 KPQET----------------------EQQKSQEVA-EELPQKPEEQV-------------VAIV 1701
            .|..:                      :..||:.|. ..:....||:|             ||.:
Mouse  1275 LPPSSVTTIYELGPNYVGSFQAVCVPCKDAKSEGVTPSPVSLVAEEKVSFGLYALSVSSLTVARI 1339

  Fly  1702 NQVLDTLVDDTVKAVAAEQTTQTSPAPEEQSPQILA------MESPATSVRVK-------PTEVD 1753
            .:|.:.|  |: ||:|.:....:.   |..:|..|.      :..||.::...       .|.|.
Mouse  1340 RKVYNKL--DS-KAIAKQLGISSH---ENATPVKLVHNAAGHLNGPARTIGAALIGYLGVRTFVP 1398

  Fly  1754 STTQTTPKNEAGSSLLVEQVQQVLQEDDAQQSAGMTIEDEDYSNQQAAAAVENANSSQLDANHYG 1818
            ....||.:...|::.::..|..      |....|:      |:..:|...|..:
Mouse  1399 KPVATTLQYIGGAAAILGLVAM------ASDVEGL------YAAVKALVCVVKS----------- 1440

  Fly  1819 PGNPESKQQQQRSKSGSTRPMFSPGPTRPPFRIPEFKWSYIHQRLLSDVLFSL--------ET-- 1873
              ||.:.::.:|.|......|           :.:.|.|.::..:| .:.|||        ||
Mouse  1441 --NPLASKEMERIKGYQLLAM-----------LLKKKRSLLNSHIL-HLTFSLVGTVDSGHETSI 1491

  Fly  1874 ------------DIQVWR-----------SHSTKSVLDFVNSSENAIFVVNTVHLISQLADNLII 1915
                        |.:||.           .|..:.:.:...:|:|| .::....||.:|
Mouse  1492 IPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTESSEASKNA-KLMREFQLIPKL------ 1549

  Fly  1916 ACGGLLPLLASATSPNSELDVLEPTQGMPLEVAVSFLQRLVNMADVL-----------IFATSLN 1969
                ||.|        .::.:.:||......|....||...|..|:|           .||....
Mouse  1550 ----LLTL--------RDMSLSQPTIAAISNVLSFLLQGFPNSNDLLRFGQFISSTLPTFAVCEK 1602

  Fly  1970 FGELE----------AEKNMSSGGILRQCLRLVCTCAVRNCL---------ECKERTRYNVGALA 2015
            |..:|          ||:..  ||::...|.|     :||.|         ..||:|..|
Mouse  1603 FVVMEINNEEKPDPGAEEEF--GGLVSANLIL-----LRNRLLDILLKLVYTSKEKTNIN----- 1655

  Fly  2016 RDVPGAAHLQALIRGAQASPKNIVESITGQLSPVKDPEKLLQDMDVNRLRAVIYRDVEETKQAQF 2080
                    |||.                         |:|::.:..:.:...:...:..|.....
Mouse  1656 --------LQAC-------------------------EELVRTLGFDWIMMFMEEHLHPTTVTAA 1687

  Fly  2081 LSLAIVYFISVLMVSKYRDILEPPAEPQIQRQSPVLQ------------RTAGGEAASARPLFPQ 2133
            :.:.:|...:..::.|:::.|.  ....:::...||.            |:|||. ::.|.:...
Mouse  1688 MRILVVLLSNQSILIKFKEGLS--GGGWLEQTDSVLTNKIGTVLGFNVGRSAGGR-STVREINRD 1749

  Fly  2134 WSHHVYPQFLPESHQNHNSNMQHQQQQQQQQQHQQQQHYYQQQQQQQVVHNHSH----HHMTAAY 2194
            ..|  :|.||                                 ..|..:..|::    :.:..|.
Mouse  1750 ACH--FPGFL---------------------------------VLQSFLPKHTNVPALYFLLMAL 1779

  Fly  2195 YQQQQHQQVAAGQQQHSPTPLATHSTSS-----------SASSTATSQPASSSS-LSSLASQSQQ 2247
            :.||...::....|...|.      |||           |..:.....||||.: :||:.:...:
Mouse  1780 FLQQPVSELPENLQVSVPV------TSSRCKQGCQFDLDSIWTFIFGVPASSGTVVSSIHNVCTE 1838

  Fly  2248 QSHRQLHKQQQQQQQQQQQQQPHYHPHQPHYGLINGHQQHPQLNGKHYAENGSTAGYHPHSHPHP 2312
            .:...|                         |::..     .||....:|.
Mouse  1839 SAFLLL-------------------------GMLRS-----MLNSPWQSEE-------------- 1859

  Fly  2313 HGGYMRNGDTSTLQ-----QNGMPDYQAVGLMNGHGSGGTGNNNNSSLMNNMRNLRNGGGANSSS 2372
            .|.::|....:.:|     .:.:||..::.|
Mouse  1860 EGSWLREYPVTLMQFFRYLYHNVPDLASMWL---------------------------------- 1890

