DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment rg and Nbeal2

DIOPT Version :9

Sequence 1:NP_001284879.1 Gene:rg / 44531 FlyBaseID:FBgn0266098 Length:3785 Species:Drosophila melanogaster
Sequence 2:NP_899099.2 Gene:Nbeal2 / 235627 MGIID:2448554 Length:2750 Species:Mus musculus


Alignment Length:2342 Identity:561/2342 - (23%)
Similarity:870/2342 - (37%) Gaps:711/2342 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1621 NEIGKEEILLQLEEKPASTEVQETKIEG------DLKKPEDPKGHSSVEPKTPNLEEPKPQETEQ 1679
            |.:|...:||.|.|:.|   ||..:.|.      ||..||...|.:     |..|..|..:.:|.
Mouse   886 NCVGGMGVLLPLLERVA---VQPQEAEAGPCETHDLVGPELTSGRN-----TQGLLLPLGKSSED 942

  Fly  1680 QKSQEVAEELPQKPEEQVVAIVNQVLDTLVDDTVKAVAAEQTTQTSPAPEEQSPQILAMESPATS 1744
            :..:..           |.|.:..:.:.|.:.||...:..|.         |.|.|         
Mouse   943 RMERNA-----------VAAFLLMLRNFLQNHTVNQESLVQC---------QGPAI--------- 978

  Fly  1745 VRVKPTEVDSTTQTTPKNEAGSSLLVEQVQQVLQEDDAQQSAG----------------MTIEDE 1793
                   :.:..:..|.:....::|:.  .|:|.|..|....|                .|:.| 
Mouse   979 -------IGALLRKVPSSAMDMNVLMS--AQLLMEQAAADGGGPLLYLLYQHLLFNFHLWTLSD- 1033

  Fly  1794 DYSNQQAAAAVENANSSQLDANHYGPGNPESKQQQQRSKSG------STRPMFSPGPTRPPFRIP 1852
                    .||      :|....|........:|:.|.|.|      :.|..:||...||     
Mouse  1034 --------FAV------RLGHIQYMSSMVREHRQKLRKKYGVQFLLDALRTHYSPQRERP----- 1079

  Fly  1853 EFKWSYIHQRLLSDVLFSLETDIQ------VWRSHSTKS---VLDFVNSSENAIFVVNTVHLI-- 1906
                      |.:|.|.:::|.:.      :.|:.|.:.   ||:|:.::.:...||.|:.|:  
Mouse  1080 ----------LAADDLRTVQTSLLGLVREFLVRNFSVEDMQVVLNFLAATGDDGQVVGTLELLLT 1134

  Fly  1907 ----SQLADNL---IIACGGLLPLLASATSPNSELDVLEPTQGMPL--EVAVSFLQRLVNMADVL 1962
                |.:.|.|   ::..|.|..|||....|.|          .||  :.....|:||..     
Mouse  1135 LLQGSPVQDPLAAFLLELGNLEVLLALLVRPKS----------TPLLTDRVCKILRRLQQ----- 1184

  Fly  1963 IFATSLNFGELEAEKNMSSGGILRQCLRLVCTCAVRNCLECKERTRYNVGALARDVPGAAHLQAL 2027
                    .|...|:|       ||.:||      .:|                   |...|.|.
Mouse  1185 --------NERLPERN-------RQRIRL------HDC-------------------GLQGLVAS 1209

  Fly  2028 IRGAQASP---KNIVESITGQLSPVKDPEKLLQDMDVNRLRAVIYRDVEETKQAQF-LSLAIVYF 2088
            :.....||   :.:.:...|.:..|..|:.|    :::.|.||:...::.....:. :...:.|.
Mouse  1210 LSEESISPQLCQGLYKLFVGTVPQVVSPDCL----NLSDLLAVVQLSLQADLSVRLDICRQLFYL 1270

  Fly  2089 ISVLMVSKYRDILEPPAEPQIQRQSPVLQRTAGGE-----------AASARPLFPQWSHHVYPQF 2142
            |.              .:|.:.|   :|.|.||.:           |..:.|          |:|
Mouse  1271 IY--------------GQPDVVR---LLARQAGWQDVLTRLYVLEAATDSSP----------PRF 1308

