DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo2 and robo4

DIOPT Version :9

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_689255.3 Gene:robo4 / 560765 ZFINID:ZDB-GENE-020809-1 Length:1134 Species:Danio rerio


Alignment Length:1559 Identity:312/1559 - (20%)
Similarity:480/1559 - (30%) Gaps:689/1559 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 QC-------LTNESEIQIKIKSKIKNKTASEIKRRHRNNRDFHGERLKIMPVDRSRRAVFPLLLL 73
            ||       :...||.:..::.::.::.||...|.||..    |.||                  
Zfish    22 QCACPPDEQVAQRSEGKGHLRHRLMHQRASHRDRAHRRK----GSRL------------------ 64

  Fly    74 LAGLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGREL---KTDT 135
                  ::::..     |||:.||.|..|....|.|.:|:|||||.|||||.::|:.|   |.|.
Zfish    65 ------VSEINL-----PRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDA 118

  Fly   136 GSHRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTR 199
            .|..|:||.|.|||..|:..|: :|....|.|.|.|..|.|.||||:|.:|.||::||::|::..
Zfish   119 QSQPIVLPDGSLFFFSVVPGRKGQSHEAVYACIAHNSIGNATSRNASLHIAALREDFRVQPSDVE 183

  Fly   200 VAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQCVVK 264
            ||.||:|.:.|..|.|.|||.::|||:|..:|........:  .|.|.|..|:::|.|.|.|:..
Zfish   184 VAIGEMATINCSPPVGHPEPNVTWRKDGILINSSNEHYTEL--KGKLIIAPAQKNDSGVYSCIAS 246

  Fly   265 NVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRR 329
            |::|.|||..|.|.|..:|.|:|.|::.:..:|.|..|.|...|||:|.:.|.|  ..|.:|..|
Zfish   247 NMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFFCEADGDPMPSIEWSR--EQGPLPNGR 309

  Fly   330 VHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFE 394
            ..:..|.||::..||.:|||.|:|..:|.:|...|:..|               |||        
Zfish   310 YLINPDHSLQIHYVTAQDMGRYSCTVENKLGVSVASAQL---------------LVE-------- 351

  Fly   395 CQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAV 459
                                                                             
Zfish   352 ----------------------------------------------------------------- 351

  Fly   460 GSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEH 524
                                                                             
Zfish   352 ----------------------------------------------------------------- 351

  Fly   525 ERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPG 589
                  |||...:.||.:                                        |||.   
Zfish   352 ------DAGGTRLRDLHK----------------------------------------ELSA--- 367

  Fly   590 PPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLP 654
                   :.....:||:..|.||    .|.|.:.::.||                          
Zfish   368 -------LRVSLENVTVMSTASN----MSQVMWKLQSFG-------------------------- 395

  Fly   655 GVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSM 719
                                  |:|                                        
Zfish   396 ----------------------SQP---------------------------------------- 398

  Fly   720 KLTWQIINGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIA 784
                     .|:|||.|..|.|                         ..||:..:|....:|:: 
Zfish   399 ---------HYLEGFEVLYRSL-------------------------LPASSDWTAQRVPQPSL- 428

  Fly   785 AAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPS 849
                   .|:..      ||...|:                       |||.:.|:..|:.|:.|
Zfish   429 -------HTHVG------PLKRGYK-----------------------YEFKVRPYGSSLYGRES 457

  Fly   850 NSRIARTLEDVPSEAPYGMEALL--LNSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSR 912
            |:|..|..|.|||.||..:...:  ..:..|.|.|:.|.....:|::..|.|.....:...:|  
Zfish   458 NTRHLRVPEIVPSAAPQDVSITMPAERNDTVHLSWEPPPHDAHNGIIQGYQVWCVESEEQTSF-- 520

  Fly   913 ILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKRLDPFINQRYPI 977
               |.|:|:.:.::.:..|....:|.|.|||.|.||||....|..|.::   .||:....|...:
Zfish   521 ---NWTVDSGTHSIEIFTLLPSRLYWVTVAAVNGAGVGVQSDPYKLLIE---SRLEATPYQTGIL 579

  Fly   978 NQDHVNDVLTQPWFIILLGAIL-AVLMLSFGAMVFVKRKHMMM-----KQSALNTMRGNHTSDVL 1036
            :..|...|:.:|.||..:|.:| .|||::   .||:.|:|:..     |.|.|..:   .:.|::
Zfish   580 SMSHFVSVIKEPVFIGSVGTLLWCVLMIT---AVFLYRRHIRPANPSGKSSGLYRL---ESEDLI 638

