DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and ROBO4

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:NP_061928.4 Gene:ROBO4 / 54538 HGNCID:17985 Length:1007 Species:Homo sapiens


Alignment Length:1140 Identity:246/1140 - (21%)
Similarity:370/1140 - (32%) Gaps:392/1140 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 RAVFPLLLLLAGLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGR 129
            |...||||||. :.|:.|     ...|:|:.||.|.......|...:|||.|.|.|||:|..:|:
Human    12 RGSLPLLLLLI-MGGMAQ-----DSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQ 70

  Fly   130 ELKTDTGSHRIMLPAGGLFFLKV-----IHSRR--ESDAGTYWCEAKNEFGVARSRNATLQVAFL 187
            .|.........:||.|.|..|:.     .|..:  .:|.|.|.|||.|..|.|.||.|.|.||.|
Human    71 PLSMVPPDPHHLLPDGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVL 135

  Fly   188 RDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEAR 252
            |::|:::|.:.....||...:|||.|.|.|||.:||.|:|:.|.|...:  ..|.||:|.:..|.
Human   136 REDFQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR--HTVSGGSLLMARAE 198

  Fly   253 QSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWR 317
            :||:|.|.||..|..|.|||..|.:.       |:.||:.|               :|       
Human   199 KSDEGTYMCVATNSAGHRESRAARVS-------IQEPQDYT---------------EP------- 234

  Fly   318 RTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKN 382
                        |.:|..| ::|::|||       ...|.|.|                   || 
Human   235 ------------VELLAVR-IQLENVTL-------LNPDPAEG-------------------PK- 259

  Fly   383 QLVEIGDEVLFECQANGHPRPTLY--WSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFARE 445
                              |||.::  |.|.|.::                               
Human   260 ------------------PRPAVWLSWKVSGPAA------------------------------- 275

  Fly   446 DSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQV 510
                                                         |.:|...| .||...|..|.
Human   276 ---------------------------------------------PAQSYTAL-FRTQTAPGGQG 294

  Fly   511 SWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNR-NGKSSWSGYLRLDTPTNP 574
            :.:.:.:....|..|           :..|...:|.......:|.| .|..|             
Human   295 APWAEELLAGWQSAE-----------LGGLHWGQDYEFKVRPSSGRARGPDS------------- 335

  Fly   575 NIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLV-GYVIEMFGKNETD--GWV 636
            |:...|.||  ..|..|.:...::.|..:|.:||........:.:: ||.:...|.....  .|.
Human   336 NVLLLRLPE--KVPSAPPQEVTLKPGNGTVFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWT 398

  Fly   637 AVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPS-PM------------SEPITVGTRYFN 688
            .||.:.|....|.   :|| :|...:.|....|...|| |:            .||...|.    
Human   399 VVGEQTQLEIATH---MPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGP---- 455

  Fly   689 SGLDLSEARASLLSGDVVELSNASVVDSTSMKLTWQIINGKYV-------------EGFYVYARQ 740
              ..|.:.||:|...:|:.....::         |.::.|..|             .|.|.|..:
Human   456 --WTLEQLRATLKRPEVIATCGVAL---------WLLLLGTAVCIHRRRRARVHLGPGLYRYTSE 509

  Fly   741 LPNPIVNNPAPVTSNTNPLLGST--STSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTP 803
              :.|:.:  .:..:.:..|..|  |||.|...|:|:.:|::               .|..|..|
Human   510 --DAILKH--RMDHSDSQWLADTWRSTSGSRDLSSSSSLSSR---------------LGADARDP 555

  Fly   804 LNTKYRMLT-ILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNS-----RIARTLEDVPS 862
            |:.:..:|: .....|......|.    |.|...|.....|...:||..     |:...|..:.|
Human   556 LDCRRSLLSWDSRSPGVPLLPDTS----TFYGSLIAELPSSTPARPSPQVPAVRRLPPQLAQLSS 616

  Fly   863 EAPYGMEALL----LNSSAVFL----KWKAPELKD-RHGVLLNYHVIVRGIDTAHNFSRILTNVT 918
            ... ..::|.    |:|..:.|    .|||.:.:: :|.   |...::||   :|       ::.
Human   617 PCS-SSDSLCSRRGLSSPRLSLAPAEAWKAKKKQELQHA---NSSPLLRG---SH-------SLE 667