  Fly  2373 SPPGSHQVIQGVATAGAVNANAAVGVGMGGAVGVGMGGVAGGLDGGVVYKTSAINNNYRYNGRNA 2437
            ||...      .|.|..|                                       :.:|.|..
Mouse  1891 SPDFL------CALAATV---------------------------------------FPFNIRPY 1910

  Fly  2438 SAGTGGRQIQDSDYEIIVVDENNPSVLADNDSHSSGPPS--IKANQTTTIATTTTTTATTHINNN 2500
            |     ..:.|.|.|:                   |.|:  .||    ..|.|....:.:...|.
Mouse  1911 S-----EMVTDLDDEV-------------------GSPAEEFKA----FAADTGMNRSQSEYCNV 1947

  Fly  2501 NTKTTTSNAPTATI-----------KIQQQPLSPPKPLVPQKLPKSVDSDVGSLNMNSTENEVPE 2554
            .|||..:|.|....           .:...|.|...||:...|..|.:        .||..:..|
Mouse  1948 GTKTYLTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPE--------RSTRTQQKE 2004

  Fly  2555 VESSSEILIDDHKPSHSNDESWTDVNLNEDAAVQAASAGIVVGLVDN------RGNVISDKHDPS 2613
            .::.....:.||..:       .||.|.|||::...|.|....||:|      |   :.||....
Mouse  2005 FQTHVLDSVMDHLLA-------ADVLLGEDASLPITSGGSYQVLVNNVFYFTQR---VVDKLWQG 2059

  Fly  2614 HHNQQQQQQAGIIGQ---QQQHGSLGHS----------------ERGDKPDSE----ISVVRVPD 2655
            ..|::.:.....|.|   |.:..|.|.|                .|..|...:    :..:||..
Mouse  2060 MFNKESKLLIDFIIQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVALLDSLRVLT 2124

  Fly  2656 GYGGAGSGGG--------------VNSGQGQGVPSNQRPRPEELPMKAPALVAQLPLTTPS---R 2703
            .......|.|              :|...|..|        |...::|.|.:....:..||   .
Mouse  2125 VNRNLILGPGNHDQEFISCLAHCLINLHAGSSV--------EGFGLEAEARMTTWHIMIPSDIEP 2181

  Fly  2704 EASLTQKLEIALGPVCPLLREIMVDFAPFLSKTLVGSHGQ--------ELLMEGKGLTTFKNSHS 2760
            :...:|  :|:.|      |::::.....:...|:.|..|        .|.:..:|......:..
Mouse  2182 DGGYSQ--DISEG------RQLLIKAVNRVWTELIHSKKQVLEELFKVSLPVNDRGHVDIALARP 2238

  Fly  2761 VVELVMLLCSQEWQNSLQKHAGLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRM-------R 2818
            ::|...|.|   |||.|....     :.|:.|..|....:..:.||:  :.|.|:::       :
Mouse  2239 LIEEAGLKC---WQNHLAHEK-----KCISRGEALVPTTQSKLSRVS--SGFGLSKLTGSRRNRK 2293

  Fly  2819 ADDVLKHADFESQCAQTLLERREEER-MCDHLITAARRRDNVIASRLLEKVRNIMC---NRHGAW 2879
            ...:.||:....:.:|.:.......| :.|......:.|.......:.|:...|.|   ...|.|
Mouse  2294 ESGLHKHSPSPQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELLRERGLW 2358

  Fly  2880 GDSSSTSSGGAIVGA-VQKSPYWKLDAWEDDARRRKRMVQNPRGSSH----PQATLKAA------ 2933
            |..         :|: :.|   |.|:..|...|.||:||:|....:|    |:...:|:
Mouse  2359 GPP---------IGSHLDK---WMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQEASVGSEIP 2411

  Fly  2934 ---------------------------------LENGGP---EDAILQTRDEFHTQ--------- 2953
                                             |.:|.|   :|||:::.:...||
Mouse  2412 SKQPEPPDDVIAQKKPARYRRAISYDSKEYYLRLASGNPAIVQDAIVESSEGEATQQEPEHGEDT 2476

  Fly  2954 -----------IAVSRTHPSG--QHNGELLDD--AEL-LIEDRELDLDLTGPVNISTKARLIAPG 3002
                       :..||:.|.|  :...|.|.|  ||. .||:.|       ..:.:|..||:..|
Mouse  2477 IAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQIAESGSIEEEE-------KTDNATLLRLLEEG 2534

  Fly  3003 ------LVAPGTVSITSTEMFFEVDEEHPEFQKIDG----------EVLKYCDHLH--------- 3042
                  ........:.::|......:||  |..|||          ::.....::|
Mouse  2535 EKIQHMYRCARVQGLDTSEGLLLFGKEH--FYVIDGFTMTATREIRDIETLPPNMHEPIIPRGAR 2597

  Fly  3043 ----------GKWYFSEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKK--------VI 3089
                      ..:.:.:::.:..||||||.:|:|:|.....:.|.||  |..::.        |:
Mouse  2598 QGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAF--QKGIRNKVYQRFLAVV 2660

