DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and ROBO2

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1576 Identity:458/1576 - (29%)
Similarity:689/1576 - (43%) Gaps:334/1576 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 VFPLLLLLAG--LNGLTQV----------GALKGEN--PRIIEHPMDTTVPKNDPFTFNCQAEGN 117
            :|.|:|.|:|  |:.||:.          ..|:.|:  |||:|||.|..|.|.:|.|.||:|||.
Human    16 LFVLMLFLSGPTLSKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGR 80

  Fly   118 PTPTIQWFKDGRELKTDTG---SHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSR 178
            |||||:|:|||..::||..   |||::||:|.||||:::|.|| :.|.|:|.|.|:|..|.|.||
Human    81 PTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR 145

  Fly   179 NATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRI-VD 242
            ||:|:||.|||:||..|.:..||.||.|::||..|||.|||.|.|:|:...::   :|..|| :.
Human   146 NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID---DKEERISIR 207

  Fly   243 GGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIG 307
            ||.|.|...|:||.|.|.||..|:||.|:|..|.|.|..||..:|.|.||..:...:|.|:|::.
Human   208 GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 272

  Fly   308 GDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVH- 371
            |||.|.|.|::  ...::|..|..:.:|.:|::......|.|.|.|.|:|.||.:.|:..|||. 
Human   273 GDPQPTVRWKK--DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 335

  Fly   372 ---APPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGY-RDGRMEVTLTPE 432
               |||:||:||::|:|..|..|.|.|:..|:|:|.::|..||:.:||.|.. :......:::|.
Human   336 RPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 400

  Fly   433 GRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSV-DTQFELPPPIIEQGPVNQTLPVKSIV 496
            |.  |:|....|.|:|..: |.||...||:.::..:.| |...:.|||||.|||.||||.|....
Human   401 GD--LTITNIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 462

  Fly   497 VLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSS 561
            :|.|:..|.|:|.:||..:|.....:: .|..:.:.|.|.|.:| |..|.|.|||||::.:|::|
Human   463 LLKCKATGDPLPVISWLKEGFTFPGRD-PRATIQEQGTLQIKNL-RISDTGTYTCVATSSSGETS 525

  Fly   562 WSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEM 626
            ||..|.:   |.......:..:||..||||.|||:.:..:||||||| :....|......|:||.
Human   526 WSAVLDV---TESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGTLPASAYIIEA 586

  Fly   627 FGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFN--- 688
            |.::.::.|..|...|:.|.:|..||.|...|.|::||.|..|||.|||||:|  |.|:..:   
Human   587 FSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP--VRTQDISPPA 649

  Fly   689 SGLDLSEARASLLSGDV-VELSNASVVDSTSMKLTWQI-INGKYVEGFYVYARQLPNPIVNNPAP 751
            .|:|..:.:..|  ||| |.|.|..|:..|::::||.: ...::::|:.|..||           
Human   650 QGVDHRQVQKEL--GDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQ----------- 701

  Fly   752 VTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNG 816
             ||      |..:||:..:..|.                         .||              
Human   702 -TS------GLQATSSWQNLDAK-------------------------VPT-------------- 720

  Fly   817 GGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALLL---NSSAV 878
              ..|..:..|.:...||..:.|::...:|..|.|:..||.|:.||..|..:..|.:   ||:::
Human   721 --ERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 783

  Fly   879 FLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAA 943
            .:.|..|....::|::..|.:...|     |.:|...|.|:|||..::::..|..|:.|.|.|||
Human   784 SVSWDPPPPDHQNGIIQEYKIWCLG-----NETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 843

  Fly   944 GNNAGVGPYCVPATLRLDPITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSFGA 1008
            ..:||||....|..:   .|.:|.:..|.:......:.:.||:.||.||..:|....|:::.|..
Human   844 STSAGVGVKSEPQPI---IIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSI 905

