DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo2 and DIP-eta

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	361	Identity:	97/361 - (26%)
Similarity:	135/361 - (37%)	Gaps:	71/361 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 RESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTR--VAQGEVALMECGAPRGSPEP 219
            :|||.|.|.|:...:  ..:|:...|.|....|.... |.:|.  |.:|....::|.| .|||||
  Fly   116 KESDKGWYMCQINTD--PMKSQMGYLDVVVPPDILDY-PTSTDMVVREGSNVTLKCAA-TGSPEP 176

  Fly   220 QISWRK-NGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRP 283
            .|:||: :|..:.|...:.:..::|.:|.|...|:...|.|.|:..|.|....|....|.||..|
  Fly   177 TITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVVHFPP 241

  Fly   284 FLIRGPQNQT--AVVGSSVVFQCRIGGDPLPDVLWRR----------------TASGGNMPLRRV 330
            .:.  .|||.  ||.|..|...|.....|.....|.|                |..||.....|:
  Fly   242 MIT--VQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSMRL 304

  Fly   331 HVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFEC 395
            |:        :.:|..:.|.|.|.|.|::|....| |.....||..|...:|          ||.
  Fly   305 HI--------NPLTQAEFGSYRCVAKNSLGDTDGT-IKLYRIPPNAVNYVEN----------FEA 350

  Fly   396 QANG----------HPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPE------GRSVLSIARFAR 444
            :..|          ||......|.|...:   ||.|  :.:::|..|      |.|.....|  |
  Fly   351 RHKGKKRTKSSESHHPARAQEHSGEDMEN---PGKR--KADLSLGAESIDSIYGNSAAGSRR--R 408

  Fly   445 EDSGKVVTCNALNAVGSVSSRTVVSV--DTQFELPP 478
            :|.|.|:......||....|.....|  :||..|||
  Fly   409 QDLGGVLLLLLPVAVAVAMSLATAGVMRETQMTLPP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	8/27 (30%)
		I-set	91..184	CDD:254352	8/26 (31%)
		I-set	190..279	CDD:254352	27/91 (30%)
		Ig2_Robo	193..279	CDD:143201	27/88 (31%)
		I-set	283..370	CDD:254352	26/104 (25%)
		Ig	300..370	CDD:299845	19/85 (22%)
		Ig	388..>457	CDD:299845	19/84 (23%)
		I-set	479..561	CDD:254352	97/361 (27%)
		Ig	496..561	CDD:143165
		FN3	588..681	CDD:238020
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	8/26 (31%)
		IG_like	51..137	CDD:214653	7/22 (32%)
		IG_like	153..237	CDD:214653	26/84 (31%)
		Ig	161..224	CDD:299845	20/63 (32%)
		IG_like	252..335	CDD:214653	22/91 (24%)
		Ig	258..333	CDD:143165	18/83 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010