DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and boi

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:NP_001096868.3 Gene:boi / 31229 FlyBaseID:FBgn0040388 Length:1105 Species:Drosophila melanogaster


Alignment Length:1410 Identity:288/1410 - (20%)
Similarity:440/1410 - (31%) Gaps:534/1410 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 PMDTTVPKNDPFTFNCQAEGNPTPTIQW-FKDGRE------LKTDTGSHRIMLPAGGLFFLKVIH 154
            |.....||.|...|.|:....| ..::| |:.|..      |:...| :.:...:.||.:...|:
  Fly    42 PESAVAPKGDEVVFECELNLKP-DRLEWRFRRGDSSEPYLYLRPSAG-YNVTSGSDGLAWRLRIY 104

  Fly   155 SRRESDAGTYWCEAKNEFGVARSRNATLQVAFL-----------RDEFRLEPANTRVAQGEVALM 208
            ...:: ||.|.|.|....|...|..|.|.:..:           |...|..     ||.....|:
  Fly   105 VSAQT-AGDYQCVAWYGPGALASTPARLALVSIALDVGQGSMGARSSIRWS-----VAPKNCLLI 163

  Fly   209 ECGAPRGSPEPQISWRKNGQTLNLVGNKRIRIVDG--GNLAIQEARQSDDGRYQCVVKN-VVG-- 268
            .||:...:|....|:.:||:.|     .:..::.|  |.|.:......|.|.|.||..| :.|  
  Fly   164 RCGSVISNPPAIWSFYRNGKKL-----PQSELLPGAAGALVLDTVTAKDAGNYSCVATNSITGDE 223

  Fly   269 TRESATAFLKVHVRP-----FLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLR 328
            .|...|..|:|....     ||.|.|...:|..|.:||.:|...|.|.|.|:|    |..|:   
  Fly   224 LRLPQTIELRVDYTDRTPPYFLQRPPIEYSARPGETVVLECPGVGSPRPRVIW----SSPNV--- 281

  Fly   329 RVHVLEDRS------LKLDDVTLEDMGEYTCEADNAVG-GITATGILTVHAPPKFVIRPKNQLVE 386
             |.:..:||      |::.||..||.|.|.|..||.:. .|..|..|:|...|..:..|...|..
  Fly   282 -VEIYNNRSTILSYGLQITDVKPEDQGSYICMLDNGIAPPIDHTIKLSVLQRPTILRGPAATLTN 345

  Fly   387 IGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRMEVTLTPE----GRSVLSIARFAREDS 447
            ..:.:|.:|.|:|:|:|.:||.:.|.             :.|..||    .|| |.:.|..:..:
  Fly   346 ESNPLLLDCSASGNPQPDIYWLINGE-------------DATKDPEAVVDNRS-LQLKRVQKRHA 396

  Fly   448 GKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSW 512
            | ||.|.|.|.:|..|...::.|:       |:...|..::  |:..:.|.|.            
  Fly   397 G-VVQCFAKNILGETSEGNILRVN-------PLEITGEDDE--PLGEVPVWPV------------ 439

  Fly   513 YLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIK 577
                       ||    |:.|..|                :|...|..:.||..:          
  Fly   440 -----------HE----SNTGMGT----------------SSTSGGSKNKSGRRK---------- 463

  Fly   578 FFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMF---------GKNETD 633
             |:|..:     ||.:|.:....:.||.|.|:    |..:|  |..|..|         |||...
  Fly   464 -FKASMV-----PPSRPNVTRLSDESVMLRWS----VPQNS--GLQITFFKVQYRMLGDGKNRRK 516

  Fly   634 GW--------------------------------VAVGTRVQNTTFTQTGLLPGVNYFFLIRA-- 664
            .|                                ..:|...:|.|.:.|||..|..|.|.|.|  
  Fly   517 NWQTTSDNIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVY 581

  Fly   665 ---ENSHGLSLPSPMSEPITVGTRYF------NSGLDLSEARASLLSGDVVELSNASVVDSTSMK 720
               :|..|           ....::|      .|.|.:.|.|      :|..||.::||      
  Fly   582 SNNDNKEG-----------NTSLKFFLQNGTSKSNLPVPELR------EVETLSESAVV------ 623

  Fly   721 LTWQIIN---GKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPN 782
            |.|.:::   .:.::|:|.|.|                            .|.::|..|.:|   
  Fly   624 LHWSLVSSTQNEDIDGYYAYYR----------------------------PADSAAEYLKAT--- 657

  Fly   783 IAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGK 847
                                           ::||.:.|..|..|...|.|||.:..|......:
  Fly   658 -------------------------------VDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASE 691

  Fly   848 PSNSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPELKDRH--------------GVLLNYH 898
            .|..|.|||.:  ..|.|       .:|||..:  .|.:..::|              |:||   
  Fly   692 FSAIRQARTRK--THEQP-------ASSSATPV--PANKAVEQHQNSLYPLIAGAAGGGILL--- 742

  Fly   899 VIVRGIDTAHNFSRILTNVTIDAASPTL--VLAN-LTEGVMYTVGVAAGNNAGVGPYCVPATLRL 960
             ::..:.......|...:...|...|.|  :.|: :|..|:   ||...:.:|       ...||
  Fly   743 -LIASLVVCLCLKRRENSQPEDENKPQLEHIQADFVTSAVL---GVGGHHKSG-------DVRRL 796