  Fly  1009 MVFVKRKHMM-MKQSALNTMRGNHTSDVLKMPSLSARNGNGYWLDSSTGGMVWRPS-PG----GD 1067
            .::.:||... :...|:...||:                         ||::...| ||    ||
Human   906 WLYWRRKKRKGLSNYAVTFQRGD-------------------------GGLMSNGSRPGLLNAGD 945

  Fly  1068 SLEMQKDHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDI---HGGHGSERNQQRYVGE- 1128
            .   ....:||..|....|.:.:..|.:..|:.|.|       |:   ..|.|.:.......|. 
Human   946 P---SYPWLADSWPATSLPVNNSNSGPNEIGNFGRG-------DVLPPVPGQGDKTATMLSDGAI 1000

  Fly  1129 YSNIPTDYAEVSSFGKAPSEYGRHGNASPAPYATSSIL---SPHQ------QQQQQQPRYQQRPV 1184
            ||:|  |:...:|:..:..      .....||||:.||   |.|:      ..|.:....|:..:
Human  1001 YSSI--DFTTKTSYNSSSQ------ITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDL 1057

  Fly  1185 PGYGLQRPMHPHYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSV 1249
            .|:|...|       .|::...|......::..:......|.|..|..||||....:....|.|.
Human  1058 MGFGYSLP-------DQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSG 1115

  Fly  1250 YSEQYYYPKDKQRHIHITENKLSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARF 1314
            ..     ...|:::.:.::.:.:|..|:...|  ....|:         |.||     |.|...:
Human  1116 GK-----GGKKKKNKNSSKPQKNNGSTWANVP--LPPPPV---------QPLP-----GTELEHY 1159

  Fly  1315 KVLNTDQGKNQQNLLDLDGSSMC---------YNGLADS--------------GCGGS------- 1349
            .|      :.|:|..|.|  |.|         :.||.|.              |...|       
Human  1160 AV------EQQENGYDSD--SWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQ 1216

  Fly  1350 -------PSP----MAMLMSHEDE----------HALYH-------------------------- 1367
                   |||    ..||.:|.||          ...:|                          
Human  1217 QSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDL 1281

  Fly  1368 ---TADGDLDDMERLY-----VKVDEQQPPQQQQQLIPLVPQHPAEGHLQSWRNQSTR----SSR 1420
               .||.|.||.|...     ::..:|.|......|...|......|    |.:.|..    ||.
Human  1282 ETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGSMVNG----WGSASDEDRNFSSH 1342

  Fly  1421 KNGQECIKEPSELIYAPGSVAS-------------ERSLLSNSGSG-TSSQ-PAGHNVXPLLPGS 1470
            ::......:.|  |:|.||.|.             :.:.|:.:|.. |||| |.        |.|
Human  1343 RSSVGSSSDGS--IFASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPR--------PTS 1397

