DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo2 and Robo3

DIOPT Version :9

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_038937330.1 Gene:Robo3 / 315564 RGDID:1311018 Length:1451 Species:Rattus norvegicus


Alignment Length:1666 Identity:444/1666 - (26%)
Similarity:657/1666 - (39%) Gaps:425/1666 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LTNESEIQIKIKSKIKNKTASEIKRRHRNNRDFHGERLKIMPVDRSRRAVFPLLLLLAGLNGLTQ 82
            :||.||:.....|.:.....|                 .:.|.|.|.....|....|....| ::
  Rat    23 ITNSSELLFGFNSSLAALNPS-----------------LLPPGDPSLNVALPGHFELPPSPG-SR 69

  Fly    83 VGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGRELKT---DTGSHRIMLPA 144
            ||. :...|||:|.|.|..|.:.:|.|..|:|||.|.|.|:|:|:|..:.|   |..:||::||:
  Rat    70 VGP-EDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATAREDPRAHRLLLPS 133

  Fly   145 GGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVAQGEVALM 208
            |.|||.:::|.|| ..|.|.|.|.|:|..|.|.||||:|:||.|||:||..|.|..||.||.|:|
  Rat   134 GALFFPRIVHGRRSRPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAVM 198

  Fly   209 ECGAPRGSPEPQISWRKNGQTLNLVGNKRIR------IVDGGNLAIQEARQSDDGRYQCVVKNVV 267
            ||..|:|.|||.::|:|        ||.:::      .:.||.|.:....:||.|.|.||..|:.
  Rat   199 ECVPPKGHPEPLVTWKK--------GNTKLKEEEGRITIRGGKLMMSHTFKSDAGMYMCVASNMA 255

  Fly   268 GTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHV 332
            |.|||..|.|.|..||..:|.|.||..:..:.|.|.|.:.|||.|::.||:  ..|.:|..|..:
  Rat   256 GERESGAAELVVLERPSFLRRPINQVVLADAPVNFLCEVQGDPQPNLRWRK--DDGELPTGRYEI 318

  Fly   333 LEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHAPPKFVIRPKNQLVEIGDEVLFECQA 397
            ..|.||.::.|:.||.|.|||.|:|:||...|:|.|:||.||:||.:|:||....|:.|.|:|:.
  Rat   319 RSDHSLWIEQVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQFVTKPQNQTAAPGENVSFQCET 383

  Fly   398 NGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPEGRSV------LSIARFAREDSGKVVTCNAL 456
            .|:|.|.::|..||:..||.|..       :|.|.||.:      |:|......|.|..| |.|:
  Rat   384 KGNPPPAIFWQKEGSQVLLFPSQ-------SLQPMGRLLVSPRGQLNITEVKIGDGGYYV-CQAV 440

  Fly   457 NAVGSVSSRTVVSV-DTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSW-----YLD 515
            :..||:.::.::.: ....:..||||.|||.||||.:.|.|.||||.:|.|.|.|.|     :|.
  Rat   441 SVAGSILAKALLEIKGASIDGLPPIILQGPANQTLVLGSSVWLPCRVIGNPQPNVQWKKDETWLQ 505

  Fly   516 GIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLR-----------LD 569
            |      ::.:.||.|.|.|.|:.:| ..|.|.|:|||.:..|:::|:.:||           ..
  Rat   506 G------DNSQFNLMDNGTLYIASVQ-EMDMGFYSCVAKSSIGEATWNSWLRKREHWGASPGPAT 563

  Fly   570 TPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDG 634
            .|.||             ||||.:|.:.|...||:||:| :.|...|:....||||.|.:...:.
  Rat   564 EPGNP-------------PGPPSQPIVTEVTTNSITLTW-KPNPQSGARATSYVIEAFSQAAGNT 614

  Fly   635 WVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPITVGTRYFNSGLDLSEARAS 699
            |..|...||..|.|.:||.|...|.||:||..:.|||.|||:|||:              :.:.|
  Rat   615 WRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPV--------------QTQDS 665

  Fly   700 LLSGDV--------------VELSNASVVDSTSMKLTWQIIN-GKYVEGFYVYARQLPNPIVNNP 749
            .||..|              |.:....|:...:::::|.:.. |:.|:||.|..|          
  Rat   666 SLSRPVEDPWKGQQGLAEVAVRMQEPIVLGPRTLQVSWTVEGPGQLVQGFRVSWR---------- 720

  Fly   750 APVTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTIL 814
                                               .||.      ..|......:.:.::..|:|
  Rat   721 -----------------------------------IAGL------DQGSWTALDVQSPHKQSTVL 744