  Fly  3090 KALPRVGVGIKYGIPQT---RRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYND 3151
            .:|......:....|.|   :.:.::|  .|:...::||:|:|.|||||:|||.|||:|||:|||
Mouse  2661 PSLTDSSESVSGQRPNTSVEQGSGLLS--TLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYND 2723

  Fly  3152 LNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESWD--SDTIPPFHYG 3214
            |.|||:|||:|::|:|:::||:.|..:|:|:||:||....|.|.:::||:.|:  :...|.:|||
Mouse  2724 LMQYPVFPWILSDYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYG 2788

  Fly  3215 THYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQR-DTSDVKELIPEWYF 3278
            ||||:|....::|||:||||.:||.||||.||..||:|.||..:|.:..: :.:||||||||:::
Mouse  2789 THYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFY 2853

  Fly  3279 LPEMFYNSSGYRLGHREDGALVDDIELPPWAK-SPEEFVRINRMALESEFVSCQLHQWIDLIFGY 3342
            |||..:||:.:.||.:::|..:.|:.|||||| .|.||:|::|.|||.::||..||:||||||||
Mouse  2854 LPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGY 2918

  Fly  3343 KQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPR--SSAM 3405
            ||:||.|:.|.|||::|.|||.||:..:.||:...|....|.||||.|.||..:||||:  .|.:
Mouse  2919 KQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRL 2983

  Fly  3406 HLSPMMFSAMPEDLCQMLKFYQNSPVIHISANTYPQLSLP---------SVVTVTAGHQFAVNRW 3461
            :...:..|..|......: |:.:...:..|.....:|..|         .::.|..........|
Mouse  2984 NGDNIGISVPPGATSDKI-FFHHLDNLRPSLTPVKELKEPVGQIVCTDKGILAVEQNKVLIPPAW 3047

  Fly  3462 NCNYTASVQSPSYAESPQSPGSNQPLTIDPVLAVH-GTNNNSNAASRRHLGDNFSQML-KIRSNC 3524
            |..:     :..||:                |:.. ||..:..|.:.......:.|:| .:..|.
Mouse  3048 NKTF-----AWGYAD----------------LSCRLGTYESDKAVTVYECLSEWGQILCAVCPNP 3091

  Fly  3525 FVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCT 3589
            .:........:.| .|:........:...:.|.:.||...|||...|    .:...|.|||.|.|
Mouse  3092 KLVITGGTSTVVC-VWEMGTSKEKAKPLTLKQALLGHTDTVTCATAS----LAYHIIVSGSRDRT 3151

  Fly  3590 VLLWHWNA---RTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTFGD 3651
            .::|..|.   .||              |.||...|:::.|:...|.:||.:..
Mouse  3152 CIIWDLNKLSFLTQ--------------LRGHRAPVSALCINELTGDIVSCAGT----------- 3191

  Fly  3652 LLRSLDPPAEFHSPELITMSREGFIVINYDKGN--VAAYTINGKKLRHETHNDNLQCMLLSRDGE 3714
                                   :|.:....||  |:..|..|:       :..:.|..:|...|
Mouse  3192 -----------------------YIHVWSINGNPIVSVNTFTGR-------SQQIVCCCMSEMNE 3226

  Fly  3715 Y-----LMTAGDRGIVEVWR 3729
            :     ::|....|:|..||
Mouse  3227 WDTQNVIVTGHSDGVVRFWR 3246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rg	NP_001284879.1	Laminin_G_3	210..358	CDD:463865
		DUF4704	629..1123	CDD:464870	99/534 (19%)
		PspC_subgroup_2	<1433..1807	CDD:468202	84/488 (17%)
		DUF1088	2791..2972	CDD:461925	46/260 (18%)
		PH_BEACH	2996..3093	CDD:434260	25/139 (18%)
		Beach	3125..3401	CDD:460459	146/279 (52%)
		NBCH_WD40	3502..3774	CDD:466575	45/239 (19%)
		WD40 repeat	3524..3560	CDD:293791	3/35 (9%)
		WD40 repeat	3566..3617	CDD:293791	14/53 (26%)
		WD40 repeat	3622..3657	CDD:293791	5/34 (15%)
		WD40 repeat	3669..3699	CDD:293791	6/31 (19%)
		WD40 repeat	3704..3739	CDD:293791	8/31 (26%)
Wdfy3	XP_006535283.1	PH_BEACH	2535..2658	CDD:275391	21/126 (17%)
		Beach	2697..2977	CDD:460459	146/279 (52%)
		WD40 repeat	3046..3073	CDD:293791	8/47 (17%)
		WD40	<3067..3248	CDD:475233	45/240 (19%)
		WD40 repeat	3085..3126	CDD:293791	4/41 (10%)
		WD40 repeat	3132..3168	CDD:293791	14/53 (26%)
		WD40 repeat	3173..3210	CDD:293791	10/70 (14%)
		WD40 repeat	3217..3252	CDD:293791	8/30 (27%)
		FYVE_WDFY3	3450..3514	CDD:277259