DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rg and nbeal1

DIOPT Version :9

Sequence 1:	NP_001284879.1	Gene:	rg / 44531	FlyBaseID:	FBgn0266098	Length:	3785	Species:	Drosophila melanogaster
Sequence 2:	XP_021332659.1	Gene:	nbeal1 / 100332617	ZFINID:	ZDB-GENE-130530-544	Length:	2723	Species:	Danio rerio

Alignment Length:	1582	Identity:	447/1582 - (28%)
Similarity:	677/1582 - (42%)	Gaps:	371/1582 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2372 SSPPGSHQVIQGVATAGAVNANAAVGVGMGGAVGVGMGGVAGGLDGGVVYKTSAINNNYRYNGRN 2436
            |.|..:.|:.:.|...|.:........|..|..|.|.....|.|:
Zfish  1288 SQPDAALQISKQVCWQGTLMRLFVRSPGSDGGSGRGDAASLGSLE-------------------- 1332

  Fly  2437 ASAGTGGRQIQ---------DSDYEIIVVDENNPSVLADNDSHSSGPPSIKANQTTTIATTTTTT 2492
            .|..:||.:::         ||   :..::|...||   :||.     ||.:.....:.:.:.|.
Zfish  1333 LSRSSGGNRLEPPLERRPLGDS---VNRLNEERDSV---SDSR-----SIDSLDNGELMSLSDTP 1386

  Fly  2493 ATTHINNNNTKTTTSNAPTATIKIQQ------------QPLSPPKPLVPQK-LP--KSVDSD--- 2539
            ...|    ..||....|...::.:.|            ...|.|.||...| .|  .|::.|
Zfish  1387 VEAH----TPKTWPGKAGVLSLDLSQLDRGDSGSQTPGSMQSTPSPLENAKPFPGASSLNDDNFL 1447

  Fly  2540 ------VG-SLNMNSTENEVPEVESSSEILIDDHKPSHSNDESWTDVNLNEDAAVQAASAGIVV- 2596
                  :| |.|...||.|:..|.....:.:.......|:|.:|.|......|..:..:|..::
Zfish  1448 FSDNVSLGESFNSERTEEELSRVLLEVVLCVMWRGVEGSDDSAWLDRGQVFSALTKLGTANELLL 1512

  Fly  2597 ----------------GLVDNR--GNVISDKHDPS-----HHNQQQQQQAGIIG----------- 2627
                            .:.|||  ..|...:|..:     |..|...|..|::.
Zfish  1513 PVDHIKLSLMERMLEWAVTDNREASAVTLPQHTENAVRLLHVVQDFLQAEGLVNPALWTEKLLEE 1577

  Fly  2628 -------------------QQQQHG---SLGHSERGDKPDSEISVVRVPDGYGGAGSGGGVNS-- 2668
                               |..|.|   .||...:.|.....::..::    .|......|||
Zfish  1578 TVTLMDGLMVWYASGTQWLQLSQVGLRLLLGFMAQEDPQVCAMATAKL----NGILQTKTVNSQD 1638

  Fly  2669 ------GQGQGVPSNQRPRPEELPMKAPALVAQLPLTTPSREASLTQKLEIALGPVCPLLREIMV 2727
                  |:.:|:                           .|.:...:::|.....:.||||.:
Zfish  1639 EACYLLGRVEGI---------------------------LRRSLSEERIEDTYSFLVPLLRTL-- 1674

  Fly  2728 DFAPFLSKTLVGSHGQELLMEGKGLTTFKNSHS----VVELVMLLCSQEWQNSLQKHAGLAF--- 2785
                 |||.      .:||.....|.:..|::.    ..:....:.|.||:..|.|:. :.:
Zfish  1675 -----LSKI------HKLLYMELHLPSLPNTNGSPSFFEDFQQYVTSPEWRVYLDKYI-IPYMKQ 1727

  Fly  2786 --IELINEG-RLLSHAMKDHIVRVANEAEFILN-----RMRADDVLKHADFESQCAQTLLER-RE 2841
              ||..::| ..::...||     ..|| |:||     |.|.:..::   |:.|..:....| |:
Zfish  1728 YEIETFSQGHENMALYWKD-----CYEA-FMLNLHRRDRDRGESKIR---FQEQFVEPFSRRGRQ 1783