  Fly  1037 KMPSLSARNG---NGYWLDSSTG----GMVWRPSPGGDSLE-------MQKD--HIADYAPV--- 1082
            ....::|.:.   :|.|...|..    |: |.||.....|.       ::||  .:....|:   
Zfish   639 IKHRMAAPDSPWISGGWRPGSNSEPKQGL-WTPSQENSGLRRTTLPITVKKDPNPLRSAVPIVPD 702

  Fly  1083 -CGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQRYVGEYSNIPTDYAEVSSFG-KA 1145
             ||..|                                              |.|.:::..| |.
Zfish   703 NCGVYG----------------------------------------------TFYVDLTGNGLKT 721

  Fly  1146 PSEYGR-----HGNASPAPYATSSILSPHQQQQQQQPRYQQRPVPGYGLQRPMHPHYQQQQHQQQ 1205
            .:..||     |||:              |.|..:..|..: |:....:.|.:            
Zfish   722 FNSPGRCPRMPHGNS--------------QLQNSETIRITE-PIVKTAVVREL------------ 759

  Fly  1206 QAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDKQRHIHITENK 1270
                     |||...:.||..                  |:..|..|.  :.|:.:|.:      
Zfish   760 ---------QALPWKRTLPAQ------------------PNMGVKKES--WEKNVKREL------ 789

  Fly  1271 LSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARFKVLNTDQGKNQQNLLDLDGSS 1335
                |..::||    ..|::.|..:|        ||......||                     
Zfish   790 ----HAVKSAP----LMPLNQQALAV--------CSAPNHQQRF--------------------- 817

  Fly  1336 MCYNGLADSGCGGSPSPMAMLMSHEDEHALYHTADGDLDDMERLYVKVDEQQPPQQQQQLIPLVP 1400
                  :....||...|:..|.|   ...|:::|...|.||                   :|..|
Zfish   818 ------SQHPAGGVSEPVKPLSS---PRILHYSASLQLVDM-------------------LPSPP 854

  Fly  1401 QHPAE-GHLQSWRNQSTRSSRKNGQECIKEPSELIYAPGSVASERSLLSNSG-----SGTSSQPA 1459
            ..|.| .|..|..::||||::               ....:.|::|:.:.||     |..:..|.
Zfish   855 PLPMEDNHSLSSEDESTRSTK---------------LTVDIGSQQSVCAASGLQGPASANTGCPN 904

  Fly  1460 GHNVXPLLPG---------------------SSLGQSQ-----SKSQSQSQSQSDLQSQEQLYA 1497
            .|:...|.|.                     |:.|.:|     .|.|.||.|.....|..:.::
Zfish   905 NHSPAQLSPSYSHLSTASFCLSTDDYQDTTLSTQGHTQYMEISPKPQGQSTSHQSTPSMPRPFS 968

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 46/98 (47%)
I-set 91..184 CDD:254352 46/96 (48%)
I-set 190..279 CDD:254352 34/88 (39%)
Ig2_Robo 193..279 CDD:143201 32/85 (38%)
I-set 283..370 CDD:254352 31/86 (36%)
Ig 300..370 CDD:299845 25/69 (36%)
Ig 388..>457 CDD:299845 0/68 (0%)
I-set 479..561 CDD:254352 5/81 (6%)
Ig 496..561 CDD:143165 5/64 (8%)
FN3 588..681 CDD:238020 11/92 (12%)
FN3 <817..856 CDD:238020 9/38 (24%)
fn3 864..952 CDD:278470 24/89 (27%)
robo4XP_689255.3 Ig1_Robo 70..169 CDD:143317 46/103 (45%)
I-set 71..168 CDD:254352 46/96 (48%)
I-set 175..261 CDD:254352 34/87 (39%)
Ig2_Robo 177..261 CDD:143201 32/85 (38%)
I-set 265..350 CDD:254352 31/101 (31%)
Ig 282..350 CDD:299845 25/84 (30%)
FN3 373..448 CDD:214495 29/237 (12%)
FN3 472..560 CDD:238020 24/92 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I8418
eggNOG 1 0.900 - - E1_KOG4222
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
43.860

Return to query results.
Submit another query.