Protein Alignment rg and WDFY4

DIOPT Version :10

• Sequence 1: NP_001284879.1
• Gene: rg / 44531
• FlyBaseID: FBgn0266098
• Length: 3785
• Species: Drosophila melanogaster
• Sequence 2: XP_054222398.1
• Gene: WDFY4 / 57705
• HGNCID: 29323
• Length: 3224
• Species: Homo sapiens
• Alignment Length: 3679
• Identity: 739/3679 - (20%)
• Similarity: 1226/3679 - (33%)
• Gaps: 1265/3679 - (34%)

  Fly   869 MIGNGVKEDELQSILNYLTTMHEDENLHDVLQMLISLMSEHPSS--------MVPAFDVKHGVRS 925
            ::.:|::.::|...        ||.|             |.|.|        :.|  ||.||.:|
Human    36 LLCHGMEAEDLSKA--------EDRN-------------EDPGSKNEGQLAAVQP--DVPHGGQS 77

  Fly   926 -----IFKLLAAESQLIRLQALKLLGFFLSRSTHKRKYDVMSP----HNLYTLLAERLLLYEESL 981
                 ::.:|  |.:.:..|.|          |||      ||    .:|.:||...|..:|.|:
Human    78 SSPTALWDML--ERKFLEYQQL----------THK------SPIERQKSLLSLLPLFLKAWEHSV 124

  Fly   982 SL---PTYNVLYEIMTEHISQQILYTRHPEPESHYRL--------------ENPMILKVVATLIR 1029
            .:   |:...|.|.:::.::||:......:|....||              :..::||.|..|..
Human   125 GIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQARLAAGQLLWWKGDVDQDGYLLLKSVYVLTG 189

  Fly  1030 QSKQT-------------------------------ESLIDVKKLFLQDMTLLCNSNRENRRTVL 1063
            ...:|                               ||.:.|:|:|:|.:..:| |:.:....:|
Human   190 TDSETLGRVAESGLPALLLQCLYLFFVFPLDKDELLESDLQVQKMFVQMLLNIC-SDSQGLEGLL 253

  Fly  1064 QMSVWQEWLIAMAYIHPKS---------------SEEQKISDMVY----SLFRMLLHHAIKHEYG 1109
            ..|..|..|||...:...|               |:.|.:|.:.|    ...|:.|.:..:
Human   254 SGSELQSLLIATTCLREHSCCFWKEPTFCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSR---- 314

  Fly  1110 GWRVWVDT-----------LAIVHSKVSYEEFKLQFAQMYEHYERQ--------RTDNIT----D 1151
                ..||           |.:...|.||......|.: :|:.|..        |.|.:|    |
Human   315 ----LTDTLPAPEVSEAVSLILGFVKDSYPVSSALFLE-FENSEGYPLLLKVLLRYDGLTQSEVD 374

  Fly  1152 PALRQARPI---STISGWEREEL----------------HQQQNG---GSAAAVATNQTAAVKGS 1194
            |.|.:...:   .|..|  |.||                |.:.:|   .:..|....|....|.|
Human   375 PHLEELLGLVVWLTTCG--RSELKVFDSITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKAS 437

  Fly  1195 VSIASLEDVPPV-------------VEEEVEELE--LEEVEIQEGPITEETEQ--KSVIANISDV 1242
            .|:..::.:..:             :|..::.:.  :|.:.::..|:.|...|  ::::..:..|
Human   438 DSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYV 502

  Fly  1243 YNEQLKTDATCNGNLEDVKEEEPVQQQIGDLEKQPEPSTPLGALRETLQL--GDDM------DVE 1299
            .:|.|:                .||..|   ::.|.||..|.||:..|.:  ||.:      |..
Human   503 PHEILR----------------KVQHLI---KESPGPSCTLMALQSILSIAGGDPLFTDIFRDSG 548

  Fly  1300 ELELATAKDALNAEQHVSR----------------------------VLQAS---EAALND---- 1329
            .|.|..|:  |..:..:.|                            :|:.|   ...|.|
Human   549 LLGLLLAQ--LRKQAKIMRKSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGMV 611

