DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo2 and Igdcc3

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001359088.1	Gene:	Igdcc3 / 315759	RGDID:	1307338	Length:	812	Species:	Rattus norvegicus

Alignment Length:	791	Identity:	198/791 - (25%)
Similarity:	282/791 - (35%)	Gaps:	228/791 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PLLLLLAGLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGRELKT 133
            ||||||..| .:..:|............|.|.......|....|:.||:|...:.|.|:|.||..
  Rat    31 PLLLLLLPL-PVPSLGLGHSAELAFSVEPNDDIANLGQPIMLGCKVEGSPPVQVSWRKNGAELPE 94

  Fly   134 DTGSHRIMLPAGGLFF--LKVIHSRRESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPA 196
            ||  |..:|..|.|..  |::......||.|.|.|.|:|.||:..||.|.:|||.:.| |.:.|.
  Rat    95 DT--HTTLLANGSLLIHHLRLEQGESPSDEGDYECVAQNRFGLLVSRKARIQVATMSD-FHVHPQ 156

  Fly   197 NTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQC 261
            .....:|.||..:|.. .|.|:|.|:|.||...:: ..::|..::..|.|.|...|..|.|.:.|
  Rat   157 AVMGEEGGVARFQCQI-HGLPKPLITWEKNRVPID-TDDERYTLLPKGVLQITGLRAEDSGVFHC 219

  Fly   262 VVKNVVGTRESATAFLKV-------HVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRT 319
            |..|:...|.|..|.|.|       :..|.::.||:|.|..|..:.|.:|...|:|.|.|.|.|
  Rat   220 VASNMASVRVSHGARLTVSGSGSGTYKEPTILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR- 283

  Fly   320 ASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYTCEADNAVGGI--TATGILTVHAPPKFVIRPKN 382
            ..|..:.:..:.||...:|.:.|||::..|.|.|.|:.....:  ||.|.|.|.||.:||..|::
  Rat   284 LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAPAEFVQHPQS 348

  Fly   383 QLVEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSVLSIARFAREDS 447
            .....|...:|.|||.|.|.|.:.|...|
  Rat   349 ISRPAGTTAMFTCQAQGEPPPHVTWLKNG------------------------------------ 377

  Fly   448 GKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSW 512
                  ..|.|.|.|..:.                   .|.||
  Rat   378 ------QVLGAGGHVRLKN-------------------NNSTL---------------------- 395

  Fly   513 YLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIK 577
                           ::|..|.         |||.:|.|||.|..|.|..|..|.:
  Rat   396 ---------------SISGVGP---------EDEAIYQCVAENIAGSSQASARLTV--------- 427

  Fly   578 FFRAPELSTYPGPPGKPQMVEKGENSVTLSW----TRSNKVGGSSLVGYVIEMFGKNETDGWVAV 638
             ..|..|   ||||...:.|......|.:||    |.:.::     :|||:.: .|......:..
  Rat   428 -LWAEGL---PGPPRNVRAVSVSSTEVRVSWSEPLTHTKEI-----IGYVLHI-RKAADSPKLEY 482

  Fly   639 GTRVQNTTFTQ--TGLLPGVNYFFLIRAENSHGLSLPS-----------PMSEPITVGTRYFNSG 690
            ...|..:||..  ..|.|...|.|.|:|....|.||.|           |:..|::|
  Rat   483 QEAVSKSTFQHLVRDLEPSTAYSFYIKAYTPRGASLASVPTLASTLGEAPVPPPLSV-------- 539

  Fly   691 LDLSEARASLLSGDVVELSNASVVDSTSMKLTWQ------IINGKYVEGFYVYARQLPNPIVNNP 749
                                 .::.|:|::|.|:      ..||    ||.::.|         |
  Rat   540 ---------------------RLLGSSSLQLLWKPWPRLAQHNG----GFKLFYR---------P 570

  Fly   750 APVTSNTNPLL--GSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLT 812
            |...|.|.|:|  |:.|:...:....|.:...|  :.|       .||:|.|     |...|.::
  Rat   571 ASAASFTGPILLPGTVSSYNLSQLDPSTVYEVK--LLA-------YNQNGDG-----NATVRFVS 621

  Fly   813 ILNGGGASSCT 823
            :   .|||..|
  Rat   622 L---KGASERT 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	32/96 (33%)
		I-set	91..184	CDD:254352	31/94 (33%)
		I-set	190..279	CDD:254352	27/88 (31%)
		Ig2_Robo	193..279	CDD:143201	26/85 (31%)
		I-set	283..370	CDD:254352	29/88 (33%)
		Ig	300..370	CDD:299845	23/71 (32%)
		Ig	388..>457	CDD:299845	10/68 (15%)
		I-set	479..561	CDD:254352	14/81 (17%)
		Ig	496..561	CDD:143165	11/64 (17%)
		FN3	588..681	CDD:238020	28/109 (26%)
		FN3	<817..856	CDD:238020	4/7 (57%)
		fn3	864..952	CDD:278470
Igdcc3	NP_001359088.1	Ig	54..145	CDD:386229	31/92 (34%)
		Ig	153..237	CDD:386229	26/85 (31%)
		IG_like	254..336	CDD:214653	27/82 (33%)
		I-set	341..427	CDD:369462	34/192 (18%)
		FN3	434..527	CDD:238020	26/98 (27%)
		fn3	<554..613	CDD:365830	19/80 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910