DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and robo3

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_005172693.1 Gene:robo3 / 30770 ZFINID:ZDB-GENE-000209-4 Length:1424 Species:Danio rerio


Alignment Length:1490 Identity:442/1490 - (29%)
Similarity:660/1490 - (44%) Gaps:292/1490 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 GLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGRELKT---DTGS 137
            ||||...  .|:...|||:|||.|..|.|.:|.|.||:|||.|||.::|:|||..::|   |..|
Zfish    50 GLNGSRP--RLEDAAPRIVEHPSDLIVSKGEPATLNCKAEGRPTPMVEWYKDGERVETDREDPRS 112

  Fly   138 HRIMLPAGGLFFLKVIHSRR-ESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVA 201
            ||::||:|.||||:::|.|| :.|.|.|.|.|:|..|.|.||||:|:||.|||:||..|::..||
Zfish   113 HRMLLPSGSLFFLRIVHGRRSKPDEGVYVCVARNYLGEAVSRNASLEVAILRDDFRQTPSDVVVA 177

  Fly   202 QGEVALMECGAPRGSPEPQISWRKNGQTLNLVGNKRIRI-VDGGNLAIQEARQSDDGRYQCVVKN 265
            .||.|:|||..|||.|||.|||::|...:|   :|..|| :.||.|.|...|:||.|.|.||..|
Zfish   178 AGEPAVMECIPPRGHPEPTISWKRNNVKVN---DKDERITIRGGKLMISNTRKSDAGMYVCVGTN 239

  Fly   266 VVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRV 330
            :||.::|..|.|.|..||..:|.|.||..:...:|.|||.:.|||.|.:.|::  ..|.:|..|.
Zfish   240 MVGEKDSDPAELVVFERPMFVRRPVNQVVLADDTVDFQCEVQGDPAPTIRWKK--EEGELPRGRF 302

  Fly   331 HVLEDRSLKLDDVTLEDMGEYTCEADNAVGGITATGILTVHA----PPKFVIRPKNQLVEIGDEV 391
            .:..|.||:|..|..||.|.|||.::|:||...|:|.|.||.    ||:.|:||::|:...|..|
Zfish   303 EIRADNSLRLTQVKAEDEGSYTCLSENSVGKAEASGSLQVHVGPSLPPQIVVRPRDQISAQGRTV 367

  Fly   392 LFECQANGHPRPTLYWSVEGNSSLLLPGY---RDGRMEVTLTPEGRSVLSIARFAREDSGKVVTC 453
            .|.|...|:|.|.::|..||:..||.|..   :.||..|:|:.|    |:|.....||||..: |
Zfish   368 TFLCGTKGNPPPAVFWQKEGSQVLLFPSQPPSQSGRFSVSLSGE----LTITDVHSEDSGYYI-C 427

  Fly   454 NALNAVGSVSSRTVVSVD-TQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDG- 516
            .|::..||:.::.::.|: |..:..||||.|||.||||...:...|.|..:|.|:|.:.|..|| 
Zfish   428 QAISVAGSILTKALLEVESTPSDRIPPIIRQGPANQTLAPGTTAQLQCHVMGNPLPSIQWERDGQ 492

  Fly   517 --IPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFF 579
              :.||    ||.:|.:.|.|.|:.|| ..|.|.||||||:.:|::||||.|.:.....    ..
Zfish   493 RILGID----ERISLMENGTLQITALQ-ETDSGAYTCVASSLSGETSWSGVLTVKESGG----LS 548

  Fly   580 RAPELSTY--PGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRV 642
            .:|....|  ||||.||.:.:...|||||:|..:...||:::..|:||.|.::....|..|...|
Zfish   549 ASPVSEPYQLPGPPQKPVVTDVTRNSVTLTWQPNAHEGGAAVTSYIIEAFSQSAGSTWQTVADFV 613

  Fly   643 QNTTFTQTGLLPGVNYFFLIRAENSHGLSLPSPMSEPI-TVGTRYFNSGLDLSEARASLLSGDV- 705
            :....|.|||.|...|.|::||.|::|||.|||:|||: |........|:|..:.:..|  |:: 
Zfish   614 KLEKHTVTGLSPNTIYLFIVRAVNAYGLSDPSPISEPVRTQDVSPTGQGVDHRQVQREL--GEMS 676

  Fly   706 VELSNASVVDSTSMKLTWQI-INGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASA 769
            |:|....::.::|:|::|.: ...:|::|:    |.|..|:                        
Zfish   677 VQLHEPVLLTASSVKISWNVDRQSQYIQGY----RLLYRPV------------------------ 713

