DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo2 and ihog

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_609085.1	Gene:	ihog / 33972	FlyBaseID:	FBgn0031872	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	968	Identity:	214/968 - (22%)
Similarity:	334/968 - (34%)	Gaps:	253/968 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 RIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGRELKTDTGSHR-IMLPAGGLFFLKVIHS 155
            ||:..|.....|..|.....|:....| ...:|            ||| ...|..|..:||...:
  Fly    54 RILRAPESLVAPLGDEVVLECETSLQP-ERFEW------------SHRSSRSPGAGFKYLKTGTA 105

  Fly   156 R----------------RESDAGTYWCEAKNEFG--VARSRNATLQVA--FLRDEFRLE-PANTR 199
            :                |....|.|.|  ...||  |..|..|.|::|  .|.|....| |...|
  Fly   106 KANVSQEAAISRLRVLVRPDTLGEYRC--VGWFGPLVVTSTIARLELASTSLVDAQESESPLQWR 168

  Fly   200 VAQGEVALMECGAP-RGSPEPQISWRKNGQTL--NLVGNKRIRIVDGGNLAIQEARQSDDGRYQC 261
            |:.|...|..||.. :.:|....|:.:||..:  ..:|.       .|||.:........|.|.|
  Fly   169 VSAGNSVLWSCGQQVQSNPSASWSYYRNGVEIKPEFIGT-------NGNLFLSNVSSESSGSYSC 226

  Fly   262 VVKN-VVGTRESATAFLKVHV---------RPFLIRG-PQNQTAVV--GSSVVFQCRIGGDPLPD 313
            ...| ..|.|......|::.|         .|.|:|| |.:|...:  |||::..|...|.|.|.
  Fly   227 QATNPASGERIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCPGVGSPPPT 291

  Fly   314 VLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGI-LTVHAPPKFV 377
            |:|......|.:..:|..|. ..:|::.:..:.|.|.|.|..||.|.......| :.|..||:.|
  Fly   292 VVWSSPDVVGAVKNKRSKVF-GHALEISNTRVNDAGTYICFQDNGVRPALEHYIKVHVEQPPQIV 355

  Fly   378 IRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARF 442
            ..|...|...||.:..||:|.|.|.|.:||.:.|:||:     .|...|::     .:.|.:...
  Fly   356 RPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSI-----DDSEAELS-----NNFLILHSV 410

  Fly   443 AREDSGKVVTCNALNAVGSVSSRTVVSVD-TQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTP 506
            .:..:| .|.|.|.|.:|..|:.|::.|: .|.:.|.   |.|..::..|.:.   ...:.:..|
  Fly   411 LKRHAG-YVQCFARNRLGEHSAGTLLQVNPKQIQEPR---ESGGTHRPKPNQG---SRQKQMYPP 468

  Fly   507 VP-----------QVSWYL---DGIPI---DVQEH---ERRN------------------LSDAG 533
            .|           .:.|.:   ||:||   .||..   :|:|                  |..:.
  Fly   469 TPPNVTRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSF 533

  Fly   534 ALTISDLQ-RHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGP-PGKPQM 596
            ..:::||: :|........|.||.:.|.|           |.:.||:..|..:..|.| |...::
  Fly   534 TASVTDLKPQHTYRFRILAVYSNNDNKES-----------NTSAKFYLQPGAALDPMPVPELLEI 587

  Fly   597 VEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFL 661
            .|..|.:|.|.|:.::......:.|| ...:..:.:.|                       .:|.
  Fly   588 EEYSETAVVLHWSLASDADEHLITGY-YAYYRPSSSAG-----------------------EYFK 628

  Fly   662 IRAENSHGLSLPSPMSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSMKLTWQII 726
            ...|.:|..|.   ...|:...|.|.......|.|.||..|. :.:........||:.:.|.|:.
  Fly   629 ATIEGAHARSF---KIAPLETATMYEFKLQSFSAASASEFSA-LKQGRTQRPKTSTTEEPTLQMG 689

  Fly   727 NGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALIST------KPNIAA 785
            :           |....|..|.    |.|.:|:|  |.|....:.....||||      :.|..:
  Fly   690 D-----------RDTTTPSHNE----TFNMSPML--TGTIGGGAVLILLLISTCFCVCRRRNSRS 737

  Fly   786 AGKRDGETNQS---------GGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFY 841
            .|....:...:         |..:||....:.|.:.|         |:..|.|..         .
  Fly   738 RGNNPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHI---------TLNPLAQQQ---------Q 784

  Fly   842 KSVEGKPSNSRIARTLEDVPSEAP-------YGMEALLLNSSAVFLKWKAPELKDRHGVLLNYHV 899
            :::|.|          .|...:||       |..:..|...|:..|: ::....:|.|
  Fly   785 QALEEK----------NDTDQDAPYYQRPSSYDYDPTLRRMSSSSLR-RSQRTLERAG------- 831

  Fly   900 IVRGIDTAHNFSRILTNVTIDAAS------PTLVL----------ANLTEGVMYTVGV 941
               |.:.::|.:....|.:.:|.|      |..||          .||:.|.:.:|||
  Fly   832 ---GSNGSNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSENLSSGSLNSVGV 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	25/111 (23%)
		I-set	91..184	CDD:254352	25/110 (23%)
		I-set	190..279	CDD:254352	23/93 (25%)
		Ig2_Robo	193..279	CDD:143201	23/90 (26%)
		I-set	283..370	CDD:254352	27/90 (30%)
		Ig	300..370	CDD:299845	18/70 (26%)
		Ig	388..>457	CDD:299845	20/68 (29%)
		I-set	479..561	CDD:254352	22/120 (18%)
		Ig	496..561	CDD:143165	19/103 (18%)
		FN3	588..681	CDD:238020	16/93 (17%)
		FN3	<817..856	CDD:238020	5/38 (13%)
		fn3	864..952	CDD:278470	22/101 (22%)
ihog	NP_609085.1	IG_like	59..145	CDD:214653	21/100 (21%)
		ig	265..330	CDD:278476	18/65 (28%)
		IG_like	267..348	CDD:214653	22/81 (27%)
		Ig	314..>377	CDD:299845	20/62 (32%)
		IG_like	364..437	CDD:214653	24/83 (29%)
		IGc2	365..427	CDD:197706	21/72 (29%)
		FN3	467..565	CDD:238020	21/108 (19%)
		fn3	580..655	CDD:278470	17/101 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452287
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840