DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo2 and fipi

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	99/447 - (22%)
Similarity:	157/447 - (35%)	Gaps:	102/447 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 SATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWR-------RTASGGNMPLRR 329
            :|.|:...|....|.....:.......|::.||| ..||..::.|:       |...|      |
  Fly    14 TAVAWANHHESLSLSPAEHSVVRYTNESLIVQCR-SPDPKVELHWKSPKGEIIREHKG------R 71

  Fly   330 VHV----LEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGI-LTVHAPPKFVIRPKNQLVEIGD 389
            :|:    .|...:....:.|.|.|.::|||  |.|.:.:... |.|:....|........|:.|:
  Fly    72 IHIEQTSTEQLKIVFAHIALADKGNWSCEA--ADGSLHSKSFDLIVYQKITFTENATVMTVKEGE 134

  Fly   390 EVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFAREDSGKVVTCN 454
            :....|:..|.|:|.:.|...|..  :..|..|. .:..:..:|   |.|.:..:.|:|: ..|.
  Fly   135 KATILCEVKGEPQPNVTWHFNGQP--ISAGAADD-SKFRILADG---LLINKVTQNDTGE-YACR 192

  Fly   455 A--LNAVGS-VSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSI--------VVLPCRTLGTPVP 508
            |  :|::.| :..|||:..          ||..|:....|..|:        ..|.|..|..|..
  Fly   193 AYQVNSIASDMQERTVLMK----------IEHKPIWSKTPFVSLKYAYINGTATLMCEALAEPPA 247

  Fly   509 QVSWYLDGIPIDVQEHERRN--------LSDA--GALTISDLQRHEDEGLYTCVASNRNGKSSWS 563
            ..:||        ::|.:.:        .||:  .:|||..|.....:. |.|.|  ||...:..
  Fly   248 NFTWY--------RKHNKLHSNNRLYTIQSDSYWSSLTIHVLNTSAFDN-YRCRA--RNDLGTIE 301

  Fly   564 GYLRLD------TPTNPNIKFFRAPE----LSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSS 618
            ...||:      :|.|..::.|.:..    ||...|||..|.    |.|...:.
  Fly   302 RTTRLEQGEKPPSPANFQLRGFNSNTFDVVLSAPRGPPDSPM----GVNGFRIE----------- 351

  Fly   619 LVGYVIEMFGKNETDGWVAVGTR----VQNTTFTQTGLLPGVNYFFLIRAENSHGLS 671
               |:.||..|.:...|.....:    .:..||..|.|.|...|.....:.|..|.|
  Fly   352 ---YMTEMEFKTDAGKWTNARRKDYAFEEGATFLLTNLEPDTVYLVRAASRNLAGFS 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317
		I-set	91..184	CDD:254352
		I-set	190..279	CDD:254352	2/6 (33%)
		Ig2_Robo	193..279	CDD:143201	2/6 (33%)
		I-set	283..370	CDD:254352	22/98 (22%)
		Ig	300..370	CDD:299845	20/81 (25%)
		Ig	388..>457	CDD:299845	16/70 (23%)
		I-set	479..561	CDD:254352	23/99 (23%)
		Ig	496..561	CDD:143165	18/74 (24%)
		FN3	588..681	CDD:238020	20/88 (23%)
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
fipi	NP_787975.1	IG_like	33..115	CDD:214653	21/90 (23%)
		I-set	128..202	CDD:254352	18/80 (23%)
		Ig	133..>193	CDD:299845	15/66 (23%)
		IG_like	228..307	CDD:214653	19/89 (21%)
		Ig	235..305	CDD:143165	18/80 (23%)
		FN3	312..415	CDD:238020	25/112 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100