DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and robo4

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:1559 Identity:312/1559 - (20%)
Similarity:480/1559 - (30%) Gaps:689/1559 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 QC-------LTNESEIQIKIKSKIKNKTASEIKRRHRNNRDFHGERLKIMPVDRSRRAVFPLLLL 73
            ||       :...||.:..::.::.::.||...|.||..    |.||                  
Zfish    22 QCACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRK----GSRL------------------ 64

  Fly    74 LAGLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGREL---KTDT 135
                  ::::..     |||:.||.|..|....|.|.:|:|||||.|||||.::|:.|   |.|.
Zfish    65 ------VSEINL-----PRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDA 118

  Fly   136 GSHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTR 199
            .|..|:||.|.|||..|:..|: :|....|.|.|.|..|.|.||||:|.:|.||::||::|::..
Zfish   119 QSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQPSDVE 183

  Fly   200 VAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQCVVK 264
            ||.||:|.:.|..|.|.|||.::|||:|..:|........:  .|.|.|..|:::|.|.|.|:..
Zfish   184 VAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTEL--KGKLIIAPAQKNDSGVYSCIAS 246

  Fly   265 NVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRR 329
            |::|.|||..|.|.|..:|.|:|.|::.:..:|.|..|.|...|||:|.:.|.|  ..|.:|..|
Zfish   247 NMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSR--EQGPLPNGR 309

  Fly   330 VHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFE 394
            ..:..|.||::..||.:|||.|:|..:|.:|...|:..|               |||        
Zfish   310 YLINPDHSLQIHYVTAQDMGRYSCTVENKLGVSVASAQL---------------LVE-------- 351

  Fly   395 CQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAV 459
                                                                             
Zfish   352 ----------------------------------------------------------------- 351

  Fly   460 GSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEH 524
                                                                             
Zfish   352 ----------------------------------------------------------------- 351

  Fly   525 ERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPG 589
                  |||...:.||.:                                        |||.   
Zfish   352 ------DAGGTRLRDLHK----------------------------------------ELSA--- 367

  Fly   590 PPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLP 654
                   :.....:||:..|.||    .|.|.:.::.||                          
Zfish   368 -------LRVSLENVTVMSTASN----MSQVMWKLQSFG-------------------------- 395

  Fly   655 GVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSM 719
                                  |:|                                        
Zfish   396 ----------------------SQP---------------------------------------- 398

  Fly   720 KLTWQIINGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIA 784
                     .|:|||.|..|.|                         ..||:..:|....:|:: 
Zfish   399 ---------HYLEGFEVLYRSL-------------------------LPASSDWTAQRVPQPSL- 428

  Fly   785 AAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPS 849
                   .|:..      ||...|:                       |||.:.|:..|:.|:.|
Zfish   429 -------HTHVG------PLKRGYK-----------------------YEFKVRPYGSSLYGRES 457

  Fly   850 NSRIARTLEDVPSEAPYGMEALL--LNSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSR 912
            |:|..|..|.|||.||..:...:  ..:..|.|.|:.|.....:|::..|.|.....:...:|  
Zfish   458 NTRHLRVPEIVPSAAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTSF-- 520

  Fly   913 ILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKRLDPFINQRYPI 977
               |.|:|:.:.::.:..|....:|.|.|||.|.||||....|..|.::   .||:....|...:
Zfish   521 ---NWTVDSGTHSIEIFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIE---SRLEATPYQTGIL 579

  Fly   978 NQDHVNDVLTQPWFIILLGAIL-AVLMLSFGAMVFVKRKHMMM-----KQSALNTMRGNHTSDVL 1036
            :..|...|:.:|.||..:|.:| .|||::   .||:.|:|:..     |.|.|..:   .:.|::
Zfish   580 SMSHFVSVIKEPVFIGSVGTLLWCVLMIT---AVFLYRRHIRPANPSGKSSGLYRL---ESEDLI 638

  Fly  1037 KMPSLSARNG---NGYWLDSSTG----GMVWRPSPGGDSLE-------MQKD--HIADYAPV--- 1082
            ....::|.:.   :|.|...|..    |: |.||.....|.       ::||  .:....|:   
Zfish   639 IKHRMAAPDSPWISGGWRPGSNSEPKQGL-WTPSQENSGLRRTTLPITVKKDPNPLRSAVPIVPD 702

  Fly  1083 -CGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQRYVGEYSNIPTDYAEVSSFG-KA 1145
             ||..|                                              |.|.:::..| |.
Zfish   703 NCGVYG----------------------------------------------TFYVDLTGNGLKT 721

  Fly  1146 PSEYGR-----HGNASPAPYATSSILSPHQQQQQQQPRYQQRPVPGYGLQRPMHPHYQQQQHQQQ 1205
            .:..||     |||:              |.|..:..|..: |:....:.|.:            
Zfish   722 FNSPGRCPRMPHGNS--------------QLQNSETIRITE-PIVKTAVVREL------------ 759

  Fly  1206 QAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDKQRHIHITENK 1270
                     |||...:.||..                  |:..|..|.  :.|:.:|.:      
Zfish   760 ---------QALPWKRTLPAQ------------------PNMGVKKES--WEKNVKREL------ 789