  Fly  2143 LPESHQNHNSNMQHQQQQQQQQQHQQQQHYYQQQQQQQVVHNHSHHHMTAAYYQQQQHQQVAAGQ 2207
            |||                                                              
Mouse  1309 LPE-------------------------------------------------------------- 1311

  Fly  2208 QQHSPTPLATHSTSSSASSTATSQPASSSSLSSLASQSQQQSHRQLHKQQQQQQQQQQQQQPHYH 2272
                 .|:   |:..:.|...|..||.||.:                                  
Mouse  1312 -----LPI---SSELALSPPPTELPADSSDV---------------------------------- 1334

  Fly  2273 PHQPHYGLINGHQQHPQLNGKHYAENGSTAGYHPHSHPHPHGGYMRNGDTSTLQQNGMPDYQAVG 2337
                                           :.|...|.|        |.....|...|......
Mouse  1335 -------------------------------FLPSESPCP--------DQDAFYQALSPFSTPFD 1360

  Fly  2338 LMNGHGSGGTGNNNNSSLMNNMRNLRNGGGANSSSSPPGSHQVIQGVATAGAVNANAAVGVGMGG 2402
            |.....|.|:||.             .|||:::.:..|.|..                       
Mouse  1361 LGLERASIGSGNT-------------AGGGSSNGTVTPASQP----------------------- 1389

  Fly  2403 AVGVGMGGVAGGLDGGVVYKTSAINNNYRYNGRNASAGTGGRQIQDSDYEIIVVDENN---PSVL 2464
                   |....|||...:.|:        .||::|:.:.            |:::.:   |::.
Mouse  1390 -------GTPSPLDGPRPFPTA--------QGRHSSSLSN------------VLEDGSLLEPNIS 1427

  Fly  2465 ADNDSHSSGPPSIKANQTTTIATTTTTTATTHINNNNTKTT-----------TSNAPTATIKIQQ 2518
            .|:.|::|.|......:...:.|....:.|......:.:..           |....:||:    
Mouse  1428 GDDTSNTSNPQQTPEEELCNLLTNVLFSVTWRGVEGSAEAAWRERGQVFSVLTQLGASATL---- 1488

  Fly  2519 QPLSPP---KPLVPQKLPKSVDSDV-----GSLNMNSTENEVPEVESSSEILIDDHKPSHSNDES 2575
              :.||   |..:.:.:.:|..:|:     |.| .|.::..:..:....:.|..:   .|.|.|.
Mouse  1489 --VRPPDCIKRSLLEMMLESALTDIKEAPPGGL-ANLSQQALWLLRLLQDFLCAE---GHGNQEL 1547

  Fly  2576 WTDVNLNEDAAVQAASAGIVVGLVDNRG------NVISDKHDPSHHNQQQQQQAG---IIGQQQQ 2631
            |:: .|.|.          |..|:|..|      |..:|        .::..|.|   ::|....
Mouse  1548 WSE-KLFEG----------VCNLLDRLGAWPHLANSTAD--------LREMAQIGLRLVLGYILL 1593

  Fly  2632 HGSLGHSERGDKPDSEISVVRVPDGYGGAGSGGGVNSGQGQGVPSNQRPRPEELPMKAPALVAQL 2696
            .....|::...|..:.:..                      .||:    |.||.......|.|.|
Mouse  1594 EDPQLHAQAYVKLHTLLQT----------------------AVPT----RREEACYVLSKLEAAL 1632

  Fly  2697 --PLTTPSREASLTQKLEIALGPVCPLLREIMVDFAPFLSKTLVGSHGQELLMEG-KGLTTFKNS 2758
              .|||.|.|.. .....:|....|..|       .|.:...|..::|...|..| ..|.....|
Mouse  1633 SRALTTSSSETE-HASTAVAASERCSWL-------VPLVRTLLDRAYGPLGLQWGLPSLPPTNGS 1689

  Fly  2759 HSVVELVMLLC-SQEWQNSLQKHAGLAFIELINEGRLLSHAMKDHIVRVANEAEFILNRMRADDV 2822
            .:..|.....| :.||::.:.|                             :.:..:::...|..
Mouse  1690 PTFFEDFQAFCATAEWRHFIDK-----------------------------QVQPTMSKFEMDTY 1725