  Fly  1330 --CKMAVDD---------VLQESSSVLKDEEIELAVNEVVQGVLNNEKKTQSQDNKDNKEQPGEQ 1383
              .|:.:||         :|::.|::..:|.:.:.|..:.       ..||           ||.
Human   612 PFIKIFLDDECYREASLSILEQLSAINAEEYMSIIVGALC-------SSTQ-----------GEL 658

  Fly  1384 DVNVSLLNSKNLLNNNNNNNNNSPSPTPTTATATAETEAETEVNA---------NEIVSSTEAPK 1439
            .:.:.||  |:||.                ...|.:..|...|::         :::..|.:.|.
Human   659 QLKLDLL--KSLLR----------------ILVTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPP 705

  Fly  1440 AETETSVAPEVETPETAKPSPIVPSPVLATNQKTEDAANKLNNNEKLAE-------ISASPEPPI 1497
            .:...:|:|. :|.|....:....|..|..:........:....|||||       ..|..|...
Human   706 LQAWGAVSPR-QTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGN 769

  Fly  1498 VVET-------PEADLL--QLSDSETKPNKETEA------EDSVA---LAVR-DIVEQLIDK--- 1540
            ::.:       |.||||  ..|.|.:.|.:....      .||:|   |.:| |:.|.|..|
Human   770 LLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDLKESLRTKQGP 834

  Fly  1541 VIDATEAESASETKTETNNNEIPKKEKQTSE----------------------EPEDVETAETLA 1583
            |:|..:.|:.|:  .:.|..:.|..|::..|                      ..:..:.:|.:.
Human   835 VVDVQKGETGSD--PQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQLSEEIQ 897

  Fly  1584 AAAKEIVQEVVEAALVMVQEESTQEKPEKG------ANSEEEKNEIGK--EEILLQLEEKPASTE 1640
            .:....:|.:|::      |::.|...|.|      |:........|.  ...|:::.||.||..
Human   898 CSLASHIQSLVKS------EKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFEKLASQA 956

  Fly  1641 VQ------------------ETKI-----------------------EGDLKKPEDPKGHSSVEP 1664
            ::                  .|||                       ||......|...|..|..
Human   957 IEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAPDAGLHPGVTQ 1021

  Fly  1665 KTPNLEEPKPQETEQQKSQE-VAEELPQKPEEQVVAI---------------------VNQVLDT 1707
            ....|.|.:...|..|.:.. ::...|:..:.|..|:                     ::.|:.|
Human  1022 APQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLFIPTLSTVMGT 1086

  Fly  1708 LVDDTVKAVAAEQTTQTSPAP-----------------EEQSP--------QILAMESP--ATSV 1745
            ..:.:|........|:..|.|                 .|..|        .:...|.|  ..||
Human  1087 STEYSVSGGIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLARTEQPFVCFSV 1151

  Fly  1746 RVKPTEVDSTTQTTPKNEAGSSLLVEQVQQVLQEDDAQQSAGMTIEDEDYSNQQAAAAVENANSS 1810
            .:.|.::.....|..|.       .:.:..:..|||::.|||..::               ....
Human  1152 SLCPDDLSLVVSTEEKE-------FQPLDVMEPEDDSEPSAGCQLQ---------------VRCG 1194

  Fly  1811 QLDA----NHYG-PGNPESKQQQQRSKS------GSTRPMF---SPGPTRPPFRIPEFKWSYIHQ 1861
            ||.|    :|.. ....|.|:....|..      ||.:.::   .|||           :..:..
Human  1195 QLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALPGP-----------FLSMDP 1248

  Fly  1862 RLLSDVLFSLETDIQVWRSHSTKSVLDFVNSS---ENAIFVVNTVHLISQLADNLIIACGGLLPL 1923
            ....||...:.|. :||:..|  |::..:..:   |.|| .:.|:.:|::|....   ||....:
Human  1249 SAFVDVYGYIATP-RVWKQKS--SLIWRLGPTYLFEEAI-SMETLEVINKLGPRY---CGNFQAV 1306

