DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and Robo2

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_038944599.1 Gene:Robo2 / 84409 RGDID:620167 Length:1625 Species:Rattus norvegicus


Alignment Length:1622 Identity:457/1622 - (28%)
Similarity:680/1622 - (41%) Gaps:392/1622 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 VFPLLLLLAG--LNGLTQV----------GALKGEN--PRIIEHPMDTTVPKNDPFTFNCQAEGN 117
            :|.|:|..||  |..||:.          ..|:.|:  |||:|||.|..|.|.:|.|.||:|||.
  Rat    16 LFVLMLFFAGPTLGKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGR 80

  Fly   118 PTPTIQWFKDGRELKTDTG---SHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSR 178
            |||||:|:|||..::||..   |||::||:|.||||:::|.|| :.|.|||.|.|:|..|.|.||
  Rat    81 PTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGTYVCVARNYLGEAVSR 145

  Fly   179 NATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRI-VD 242
            ||:|:||.|||:||..|.:..||.||.|::||..|||.|||.|.|:|:...::   .|..|| :.
  Rat   146 NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID---EKEERISIR 207

  Fly   243 GGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIG 307
            ||.|.|...|:||.|.|.||..|:||.|:|..|.|.|..||..:|.|.||..:......|:|::.
  Rat   208 GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEDEPAEFRCQVQ 272

  Fly   308 GDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVH- 371
            |||.|.|.|::  ...::|..|..:.:|.:|::......|.|.|.|.|:|.||.:.|:..|||. 
  Rat   273 GDPQPTVRWKK--DDADLPRGRYDIKDDYTLRIKKAISADEGTYVCIAENRVGKVEASATLTVRV 335

  Fly   372 ---APPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGY-RDGRMEVTLTPE 432
               |||:||:||::|:|..|..|.|.|:..|:|:|.::|..||:.:||.|.. :......:::|.
  Rat   336 RPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 400

  Fly   433 GRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSV-DTQFELPPPIIEQGPVNQTLPVKSIV 496
            |.  |:|....|.|:|..: |.||...||:.::..:.| |...:.|||||.|||:||||.|....
  Rat   401 GD--LTITNIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPINQTLAVDGTA 462

  Fly   497 VLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSS 561
            :|.|:..|.|:|.:||..:|... :....|..:.|.|.|.|.:| |..|.|.|||||::.:|::|
  Rat   463 LLKCKATGEPLPVISWLKEGFTF-LGRDPRATIQDQGTLQIKNL-RISDTGTYTCVATSSSGETS 525

  Fly   562 WSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEM 626
            ||..|.:   |.......:..:.:..||||.|||:.:..:||||||| :....|......|:||.
  Rat   526 WSAVLDV---TESGATISKNYDTNDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGVLPASAYIIEA 586

  Fly   627 FGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFN--- 688
            |.::.::.|..|...|:.|.:|..||.|...|.|::||.|..|||.|||||:|  |.|:..:   
  Rat   587 FSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP--VRTQDISPPA 649

  Fly   689 SGLDLSEARASLLSGDV-VELSNASVVDSTSMKLTWQI-INGKYVEGFYVYARQLPNPIVNNPAP 751
            .|:|..:.:..|  ||| |.|.|..|:..|::::||.: ...::::|:.|..||           
  Rat   650 QGVDHRQVQKEL--GDVTVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQ----------- 701

  Fly   752 VTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNG 816
                |:.|..||     ...:..|.:.|:.:......:.|.|                       
  Rat   702 ----TSGLQAST-----VWQNLDAKVPTERSAVLVNLKKGVT----------------------- 734

  Fly   817 GGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALLL---NSSAV 878
                            ||..:.|::...:|..|.|:..||.|:.||..|..:..|.:   ||:::
  Rat   735 ----------------YEIKVRPYFNEFQGMDSESKTIRTTEEAPSAPPQSVTVLTVGSHNSTSI 783

  Fly   879 FLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAA 943
            .:.|..|....::|::..|.:...|     |.:|...|.|:||...::|:..|..|:.|.|.|||
  Rat   784 SVSWDPPPADHQNGIIQEYKIWCLG-----NETRFHINKTVDATIRSVVIGGLFPGIQYRVEVAA 843

