DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2841 and cobll1a

DIOPT Version :9

Sequence 1:	NP_001284821.1	Gene:	CG2841 / 44529	FlyBaseID:	FBgn0003159	Length:	1239	Species:	Drosophila melanogaster
Sequence 2:	XP_005165843.1	Gene:	cobll1a / 100536063	ZFINID:	ZDB-GENE-120215-171	Length:	737	Species:	Danio rerio

Alignment Length:	871	Identity:	159/871 - (18%)
Similarity:	263/871 - (30%)	Gaps:	329/871 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 NSSMGKLSKSSTQLHHLSTDTDINETSQLEYNRITP-VPAATSNAPFEQTFRITVLLPKDQLFVA 94
            ||.:|.|......|....:|.          |:..| :|.|        |.|:.:...|....||
Zfish    69 NSMIGSLEFEKVVLQVKGSDD----------NKKKPHIPVA--------TVRLLINYKKSHKAVA 115

  Fly    95 RLGARVPLSKLLSLVCDNKQLDADKYEFRSPVDASQVYSCESTIGTVGLSEIRLCHKSESYDNFN 159
            |:...|||::|:..||:                     .||                      |:
Zfish   116 RVNPAVPLAELMPAVCE---------------------KCE----------------------FH 137

  Fly   160 PDVMHKFQRTGVARDSLSSSSDFSSSRHSKVTAKTPSPYSSSNSLNSMDSTGMNYTRTPVVVPPA 224
            ||.      |.:.|                 |.::..|...:.|||......:...:|.|
Zfish   138 PDA------TVLLR-----------------TDQSEEPLDLTKSLNDYGIRELYAKQTKV----- 174

  Fly   225 KVLAPPPRKKRTAPRPPSQVCIPEQSVPDIPAANSK---SEPAYAVIVKRPQLCMSTPNLSGPLE 286
             |.|.||    :.|...::....||..| :...|.:   ::..:.:.:|..:......:.|.|..
Zfish   175 -VSADPP----SDPVSTNKGADEEQKTP-VKEKNHREKANKGFFGLFIKSKKTSEQAVDDSAPAS 233

  Fly   287 LDCNGNGSKSPDEDSTDG---HYATLDLKPPIAGGPEPTPRKRLLQIKKKTAPAPP-PDFQSGGD 347
            .:.||..:     |..:|   |:.     |.|...          ..||:.||.|| ...||...
Zfish   234 PELNGQCT-----DRVNGFNDHFL-----PTIPAD----------MSKKRRAPLPPMVASQSVAC 278

  Fly   348 NISLASLPEPVTPTPNIPQPAPRITTPLPIAPTANPPLAQVNGNGNGSPNGNVSKVLLNRTP--T 410
            ::.:...||        ..||.:           ..||::::...:.          |.||.  .
Zfish   279 DLQIKDFPE--------SDPAGK-----------QGPLSRISSTESS----------LKRTKRRA 314

  Fly   411 PEPRSLGSATEDDDN--------DTAS----------------------------KQADSGIGEP 439
            |.|...|||:...||        |.:|                            :|:.......
Zfish   315 PPPPCDGSASTKSDNKVEEAEGQDRSSDKHRAVISDRCPEFDKVMSEFAELLQEWRQSTPAYANS 379

  Fly   440 APSPSVSPE-----------PEAEKS-----QQESSSEDDEAIKVY---------NFKL---CQT 476
            :||.:..||           ||||..     |....|.:.|.:..:         :|:|   .||
Zfish   380 SPSSNQPPESPLGLYTCLHTPEAELKALPGCQLLRKSSEREGLATFTVVPQRRQLSFELPFTSQT 444

  Fly   477 SKKPE-PSA-ATLAELTALTAQDIEEEDNHVDQPAS-------ITNGNLATPSSETSLTSWNYLD 532
            ::.|| |.. :|:...|.:..:..|.|  |:.:...       :.|||         |....|:
Zfish   445 NQSPEHPEIHSTVRVETQIFTRTYESE--HLIEAGENSQVGMCVKNGN---------LNEHQYI- 497

  Fly   533 PISPPPDFSDQQMQKRNAGSLSPGSPLDEIVDELATIINQQRLD--------------TLIKKQ- 582
                .|:....:..|.....|..|..|:.:....:.:..::|||              :.::::
Zfish   498 ----YPELKSWERSKEAKKRLKRGQNLERLDSRRSNLDLEERLDGRSLADWSAIDFHTSHVEQEE 558

  Fly   583 -PDPQMVEIESAKPNRLANFSITTAKSTTRIGRADSFQAGASGGGTEVASSGRALSHRSSSHV-- 644
             .:|.:||.|..| :.:..|.          .|...|......|..::...||.....:|:.|
Zfish   559 IEEPDLVESEEEK-DWVEEFK----------ERRMRFLGSHDDGIKKLDVWGRIQKEFTSTQVFW 612

  Fly   645 -------SLNKLE----QNGIGLGQRRSSSELSIGESPSLQSPEVIKTILNSRKNSLAESGGSAS 698
                   ..:|||    ...:.....|..|:..:........|....|:.|.:.||
Zfish   613 DEDSREHEEDKLEMQICNENLTNFHLRMDSKTKLAAYSYYGKPGAHSTLTNIQPNS--------- 668

  Fly   699 TPVTEQPKIIKQLESLAKEQSSVDGVKDIS--SSRSEASQQSPTPVP---------KKSNPGVEK 752
                          |.||...|......::  ||:|.:..:|..|:.         ||:.
Zfish   669 --------------SCAKNNFSFTSEAHLNTLSSKSHSGFESRPPIQLSLFAMAVFKKAK----- 714

  Fly   753 PTSPTFRAVQEPYPSSPALQKSSPAV 778
                .|:.|.:|   ||..::..||:
Zfish   715 ----CFKPVFDP---SPVRRRELPAL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2841	NP_001284821.1	Ehrlichia_rpt	372..958	CDD:118064	92/522 (18%)
cobll1a	XP_005165843.1	TGS	13..78	CDD:330245	4/8 (50%)
cobll1a	XP_005165843.1	Cobl	100..169	CDD:312839	24/134 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3751
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900