  Fly  1924 LASATSPNSELD--VLEPTQGMPLEVAVSFLQRLVNMADVLIFATSLNFGELEAEKNMSSGGILR 1986
            .......:||..  |.|......|.:|.|   .:.::||:......::...:..|.|:||..
Human  1307 HVQGEDLDSEATPFVAEERVSFGLHIASS---SITSVADIRNAYNEVDSRLIAKEMNISSRD--- 1365

  Fly  1987 QCLRLVCTCAVRNCLECKERTRYNVGALARDVPGAAHLQALIRGAQASPKNIVESITGQLSPVKD 2051
               ..:....:|||......:...:||:|....|       :|...:||      ....|..:..
Human  1366 ---NAMPVFLLRNCAGHLSGSLRTIGAVAVGQLG-------VRVFHSSP------AASSLDFIGG 1414

  Fly  2052 PEKLL-------QDMDVNRLRAVIYRDVEETKQAQFLSLAIV-YFISVLMVSKYRDILEPPAEPQ 2108
            |..||       .|..:.....|::..:.......||...|. |.|...::.|...:|.
Human  1415 PAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLN------ 1473

  Fly  2109 IQRQSPVLQRTAG-------GEAASARPLFPQWSHHVYPQFLPESHQNHNSNMQ-----HQQQ-- 2159
             .|...::...||       ..|.:...:|    .|:...|  |...|...|::     |..:
Human  1474 -HRIFQLILSVAGTVELGFRSSAITNTGVF----QHILCNF--ELWMNTADNLELSLFSHLLEIL 1531

  Fly  2160 QQQQQQHQQQQHYYQQQQQQQVVHNHSHHHMTAAYYQQQQHQQVAAGQQQHSPTPLAT------- 2217
            |..::..:..:..:|.|...:::...:...:.                    |:.::|
Human  1532 QSPREGPRNAEAAHQAQLIPKLIFLFNEPSLI--------------------PSKISTIIGILAC 1576

  Fly  2218 -----HSTSS------------SASSTATSQPASSSSLS-SLASQSQQQ---------------- 2248
                 .||..            ..||....|.....:|. ||.:.||..
Human  1577 QLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLS 1641

  Fly  2249 --SHRQLHKQQQQQQQQQQQQQPHYHPHQPHYGLINGHQQ----------------HPQLNGKHY 2295
              |..|||...:.:::...:..|.:     ...|:.||..                .|.|..:.
Human  1642 VISSPQLHLSSESKEEMFLKLGPDW-----FLLLLQGHLHASTTVLALKLLLYFLASPSLRTRF- 1700

  Fly  2296 AENGSTAGYHPHSHPHPHGGYMRNGDTSTLQQNGMPDYQAVGLMNGHGSGGTGNNNNSSLMNN-- 2358
             .:|..||.............|.|    ...|:.:|: |:..|:.|.           .::|:
Human  1701 -RDGLCAGSWVERSTEGVDIVMDN----LKSQSPLPE-QSPCLLPGF-----------RVLNDFL 1748

  Fly  2359 ---------------------MRNLRNGGGANSSSSPPGS------------HQ--VIQ-GVATA 2387
                                 :..|.:|        |..|            ||  |:| |:.|.
Human  1749 AHHVHIPEVYLIVSTFFLQTPLTELMDG--------PKDSLDAMLQWLLQRHHQEEVLQAGLCTE 1805

  Fly  2388 GAV----NANAAVGVGMGGAVGVGMGGVAGGLDGGVVYKTSAINNNYRYNGR------------- 2435
            ||:    ...|.:...:.|:..   |..|......|:...|.::..|..:..
Human  1806 GALLLLEMLKATMSQPLAGSED---GAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIA 1867

  Fly  2436 ----NASAGTGGRQIQDSDYEIIVVDENNPSVLADNDSHSSGPPSIKANQTTTIATTTTTTATTH 2496
                .|..|.|....:::         ::|...|:.||      :::..|..|.|         |
Human  1868 AFPLGAQKGVGAESTRNT---------SSPEAAAEGDS------TVEGLQAPTKA---------H 1908

  Fly  2497 INNNNTKTTTSNAPTATIKIQQQPL--SPPKPLVPQKLPKSVDSDVGSLNMNSTENEVPEVESSS 2559
            ......:..|.      :.:::..|  |.||..:|.::......|      ::|..:..:.:  |
Human  1909 PARRKLREFTQ------LLLRELLLGASSPKQWLPLEVLLEASPD------HATSQQKRDFQ--S 1959