  Fly   944 GNNAGVGPYCVPATLRLDPITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSFGA 1008
            ..:||||....|..:   .|..|.:..|.:......:.:.||:.||.||..:|....|:::.|..
  Rat   844 STSAGVGVKSEPQPI---IIGGRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSI 905

  Fly  1009 MVFVKRKHMM-MKQSALNTMRGNHTSDVLKMPSLSARNGNGYWLDSSTGGMVWRPS-PG----GD 1067
            .::.:||... :...|:...||:                         ||::...| ||    ||
  Rat   906 WLYWRRKKRKGLSNYAVTFQRGD-------------------------GGLMSNGSRPGLLNTGD 945

  Fly  1068 SLEMQKDHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGH-------GSERNQQRY 1125
            .   ....:||..|....|.:.:..|.:..|:.|.|......:.....|       |.|||:...
  Rat   946 P---SYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDFKHNVNKNLAEHGIKKEFLGMERNKNDV 1007

  Fly  1126 V------GE-----------YSNI----PTDYAEVSSFGKAPSEYGRHGNASPAPYATSSIL--- 1166
            :      |:           ||:|    .|.|...|...:|            .||||:.||   
  Rat  1008 LPPVPGQGDKTATMLSDGAIYSSIDFTTKTTYNSSSQITQA------------TPYATTQILHSN 1060

  Fly  1167 SPHQ-----QQQQQQPRYQQRP---------------------VPGY----GLQRPMHPHYQQQQ 1201
            |.|:     ...|.:...||:.                     :|.|    ||...| ||.|.|.
  Rat  1061 SIHELAVDLPDPQWKSSVQQKSDLMGFAYSLPDQNKGNNALLYIPDYRLAEGLSNRM-PHNQSQD 1124

  Fly  1202 HQQQQAQQTHQQHQALQ------------------------QHQQLPPSNIYQQMSTTSEIYPTN 1242
            .....:..:.::..:|.                        .:..|||..:.....|....||..
  Rat  1125 FSTTSSHNSSERSGSLSGGKGGKKKKTKNSSKAQKNNGSTWANVPLPPPPVQPLPGTELGHYPAE 1189

  Fly  1243 TGPSRSVYSEQYYYPKDKQRHIHI-TENKLSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCS 1306
              ......|:.:..|...|.::|. .|::|.........|      |:....:|       |..|
  Rat  1190 --QENGYDSDSWCPPLPVQTYLHQGMEDELEEDEDRVPTP------PVRGVASS-------PAIS 1239

  Fly  1307 IGRESARFKVLNTDQGKNQQNLLDLDGSSMCYNGLADSGCGGSPSP----MAMLMSHEDEHALYH 1367
            .|                ||:...|                 :|||    ..||.:|        
  Rat  1240 FG----------------QQSTATL-----------------TPSPREEMQPMLQAH-------- 1263

  Fly  1368 TADGDLDDMERLYV--------KVDEQQPPQQQQQLIPLVPQHPAEGHLQSWRNQSTRSSRKNGQ 1424
                 ||::.|.|.        .:....||.|.    |:.|...|.|.|.|...........:.:
  Rat  1264 -----LDELTRAYQFDIAKQTWHIQSNTPPPQP----PVPPLGYASGALISDLETDVPDEDADDE 1319

  Fly  1425 ECIKEPSE-------LIYAPGS--------------------------VASERSLLSNSGSGT-- 1454
            |   ||.|       |...|||                          .:|.||.:.:|..|:  
  Rat  1320 E---EPLEIPRPLRALDQTPGSSMDNLDSSVTGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIF 1381