  Fly  2823 LKHAD----FESQCAQTLL---ERREEERMCDH------LITAARRRDNVIASRLLEKVRNIMCN 2874
            .|..|    |.:.|..||:   :|.:.:|:...      ::..|:||..|...|....::.....
Mouse  1726 AKSHDLMSGFWNACYDTLMSSGQRHQRDRIQSRRAFKELVLEPAQRRARVEGLRYASVLKQQAAQ 1790

  Fly  2875 RHGA---WGD--SSSTSSGGAIVGAVQKSPYWKLDAWEDDARRRKRMVQNPRGSSHPQATLKAAL 2934
            ...|   ||.  ...:|..||....:..:|:|||.:.|..:|.|.::|.|.....|.:|:  |..
Mouse  1791 HSTALLHWGALWRQLSSPCGAWALRIPPAPHWKLSSAETYSRMRLKLVPNHHFDPHLEAS--ALR 1853

  Fly  2935 ENGGPEDAILQTRDEFHTQIAVSRTH---------PSGQHNGELLDDAELLIED-RELDLDLTGP 2989
            :|.|  :|.:...:|....:||::..         |..|...|.|...|.|:|: .||| :....
Mouse  1854 DNLG--EAPMTPTEETSLPLAVTKEAKISAPPEELPEEQLGEEDLAALESLMEEAAELD-EKREK 1915

  Fly  2990 VNISTKARLIAPGLVAPGTVSITSTEM-FFEVDEEHPEFQKIDGEVLKYCDHLHGKWYFSEVRAI 3053
            :.:|.:.:|:....|.||.:.||:..: |::...|..|.::..|...:.        ..:::|.:
Mouse  1916 LVLSAECQLVTVVAVVPGLLEITTQHVYFYDGSTERVETEEGIGHDFRR--------PLAQLREV 1972

  Fly  3054 FSRRYLLQNVALEIFLASRTSILFAFPDQHTVKKVIK--ALPRVGVGIKYGIP---QTRR----- 3108
            ..||:.|:..|||:|...:::....||.:........  ..||..:   |.||   |.|.     
Mouse  1973 HLRRFNLRRSALELFFIDQSNYFLNFPHKVAASSASSPCQAPRPQL---YPIPSHTQLRNQVYSL 2034

  Fly  3109 -----------ASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVL 3162
                       .|..||.:::|.|.:||||.:||||||||||.||||||||||||:|||:|||||
Mouse  2035 LLRLRPPTQGYLSSRSPLEMLRASGLTQKWVQREISNFEYLMQLNTIAGRTYNDLSQYPVFPWVL 2099

  Fly  3163 TNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESWD--SDTIPPFHYGTHYSTAAFTLN 3225
            .:|.|..||||.|:.:||||||||.:||.......|:|||::  :.||..||||||||.||..::
Mouse  2100 QDYVSPVLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYESFEDPAGTIDKFHYGTHYSNAAGVMH 2164

  Fly  3226 WLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYR 3290
            :|:||||||::.:.||.|:||..||.|.||:.:|:......:||||||||:::.|:...|.:|:.
Mouse  2165 YLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAAWQARLESPADVKELIPEFFYFPDFLENQNGFD 2229

  Fly  3291 LGHRE-DGALVDDIELPPWAKSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATN 3354
            ||..: ....|.|:.|||||.|||:|::.:|.|||||:||..||:|||||||||||||.|..|.|
Mouse  2230 LGCLQLTNEKVGDVVLPPWAGSPEDFIQKHRQALESEYVSTHLHEWIDLIFGYKQRGPAAEEALN 2294

  Fly  3355 VFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHL----------SP 3409
            ||||.||||:||||.|.|...|:|:|..|.||||||.|||.||||||.||...          ||
Mouse  2295 VFYYCTYEGAVDLDHVADERERKALEGIISNFGQTPCQLLKEPHPPRLSAEEAANRLARLDTNSP 2359

  Fly  3410 MMFSAMPEDLCQMLKFY-----QNSPVI-----HISANTY-PQLSLPSVVTVTAGHQFAVNRW-- 3461
            .:|    ::|.|:..|:     :..|::     |..:::: .|.|...:|||:|......:.|  
Mouse  2360 SIF----QNLNQLKAFFAEVVSEAVPLVLALVPHRQSHSFITQSSSDMLVTVSASGLLGTHTWLP 2420