  Fly  2560 EILI------------------DDHKPSHSND----ESWTDVNLNEDAAVQAASAG--------I 2594
            |:|:                  |..:|..|.:    .|..:::......|:...:|        |
Human  1960 EVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHI 2024

  Fly  2595 VVGLVDN-----------RGNVISDKHDPSHH------NQQQQQQA------GIIGQQQQHGSLG 2636
            ::.::::           |..|:|..:...:.      ::.||..:      .|:|..|:|..:.
Human  2025 LLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVV 2089

  Fly  2637 HSERGDKPDSEISVV-------------RVPDGYGGAGSGGGVNSGQGQGVPSNQRPRP------ 2682
            .:..    :|.||.:             ..|:|:|                   ..|:|
Human  2090 FATY----NSNISFLLCLMHCLLLLNERSYPEGFG-------------------LEPKPRMSTYH 2131

  Fly  2683 --------------EELPMKAPA--------------LVAQLPLTTPSREASLTQKLEIALGPVC 2719
                          |:||..:..              ||||       |:.:|....:|.|. |.
Human  2132 QVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQ-------RQQTLEDAFKIDLS-VK 2188

  Fly  2720 PLLREIMV-DFAPFLSKTLVGSHGQELLMEGKGLTTFKN--SHSVVELVMLLCSQEWQNSLQKHA 2781
            |..||:.: :..|...:|::.:....|..|.|.|.:..|  .||.|.|        |..|
Human  2189 PGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTL--------WSGS----- 2240

  Fly  2782 GLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRMRADDVLKHADFESQCAQTLLERREE---E 2843
                         ||.|||           .:..|...|...|..||.| |.:....|.:|   .
Human  2241 -------------LSSAMK-----------LMPGRQAKDPECKTEDFVS-CIENYRRRGQELYAS 2280

  Fly  2844 RMCDHLITAARRRDNVIASRLLEKVRNIMCNRHGAWGDSSSTSSGGAIVGAVQKSPYWKLDAWED 2908
            ...||:  ..|:..|:.|:....:::..:....|.|.....|.         ..|| |:||..|.
Human  2281 LYKDHV--QRRKCGNIKAANAWARIQEQLFGELGLWSQGEETK---------PCSP-WELDWREG 2333

  Fly  2909 DARRRKRM-----------------------VQNPRGSSHPQATLKAALENGGPEDAILQTRDEF 2950
            .||.|||:                       :......:..:.||:.|  .|.|::..:..
Human  2334 PARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREA--EGEPDEVGVDC---- 2392

  Fly  2951 HTQIAVSRTHPSGQHNGELLDDAELLIEDRELDL-DLTGPVNISTKARL-IAPG-LVAPGTVSIT 3012
             ||:..........|:.:.|:    |..:|::.| :|.....::.|..| |..| ||:.|.:
Human  2393 -TQLTFFPALHESLHSEDFLE----LCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVL--- 2449

  Fly  3013 STEMFFEVDEEHPEFQKIDGEVLK-----YC-----------------------DHLHGKWY-FS 3048
               :|     .|..|...:...|.     ||                       ||...:.: ::
Human  2450 ---LF-----GHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYA 2506

  Fly  3049 EVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIKALPRVGVGIKYGIPQTRRASMMS 3113
            ::|.:...|:|||::|||||..:..|....|.:... .|..|:.......:|      .:|:...
Human  2507 DMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDR-SKAFKSFCSFQPSLK------GKATSED 2564

  Fly  3114 PRQLMR----NSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSL 3174
            ...|.|    :..|.||||:|:||||||||:|||.||||.||..|||:|||||.:|.|:.|:|:.
Human  2565 TLNLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLAN 2629

  Fly  3175 PSNYRDLSKPIGALNPSRRAYFEERY---ESWDSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTM 3236
            |..:||||||:||....|:..|.:|:   |..:.|.....||.||||:|....::|||:.|||..
Human  2630 PKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQA 2694