  Fly   770 SASASALISTKPNIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYE 834
                                        ||:.:....|        |....|..|..|::.|.||
Zfish   714 ----------------------------GGSWSQQEVK--------GATERSAVIANLLKGTEYE 742

  Fly   835 FFIVPFYKSVEGKPSNSRIARTLEDVPSEAPYGMEAL---LLNSSAVFLKWKAPELKDRHGVLLN 896
            ..|.|::...:|..|.|:..||.|:|||..|..:...   |.|||::.:.|:.|....::||:..
Zfish   743 IKIRPYFNEFQGLDSRSQTLRTPEEVPSAPPRAVNVATVKLSNSSSISVSWQPPPTDMQNGVIQE 807

  Fly   897 YHVIVRGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLD 961
            |.|...|.|:.   :|...|.|:|.:..:.||..|..||:|.|.|||..:||||.:..|.::.: 
Zfish   808 YKVWCLGNDSQ---TRYNINQTVDGSVLSTVLKGLLPGVLYQVEVAAVTSAGVGKHSQPVSVLI- 868

  Fly   962 PITKRLDPFINQRYPINQ-----------------DHVNDVLTQPWFIILLGAILAVLMLSFGAM 1009
                        :.|..|                 :.:.||:.||.||..:|....|:::.|...
Zfish   869 ------------KLPAEQPTVTGGGSESEENVSLAEQITDVVKQPAFIAGIGGACWVILMGFSVW 921

  Fly  1010 VFVKRKHMMMKQSALNTMRGNHTSDVLKMPSL-------SARNGNGYWLDSSTGGMVWRPSPGGD 1067
            ::.:||    |:..|:    ::|:.....|::       |..||....|.::.|...|       
Zfish   922 IYCRRK----KRKELS----HYTASFAYTPAVGFPHGESSGLNGRPGMLGANMGNYPW------- 971

  Fly  1068 SLEMQKDHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQRYVGEYSNI 1132
                    :||..|.....                   .:|.|.::.........:||..|    
Zfish   972 --------LADSWPTTNLV-------------------HNGKDSVNCCTSKHETPERYYNE---- 1005

  Fly  1133 PTDYAEVSSFGKAPSEYGRHGNASPAPYAT-----SSILSPHQQQQQQQPRYQQRPVPGYGLQRP 1192
                |.:|::.....:|....|..|. |:|     ..:.|...|..|....|...|:..:..|.|
Zfish  1006 ----AGISNYLNQNEKYSADSNEGPI-YSTIDPTSEDLRSFTAQYSQHTTPYASTPIMPFTNQAP 1065

  Fly  1193 MHPHYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYP 1257
            ..|. |...|...|...::.|               |.|             |.|| .:|....|
Zfish  1066 CSPE-QDGSHWMTQPGTSNAQ---------------YAQ-------------PDRS-KTENVKQP 1100

  Fly  1258 KDKQRHIHITENKLSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARFKVLNTDQG 1322
            |.|.....:   |..:.:..:|.|    ..|||...         ..|....::.    |..|.|
Zfish  1101 KQKLMGKPV---KTPSLNWMDALP----PPPISGDL---------EQCDEEDDNE----LIQDMG 1145

  Fly  1323 KNQQNLL-DLDGSSMCYNGLADSG-----CGGSPSPMAMLMSHEDEHALYHTA--DGDLDDMERL 1379
            .:::... .|...|...:|:.:.|     .|.:.||... .||:....|..:.  ||...|:.||
Zfish  1146 SDEEEWCPPLPERSYLMDGMVEDGPVPPPRGEASSPTTS-YSHQSTATLTPSPRDDGHFHDIPRL 1209

  Fly  1380 YVKVDEQQPPQQQQQL----IPLVPQHPAEGHLQSWRNQSTRSSRKNGQECIKEPSELIYAPGSV 1440
            :    :.:.|...::|    :| ||:.|:....||..|.|.      .|||   |...:  |...
Zfish  1210 H----QLEQPHMTRRLPCGPVP-VPRAPSPPLTQSNPNLSA------NQEC---PDNTV--PHRS 1258