  Fly  1271 LSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARFKVLNTDQGKNQQNLLDLDGSS 1335
                |..::||    ..|::.|..:|        ||......||                     
Zfish   790 ----HAVKSAP----LMPLNQQALAV--------CSAPNHQQRF--------------------- 817

  Fly  1336 MCYNGLADSGCGGSPSPMAMLMSHEDEHALYHTADGDLDDMERLYVKVDEQQPPQQQQQLIPLVP 1400
                  :....||...|:..|.|   ...|:::|...|.||                   :|..|
Zfish   818 ------SQHPAGGVSEPVKPLSS---PRILHYSASLQLVDM-------------------LPSPP 854

  Fly  1401 QHPAE-GHLQSWRNQSTRSSRKNGQECIKEPSELIYAPGSVASERSLLSNSG-----SGTSSQPA 1459
            ..|.| .|..|..::||||::               ....:.|::|:.:.||     |..:..|.
Zfish   855 PLPMEDNHSLSSEDESTRSTK---------------LTVDIGSQQSVCAASGLQGPASANTGCPN 904

  Fly  1460 GHNVXPLLPG---------------------SSLGQSQ-----SKSQSQSQSQSDLQSQEQLYA 1497
            .|:. .|.|.                     |:.|.:|     .|.|.||.|.....|..:.::
Zfish   905 NHSPAQLSPSYSHLSTASFCLSTDDYQDTTLSTQGHTQYMEISPKPQGQSTSHQSTPSMPRPFS 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 46/97 (47%)
Ig strand A 91..95 CDD:409490 3/3 (100%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 3/7 (43%)
Ig strand C 121..126 CDD:409490 4/4 (100%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 1/2 (50%)
Ig strand E 145..151 CDD:409490 4/5 (80%)
Ig strand F 162..170 CDD:409490 3/7 (43%)
Ig strand G 173..185 CDD:409490 7/11 (64%)
IgI_2_Robo 192..279 CDD:409389 33/86 (38%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 2/6 (33%)
Ig strand C 220..225 CDD:409389 1/4 (25%)
Ig strand C' 227..230 CDD:409389 1/2 (50%)
Ig strand D 237..241 CDD:409389 0/3 (0%)
Ig strand E 244..250 CDD:409389 3/5 (60%)
Ig strand F 257..265 CDD:409389 3/7 (43%)
Ig strand G 268..279 CDD:409389 6/10 (60%)
Ig 286..370 CDD:472250 29/83 (35%)
Ig strand B 300..304 CDD:409353 1/3 (33%)
Ig strand C 313..317 CDD:409353 0/3 (0%)
Ig strand E 336..340 CDD:409353 2/3 (67%)
Ig strand F 350..355 CDD:409353 2/4 (50%)
Ig strand G 363..366 CDD:409353 1/2 (50%)
Ig_3 373..457 CDD:464046 3/83 (4%)
Ig 480..566 CDD:472250 5/85 (6%)
Ig strand B 496..500 CDD:409353 0/3 (0%)
Ig strand C 509..513 CDD:409353 0/3 (0%)
Ig strand E 533..537 CDD:409353 1/3 (33%)
Ig strand F 548..553 CDD:409353 0/4 (0%)
Ig strand G 561..564 CDD:409353 0/2 (0%)
COG3979 586..>800 CDD:443178 23/213 (11%)
FN3 588..681 CDD:238020 11/92 (12%)
fn3 864..952 CDD:394996 24/89 (27%)
robo4XP_689255.3 IgC_1_Robo 71..169 CDD:409490 46/97 (47%)
Ig strand A 71..75 CDD:409490 3/3 (100%)
Ig strand A' 78..83 CDD:409490 1/4 (25%)
Ig strand B 87..95 CDD:409490 3/7 (43%)
Ig strand C 101..106 CDD:409490 4/4 (100%)
Ig strand C' 109..111 CDD:409490 0/1 (0%)
Ig strand D 122..125 CDD:409490 1/2 (50%)
Ig strand E 128..134 CDD:409490 4/5 (80%)
Ig strand F 146..154 CDD:409490 3/7 (43%)
Ig strand G 157..169 CDD:409490 7/11 (64%)
IgI_2_Robo 176..261 CDD:409389 33/86 (38%)
Ig strand A 176..179 CDD:409389 1/2 (50%)
Ig strand A' 181..185 CDD:409389 0/3 (0%)
Ig strand B 189..196 CDD:409389 2/6 (33%)
Ig strand C 204..209 CDD:409389 1/4 (25%)
Ig strand C' 211..214 CDD:409389 1/2 (50%)
Ig strand D 220..224 CDD:409389 0/3 (0%)
Ig strand E 226..232 CDD:409389 3/5 (60%)
Ig strand F 239..247 CDD:409389 3/7 (43%)
Ig strand G 250..261 CDD:409389 6/10 (60%)
Ig 268..350 CDD:472250 29/98 (30%)
Ig strand B 282..286 CDD:409353 1/3 (33%)
Ig strand C 295..299 CDD:409353 0/3 (0%)
Ig strand E 316..320 CDD:409353 2/3 (67%)
Ig strand F 330..335 CDD:409353 2/4 (50%)
Ig strand G 343..346 CDD:409353 1/2 (50%)
FN3 373..448 CDD:214495 29/237 (12%)
FN3 472..560 CDD:238020 24/92 (26%)

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