Protein Alignment rg and nbeal1

DIOPT Version :10

• Sequence 1: NP_001284879.1
• Gene: rg / 44531
• FlyBaseID: FBgn0266098
• Length: 3785
• Species: Drosophila melanogaster
• Sequence 2: XP_002937765.2
• Gene: nbeal1 / 100494980
• XenbaseID: XB-GENE-990549
• Length: 2716
• Species: Xenopus tropicalis
• Alignment Length: 1174
• Identity: 384/1174 - (32%)
• Similarity: 555/1174 - (47%)
• Gaps: 246/1174 - (20%)

  Fly  2707 LTQKLEIALGPVCPLLREIMVDFAPFLSKTLVGSHGQELLM--EGKGLTTFKNSHSVVELVMLLC 2769
            |..|||..||.......|......|.: :|||....|.|.|  ....|.....:.|:.|.....|
 Frog  1644 LLGKLEGILGKSIKEKTETYSFLIPIV-RTLVSKIYQLLFMHLHLPSLPITNGNPSLFEDFQEYC 1707

  Fly  2770 -SQEWQNSLQKHAGLAF--IELINEGRLLSHAMKDHIVRVANEAEFI----LNRMRADDVLKHAD 2827
             |.||:..:.|:..|..  .|:...|:  .|.......:...||:.:    ..|.|.:..||..:
 Frog  1708 NSDEWRIFIDKYIILYMKQYEVDTFGK--CHEQMATYWKECYEAQMVNMHKRERERGESKLKFKE 1770

  Fly  2828 FESQCAQTLLE-----RREEERMCDHLITAARRRDNVIASRLLEKVRNIMCNRHGAWGDSSSTSS 2887
            |       .||     .|:|....::::.....:......:.....|.:.|.| |.|.|..
 Frog  1771 F-------FLEPFNRKTRQENSRYNNMLKQVNSQYTATLRQWKAAQRYLFCER-GPWADRK---- 1823

  Fly  2888 GGAIVGAVQKSPYWKLDAWEDDARRRKRMVQNPRGSSHPQATLKAALENGGPEDAILQTRDEFHT 2952
                    :...||||...|:.:|.|.::|||....:|.:|   :||            ||
 Frog  1824 --------ENWQYWKLSTVENYSRMRLKLVQNLNFDAHLEA---SAL------------RD---- 1861

  Fly  2953 QIAVSRTHPSGQHNGELLDDA-ELLIEDRELD-LDLTGPVNI-----------------STKARL 2998
            .:.|.:|.||.:  ..||:.| ::.:.|.|.| |:|....|:                 |.:..|
 Frog  1862 NLGVQQTEPSSE--SLLLEAAKQVKVSDLEEDQLELPEEENVVNMNDKEEQIQKEKLVLSEECDL 1924

  Fly  2999 IAPGLVAPGTVSITSTEMFFEVDEEHPEFQKIDGEVLKYCDHLHG-----KWYFSEVRAIFSRRY 3058
            |.......|.:.:|:..::|           .||...|.    .|     ||..|::|.|..|||
 Frog  1925 ITVMDAISGHLEVTTQHIYF-----------YDGSTEKE----EGVGFDFKWPLSQIREIHLRRY 1974

  Fly  3059 LLQNVALEIFLASRTSILFAFPDQHTVKKVIK----------ALPRVGVGIKYGIPQTRRASMMS 3113
            .|:..||||||..:|:....|      ||.::          .||.:     ||   ||     |
 Frog  1975 NLRRSALEIFLIDQTNYFLNF------KKEVRNKVYSRILSLRLPNI-----YG---TR-----S 2020

  Fly  3114 PRQLMRNSNMTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNY 3178
            |::|::.|.:||||..||||||:||:.||||||||||||.|||:|||||.:|.|::|||:.|:.:
 Frog  2021 PQELLKASGLTQKWVNREISNFDYLIQLNTIAGRTYNDLAQYPVFPWVLQDYTSEELDLNNPAVF 2085

  Fly  3179 RDLSKPIGALNPSRRAYFEERYESWDS--DTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQ 3241
            ||||||||.:|....|..:::|||::.  .||..||||||||.||..:::|:||||:||:.:.||
 Frog  2086 RDLSKPIGVVNEKNAAIVKDKYESFEDPLGTIDKFHYGTHYSNAAGVMHYLIRVEPYTTLHIQLQ 2150

  Fly  3242 GGKFDYPDRLFSSVSLSWKNCQRDTSDVKELIPEWYFLPEMFYNSSGYRLGH----REDGALVDD 3302
            .|:||..||.|.|:..:|:....:.:||||||||:::.||...|.:|:.|||    :|.   |:|
 Frog  2151 SGRFDCADRQFHSIPATWQALMDNPNDVKELIPEFFYFPEFLENKNGFDLGHLQITKEQ---VND 2212

