DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and ROBO2

DIOPT Version :9

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1576 Identity:458/1576 - (29%)
Similarity:689/1576 - (43%) Gaps:334/1576 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 VFPLLLLLAG--LNGLTQV----------GALKGEN--PRIIEHPMDTTVPKNDPFTFNCQAEGN 117
            :|.|:|.|:|  |:.||:.          ..|:.|:  |||:|||.|..|.|.:|.|.||:|||.
Human    16 LFVLMLFLSGPTLSKLTRTPWKGKPWKGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGR 80

  Fly   118 PTPTIQWFKDGRELKTDTG---SHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSR 178
            |||||:|:|||..::||..   |||::||:|.||||:::|.|| :.|.|:|.|.|:|..|.|.||
Human    81 PTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSR 145

  Fly   179 NATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRI-VD 242
            ||:|:||.|||:||..|.:..||.||.|::||..|||.|||.|.|:|:...::   :|..|| :.
Human   146 NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRID---DKEERISIR 207

  Fly   243 GGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIG 307
            ||.|.|...|:||.|.|.||..|:||.|:|..|.|.|..||..:|.|.||..:...:|.|:|::.
Human   208 GGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQ 272

  Fly   308 GDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVH- 371
            |||.|.|.|::  ...::|..|..:.:|.:|::......|.|.|.|.|:|.||.:.|:..|||. 
Human   273 GDPQPTVRWKK--DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 335

  Fly   372 ---APPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGY-RDGRMEVTLTPE 432
               |||:||:||::|:|..|..|.|.|:..|:|:|.::|..||:.:||.|.. :......:::|.
Human   336 RPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPT 400

  Fly   433 GRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSV-DTQFELPPPIIEQGPVNQTLPVKSIV 496
            |.  |:|....|.|:|..: |.||...||:.::..:.| |...:.|||||.|||.||||.|....
Human   401 GD--LTITNIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTA 462

  Fly   497 VLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSS 561
            :|.|:..|.|:|.:||..:|.....:: .|..:.:.|.|.|.:| |..|.|.|||||::.:|::|
Human   463 LLKCKATGDPLPVISWLKEGFTFPGRD-PRATIQEQGTLQIKNL-RISDTGTYTCVATSSSGETS 525

  Fly   562 WSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEM 626
            ||..|.:   |.......:..:||..||||.|||:.:..:||||||| :....|......|:||.
Human   526 WSAVLDV---TESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSW-QPGTPGTLPASAYIIEA 586

  Fly   627 FGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFN--- 688
            |.::.::.|..|...|:.|.:|..||.|...|.|::||.|..|||.|||||:|  |.|:..:   
Human   587 FSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDP--VRTQDISPPA 649

  Fly   689 SGLDLSEARASLLSGDV-VELSNASVVDSTSMKLTWQI-INGKYVEGFYVYARQLPNPIVNNPAP 751
            .|:|..:.:..|  ||| |.|.|..|:..|::::||.: ...::::|:.|..||           
Human   650 QGVDHRQVQKEL--GDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQ----------- 701

  Fly   752 VTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNG 816
             ||      |..:||:..:..|.                         .||              
Human   702 -TS------GLQATSSWQNLDAK-------------------------VPT-------------- 720

  Fly   817 GGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEALLL---NSSAV 878
              ..|..:..|.:...||..:.|::...:|..|.|:..||.|:.||..|..:..|.:   ||:::
Human   721 --ERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSI 783

  Fly   879 FLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAA 943
            .:.|..|....::|::..|.:...|     |.:|...|.|:|||..::::..|..|:.|.|.|||
Human   784 SVSWDPPPPDHQNGIIQEYKIWCLG-----NETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAA 843

  Fly   944 GNNAGVGPYCVPATLRLDPITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSFGA 1008
            ..:||||....|..:   .|.:|.:..|.:......:.:.||:.||.||..:|....|:::.|..
Human   844 STSAGVGVKSEPQPI---IIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSI 905

  Fly  1009 MVFVKRKHMM-MKQSALNTMRGNHTSDVLKMPSLSARNGNGYWLDSSTGGMVWRPS-PG----GD 1067
            .::.:||... :...|:...||:                         ||::...| ||    ||
Human   906 WLYWRRKKRKGLSNYAVTFQRGD-------------------------GGLMSNGSRPGLLNAGD 945

