DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2841 and Grb10

DIOPT Version :9

Sequence 1:	NP_001284821.1	Gene:	CG2841 / 44529	FlyBaseID:	FBgn0003159	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	NP_001357532.1	Gene:	Grb10 / 14783	MGIID:	103232	Length:	621	Species:	Mus musculus

Alignment Length:	334	Identity:	67/334 - (20%)
Similarity:	110/334 - (32%)	Gaps:	116/334 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 CNGNGSKSPDEDST----DG-HYATLDLKPPIAGGPEPTPRKRL-----LQIKKKTAPAPPPDFQ 343
            ||    ...|.|:.    || |.:.........|.|:.:||:::     :.|.::        .|
Mouse    16 CN----MQSDTDTAPLLEDGQHASNQGAASSSRGQPQASPRQKMQRSQPVHILRR--------LQ 68

  Fly   344 SGGDNISLASLPEPVTPTPNIPQPAPRIT-----TPLPIAPTANPP----------------LAQ 387
            .....:..||||.       ||.|.|.:|     :|..:||::.||                :..
Mouse    69 EEDQQLRTASLPA-------IPNPFPELTGAAPGSPPSVAPSSLPPPPSQPPAKHCGRCEKWIPG 126

  Fly   388 VNGNGNGS---------PNGNVSKVLLNRTPTPEPRSLGSATEDDDNDTASKQADSGIGEPAPSP 443
            .|..|||.         |...:||  |.|.        |..|:     |.::.:........|:.
Mouse   127 ENTRGNGKRKIWRWQFPPGFQLSK--LTRP--------GLWTK-----TTARFSKKQPKNQCPTD 176

  Fly   444 SVSPEPEAEKSQQESSSEDDEAIKVYNFKLCQTSKKPEPSAATLAE-LTALTAQDIEE------- 500
            :|:|......||.|......: :||::          |...:.:.| ||.:||:|:.:
Mouse   177 TVNPVARMPTSQMEKLRLRKD-VKVFS----------EDGTSKVVEILTDMTARDLCQLLVYKSH 230

  Fly   501 --EDNH---------------VDQPASITNGNLATPSSETSLTSWNYL------DPISPPPDFSD 542
              :||.               ::....:.......||....|...||.      :|::..||...
Mouse   231 CVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMV 295

  Fly   543 QQMQKRNAG 551
            ...|:.|.|
Mouse   296 NWCQQSNGG 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	Ehrlichia_rpt	372..958	CDD:118064	46/241 (19%)
Grb10	NP_001357532.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		27/120 (23%)
		RA_GRB10	197..285	CDD:340558	16/98 (16%)
		PH_APBB1IP	314..436	CDD:269961
		BPS	453..494	CDD:312490
		SH2_Grb10	514..621	CDD:198278
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900