  Fly   815 NG-GGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNS-RIARTL-EDVPSEAPYGMEALL--LN 874
            .| ...|...|...||             ..||..:.| .:.|:: |:.||..|.|:...|  ..
  Rat   745 RGLPPGSQIQIKVQVQ-------------GQEGLGAESPSVTRSIPEEAPSGPPQGVAVALGGDR 796

  Fly   875 SSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTV 939
            :|::.:.|:.|....::||:..|.:...|     |.||...|.:....:.:::...|..|::|..
  Rat   797 NSSITVSWEPPLPSQQNGVITEYQIWCLG-----NESRFHLNRSAAGWARSVMFRGLLPGLLYRA 856

  Fly   940 GVAAGNNAGVGPYCVPATLRLD-PITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLM 1003
            .|||..:||||....|..::|. |......|.:::..   .:.::.||.:|.|:....|....|:
  Rat   857 IVAAATSAGVGVASAPVLVQLPFPPVAEPGPEVSEGL---AERLSRVLRKPAFLAGSSAACGALL 918

  Fly  1004 LSFGAMVFVKRKHMMMKQSALNTMRGNHT-------SDVLKMP-------------SLSARNGNG 1048
            |...|.::  |:....|:.:..|....:|       |..|:.|             |:|..:..|
  Rat   919 LGLCAALY--RRQKQRKELSHYTASFAYTPAGKRLYSSGLRTPIPALLLPLSPLSSSVSFPHSEG 981

  Fly  1049 Y-----------------WLDSSTGGMVW-RPS-------PGGDSLEMQKD-------------H 1075
            .                 ||..|     | .||       |.|.......|             :
  Rat   982 LSGSSSRPPMGLGPAAYPWLADS-----WPHPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLY 1041

  Fly  1076 IADYAPVCGAPG--------SPAG-------GGTSSGGSGGAGSGA-------SGGDD-IHGGHG 1117
            :|..|....|||        .|.|       ||.....||...:.:       |.||. ..||.|
  Rat  1042 LAQTARGANAPGEGPVYSTIDPVGEELQTFHGGFPQHSSGDPSTWSQYAPPEWSEGDSGARGGKG 1106

  Fly  1118 SERNQQRYVGEYSNIPT-DYAEV---------SSFGKAPSEYGRHGN-----ASPAPYATSSILS 1167
                  :.:|:...:|: .:.|.         .|..:.|.|..:..:     ..|.|.....|.|
  Rat  1107 ------KLLGKPVQMPSLSWPEALPPPPPSCELSCPEGPEEELKGSSDLEEWCPPMPEKKHLIDS 1165

  Fly  1168 PHQQQQQQQPRYQQRPVP--GYGLQRPMHPHYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNI-- 1228
            .........|...:.|.|  .||              ||..|..|.......|     |||:|  
  Rat  1166 RSSGACMVAPARGETPSPTSSYG--------------QQSTATLTPSPPDPPQ-----PPSDIPH 1211

  Fly  1229 YQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDKQRHIHITENKLSNCH--------TYEAAPG--- 1282
            ..||.....:     |||..:...|........|.:.:....:.:.|        |..:|||   
  Rat  1212 LHQMPRRVPL-----GPSSPLSVSQPALSSHDGRPVGLGAGPIVSYHPSPSPVPSTASSAPGRTR 1271

  Fly  1283 ---AKQSSPISSQFASVRR--QQLPPNCSIGRESARFKVLNTDQGKNQQNLLDLDGSSMCYNGLA 1342
               .:.:.|:....|.:|:  :.||..    ||.:.                             
  Rat  1272 QVTGEMTPPLHGHRARIRKKTKALPHR----REHSP----------------------------- 1303

  Fly  1343 DSGCGGSPSPMAMLMSHEDEHALYHTADGDLDDMERLYVKVDEQQPPQQQQQLIPLVPQHPAEGH 1407
                |..|.|.......|....|...|.|.:..:||      |....::..|.:||..|.|.   
  Rat  1304 ----GDLPPPPLPPPEEETSWPLGLRAAGSMSSLER------EHSGERRVAQAVPLGAQPPG--- 1355

  Fly  1408 LQSWRNQSTRSSRKNGQ--ECIKEPSELIYAPGSVASERSLLSNSGSGTSS-QPAGHNVXPLLPG 1469
                   :.|....:..  .|..|.:.|.|...|..|.       |.|||: ..||.|.    .|
  Rat  1356 -------AQRGPHPDAALLGCAAEEAWLPYGRPSFLSH-------GQGTSTCSTAGSNSS---RG 1403

