Protein Alignment CG2841 and COBLL1

DIOPT Version :9

• Sequence 1: NP_001284821.1
• Gene: CG2841 / 44529
• FlyBaseID: FBgn0003159
• Length: 1239
• Species: Drosophila melanogaster
• Sequence 2: NP_001265387.1
• Gene: COBLL1 / 22837
• HGNCID: 23571
• Length: 1233
• Species: Homo sapiens
• Alignment Length: 1301
• Identity: 259/1301 - (19%)
• Similarity: 427/1301 - (32%)
• Gaps: 396/1301 - (30%)

  Fly    39 KSSTQLHHLSTDTDINETSQLEYNRITPVPAATSNAPFEQTFRITVLLPKDQLFVARLGARVPLS 103
            |.:|.:..|..:..|.:...|:..:.||:      .| |:|.|:.:...|.|..:.|:.....|.
Human   166 KPNTPIGMLEVEKVILKPKMLDKKKPTPI------IP-EKTVRVVINFKKTQKTIVRVSPHASLQ 223

  Fly   104 KLLSLVCDNKQLD------ADKYEFRSPVDASQVYSCESTIGTVGLSEI---------------- 146
            :|..::|...:.|      ...|:.:.|:|.::      ::..:||.|:
Human   224 ELAPIICSKCEFDPLHTLLLKDYQSQEPLDLTK------SLNDLGLRELYAMDVNRATSVTVFSK 282

  Fly   147 ----RLCHKSESYDNFNPDVMHK---------FQRTGVARDSLSSSSDFSSSRHSKVTAKTPSPY 198
                ..|..|:     |.|:|.:         |||:...||.               ||..|
Human   283 SSLQESCQISQ-----NLDIMKEKENKGFFSFFQRSKKKRDQ---------------TASAP--- 324

  Fly   199 SSSNSLNSMDSTGMNYTRTPVVVPP--AKVLAPPPRKKRTAPRPPSQVCIPEQSVP-DIPAANSK 260
             ::..:|....|   :||:..:..|  :..|.....|||.||.||...   .|||| |:
Human   325 -ATPLVNKHRPT---FTRSNTISKPYISNTLPSDAPKKRRAPLPPMPA---SQSVPQDL------ 376

  Fly   261 SEPAYAVIVKRPQLCMSTPNLSGPLELDCNGNGSKSPDEDSTDG--------HYATLDLKPPIAG 317
                 |.|.:||..|:                 .||...|.||.        ...:|.|....||
Human   377 -----AHIQERPASCI-----------------VKSMSVDETDKSPCEAGRVRAGSLQLSSMSAG 419

  Fly   318 GPEPTPRKRLLQIKKKTAPAPP---PDFQSGGDNISLASLPEPVTPTPNIPQPAPRITTP--LPI 377
            ...       |:..|:.||:||   |..||  |..|..:..:||...|  |..|....:|  |..
Human   420 NSS-------LRRTKRKAPSPPSKIPPHQS--DENSRVTALQPVDGVP--PDSASEANSPEELSS 473

  Fly   378 APTANPPLAQVNGNGNGSPNGNVSKVLLNRTP------TPEPRSLGSATEDDDNDTASKQADSGI 436
            ..|.:|        |..|.....:..|:..|.      ||| .::.|.|....:|.:.::.|.
Human   474 PETFHP--------GLSSQEQCTAPKLMEETSVFECPGTPE-AAITSLTSGISSDYSLEEIDE-- 527

  Fly   437 GEPAPSPSVSPEPEAEKSQQESSSEDDEAIKVYNFKLCQTSKKPEPSAATLAELTALTAQDIEEE 501
                 ...:|..|:.|.......|:|   |...:..:..|.|....||  |...:...:|:..||
Human   528 -----KEELSEVPKVEAENISPKSQD---IPFVSTDIINTLKNDPDSA--LGNGSGEFSQNSMEE 582

  Fly   502 DNHVDQPASITNGNLATPSSETSLTS--WNYLDPISPPPDFSDQQMQKRNAGSLSPGSPLDEIVD 564
                .|....|:|.  .|.|....||  ...:|.|             ||..||.|.   .|.|.
Human   583 ----KQETKSTDGQ--EPHSVVYDTSNGKKVVDSI-------------RNLKSLGPN---QENVV 625