  Fly  3462 ---NC-NYTASVQSPSYAESPQSPGSNQPLTIDPVLAVHGTNNNSNAASRRHLGDNFSQMLKIRS 3522
               |. ||....:.|:.. ||:.    |.|...|.::..|                      :.:
Mouse  2421 YDRNINNYFTFSKDPTMG-SPKV----QKLLSGPWVSDSG----------------------VSA 2458

  Fly  3523 NCFVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSAD 3587
            .......|.:.|.:.|.||.|.||.:....:::..:..|..:|||:|...|.|    |:.|||.|
Mouse  2459 QALAVAPDGKLLFSGGHWDGSLRVTSLPRGRLLNQLSRHLDIVTCLALDTCGI----YLISGSRD 2519

  Fly  3588 CTVLLWHWNARTQSIVGEGDVPTPRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHTT-FGD 3651
            .|.::  |....||.:..|..|.|...|.||..||:.|.||.||.:.||||.:|.|:|||. .|.
Mouse  2520 TTCMV--WRLLQQSGLSAGLAPKPVQVLYGHVAAVSCVAISTELDMAVSGSEDGTVIIHTVRRGQ 2582

  Fly  3652 LLRSLDPP-AEFHSP-ELITMSREGFIV------------INYDKGNVAAYTINGKKLRHETHND 3702
            .:.:|.|| |....| ..:.:..||.||            :.|   ::..|::||:.....|..:
Mouse  2583 FVAALRPPGATLPGPISHLALGAEGQIVVQSSACERPGAQVTY---SLHLYSVNGRLRASVTLTE 2644

  Fly  3703 NLQCMLLSRDGEYLMTAGDRGIVEVWRTFNLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSI 3767
            ....:.::.|...|.||  :..:.:.....|.|..........:.|:::|.::.::|.||..|.:
Mouse  2645 QPTALTVAEDFVLLGTA--QCSLHILHLNKLRPAVPPLPMKVPVHSVSVTKERSHVLVGLEDGKL 2707

  Fly  3768 IV 3769
            ||
Mouse  2708 IV 2709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rgNP_001284879.1 LamG 210..358 CDD:304605
DUF4704 634..918 CDD:292415
MARCKS 1434..1751 CDD:280269 28/135 (21%)
DUF1088 2791..2972 CDD:284000 42/207 (20%)
PH_BEACH 2996..3093 CDD:291510 20/99 (20%)
Beach 3125..3401 CDD:280327 165/278 (59%)
WD40 repeat 3524..3560 CDD:293791 8/35 (23%)
WD40 <3526..3729 CDD:295369 65/217 (30%)
WD40 <3530..3773 CDD:225201 75/255 (29%)
WD40 repeat 3566..3617 CDD:293791 18/50 (36%)
WD40 repeat 3622..3657 CDD:293791 16/35 (46%)
WD40 repeat 3669..3699 CDD:293791 8/41 (20%)
WD40 repeat 3704..3739 CDD:293791 6/34 (18%)
Nbeal2NP_899099.2 DUF4704 876..1125 CDD:292415 59/314 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1319..1340 7/85 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1363..1441 23/140 (16%)
DUF4800 1590..1856 CDD:292675 62/330 (19%)
PH_BEACH 1914..2039 CDD:275391 28/135 (21%)
Beach 2062..2341 CDD:280327 165/278 (59%)
WD 1 2382..2420 8/37 (22%)
WD 2 2444..2487 11/64 (17%)
WD40 <2459..2709 CDD:225201 73/260 (28%)
WD40 repeat 2459..2496 CDD:293791 8/36 (22%)
WD40 2460..>2614 CDD:295369 56/159 (35%)
WD 3 2490..2527 14/42 (33%)
WD40 repeat 2502..2547 CDD:293791 18/50 (36%)
WD 4 2540..2578 19/37 (51%)
WD40 repeat 2552..2588 CDD:293791 16/35 (46%)
WD 5 2585..2627 10/44 (23%)
WD40 repeat 2627..2666 CDD:293791 8/40 (20%)
WD 6 2635..2670 5/36 (14%)
WD 7 2678..2713 8/32 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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