  Fly  2842 EERMCDHLITAARRRDNVIASRLLEKVRNIMCNRHGAWGDSSSTSSGGAIVGAVQKSPYWKLDAW 2906
            |....:.::.....:::.:..:.....|.:.|.| |.|.|..            .|..:|||.:.
Zfish  1784 ENLRYNSMLKQMHTQNSGVLRQWRAARRGLFCER-GPWVDKQ------------LKDIHWKLSSA 1835

  Fly  2907 EDDARRRKRMVQNPRGSSHPQATLKAALENGGPEDAILQTRDEFHTQI--------AVSRTHPSG 2963
            |:.:|.|.::|:|....:|.:|:  |..:|.|.:          |.|:        ||.:...|
Zfish  1836 ENYSRMRLKLVRNYNFDTHREAS--ALRDNLGVQ----------HQQVNAESLLLEAVKQVKVS- 1887

  Fly  2964 QHNGELLDD-AELLIED----RELDLDLTG---PVNISTKARLIAPGLVAPGTVSITSTEMFF-- 3018
                :|.|| .|||.||    .:.|.:..|   .:.||....|:....|.||.:.:|:..::|
Zfish  1888 ----DLEDDILELLEEDPASANQADSEEAGQKEKLVISEDCELVTVVDVYPGRLELTTQHIYFYD 1948

  Fly  3019 -EVDEEHPEFQKIDGEVLKYCDHLHGKWYFSEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQ 3082
             ..::|....|..             ||..|::|.|..|||.|:..||||||..:|:....|..:
Zfish  1949 SSAEKEEGVGQDF-------------KWPLSQIREIHLRRYNLRRSALEIFLIDQTNYFLNFKKE 2000

  Fly  3083 --HTVKKVIKALPRVGVGIKYGIPQTRRASMMSPRQLMRNSNMTQKWQRREISNFEYLMFLNTIA 3145
              :||...:..|..:.:...:           ||::|:::|.:||||..||||||:|||.|||||
Zfish  2001 VRNTVYSRMLLLRSLSLHATH-----------SPQELLKSSGLTQKWVNREISNFDYLMQLNTIA 2054

  Fly  3146 GRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFEERYESWD--SDTI 3208
            |||||||.|||:|||:|::|.|::||||.|..:||||||:...|........|:|||::  :.||
Zfish  2055 GRTYNDLAQYPVFPWILSDYTSEELDLSDPRVFRDLSKPVAVQNERNAKAVREKYESFEDPTGTI 2119

  Fly  3209 PPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSSVSLSWKNCQRDTSDVKELI 3273
            ..||||||||.||..:::|:||||||::.:.||.|:||..||.|.|:..:|:....:.:||||||
Zfish  2120 DRFHYGTHYSNAAGVMHYLIRVEPFTSLHIQLQSGRFDCADRQFHSIPATWQTLMDNPNDVKELI 2184

  Fly  3274 PEWYFLPEMFYNSSGYRLGHRE-DGALVDDIELPPWAKSPEEFVRINRMALESEFVSCQLHQWID 3337
            ||:::.||...|.:|:.||..: ....|:|:.||.||||||:|:..:|.||||||||..||:|||
Zfish  2185 PEFFYFPEFLENQNGFDLGRLQISKERVNDVILPKWAKSPEDFIYKHRKALESEFVSAHLHEWID 2249

  Fly  3338 LIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLDPVMREAVENQIRNFGQTPSQLLMEPHPPRS 3402
            ||||||||||.|:.|.|||||.||||:||||.:.|...|:|||..|.||||||.|||.:|||.|.
Zfish  2250 LIFGYKQRGPAAVEALNVFYYCTYEGAVDLDAITDEKERKAVEGMISNFGQTPCQLLKDPHPVRL 2314

  Fly  3403 SAMHLSP--MMFSAMP----EDLCQMLKFY-----QNSPVIHISANTYPQLSLPSVVTVTAGHQF 3456
            |...|..  ....:.|    |.|.::..|:     .|.|::            .:||.....|.|
Zfish  2315 SLEELEKRRTRLDSCPLNIFEQLTELKSFFIEGISDNVPLV------------KAVVPKNQSHSF 2367