  Fly  1471 SLGQSQSKSQSQSQSQ 1486
            ......:.|.:.||||
Human  1398 PFSTDSNTSAALSQSQ 1413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 53/97 (55%)
Ig strand A 91..95 CDD:409490 3/3 (100%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 4/7 (57%)
Ig strand C 121..126 CDD:409490 3/4 (75%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 1/2 (50%)
Ig strand E 145..151 CDD:409490 4/5 (80%)
Ig strand F 162..170 CDD:409490 4/7 (57%)
Ig strand G 173..185 CDD:409490 7/11 (64%)
IgI_2_Robo 192..279 CDD:409389 39/87 (45%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 3/6 (50%)
Ig strand C 220..225 CDD:409389 2/4 (50%)
Ig strand C' 227..230 CDD:409389 0/2 (0%)
Ig strand D 237..241 CDD:409389 2/4 (50%)
Ig strand E 244..250 CDD:409389 3/5 (60%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 5/10 (50%)
Ig 286..370 CDD:472250 27/83 (33%)
Ig strand B 300..304 CDD:409353 2/3 (67%)
Ig strand C 313..317 CDD:409353 1/3 (33%)
Ig strand E 336..340 CDD:409353 1/3 (33%)
Ig strand F 350..355 CDD:409353 2/4 (50%)
Ig strand G 363..366 CDD:409353 1/2 (50%)
Ig_3 373..457 CDD:464046 30/84 (36%)
Ig 480..566 CDD:472250 35/85 (41%)
Ig strand B 496..500 CDD:409353 1/3 (33%)
Ig strand C 509..513 CDD:409353 1/3 (33%)
Ig strand E 533..537 CDD:409353 2/3 (67%)
Ig strand F 548..553 CDD:409353 3/4 (75%)
Ig strand G 561..564 CDD:409353 2/2 (100%)
COG3979 586..>800 CDD:443178 66/218 (30%)
FN3 588..681 CDD:238020 41/92 (45%)
fn3 864..952 CDD:394996 27/90 (30%)
ROBO2XP_011532283.1 IgC_1_Robo 54..152 CDD:409490 53/97 (55%)
Ig strand A 54..58 CDD:409490 3/3 (100%)
Ig strand A' 61..66 CDD:409490 1/4 (25%)
Ig strand B 70..78 CDD:409490 4/7 (57%)
Ig strand C 84..89 CDD:409490 3/4 (75%)
Ig strand C' 92..94 CDD:409490 0/1 (0%)
Ig strand D 105..108 CDD:409490 1/2 (50%)
Ig strand E 111..117 CDD:409490 4/5 (80%)
Ig strand F 129..137 CDD:409490 4/7 (57%)
Ig strand G 140..152 CDD:409490 7/11 (64%)
Ig 159..244 CDD:472250 39/87 (45%)
Ig strand B 173..177 CDD:409353 1/3 (33%)
Ig strand C 187..191 CDD:409353 1/3 (33%)
Ig strand E 209..213 CDD:409353 2/3 (67%)
Ig strand F 223..228 CDD:409353 2/4 (50%)
Ig strand G 237..240 CDD:409353 1/2 (50%)
Ig 251..333 CDD:472250 27/83 (33%)
Ig strand B 265..269 CDD:409353 2/3 (67%)
Ig strand C 278..282 CDD:409353 1/3 (33%)
Ig strand E 299..303 CDD:409353 1/3 (33%)
Ig strand F 313..318 CDD:409353 2/4 (50%)
Ig strand G 326..329 CDD:409353 1/2 (50%)
IgI_4_Robo 342..439 CDD:409391 33/99 (33%)
Ig strand A 342..346 CDD:409391 2/3 (67%)
Ig strand A' 348..352 CDD:409391 1/3 (33%)
Ig strand B 358..366 CDD:409391 3/7 (43%)
Ig strand C 369..376 CDD:409391 2/6 (33%)
Ig strand C' 378..381 CDD:409391 1/2 (50%)
Ig strand D 394..399 CDD:409391 0/4 (0%)
Ig strand E 401..408 CDD:409391 3/8 (38%)
Ig strand F 414..423 CDD:409391 4/9 (44%)
Ig strand G 425..436 CDD:409391 2/10 (20%)
IgI_5_Robo 446..532 CDD:409544 36/87 (41%)
Ig strand A 446..449 CDD:409544 2/2 (100%)
Ig strand A' 453..456 CDD:409544 2/2 (100%)
Ig strand B 462..469 CDD:409544 2/6 (33%)
Ig strand C 475..480 CDD:409544 2/4 (50%)
Ig strand C' 482..484 CDD:409544 1/1 (100%)
Ig strand D 491..495 CDD:409544 1/3 (33%)
Ig strand E 498..503 CDD:409544 2/4 (50%)
FN3 <510..882 CDD:442628 126/446 (28%)
Ig strand F 511..519 CDD:409544 6/7 (86%)
Ig strand G 522..532 CDD:409544 5/9 (56%)
FN3 549..642 CDD:238020 42/95 (44%)

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