  Fly  1455 -----------SSQPAGHNVXPLLPGSSL---GQSQSKSQSQ--------SQSQSDLQSQEQ 1494
                       ::..||..    |.|:||   |::.:.||.|        ..:.|..|:|.|
  Rat  1382 ASGSFAQALVAAADKAGFR----LDGTSLTRTGKAFTSSQRQRPTSPFSTDSNTSAAQNQSQ 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 54/97 (56%)
Ig strand A 91..95 CDD:409490 3/3 (100%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 4/7 (57%)
Ig strand C 121..126 CDD:409490 3/4 (75%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 1/2 (50%)
Ig strand E 145..151 CDD:409490 4/5 (80%)
Ig strand F 162..170 CDD:409490 5/7 (71%)
Ig strand G 173..185 CDD:409490 7/11 (64%)
IgI_2_Robo 192..279 CDD:409389 39/87 (45%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 3/6 (50%)
Ig strand C 220..225 CDD:409389 2/4 (50%)
Ig strand C' 227..230 CDD:409389 0/2 (0%)
Ig strand D 237..241 CDD:409389 2/4 (50%)
Ig strand E 244..250 CDD:409389 3/5 (60%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 5/10 (50%)
Ig 286..370 CDD:472250 26/83 (31%)
Ig strand B 300..304 CDD:409353 1/3 (33%)
Ig strand C 313..317 CDD:409353 1/3 (33%)
Ig strand E 336..340 CDD:409353 1/3 (33%)
Ig strand F 350..355 CDD:409353 2/4 (50%)
Ig strand G 363..366 CDD:409353 1/2 (50%)
Ig_3 373..457 CDD:464046 30/84 (36%)
Ig 480..566 CDD:472250 36/85 (42%)
Ig strand B 496..500 CDD:409353 1/3 (33%)
Ig strand C 509..513 CDD:409353 1/3 (33%)
Ig strand E 533..537 CDD:409353 2/3 (67%)
Ig strand F 548..553 CDD:409353 3/4 (75%)
Ig strand G 561..564 CDD:409353 2/2 (100%)
COG3979 586..>800 CDD:443178 68/218 (31%)
FN3 588..681 CDD:238020 41/92 (45%)
fn3 864..952 CDD:394996 27/90 (30%)
Robo2XP_038944599.1 IgC_1_Robo 54..152 CDD:409490 54/97 (56%)
Ig strand A 54..58 CDD:409490 3/3 (100%)
Ig strand A' 61..66 CDD:409490 1/4 (25%)
Ig strand B 70..78 CDD:409490 4/7 (57%)
Ig strand C 84..89 CDD:409490 3/4 (75%)
Ig strand C' 92..94 CDD:409490 0/1 (0%)
Ig strand D 105..108 CDD:409490 1/2 (50%)
Ig strand E 111..117 CDD:409490 4/5 (80%)
Ig strand F 129..137 CDD:409490 5/7 (71%)
Ig strand G 140..152 CDD:409490 7/11 (64%)
Ig 159..244 CDD:472250 39/87 (45%)
Ig strand B 173..177 CDD:409353 1/3 (33%)
Ig strand C 187..191 CDD:409353 1/3 (33%)
Ig strand E 209..213 CDD:409353 2/3 (67%)
Ig strand F 223..228 CDD:409353 2/4 (50%)
Ig strand G 237..240 CDD:409353 1/2 (50%)
Ig 251..333 CDD:472250 26/83 (31%)
Ig strand B 265..269 CDD:409353 1/3 (33%)
Ig strand C 278..282 CDD:409353 1/3 (33%)
Ig strand E 299..303 CDD:409353 1/3 (33%)
Ig strand F 313..318 CDD:409353 2/4 (50%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
IgI_4_Robo 342..439 CDD:409391 33/99 (33%)
Ig strand A 342..346 CDD:409391 2/3 (67%)
Ig strand A' 348..352 CDD:409391 1/3 (33%)
Ig strand B 358..366 CDD:409391 3/7 (43%)
Ig strand C 369..376 CDD:409391 2/6 (33%)
Ig strand C' 378..381 CDD:409391 1/2 (50%)
Ig strand D 394..399 CDD:409391 0/4 (0%)
Ig strand E 401..408 CDD:409391 3/8 (38%)
Ig strand F 414..423 CDD:409391 4/9 (44%)
Ig strand G 425..436 CDD:409391 2/10 (20%)
IgI_5_Robo 446..532 CDD:409544 37/87 (43%)
Ig strand A 446..449 CDD:409544 2/2 (100%)
Ig strand A' 453..456 CDD:409544 2/2 (100%)
Ig strand B 462..469 CDD:409544 2/6 (33%)
Ig strand C 475..480 CDD:409544 2/4 (50%)
Ig strand C' 482..484 CDD:409544 1/1 (100%)
Ig strand D 491..495 CDD:409544 1/3 (33%)
Ig strand E 498..503 CDD:409544 2/4 (50%)
FN3 <510..882 CDD:442628 122/446 (27%)
Ig strand F 511..519 CDD:409544 6/7 (86%)
Ig strand G 522..532 CDD:409544 5/9 (56%)
FN3 549..642 CDD:238020 42/95 (44%)

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