  Fly  3237 FLALQGGKFDYPDRLFSSVSLSWKNCQRDT-SDVKELIPEWYFLPEMFYNSSGYRLGHREDGALV 3300
            |.|||||.||..||:|.||..:|::..|:. |||:||.||:::|||...|.:|...|..:||.::
Human  2695 FCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVL 2759

  Fly  3301 DDIELPPWAK-SPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGS 3364
            .|::|||||. .|.:|:.::|.||||:|||..||.||||||||||:||.|:.|.|:|:...|...
Human  2760 GDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDR 2824

  Fly  3365 VDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHLSPMMFSAMPEDLCQMLKFYQNS 3429
            :||..:.||:::..:...:.||||.|.||..:|||.|::|....|....:.|
Human  2825 MDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTP------------- 2876

  Fly  3430 PVIHISANTYPQ---LSL----PSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSNQPL 3487
                :|...:||   .||    ||.|||...:.|::.               :|||:....:...
Human  2877 ----VSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLG---------------SESPKGAIGHIVS 2922

  Fly  3488 TIDPVLAVHGTNNNSNAASRRHLG---DNFSQML------KI-----------RSNCFV----TT 3528
            |...:|||............|...   |:||..|      |:           |..|.|    ||
Human  2923 TEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTT 2987

  Fly  3529 V--DSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCTVL 3591
            :  .....:.| .|:.|.........::.|.::||...|||:|.|    .:...:.|||.|||.:
Human  2988 IVTSGTSTVVC-VWELSMTKGRPRGLRLRQALYGHTQAVTCLAAS----VTFSLLVSGSQDCTCI 3047

  Fly  3592 LWHWNARTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTTFGDLLRSL 3656
            ||           :.|..|....|..|.:.::::.||...|.:||.:.
Human  3048 LW-----------DLDHLTHVTRLPAHREGISAITISDVSGTIVSCAG----------------- 3084

  Fly  3657 DPPAEFHSPELITMSREGFIVINYDKGNVAAYTINGKKLRHET----HNDNLQCMLLSR-----D 3712
                                      .:::.:.:||:.|...|    ....:.|..|..     .
Human  3085 --------------------------AHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDT 3123

  Fly  3713 GEYLMTAGDRGIVEVWRT-----------------------------FNLA-------------- 3734
            .:.::|....|:|.||:|                             .|||
Human  3124 SQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPLAQPPSPRGHKWEKNLALSRELDVSIALTGK 3188

  Fly  3735 PLYAFPACNAGIRSLALTHDQKYLLAGLSTGSIIVFHID 3773
            |....||    :.:||::.:...||.|...|.|..:..|
Human  3189 PSKTSPA----VTALAVSRNHTKLLVGDERGRIFCWSAD 3223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rg	NP_001284879.1	Laminin_G_3	210..358	CDD:463865
		DUF4704	629..1123	CDD:464870	66/348 (19%)
		PspC_subgroup_2	<1433..1807	CDD:468202	90/522 (17%)
		DUF1088	2791..2972	CDD:461925	42/206 (20%)
		PH_BEACH	2996..3093	CDD:434260	28/127 (22%)
		Beach	3125..3401	CDD:460459	140/280 (50%)
		NBCH_WD40	3502..3774	CDD:466575	65/350 (19%)
		WD40 repeat	3524..3560	CDD:293791	8/41 (20%)
		WD40 repeat	3566..3617	CDD:293791	15/50 (30%)
		WD40 repeat	3622..3657	CDD:293791	5/34 (15%)
		WD40 repeat	3669..3699	CDD:293791	3/29 (10%)
		WD40 repeat	3704..3739	CDD:293791	12/82 (15%)
WDFY4	XP_054222398.1	PH_BEACH	2428..2552	CDD:275391	29/135 (21%)
		Beach	2580..2861	CDD:460459	140/280 (50%)
		WD40	<2942..3140	CDD:475233	49/256 (19%)
		WD40 repeat	2977..3020	CDD:293791	8/43 (19%)
		WD40 repeat	3026..3062	CDD:293791	15/50 (30%)
		WD40 repeat	3067..3101	CDD:293791	8/76 (11%)
		WD40 repeat	3111..3162	CDD:293791	8/50 (16%)