DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment robo2 and CG33543

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	87/346 - (25%)
Similarity:	132/346 - (38%)	Gaps:	47/346 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 AVFPLLLLLAGLN------------GLTQVGALKGENPRIIEHPMDTTVPK-----NDPFTFNCQ 113
            |:..|||||...|            |.:..|....:.|......:..:.|.     |:.|...||
  Fly     6 ALCSLLLLLLSQNAAILGQLDSTSSGGSGTGGAPPDRPPTPPLSLQPSTPSITHFVNESFIIFCQ 70

  Fly   114 AEGNPTPTIQWFKD--GRELKTDTGSHRIMLPAGGLFFLKVIHSRRESDAGTYWCEAK-NEFGVA 175
            .......| :| :|  |:..:...|...|.....||..|...|...| |.|.:.||.. |..|
  Fly    71 TVQKDIDT-KW-RDPRGQTRENTKGRVHIEKKTTGLLALVFEHIALE-DRGNWTCEVNGNRNG-- 130

  Fly   176 RSRNATLQVAFL---------RDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLN 231
             :||..::..||         :..|........|.:|..|::.|.. .|.|.|::||..||:.:|
  Fly   131 -NRNVNVEREFLASFELLVNQKISFGKTEQVQSVREGRDAMVNCFV-EGMPAPEVSWLYNGEYIN 193

  Fly   232 LVGN-KRIRIVDGGNLAIQEARQSDDGRYQCVVKNVVGT---RESATAFLKVHVRP--FLIRGPQ 290
            .|.: |..|:.:|  |.|:...|:|.|.|.|....:..|   .:..|..|::..:|  |......
  Fly   194 TVNSTKHNRLSNG--LYIRNVSQADAGEYTCRAMRITPTFSDSDQITILLRIQHKPHWFFNETLP 256

  Fly   291 NQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHVLE-DRSLKLDDVTLEDMGEYTCE 354
            .|.|.||.:|...|...|:|.|...|.....|......|:.|.: ..:|:|........|:|.|:
  Fly   257 VQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVGFNHRIFVADYGATLQLQMKNASQFGDYKCK 321

  Fly   355 ADNAVGGITATGILTVHAPPK 375
            ..|.:|.:..  ::.:...||
  Fly   322 VANPLGMLER--VIKLRPGPK 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	25/102 (25%)
		I-set	91..184	CDD:254352	25/100 (25%)
		I-set	190..279	CDD:254352	27/92 (29%)
		Ig2_Robo	193..279	CDD:143201	26/89 (29%)
		I-set	283..370	CDD:254352	22/89 (25%)
		Ig	300..370	CDD:299845	16/70 (23%)
		Ig	388..>457	CDD:299845
		I-set	479..561	CDD:254352
		Ig	496..561	CDD:143165
		FN3	588..681	CDD:238020
		FN3	<817..856	CDD:238020
		fn3	864..952	CDD:278470
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	22/61 (36%)
		IG_like	256..336	CDD:214653	20/81 (25%)
		IGc2	263..327	CDD:197706	16/63 (25%)
		FN3	341..445	CDD:238020	87/346 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100