DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2841 and raph1b

DIOPT Version :9

Sequence 1:	NP_001284821.1	Gene:	CG2841 / 44529	FlyBaseID:	FBgn0003159	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_001352514.1	Gene:	raph1b / 560319	ZFINID:	ZDB-GENE-090311-54	Length:	1565	Species:	Danio rerio

Alignment Length:	1341	Identity:	271/1341 - (20%)
Similarity:	416/1341 - (31%)	Gaps:	475/1341 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KDQLFVARLGA--RVPLSKLLS---LVCDNKQLD------ADKY--EFRSPVD------------ 127
            |.:.|:.|...  .||..|..:   ||| ..|||      ...|  ::::|.|
Zfish   485 KKRYFLLRASGIYFVPKGKAKASRDLVC-FLQLDHVNVYYGQDYRSKYKAPTDYCLALKHPQIQK 548

  Fly   128 ASQV--YSCESTIGTV--GLSEIRLC-HKSESYDNFNPDVMHKFQRTGVARD--SLSSSSDFSSS 185
            .||.  |.|...:.|:  .::.||:. :..:.|.|:    ....:||..|.|  ||||:| ..|.
Zfish   549 KSQYIKYLCCDDVRTLHQWVNGIRIAKYGKQLYVNY----QEAMKRTEAAYDWSSLSSTS-IKSG 608

  Fly   186 RHSKVTAKTPSPYSSSNSLNSMDSTGMNYTRTPVVVPPAKVLAPPPRK-----KRTAPRPPSQVC 245
            ..|....::.|.:||.......|.|..::.|:..||  :.:.:...::     :.|..||
Zfish   609 TSSVSIPESQSNHSSQTDSGMSDGTSSSHARSQSVV--SSIFSEAWKRGTQIEESTKARP----- 666

  Fly   246 IPEQSVPDIPAANSKSEPAYAVIVKRPQLCMSTPNLSGPLELDCNGNGSKSPDEDSTDGHYATLD 310
               :|:....:::|.....:  :.::..|....|::...|:  ..|:.:::|.:..|.    ||.
Zfish   667 ---ESIRSTHSSHSSHSSHH--VSQQQHLHAQQPHVHSILQ--SRGSVTQAPAQAPTQ----TLA 720

  Fly   311 LKPP-IAGGPEPTPRKRLLQIKKKTAPAPPPDFQSGGDNISLASLPEPVTPT-----------PN 363
            ..|| :|..|.|.|         ...|.|||.        .::|:|...|||           .|
Zfish   721 QAPPQVAPAPPPPP---------PPPPPPPPP--------PISSIPHHATPTMFAKYSTITRLQN 768

  Fly   364 IPQ------PAPRITTPLPIAPTANPPLAQVNGNGNGSPNG-NVSKVLLNRTPTPEPRSL---GS 418
            ..|      |.|:|...:|..|..:.|      ..|..|:| |:..    ..|.|.|.|:   ||
Zfish   769 ASQATSHHKPQPQIQQQVPPVPPPSKP------QSNNIPSGANIPP----PPPPPPPASMPPPGS 823

  Fly   419 ATEDDDNDTASKQADSGIGEPAPS--PSVSPEPEAEKSQQESSSEDDEAIKVYNFKLCQTSKKPE 481
            |           .|...:|.||.:  |.:||.|.:........            .:.....:|:
Zfish   824 A-----------MAVLKLGPPAAAVIPQISPSPPSPPPPPPPP------------PIMPVQSQPQ 865

  Fly   482 PSAATLAELTALTAQDIEEEDNHVDQPASITNGNLATPSSETSLTSWNYLDP-------ISPPPD 539
            |....:..:.:              ||       |..|...|.:.|.|...|       :.|||.
Zfish   866 PPPPPIMPMQS--------------QP-------LPPPPPITPMQSHNLPPPPPMQSHALPPPPP 909

  Fly   540 FSDQQMQKRNAGSLSPGSPLDEIVDELATIINQQRLDTLIKKQPDPQMVEIES-AKPNRLANFSI 603
            .:..|     :.:|.|..|:        |.:....|      .|.|.:..::| |.|
Zfish   910 ITPMQ-----SHALPPPPPI--------TPMQSHAL------PPPPPITPMQSHALP-------- 947

  Fly   604 TTAKSTTRIGRADSFQAGASGGGTEVASSGRALSHRSSSHVSLNKLEQNGIGLGQRRSSSELSIG 668
                                                                     ....::..
Zfish   948 ---------------------------------------------------------PPPPITPM 955