  Fly  3303 IELPPWAKSPEEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDL 3367
            :.||.||||||:|:..:|.||||||||..||:|||||||||||||.||.|.|||||.||||:|||
 Frog  2213 VILPKWAKSPEDFILKHRKALESEFVSAHLHEWIDLIFGYKQRGPAAIEALNVFYYCTYEGAVDL 2277

  Fly  3368 DGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHLSPMMFSAMPEDLCQMLKFYQNSPVI 3432
            |.:.:...|:|:|..|.||||||.|||.||||.|.||..:                 :.:.|.:.
 Frog  2278 DAIANEKERKALEGMINNFGQTPCQLLKEPHPTRLSAEEV-----------------YLKQSKLD 2325

  Fly  3433 HISANTYPQL-------------SLPSVVTVTAGHQFAVNRWNCNYTASVQSPSYAESPQSPGSN 3484
            :::.|.:..|             .:|.|..:...:|.                   .|..||||.
 Frog  2326 NVTLNLFQNLPDLKSFFIEGISDDVPVVKAIVPKNQL-------------------RSFLSPGSP 2371

  Fly  3485 QPL-TIDPVLAV--HG------TNNN----------SNAASRRHLGDNFSQMLKIRSNCFVTTVD 3530
            :.| |:...|.:  ||      |.:|          :|..::|.:...|:..|:|.|..||.:.|
 Frog  2372 ELLVTVSQTLIIGTHGWLPYDRTISNYFTFSKDQTVTNPKTQRLVSGPFAPGLEITSKLFVVSHD 2436

  Fly  3531 SRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMARSECNITSDCYIASGSADCTVLLWHW 3595
            .:.|.:.|.||||.||.:....|:......|..:|||::...|.|    ::.|||.|.|.::|.
 Frog  2437 GKVLFSGGHWDNSIRVTSLTKGKVTSQHIRHMDIVTCLSTDFCGI----HLISGSRDTTCMIWQ- 2496

  Fly  3596 NARTQSIVGE--GDVPT-PRATLTGHEQAVTSVVISAELGLVVSGSSNGPVLIHT-TFGDLLRSL 3656
                   :|:  ||:.: |...|.||...:|||.||.||...|||:.:|.|:||| ..|..:|:|
 Frog  2497 -------IGQQGGDLSSKPLQILYGHTDEITSVCISTELDTAVSGAKDGAVIIHTIRRGQYVRTL 2554

  Fly  3657 DPPAE----FHSPELITMSREGFIVIN--------YDKGNVAAYTINGKKLRHETHNDNL--QCM 3707
            .||:|    ...|.| .||.:|.|||:        .:|..:..|:||||.|..|...:.:  .|:
 Frog  2555 KPPSESSLLMSIPNL-AMSLDGHIVIHSSIEGKSIKNKNALHLYSINGKYLVSELLKEQVTDMCI 2618

  Fly  3708 LLSRDGEYLMTAGDRGIVEVWRTF----NLAPLYAFPACNAGIRSLALTHDQKYLLAGLSTGSII 3768
            :    .|.::....:|.:.:...:    :|.||    .....|..:::|.:..::|.||..|.:|
 Frog  2619 I----SENIVLGSRQGFLSIRDLYSLNLSLTPL----VMRVPIHCVSVTKENSHILVGLEDGKLI 2675

  Fly  3769 VFHI 3772
            :..|
 Frog  2676 IVGI 2679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rg	NP_001284879.1	Laminin_G_3	210..358	CDD:463865
		DUF4704	629..1123	CDD:464870
		PspC_subgroup_2	<1433..1807	CDD:468202
		DUF1088	2791..2972	CDD:461925	41/189 (22%)
		PH_BEACH	2996..3093	CDD:434260	28/111 (25%)
		Beach	3125..3401	CDD:460459	163/281 (58%)
		NBCH_WD40	3502..3774	CDD:466575	88/293 (30%)
		WD40 repeat	3524..3560	CDD:293791	12/35 (34%)
		WD40 repeat	3566..3617	CDD:293791	15/53 (28%)
		WD40 repeat	3622..3657	CDD:293791	17/35 (49%)
		WD40 repeat	3669..3699	CDD:293791	13/37 (35%)
		WD40 repeat	3704..3739	CDD:293791	6/40 (15%)
nbeal1	XP_002937765.2	DUF4704	888..>1159	CDD:464870
		DUF4800	1610..1863	CDD:464996	59/260 (23%)
		PH_BEACH	1914..2011	CDD:275391	29/117 (25%)
		Beach	2031..2311	CDD:214982	164/282 (58%)
		NBCH_WD40	2374..2682	CDD:466575	95/327 (29%)
		WD40 repeat	2472..2514	CDD:293791	15/53 (28%)
		WD40 repeat	2519..2556	CDD:293791	18/36 (50%)
		WD40 repeat	2564..2592	CDD:293791	8/28 (29%)