  Fly  1068 SLEMQKDHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDI---HGGHGSERNQQRYVGE- 1128
            .   ....:||..|....|.:.:..|.:..|:.|.|       |:   ..|.|.:.......|. 
Human   946 P---SYPWLADSWPATSLPVNNSNSGPNEIGNFGRG-------DVLPPVPGQGDKTATMLSDGAI 1000

  Fly  1129 YSNIPTDYAEVSSFGKAPSEYGRHGNASPAPYATSSIL---SPHQ------QQQQQQPRYQQRPV 1184
            ||:|  |:...:|:..:..      .....||||:.||   |.|:      ..|.:....|:..:
Human  1001 YSSI--DFTTKTSYNSSSQ------ITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDL 1057

  Fly  1185 PGYGLQRPMHPHYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSV 1249
            .|:|...|       .|::...|......::..:......|.|..|..||||....:....|.|.
Human  1058 MGFGYSLP-------DQNKGNNALLYIPDYRLAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSG 1115

  Fly  1250 YSEQYYYPKDKQRHIHITENKLSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARF 1314
            ..     ...|:::.:.::.:.:|..|:...|  ....|:         |.||     |.|...:
Human  1116 GK-----GGKKKKNKNSSKPQKNNGSTWANVP--LPPPPV---------QPLP-----GTELEHY 1159

  Fly  1315 KVLNTDQGKNQQNLLDLDGSSMC---------YNGLADS--------------GCGGS------- 1349
            .|      :.|:|..|.|  |.|         :.||.|.              |...|       
Human  1160 AV------EQQENGYDSD--SWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQ 1216

  Fly  1350 -------PSP----MAMLMSHEDE----------HALYH-------------------------- 1367
                   |||    ..||.:|.||          ...:|                          
Human  1217 QSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDL 1281

  Fly  1368 ---TADGDLDDMERLY-----VKVDEQQPPQQQQQLIPLVPQHPAEGHLQSWRNQSTR----SSR 1420
               .||.|.||.|...     ::..:|.|......|...|......|    |.:.|..    ||.
Human  1282 ETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGSMVNG----WGSASDEDRNFSSH 1342

  Fly  1421 KNGQECIKEPSELIYAPGSVAS-------------ERSLLSNSGSG-TSSQ-PAGHNVXPLLPGS 1470
            ::......:.|  |:|.||.|.             :.:.|:.:|.. |||| |.        |.|
Human  1343 RSSVGSSSDGS--IFASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPR--------PTS 1397

  Fly  1471 SLGQSQSKSQSQSQSQ 1486
            ......:.|.:.||||
Human  1398 PFSTDSNTSAALSQSQ 1413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 53/100 (53%)
I-set 91..184 CDD:254352 53/96 (55%)
I-set 190..279 CDD:254352 40/89 (45%)
Ig2_Robo 193..279 CDD:143201 38/86 (44%)
I-set 283..370 CDD:254352 28/86 (33%)
Ig 300..370 CDD:299845 23/69 (33%)
Ig 388..>457 CDD:299845 22/69 (32%)
I-set 479..561 CDD:254352 33/81 (41%)
Ig 496..561 CDD:143165 22/64 (34%)
FN3 588..681 CDD:238020 41/92 (45%)
FN3 <817..856 CDD:238020 8/38 (21%)
fn3 864..952 CDD:278470 27/90 (30%)
ROBO2XP_011532283.1 Ig1_Robo 53..152 CDD:143317 53/98 (54%)
Ig 160..244 CDD:325142 38/86 (44%)
Ig 265..333 CDD:325142 23/69 (33%)
Ig4_Robo 355..444 CDD:143203 27/91 (30%)
IG 451..532 CDD:214652 32/82 (39%)
FN3 549..642 CDD:238020 42/95 (44%)
FN3 673..758 CDD:238020 24/143 (17%)
FN3 766..859 CDD:238020 28/100 (28%)
PTN13_u3 <1374..>1431 CDD:318742 14/48 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 104 1.000 Domainoid score I6690
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101537
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.670

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