  Fly  3457 AVNRWNCNYTASVQSPSYAESPQSPGSNQPLTIDPVLAVHG----TNNNSN------------AA 3505
            .                   |..||.:...|:.:.::..||    ..|.||            ..
Zfish  2368 I-------------------SQGSPDALVTLSQNCLMGTHGWLPYDKNISNYFTFIKDPTVTSPK 2413

  Fly  3506 SRRHLGDNFSQMLKIRSNCFVTTVDSRFLIACGFWDNSFRVFATETAKIVQIVFGHFGVVTCMAR 3570
            ::|.|...||..:.:.::.||.:.|.:.|.:.|.||||.||.:....|.|.....|..:|||:|.
Zfish  2414 TQRFLSGPFSPGVDVTAHLFVVSHDGKLLFSGGHWDNSLRVTSLVKGKTVGQHIRHMDIVTCLAT 2478

  Fly  3571 SECNITSDCYIASGSADCTVLLWHWNARTQSIVGEGDVPT-----PRATLTGHEQAVTSVVISAE 3630
            ....|    ::.|||.|.|.::|       .::.:|..|.     |...|.||...|.||.||.|
Zfish  2479 DHFGI----HLISGSRDTTCMVW-------QVLQQGGAPVGLSHKPVQVLYGHTDEVVSVSISTE 2532

  Fly  3631 LGLVVSGSSNGPVLIHTT-FGDLLRSLDPPAEFHSPELI---TMSREGFIVIN---------YDK 3682
            |.:.||||.:|.|:|||. .|..:|||.||.|...|..|   .:|.||.:|::         .||
Zfish  2533 LDMAVSGSRDGTVIIHTVRRGQYMRSLRPPCESSLPLSIMHLAVSWEGHLVVHTCIEGKATLKDK 2597

  Fly  3683 GNVAAYTINGKKLRHETHNDNLQCMLLSRDGEYLMTAGDRGIVEVWRTFNLAPLYAFPACNAGIR 3747
            ..:..|::|||.|...:..:.:..|.:|  ||:::...::|.:.|...::|:...:..|....||
Zfish  2598 NALHLYSVNGKHLCSSSLKEQVTDMCVS--GEHVVIGSEQGFLSVRDLYSLSLCVSPMAMRVPIR 2660

  Fly  3748 SLALTHDQKYLLAGLSTGSIIV 3769
            .:::|.:|.::|.||..|.:||
Zfish  2661 CVSVTKEQSHVLVGLEDGKLIV 2682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rg	NP_001284879.1	LamG	210..358	CDD:304605
		DUF4704	634..918	CDD:292415
		MARCKS	1434..1751	CDD:280269
		DUF1088	2791..2972	CDD:284000	41/195 (21%)
		PH_BEACH	2996..3093	CDD:291510	27/101 (27%)
		Beach	3125..3401	CDD:280327	160/278 (58%)
		WD40 repeat	3524..3560	CDD:293791	13/35 (37%)
		WD40	<3526..3729	CDD:295369	72/220 (33%)
		WD40	<3530..3773	CDD:225201	83/258 (32%)
		WD40 repeat	3566..3617	CDD:293791	14/55 (25%)
		WD40 repeat	3622..3657	CDD:293791	19/35 (54%)
		WD40 repeat	3669..3699	CDD:293791	11/38 (29%)
		WD40 repeat	3704..3739	CDD:293791	7/34 (21%)
nbeal1	XP_021332659.1	DUF4704	896..1146	CDD:318082
		DUF4800	1609..1864	CDD:318309	60/323 (19%)
		PH_BEACH	1916..2006	CDD:275391	28/102 (27%)
		Beach	2034..2313	CDD:307993	160/278 (58%)
		WD40	2438..2711	CDD:330360	83/258 (32%)
		WD40 repeat	2474..2519	CDD:293791	14/55 (25%)
		WD40 repeat	2524..2560	CDD:293791	19/35 (54%)
		WD40 repeat	2572..2606	CDD:293791	7/33 (21%)
		WD40 repeat	2619..2654	CDD:293791	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910