Protein Alignment CG2841 and Cobll1

DIOPT Version :10

• Sequence 1: NP_001284821.1
• Gene: CG2841 / 44529
• FlyBaseID: FBgn0003159
• Length: 1239
• Species: Drosophila melanogaster
• Sequence 2: XP_006499773.1
• Gene: Cobll1 / 319876
• MGIID: 2442894
• Length: 1274
• Species: Mus musculus
• Alignment Length: 1358
• Identity: 270/1358 - (19%)
• Similarity: 451/1358 - (33%)
• Gaps: 472/1358 - (34%)

  Fly    39 KSSTQLHHLSTDTDINETSQLEYNRITPVPAATSNAPFEQTFRITVLLPKDQLFVARLGARVPLS 103
            |.:|.:..|..:..|.:...|:..:.||:      .| |:|.|:.:...|.|..:.|:....||.
Mouse   145 KPNTPIGMLDVEKVILKPKSLDKKKPTPI------IP-EKTVRVVINFKKTQKTIVRVSPHAPLQ 202

  Fly   104 KLLSLVCDNKQLD------ADKYEFRSPVDASQVYSCESTIGTVGLSEIRLCHKSE-------SY 155
            .|..::|...:.|      ...|:.:.|:|.::      ::..:||.|:.....|.       |.
Mouse   203 DLAPIICSKCEFDPLHTVLLKDYQAQEPLDLTK------SLNDLGLRELYAMDISRAPSATAFSK 261

  Fly   156 DNF--------NPDVMHKFQRTGVARDSLSSSSDFSSSRHSK----VTAKTP-SPYSSSNSLNSM 207
            .:|        |||::.:.:..|:          ||..:.||    .||..| :|..|.:.
Mouse   262 SSFQESCQISHNPDIVKEKENKGI----------FSFFQRSKKKREQTASAPATPLVSKHR---- 312

  Fly   208 DSTGMNYTRTPVVVPP--AKVLAPPPRKKRTAPRPPSQV-------------CIPEQ-SVPDIPA 256
                .::||:..:..|  :..|.....|||.||.||...             |:... ||.|...
Mouse   313 ----PSFTRSNTISKPYISNTLPSDAPKKRRAPLPPMPTSQGAAQGQERRASCVERSTSVDDTDK 373

  Fly   257 ANSKSEPAYAVIVKRPQLCMSTPNLSGPLELDCNGNGSKSPDEDSTDGHYATLDLKPPIAGGPEP 321
            ::|:     |::|:           :|.|:|.....|:.|
Mouse   374 SSSE-----AIMVR-----------TGSLQLSSTSIGTSS------------------------- 397

  Fly   322 TPRKRLLQIKKKTAPAPP---PDFQSGGDNISLA---SLPEPVTPTPNIPQPAPRITTPLPIAPT 380
                  |:..|:.|||||   |..|:...|.::|   .|.:.:.|...:...:|
Mouse   398 ------LKRTKRKAPAPPSKTPLAQTDERNSAMAHGLPLEDGIAPDSMLELSSP----------- 445

  Fly   381 ANPPLAQVNGNGNGSPNGNVSKVLLNRTPTPEPRSLGSATEDDDNDTASKQADSGIGEPAPSPSV 445
                      .|..:|.|::....|:                        |....:.:|....|.
Mouse   446 ----------EGMSTPEGSLGPGFLS------------------------QEQCAVPKPPDEISE 476

  Fly   446 SP-EPEAEKSQQESSSEDDEAIKVYNFK--LCQTSKKPEPSAATLAELTALTAQDIEEEDNHVDQ 507
            .| .|||..:...|....|.:::..:.|  |.:.||.|..|
Mouse   477 GPGTPEAAVASLTSGVSSDYSLEEIDEKEELSEASKDPAGS------------------------ 517

  Fly   508 PASITNGNLATPSSETSLTSWNYLDPISPPPD----FSDQQMQKRNAGSLSPG------SPLDEI 562
             .|:.:.::|:.|::..:|       :...||    .||.:....:.|....|      .|...:
Mouse   518 -ISVKSPDIASASTDMRIT-------VEKDPDSALGISDGETSPSSKGKTQEGRSTEGQGPYHPV 574

  Fly   563 VDELATIINQQRLDTLIKKQPDPQMVEIESAKPNR---LANFSITTAKST----TRIGRADSFQA 620
            |..:.   |:.|:...||        ::::..||:   :.|..:..|.||    .|.|:.:
Mouse   575 VGHIG---NEDRVSDSIK--------DMKTLGPNQESVVQNEIMVCATSTDYVKNRPGKME---- 624