  Fly   669 ESPSLQSPEVIKTILNSRKNSLAESGGSASTPVTEQPKIIK-QLESLAKEQSSVDGVKDISSSRS 732
            :|.:|..|..|..:.:......|:.....|.|:...|.::: |.:.:.....:|          |
Zfish   956 QSHALPPPPPIMPMQSEPLPPPAQIMPMQSHPLPPPPPLVQMQSQPMPPPPPTV----------S 1010

  Fly   733 EASQQSPTPVPKKSNPGVEKP----TSPTFRAVQEPYPSSPALQKSSPAVQEQRTSPVERPSLPP 793
            ..||..|.|.|.....|:..|    |:...:|....:||:|  |...|...:....|...|..||
Zfish  1011 FQSQPLPPPPPPLQANGLPPPPPLITNGLKQAFAHKFPSTP--QDVLPPANQNNFPPPPPPPPPP 1073

  Fly   794 AVKSVEEQAVSLHQKEIVVQKESPPLESMKESFVIVSKMSPPAVKKVPDP--------------- 843
            .:      |.:|...:.|....:||              .||.....|.|
Zfish  1074 PL------APTLPPYQHVTSTSNPP--------------PPPPPPPPPPPAPIHLANQPAVLPKF 1118

  Fly   844 ----FPKVEAVKEES-----SGNESSQSTITPPNTPATPVSPVNLRNPNNTMAEIEQSQRDEPAP 899
                ||..:|.|...     |....:.....||..|..|..|..|:|              :|.|
Zfish  1119 FTGGFPPQKAPKPSCGILPVSPVAPALQPPPPPPPPPPPPPPAPLKN--------------QPPP 1169

  Fly   900 S-------SKPLPTTYRYSGPPSINFATWSERPKSTVAIKNEGDYIFG----------------G 941
            :       ||.||.:.:.|..||:.....|:.|.::.|:.|:.|.:..                |
Zfish  1170 TLPKQHSLSKTLPFSSQTSSVPSMVKQLASQFPVASPALTNQTDSLKAPQSPPAVKVKPKWQPVG 1234

  Fly   942 AGKSQQ----LTSPPSKLTIGVASPI----LRMGIPQGKEYHVP------ITVKPLKDEILENQQ 992
            .|:.||    ...||....:|.|||.    ....:|.|.....|      ::..|:|.....:..
Zfish  1235 QGQQQQRSPEFPPPPPDNALGFASPTPPPPPPPPLPPGPTPPPPPPPPPLMSGSPIKKSPSGSSA 1299

  Fly   993 QEKKEKPEVQELKDQEIEKESVSVKVKPKTPVKPVQKRIEKPLDQDQNSLQNHSSTL-------- 1049
            ..||..|..|         .:.|||....|..:..:|.:....:....|....:|:.
Zfish  1300 GVKKPPPTPQ---------RNSSVKYDASTEYQESRKNLVSKFNPSSASSTTSTSSCSPSKELSA 1355

  Fly  1050 -----PRPAKSNRFTLPAA------QNNQMVSHLTMNSLPRPVSSLERNRPVEA----------- 1092
                 |:|.|.|...||.|      ||.|  |.....|.|.|.:......|:|:
Zfish  1356 GPQAPPKPGKLNLANLPLALQNKFNQNRQ--SAADFPSPPPPENDFFPPPPIESDLPPPPPLPGD 1418

  Fly  1093 -----------NPAPAP-FGQSTLRRTGFKERMLAKEQQEQEQALRIRVSVNESIPSSATAPKSP 1145
                       ||.|.| :|:|:|::|            :...:||...:|.||.|.|
Zfish  1419 LNGVSPKVAVVNPQPQPAWGKSSLKKT------------QPPASLRCNNTVRESPPLS------- 1464

  Fly  1146 PESKPAPPSISGYVALKSTKVEVKLQEPETKPVSLQ-----VKLKPT------VQPATTPS---- 1195
                  ||||.|.....|.|       ..|:|..|:     :|.|.:      |.|..|..
Zfish  1465 ------PPSIHGGPIPHSPK-------GTTQPNFLEDLNKTLKRKSSRVSGDKVDPVATMDDMVL 1516

  Fly  1196 PPPPPPALQPVKTNGG---------------RSGPTAPDPR 1221
            |||||..||..:...|               |..|.||..|
Zfish  1517 PPPPPELLQDQQRLSGSGFMSGNISGYATLRRGPPPAPPKR 1557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	Ehrlichia_rpt	372..958	CDD:118064	116/655 (18%)
raph1b	NP_001352514.1	UBQ	340..421	CDD:320785
raph1b	NP_001352514.1	PH_APBB1IP	463..585	CDD:269961	24/104 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900