  Fly   961 DPITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSFGAMVFVKRKHMMMKQSALN 1025
            :.:..|::...|   |:.|:..:|                            |.:::|       
  Fly   797 NGVIPRMNITPN---PLAQETASD----------------------------KNRNVM------- 823

  Fly  1026 TMRGNHTSDVLKMPSLSARNGNG------YWLDSSTG-------------GMVWRPSPGGDSLE- 1070
                    ::..:|.|:..||||      ..|:.|..             |:....|...::|| 
  Fly   824 --------ELRFLPPLANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASSSCETLEA 880

  Fly  1071 --------MQKDHIADY--AP--VCGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQ 1123
                    :.:.|..:.  ||  |..||..|. .......:.|||...||   :|      :|..
  Fly   881 CDAAIKLNLPQKHDQEQLDAPNAVLEAPSKPL-PPLPKKPANGAGQNNSG---LH------QNGL 935

  Fly  1124 RYVGEY--SNIPT------DYAEVSSFGKAPSEYGRHGNASPAPYATSSILSPHQQQQQQQPRYQ 1180
            .:...|  ...||      ||               |....|.|        ||....||.|.:|
  Fly   936 HHAQPYHPPGTPTLMHKRLDY---------------HQQPPPVP--------PHSAYYQQAPTHQ 977

  Fly  1181 QRPVPGYGLQRPMHPHYQ-------------------QQQHQQQQAQQTHQQHQAL--------Q 1218
            ..|:    ::|.:..|.|                   ::|.:....||.|..|..|        .
  Fly   978 PSPM----MERSVRGHQQPGGFHMEEGTPTPTRIPSLRRQRRTSGNQQVHNSHSNLNIGLSHHNN 1038

  Fly  1219 QHQQLPPSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDKQRHIHITENKLSNCHTYEAAPGA 1283
            .:..|||                                    .|.|:        |.:...||.
  Fly  1039 NNNNLPP------------------------------------HHQHL--------HHHPGHPGG 1059

  Fly  1284 KQSSPISSQFASVRRQQLPPNCSIGRESARFKVLNTDQGKNQQNL 1328
            ....||......|:|..:|....|.|         |..|.:..|:
  Fly  1060 LVGIPIVPGSPRVQRSPMPSRAMIKR---------TRLGSHTDNI 1095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 24/94 (26%)
Ig strand A 91..95 CDD:409490
Ig strand A' 98..103 CDD:409490 0/4 (0%)
Ig strand B 107..115 CDD:409490 2/7 (29%)
Ig strand C 121..126 CDD:409490 1/5 (20%)
Ig strand C' 129..131 CDD:409490 0/7 (0%)
Ig strand D 139..142 CDD:409490 0/2 (0%)
Ig strand E 145..151 CDD:409490 2/5 (40%)
Ig strand F 162..170 CDD:409490 4/7 (57%)
Ig strand G 173..185 CDD:409490 4/11 (36%)
IgI_2_Robo 192..279 CDD:409389 24/91 (26%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 2/6 (33%)
Ig strand C 220..225 CDD:409389 1/4 (25%)
Ig strand C' 227..230 CDD:409389 1/2 (50%)
Ig strand D 237..241 CDD:409389 0/3 (0%)
Ig strand E 244..250 CDD:409389 2/5 (40%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 4/12 (33%)
Ig 286..370 CDD:472250 30/90 (33%)
Ig strand B 300..304 CDD:409353 2/3 (67%)
Ig strand C 313..317 CDD:409353 1/3 (33%)
Ig strand E 336..340 CDD:409353 3/9 (33%)
Ig strand F 350..355 CDD:409353 2/4 (50%)
Ig strand G 363..366 CDD:409353 0/2 (0%)
Ig_3 373..457 CDD:464046 24/87 (28%)
Ig 480..566 CDD:472250 13/85 (15%)
Ig strand B 496..500 CDD:409353 1/3 (33%)
Ig strand C 509..513 CDD:409353 0/3 (0%)
Ig strand E 533..537 CDD:409353 1/3 (33%)
Ig strand F 548..553 CDD:409353 0/4 (0%)
Ig strand G 561..564 CDD:409353 0/2 (0%)
COG3979 586..>800 CDD:443178 49/268 (18%)
FN3 588..681 CDD:238020 29/138 (21%)
fn3 864..952 CDD:394996 19/104 (18%)
boiNP_001096868.3 IG_like 42..131 CDD:214653 23/91 (25%)
Ig 161..221 CDD:409353 17/64 (27%)
Ig strand B 161..165 CDD:409353 1/3 (33%)
Ig strand C 175..179 CDD:409353 1/3 (33%)
Ig strand E 196..200 CDD:409353 2/3 (67%)
Ig strand F 210..215 CDD:409353 2/4 (50%)
Ig 242..315 CDD:472250 27/80 (34%)
Ig strand B 260..264 CDD:409353 2/3 (67%)
Ig strand C 273..277 CDD:409353 2/7 (29%)
Ig strand E 294..298 CDD:409353 1/3 (33%)
Ig strand F 308..313 CDD:409353 2/4 (50%)
Ig <352..408 CDD:472250 21/70 (30%)
Ig strand C 363..367 CDD:409353 1/3 (33%)
Ig strand E 384..388 CDD:409353 3/4 (75%)
Ig strand F 398..403 CDD:409353 3/4 (75%)
FN3 <448..>700 CDD:442628 69/374 (18%)
FN3 613..700 CDD:238020 28/154 (18%)
Blue background indicates that the domain is not in the aligned region.

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