  Fly   565 ELATIINQQRLDTLIKKQPDPQMVEIESAKPNRLANFSITTAKSTTRIGRADSFQAGASGGGTEV 629
            :...|:..:..:..:|.......:.:|....|...:..:....:                  :|.
Human   626 QNEIIVYPENTEDNMKNGVKKTEINVEGVAKNNNIDMEVERPSN------------------SEA 672

  Fly   630 ASSGRALSHRSSSHVSLNKLEQNGIGLGQRRSSSELSIGESPSLQS---------------PEVI 679
            ..:..|:|:: .:|::.:.:....:.......:.:.:|..:||..|               .|.:
Human   673 HETDTAISYK-ENHLAASSVPDQKLNQPSAEKTKDAAIQTTPSCNSFDGKHQDHNLSDSKVEECV 736

  Fly   680 KTILN--SRKNSLAESGGSAST--PVTEQPKIIKQLES--LAKEQSSVDGVKDI------SSSRS 732
            :|..|  |.::|...|..|.:|  ....|..:|...|.  ..|:.....|..|:      ....|
Human   737 QTSNNNISTQHSCLSSQDSVNTSREFRSQGTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNS 801

  Fly   733 EAS--------QQSPTPVPKKSN----PGVEKPTSPTFRAVQEPYPSSPALQK--SSPAVQEQRT 783
            .||        :|...|.||.||    ..:.|....|::.|.   |.|..:.|  .|..::.:..
Human   802 TASYLKNYPLYRQDYNPKPKPSNEITREYIPKIGMTTYKIVP---PKSLEISKDWQSETIEYKDD 863

  Fly   784 SPVERPSLPPAVKSVEEQAVSLHQKEIVVQKESP--PLESMKESFVIVSKMSPPAVKKVPD---- 842
            ..:.........::|:|.|:......|   .|||  ||.::|....:.::...|:....||
Human   864 QDMHALGKKHTHENVKETAIQTEDSAI---SESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMV 925

  Fly   843 ----PFPKVEAVKEESSGNESSQSTITPPNTPATPVSPVNLRNPNNTMAEIEQSQRDEPAPSSKP 903
                |.||:            ::.|.|.|..|       ||...||    |.:|:....|.:::.
Human   926 SPLKPAPKM------------TRDTGTAPFAP-------NLEEINN----ILESKFKSRASNAQA 967

  Fly   904 LPTTYRYSGPPSINFATWSERPKSTVAIKNEGDYIFGGAGKSQQLTSPPSKLTIGVASPILRMGI 968
            .|:::         |....:|.        .|.|:...|.||..            |:|
Human   968 KPSSF---------FLQMQKRV--------SGHYVTSAAAKSVH------------AAP------ 997

  Fly   969 PQGKEYHVPITVKPLKDEILENQQQEKKEKPEVQELKDQEIEKESVSVKVKPKTPVKPVQKRIEK 1033
                                         .|..:||.::|.|::.:....:..:|:..:...:.:
Human   998 -----------------------------NPAPKELTNKEAERDMLPSPEQTLSPLSKMPHSVPQ 1033

  Fly  1034 PL----DQDQNSLQNHSSTLPRPAKSNRFTLPAAQ-NNQMVSHLTMNSLPRPVSSLERNRPVEAN 1093
            ||    |.|... |..:...|.|......|:||:| :.|.:..|.....|||.||
Human  1034 PLVEKTDDDVIG-QAPAEASPPPIAPKPVTIPASQVSTQNLKTLKTFGAPRPYSS---------- 1087

  Fly  1094 PAPAPFGQSTLRRTGFKERMLAKEQQEQEQALRI-----------RVSVNE--SIPSSATAPKSP 1145
            ..|:||..:.::|:    :..:||:.|...|..:           ..|||:  .||....:.|..
Human  1088 SGPSPFALAVVKRS----QSFSKERTESPSASALVQPPANTEEGKTHSVNKFVDIPQLGVSDKEN 1148

  Fly  1146 PESK-------PAPPSISGYVALKSTKVEVKLQEPETKPVSL---------QVKLKPTVQPATTP 1194
            ..:.       |.|.....:..::.:.:..:..:||....||         ..|||....|:.|.
Human  1149 NSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQMRQSLLTAIRSGEAAAKLKRVTIPSNTI 1213

  Fly  1195 S 1195
            |
Human  1214 S 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	Ehrlichia_rpt	372..958	CDD:118064	122/646 (19%)
COBLL1	NP_001265387.1	UBQ	113..182	CDD:294102	4/15 (27%)
		Cobl	197..275	CDD:286545	16/83 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900