  Fly   919 IDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATL----RLDP---------ITKRLDP- 969
            :.|..               :|.....|....|..||..|    .|.|         :|:.|.| 
Human   668 LRACE---------------LGNRGSKNLSQSPGAVPQALVAWRALGPKLLSSSNELVTRHLPPA 717

  Fly   970 --FINQRYPINQDHVNDVLT--QPWFIILLGAILAVL-----------MLSFGAMVFVKRKHMMM 1019
              |.::..|.........:.  .|..|:|..|.:.:|           .|| |......|    :
Human   718 PLFPHETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLS-GPSPASSR----L 777

  Fly  1020 KQSALNTMRGNHTSDVLKMPSLSARNGNGYWLDSSTGGMVWRPSPGGDSLEMQKDHIADYAPVCG 1084
            ..|:|::: |.....||....::      ..|:.|.|....|.|               .:|:..
Human   778 SSSSLSSL-GEDQDSVLTPEEVA------LCLELSEGEETPRNS---------------VSPMPR 820

  Fly  1085 APGSPAGGG----------TSSGGSGGAGSGASGG 1109
            ||..|...|          |..|.:|| |.|..||
Human   821 APSPPTTYGYISVPTASEFTDMGRTGG-GVGPKGG 854

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 36/100 (36%)
Ig strand A 91..95 CDD:409490 2/3 (67%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 3/7 (43%)
Ig strand C 121..126 CDD:409490 3/4 (75%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 0/2 (0%)
Ig strand E 145..151 CDD:409490 2/5 (40%)
Ig strand F 162..170 CDD:409490 5/7 (71%)
Ig strand G 173..185 CDD:409490 6/11 (55%)
IgI_2_Robo 192..279 CDD:409389 34/86 (40%)
Ig strand A 192..195 CDD:409389 0/2 (0%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 2/6 (33%)
Ig strand C 220..225 CDD:409389 2/4 (50%)
Ig strand C' 227..230 CDD:409389 1/2 (50%)
Ig strand D 237..241 CDD:409389 0/3 (0%)
Ig strand E 244..250 CDD:409389 2/5 (40%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 5/10 (50%)
Ig 286..370 CDD:472250 15/83 (18%)
Ig strand B 300..304 CDD:409353 0/3 (0%)
Ig strand C 313..317 CDD:409353 0/3 (0%)
Ig strand E 336..340 CDD:409353 1/3 (33%)
Ig strand F 350..355 CDD:409353 0/4 (0%)
Ig strand G 363..366 CDD:409353 0/2 (0%)
Ig_3 373..457 CDD:464046 8/85 (9%)
Ig 480..566 CDD:472250 15/86 (17%)
Ig strand B 496..500 CDD:409353 1/3 (33%)
Ig strand C 509..513 CDD:409353 1/3 (33%)
Ig strand E 533..537 CDD:409353 0/3 (0%)
Ig strand F 548..553 CDD:409353 0/4 (0%)
Ig strand G 561..564 CDD:409353 1/2 (50%)
COG3979 586..>800 CDD:443178 47/244 (19%)
FN3 588..681 CDD:238020 24/108 (22%)
fn3 864..952 CDD:394996 15/96 (16%)
ROBO4NP_061928.4 Ig 32..133 CDD:472250 36/100 (36%)
Ig strand B 49..53 CDD:409353 0/3 (0%)
Ig strand C 62..66 CDD:409353 2/3 (67%)
Ig strand F 111..116 CDD:409353 2/4 (50%)
Ig strand G 125..128 CDD:409353 2/2 (100%)
IgI_2_Robo 140..225 CDD:409389 34/93 (37%)
Ig strand A 140..143 CDD:409389 0/2 (0%)
Ig strand A' 145..149 CDD:409389 0/3 (0%)
Ig strand B 153..160 CDD:409389 2/6 (33%)
Ig strand C 168..173 CDD:409389 2/4 (50%)
Ig strand C' 175..178 CDD:409389 1/2 (50%)
Ig strand D 183..187 CDD:409389 0/5 (0%)
Ig strand E 190..196 CDD:409389 2/5 (40%)
Ig strand F 203..211 CDD:409389 4/7 (57%)
Ig strand G 214..225 CDD:409389 5/17 (29%)
fn3 350..432 CDD:394996 18/85 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 531..551 8/34 (24%)
PHA03247 <567..876 CDD:223021 69/349 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..793 16/85 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 806..826 6/34 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..1007
Blue background indicates that the domain is not in the aligned region.

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