DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo2 and IGDCC3

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_004875.2	Gene:	IGDCC3 / 9543	HGNCID:	9700	Length:	814	Species:	Homo sapiens

Alignment Length:	784	Identity:	210/784 - (26%)
Similarity:	292/784 - (37%)	Gaps:	208/784 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RAVFPLLLLL--AGLNGLTQVGALKGENPRI---IEHPMDTTVPKNDPFTFNCQAEGNPTPTIQW 124
            |.:.||||||  |...||       |.:..:   :|...|..|| ..|...:|:.||.|...|.|
Human    19 RLLLPLLLLLLPAPSEGL-------GHSAELAFAVEPSDDVAVP-GQPIVLDCRVEGTPPVRITW 75

  Fly   125 FKDGRELKTDTGSHRIMLPAGGLFFLKVIHSRRE-----SDAGTYWCEAKNEFGVARSRNATLQV 184
            .|:|.||...|  |..:|..|.|.   :.|.|.|     ||.|.|.|.|:|.||:..||.|.:|.
Human    76 RKNGVELPEST--HSTLLANGSLM---IRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQA 135

  Fly   185 AFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQ 249
            |.:.| |.:.|..|...:|.||..:|.. .|.|:|.|:|.||...:: ..|:|..::..|.|.|.
Human   136 ATMSD-FHVHPQATVGEEGGVARFQCQI-HGLPKPLITWEKNRVPID-TDNERYTLLPKGVLQIT 197

  Fly   250 EARQSDDGRYQCVVKNVVGTRESATAFLKV-------HVRPFLIRGPQNQTAVVGSSVVFQCRIG 307
            ..|..|.|.:.||..|:...|.|..|.|.|       :..|.::.||:|.|..|..:.|.:|...
Human   198 GLRAEDGGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVAT 262

  Fly   308 GDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGI--TATGILTV 370
            |:|.|.|.|.| ..|..:.:..:.||...:|.:.|||::..|.|.|.|:.....:  ||.|.|.|
Human   263 GNPRPIVSWSR-LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVV 326

  Fly   371 HAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRS 435
            .||.:||..|::.....|...:|.|||.|.|.|.:.|.  .|..:|.||
Human   327 QAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWL--KNGQVLGPG---------------- 373

  Fly   436 VLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPC 500
                                    |.|
Human   374 ------------------------GHV-------------------------------------- 376

  Fly   501 RTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGY 565
                                      |..::...||||.: ..|||.:|.|||.|..|.|..|..
Human   377 --------------------------RLKNNNSTLTISGI-GPEDEAIYQCVAENSAGSSQASAR 414

  Fly   566 LRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKN 630
            |.:          ..|..|   ||||...:.|......|.:||:.. ......::|||:.: .|.
Human   415 LTV----------LWAEGL---PGPPRNVRAVSVSSTEVRVSWSEP-LANTKEIIGYVLHI-RKA 464

  Fly   631 ETDGWVAVGTRVQNTTFTQ--TGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDL 693
            .....:.....|..:||..  :.|.|...|.|.|:|....|   .|..|.|....|        |
Human   465 ADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRG---ASSASVPTLAST--------L 518

  Fly   694 SEARASLLSGDVVELSNASVVDSTSMKLTWQIIN--GKYVEGFYVYARQLPNPIVNNPAPVTSNT 756
            .||.|.      ..|| ..|:.|:|::|.|:...  .::..||.::.|         ||..||.|
Human   519 GEAPAP------PPLS-VRVLGSSSLQLLWEPWPRLAQHEGGFKLFYR---------PASKTSFT 567

  Fly   757 NPLL--GSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGA 819
            .|:|  |:.|:...:....:|:...|  :.|       .||.|.|     |...|.:::   .||
Human   568 GPILLPGTVSSYNLSQLDPTAVYEVK--LLA-------YNQHGDG-----NATVRFVSL---RGA 615

  Fly   820 SSCT 823
            |..|
Human   616 SERT 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	36/102 (35%)
		I-set	91..184	CDD:254352	35/100 (35%)
		I-set	190..279	CDD:254352	29/88 (33%)
		Ig2_Robo	193..279	CDD:143201	28/85 (33%)
		I-set	283..370	CDD:254352	29/88 (33%)
		Ig	300..370	CDD:299845	23/71 (32%)
		Ig	388..>457	CDD:299845	13/68 (19%)
		I-set	479..561	CDD:254352	14/81 (17%)
		Ig	496..561	CDD:143165	14/64 (22%)
		FN3	588..681	CDD:238020	25/94 (27%)
		FN3	<817..856	CDD:238020	4/7 (57%)
		fn3	864..952	CDD:278470
IGDCC3	NP_004875.2	Ig	44..135	CDD:299845	35/96 (36%)
		IG_like	48..128	CDD:214653	31/85 (36%)
		Ig	143..227	CDD:299845	28/85 (33%)
		IG_like	145..227	CDD:214653	28/83 (34%)
		Ig	242..326	CDD:299845	28/84 (33%)
		IG_like	244..326	CDD:214653	27/82 (33%)
		I-set	331..417	CDD:254352	35/192 (18%)
		Ig	347..414	CDD:143165	30/173 (17%)
		FN3	424..517	CDD:238020	25/97 (26%)
		fn3	522..603	CDD:278470	26/105 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..743
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..814
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4222
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810