  Fly  1441 ASERSLLSNSGSGTSSQPAGHNVXPLLPGSSLGQSQSKSQSQSQSQSDLQSQEQLYAREV 1500
            |.:|.|  :.|:..|.:    |:....||.:...:...|..|........|:...|.|::
Zfish  1259 AHKRDL--SQGAAQSVE----NISNTTPGRARPSADHTSSGQKSKVKKKASKSAQYRRDI 1312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 51/97 (53%)
Ig strand A 91..95 CDD:409490 3/3 (100%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 4/7 (57%)
Ig strand C 121..126 CDD:409490 1/4 (25%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 1/2 (50%)
Ig strand E 145..151 CDD:409490 4/5 (80%)
Ig strand F 162..170 CDD:409490 4/7 (57%)
Ig strand G 173..185 CDD:409490 7/11 (64%)
IgI_2_Robo 192..279 CDD:409389 41/87 (47%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 4/6 (67%)
Ig strand C 220..225 CDD:409389 3/4 (75%)
Ig strand C' 227..230 CDD:409389 0/2 (0%)
Ig strand D 237..241 CDD:409389 2/4 (50%)
Ig strand E 244..250 CDD:409389 3/5 (60%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 4/10 (40%)
Ig 286..370 CDD:472250 33/83 (40%)
Ig strand B 300..304 CDD:409353 2/3 (67%)
Ig strand C 313..317 CDD:409353 0/3 (0%)
Ig strand E 336..340 CDD:409353 2/3 (67%)
Ig strand F 350..355 CDD:409353 3/4 (75%)
Ig strand G 363..366 CDD:409353 1/2 (50%)
Ig_3 373..457 CDD:464046 32/86 (37%)
Ig 480..566 CDD:472250 40/88 (45%)
Ig strand B 496..500 CDD:409353 1/3 (33%)
Ig strand C 509..513 CDD:409353 0/3 (0%)
Ig strand E 533..537 CDD:409353 2/3 (67%)
Ig strand F 548..553 CDD:409353 3/4 (75%)
Ig strand G 561..564 CDD:409353 2/2 (100%)
COG3979 586..>800 CDD:443178 57/218 (26%)
FN3 588..681 CDD:238020 40/93 (43%)
fn3 864..952 CDD:394996 31/90 (34%)
robo3XP_005172693.1 IgC_1_Robo 63..161 CDD:409490 51/97 (53%)
Ig strand A 63..67 CDD:409490 3/3 (100%)
Ig strand A' 70..75 CDD:409490 1/4 (25%)
Ig strand B 79..87 CDD:409490 4/7 (57%)
Ig strand C 93..98 CDD:409490 1/4 (25%)
Ig strand C' 101..103 CDD:409490 0/1 (0%)
Ig strand D 114..117 CDD:409490 1/2 (50%)
Ig strand E 120..126 CDD:409490 4/5 (80%)
Ig strand F 138..146 CDD:409490 4/7 (57%)
Ig strand G 149..161 CDD:409490 7/11 (64%)
Ig 168..253 CDD:472250 41/87 (47%)
Ig strand B 182..186 CDD:409353 2/3 (67%)
Ig strand C 196..200 CDD:409353 2/3 (67%)
Ig strand E 218..222 CDD:409353 2/3 (67%)
Ig strand F 232..237 CDD:409353 2/4 (50%)
Ig strand G 246..249 CDD:409353 1/2 (50%)
IgI_3_Robo 260..342 CDD:409390 33/83 (40%)
Ig strand A 260..263 CDD:409390 1/2 (50%)
Ig strand A' 265..269 CDD:409390 2/3 (67%)
Ig strand B 272..281 CDD:409390 4/8 (50%)
Ig strand C 287..292 CDD:409390 1/4 (25%)
Ig strand C' 295..298 CDD:409390 1/2 (50%)
Ig strand D 301..306 CDD:409390 1/4 (25%)
Ig strand E 307..314 CDD:409390 4/6 (67%)
Ig strand F 321..329 CDD:409390 4/7 (57%)
Ig strand G 332..342 CDD:409390 4/9 (44%)
Ig 351..444 CDD:472250 32/97 (33%)
Ig strand B 367..371 CDD:409353 2/3 (67%)
Ig strand C 380..384 CDD:409353 0/3 (0%)
Ig strand E 410..414 CDD:409353 2/7 (29%)
Ig strand F 424..429 CDD:409353 1/5 (20%)
Ig strand G 437..440 CDD:409353 0/2 (0%)
Ig 455..541 CDD:472250 41/90 (46%)
Ig strand B 471..475 CDD:409353 1/3 (33%)
Ig strand C 484..488 CDD:409353 0/3 (0%)
Ig strand E 507..511 CDD:409353 2/3 (67%)
Ig strand F 521..526 CDD:409353 3/4 (75%)
FN3 <533..883 CDD:442628 117/435 (27%)
Ig strand G 534..537 CDD:409353 2/2 (100%)
FN3 559..653 CDD:238020 40/93 (43%)
Atrophin-1 1049..>1285 CDD:460830 66/308 (21%)
Herpes_BLLF1 <1178..>1291 CDD:282904 33/135 (24%)

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