DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo2 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	430	Identity:	102/430 - (23%)
Similarity:	150/430 - (34%)	Gaps:	121/430 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LKTDTGSHRIMLPAGGLFFLKVIHSRRESDAGTYWCEAKNEFGVARSRNATLQVAFLRD-EFRLE 194
            |.|||||                    |.:||       |..|      :||......| ||...
  Fly    26 LSTDTGS--------------------EGNAG-------NVGG------STLNNVISEDPEFTDV 57

  Fly   195 PANTRVAQGEVALMECGAPR-GSPEPQISWRKNGQTLNL-------VGNKRIRIVDGGN------ 245
            ..|..|..|....:.|.... ||  .:::|....|:..|       ..|.||.:....:
  Fly    58 IENITVPAGRNVKLACSVKNLGS--YKVAWMHFEQSAILTVHNHVITRNPRISVTHDKHDKHRTW 120

  Fly   246 -LAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVV--GSSVVFQCRIG 307
             |.|...::.|.|||.|.:..|  |.::...|:||.|.|.:.....:...:|  |.:|..:|:..
  Fly   121 FLHINNVQEEDRGRYMCQINTV--TAKTQYGFVKVVVPPNIDDALTSSDIIVREGDNVTLRCKAK 183

  Fly   308 GDPLPDVLWRRTASGGNMPLRR---VHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILT 369
            |.|.|.:.|:|. .|..:.:.:   ||.||..||:|:.::...||.|.|.|.|.|
  Fly   184 GSPEPTIKWKRD-DGNKIVINKTLEVHDLETDSLELERISRLHMGAYLCIASNGV---------- 237

  Fly   370 VHAPPKFVIRPK------------NQLV--EIGDEVLFECQANGHPRPTLYWSVEGNSSL----- 415
               ||....|.|            :|||  .||..:..||....:|....||:.|.:..:
  Fly   238 ---PPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLECFIEANPTSLNYWTRENDQMITESSK 299

  Fly   416 ----LLPGYRDGRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFEL 476
                .:||:...:..:.||        |......|.|. ..|.|.|..|.:.....:.:.:
  Fly   300 YKTETIPGHPSYKATMRLT--------ITNVQSSDYGN-YKCVAKNPRGDMDGNIKLYMSS---- 351

  Fly   477 PPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDG 516
             ||..:..|...||          |...|...:::  |||
  Fly   352 -PPTTQPPPTTTTL----------RRTTTTAAEIA--LDG 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	13/53 (25%)
		I-set	91..184	CDD:254352	13/52 (25%)
		I-set	190..279	CDD:254352	24/103 (23%)
		Ig2_Robo	193..279	CDD:143201	22/100 (22%)
		I-set	283..370	CDD:254352	25/91 (27%)
		Ig	300..370	CDD:299845	22/72 (31%)
		Ig	388..>457	CDD:299845	16/77 (21%)
		I-set	479..561	CDD:254352	9/38 (24%)
		Ig	496..561	CDD:143165	5/21 (24%)
		FN3	588..681	CDD:238020
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	24/99 (24%)
		Ig	69..139	CDD:143165	16/71 (23%)
		IG_like	165..249	CDD:214653	28/97 (29%)
		IGc2	172..237	CDD:197706	22/65 (34%)
		IG_like	267..348	CDD:214653	18/89 (20%)
		Ig	270..339	CDD:299845	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100