  Fly  1470 S--------SLGQSQSKSQSQSQSQSDLQSQEQLYAREVRE 1502
            |        |.|..:|:|:||||||...:::.|:..:.:::
  Rat  1404 SNSSRGSRGSRGPGRSRSRSQSQSQRPGRNRRQVGVKGLKK 1444

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 45/98 (46%)
I-set 91..184 CDD:254352 45/96 (47%)
I-set 190..279 CDD:254352 37/94 (39%)
Ig2_Robo 193..279 CDD:143201 35/91 (38%)
I-set 283..370 CDD:254352 34/86 (40%)
Ig 300..370 CDD:299845 29/69 (42%)
Ig 388..>457 CDD:299845 24/74 (32%)
I-set 479..561 CDD:254352 37/86 (43%)
Ig 496..561 CDD:143165 26/69 (38%)
FN3 588..681 CDD:238020 41/92 (45%)
FN3 <817..856 CDD:238020 7/39 (18%)
fn3 864..952 CDD:278470 24/89 (27%)
Robo3XP_038937330.1 Ig strand A 182..185 CDD:409353 1/2 (50%)
Ig strand A' 187..191 CDD:409353 1/3 (33%)
Ig strand B 195..202 CDD:409353 4/6 (67%)
Ig strand C 210..215 CDD:409353 1/4 (25%)
Ig strand C' 217..220 CDD:409353 1/2 (50%)
Ig strand D 226..230 CDD:409353 0/3 (0%)
Ig strand E 232..238 CDD:409353 2/5 (40%)
Ig strand F 245..253 CDD:409353 4/7 (57%)
Ig strand G 256..267 CDD:409353 6/10 (60%)
Ig 274..356 CDD:416386 33/83 (40%)
Ig strand A 274..277 CDD:409353 1/2 (50%)
Ig strand A' 279..283 CDD:409353 2/3 (67%)
Ig strand B 286..295 CDD:409353 3/8 (38%)
Ig strand C 301..306 CDD:409353 1/4 (25%)
Ig strand C' 309..312 CDD:409353 1/2 (50%)
Ig strand D 315..320 CDD:409353 1/4 (25%)
Ig strand E 321..328 CDD:409353 3/6 (50%)
Ig strand F 335..343 CDD:409353 5/7 (71%)
Ig strand G 346..356 CDD:409353 4/9 (44%)
Ig 361..458 CDD:416386 31/104 (30%)
Ig strand A 361..365 CDD:409353 2/3 (67%)
Ig strand A' 367..371 CDD:409353 2/3 (67%)
Ig strand B 377..385 CDD:409353 3/7 (43%)
Ig strand C 388..395 CDD:409353 2/6 (33%)
Ig strand C' 397..400 CDD:409353 1/2 (50%)
Ig strand D 413..418 CDD:409353 1/4 (25%)
Ig strand E 420..427 CDD:409353 2/6 (33%)
Ig strand F 433..442 CDD:409353 4/9 (44%)
Ig strand G 444..455 CDD:409353 2/10 (20%)
Ig 465..549 CDD:416386 37/90 (41%)
Ig strand A 465..468 CDD:409353 2/2 (100%)
Ig strand A' 472..475 CDD:409353 2/2 (100%)
Ig strand B 481..488 CDD:409353 5/6 (83%)
Ig strand C 494..499 CDD:409353 2/4 (50%)
Ig strand C' 501..503 CDD:409353 0/1 (0%)
Ig strand D 510..514 CDD:409353 1/3 (33%)
Ig strand E 517..522 CDD:409353 2/4 (50%)
Ig strand F 530..538 CDD:409353 5/7 (71%)
Ig strand G 541..549 CDD:409353 2/7 (29%)
FN3 569..662 CDD:238020 41/107 (38%)
FN3 693..773 CDD:238020 21/143 (15%)
FN3 783..876 CDD:238020 25/97 (26%)
Ig 77..175 CDD:416386 45/97 (46%)
Ig strand A 77..81 CDD:409353 3/3 (100%)
Ig strand A' 84..89 CDD:409353 1/4 (25%)
Ig strand B 93..101 CDD:409353 3/7 (43%)
Ig strand C 107..112 CDD:409353 2/4 (50%)
Ig strand C' 115..117 CDD:409353 0/1 (0%)
Ig strand D 128..131 CDD:409353 1/2 (50%)
Ig strand E 134..140 CDD:409353 4/5 (80%)
Ig strand F 152..160 CDD:409353 4/7 (57%)
Ig strand G 163..175 CDD:409353 7/11 (64%)
Ig 182..267 CDD:416386 36/92 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I6432
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D173520at2759
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101537
Panther 1 1.100 - - O PTHR12231
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X493
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.920

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