  Fly   621 GASGGGTEVASSGRALSHRSSSHVSLNKLEQN-GIGLGQRRSSSELSIGESP----SLQSPEVIK 680
                  |.:...|.||  :.:|.:..::|..: ...:...:||.|..:..||    .|..|.|.|
Mouse   625 ------TTIEGEGEAL--KKASDMETDRLSGSPACRMDNVKSSRENHLTASPGPDQKLNQPGVEK 681

  Fly   681 TILNSRKNSLAESGGSASTPV------------TEQPKIIKQLE----SLAKEQSSVDGVKDISS 729
            |.:        :.....:||.            :..|:..:.::    |::.:.||......:::
Mouse   682 TKM--------QDAAIQATPARGTFDGNHEVSNSSDPRADETVQTSDGSISAQHSSASLQDSVNA 738

  Fly   730 SRSEASQQSPTPV----PKKS---NPGVEKPTSPTFRAVQEPYPSSPALQKSSPAVQEQRTSPVE 787
            ||...||.:.|.|    |:|.   ..|...|.||...:.:.|   :.:..|:.| :..|.::|..
Mouse   739 SREFRSQGTSTYVQDRLPEKEPACTYGNNVPLSPVDGSNKNP---AASYLKNFP-LYRQDSNPKP 799

  Fly   788 RPS------------------LPPAVKSVEE----QAVSLHQKEIVVQKESP-----PLESMKES 825
            :||                  :||  ||:|.    ::.::.:|:  .||..|     .:|:|.|:
Mouse   800 KPSNEITREYIPKIGMTTYKIVPP--KSLEMAKDWESEAMGRKD--DQKMLPVGQRHTIENMTET 860

  Fly   826 FVIVSKMSPPAVKK-----VPDPFPKVEAVKEESSGNE--------SSQSTIT-PPNTP------ 870
            .:   :...||..|     .||..||      .|||.|        |...|.| ||..|
Mouse   861 SM---QTEVPATSKSSQQPQPDLKPK------PSSGTERHLHRTLSSPTGTETNPPKAPRVTTDT 916

  Fly   871 -ATPVSPVNLRNPNNTMAEIEQSQRDEPAPSSKPLPTTYRYSGPPSINFATWSERPKSTVAIKNE 934
             ..|.:| ||.:.||.:....:|:...|             ...||..|....:|.        .
Mouse   917 GTIPFAP-NLEDINNILESKFRSRASNP-------------QAKPSSFFLQMQKRA--------S 959

  Fly   935 GDYIFGGAGKSQQLTSP---PSKLTIGVASPILRMGIPQGKEYHVPITVKPLKDEILENQQQEKK 996
            |.|:...|.||.. |:|   |.:.||              ||......:.|.:.....:::....
Mouse   960 GHYVTSAAAKSVH-TAPGPAPKEPTI--------------KEVQRDPQLSPEQHPSSLSERTHSA 1009

  Fly   997 EKPEVQELKDQEIEKESVSVKVKPKTPVKPVQKRIE--------KPLDQDQNSLQNHSSTLPRPA 1053
            ..|.:.:..|..|:|.: .....|..| ||:..|.|        ||:...       :.|.|.|.
Mouse  1010 PLPNISKADDDIIQKPA-ETSPPPVAP-KPMTLRAETSPPPVFPKPMTLP-------AETSPPPV 1065

  Fly  1054 KSNRFTLPAAQNNQMVSHLTMNSLPRPVSSLERNR--PVEANPAPAPFGQSTLRRTGFKERMLAK 1116
            .....||||..:..:|       .|:|::......  ||.|.|...|..|.|
Mouse  1066 FPKPMTLPAETSLPLV-------FPKPMTLRAETSPPPVAAKPVALPGSQGT------------- 1110

  Fly  1117 EQQEQEQALRIRVSVNESIPSSATAPKSPPESKPAPPSISGYVALKSTKVEVKLQEPETKPVSLQ 1181
                         |:|.....:..||:....|.|:|.:::  |..:|                 |
Mouse  1111 -------------SLNLKTLKTFGAPRPYSSSGPSPFALA--VVKRS-----------------Q 1143

  Fly  1182 VKLKPTVQPATTPSPPPPPPALQPVKTN-------GGRSG-------PTAPDPRSQLL 1225
            ...|...:.|:..|...||.|.|..||:       |.:.|       |...:..||:|
Mouse  1144 SFSKACPESASEGSSALPPAATQDEKTHTVNKPTVGSQHGDGDKQNNPVQNEHSSQVL 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	PHA03247	<222..559	CDD:223021	64/371 (17%)
		PTZ00449	<660..905	CDD:185628	72/319 (23%)
		PHA03247	<729..1186	CDD:223021	112/524 (21%)
Cobll1	XP_006499773.1	RBD	92..158	CDD:460485	3/12 (25%)
		Cobl	176..252	CDD:462810	17/81 (21%)
		PHA03247	<906..1177	CDD:223021	76/368 (21%)
		WH2	1223..1248	CDD:425359