DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment robo2 and egl-15

DIOPT Version :9

Sequence 1:	NP_001259868.1	Gene:	robo2 / 44522	FlyBaseID:	FBgn0002543	Length:	1519	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	1350	Identity:	244/1350 - (18%)
Similarity:	405/1350 - (30%)	Gaps:	462/1350 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DPFTFNCQ-AEGNPTPTIQWFKDGRELKTD--------TGSHRIMLPAGGLFFLKVIHSRRESDA 161
            |...|:|| |....:..::|:::.:.||.|        ..::|:||      .||.|.   .||.
Worm    49 DEIKFDCQTAASKISAFVEWYRNDKLLKNDQIDKDKIRKDNNRMML------HLKNID---VSDQ 104

  Fly   162 GTYWCEAKNEFGVARSRNATLQVAFLRDEF---RLEPANTRVAQGEVALMECGAPRGSPEPQISW 223
            |.:.|...|.:|.. |||.|::|....|.|   .:...|..        |||         ...|
Worm   105 GLWSCRVHNAYGQI-SRNFTVEVIDFCDYFLFPDIHHLNIP--------MEC---------VCLW 151

  Fly   224 RKNGQTLNLVGNKRIRIVDGGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPF-LIR 287
            :.|                      :||::| |..|..|...|..  :.|:..:....:|. :|.
Worm   152 KYN----------------------KEAKRS-DVNYAAVTGEVCS--KYASRMINRARKPLPMIP 191

  Fly   288 GPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTL------E 346
            ...:......::.|....:.|.|..|.|.:|..                 ||.|||.:      |
Worm   192 CFGDHCKEFDTTPVSDFGLPGKPEDDPLVKRVV-----------------LKKDDVIVPVHDSEE 239

  Fly   347 DMGEYTCEADNA---------------------VGGITATGILTVHAPPKF------VIRPKNQL 384
            ...|...|..||                     ..|:|...| |...||.|      |:..:...
Worm   240 SPSESRTEFINADEKENKEDEEEDYSVSQPVAPDAGLTELNI-TAEEPPYFKSNDNIVLFNETHA 303

  Fly   385 VEIGDEVLFECQANGHPRPTLYWSVEGNSSLLLPGYRDGRM-EVTLTPEGRSVLSIARFARE--- 445
            :..|..:...|:|.|:|.|.:.|            |::|:| :.:....|.......|::.|
Worm   304 LPAGRTLKLNCRAKGYPEPQIIW------------YKNGKMLKKSSARSGGYEFKFNRWSLEVED 356

  Fly   446 ----DSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTP 506
                |||: ..|.|||.|||......|.:..:...||.|:.....||::.:.......|:.:...
Worm   357 AVVADSGE-FHCEALNKVGSAKKYFHVIIVNRMRRPPIIVPNILANQSVNINDTATFHCKVVSDL 420

  Fly   507 VPQVSW-----------------------YLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGL 548
            :|.:.|                       |.:....| :.|. .::.|...|||.::.. :|:|:
Worm   421 LPHIIWVRINKINGSYSYYNNSAEEYMFNYTEMDTFD-KAHV-HHVGDESTLTIFNVSL-DDQGI 482

  Fly   549 YTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNK 613
            |.|::.|..|.|..:..|        .:..|.|..|.|     |....:::        ||.|:.
Worm   483 YACLSGNSLGMSMANATL--------TVNEFMAIHLLT-----GDEPKIDR--------WTTSDY 526

  Fly   614 VGGSSLVGYVI--EMFG------------KNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRA 664
            :..:.|:..::  .:||            |...|..|.:..|.:....::..:          ..
Worm   527 IFTTILLFLLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPM----------NE 581

  Fly   665 ENSHGLSLPSP-----MSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASV-------VDST 717
            :|.:....|||     :..|||        ..:.:..:...::.:...||...|       |:.:
Worm   582 DNENSDDEPSPYQIQIIETPIT--------KKEAARKQRKRMNSENTVLSEYEVDSDPVWEVERS 638

  Fly   718 SMKLTWQIINGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASA-SASASALISTKP 781
            .:.|...:..|.:.|.:....::            |.|....:.......|| ......|:|...
Worm   639 KLSLVHMLGEGAFGEVWKATYKE------------TENNEIAVAVKKLKMSAHEKELIDLVSEME 691

  Fly   782 NIAAAGKRDGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEG 846
            .....|:.:               ...|::....|.|.....:.......|.:|......|..:.
Worm   692 TFKVIGEHE---------------NVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKA 741

  Fly   847 KPSNSRIARTLEDVPSEAPYGMEALLLNSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFS 911
            |.|:..:...||  |.:|....:..|:           |.|..||.|...:.| .:|:    ||
Worm   742 KKSSQELTDYLE--PRKASDKDDIELI-----------PNLTQRHLVQFAWQV-AQGM----NF- 787

  Fly   912 RILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKRLDPFINQRY- 975
                     .||..::..:|           |..|..||...|   |::.......|...|..|
Worm   788 ---------LASKKIIHRDL-----------AARNVLVGDGHV---LKISDFGLSRDVHCNDYYR 829

  Fly   976 -------PIN-------QDHVNDVLTQPWFIILLGAILAVLMLSFGAMVFVKRKHMMMKQSALNT 1026
                   ||.       ..:|..|.:..|              |:|.:::           .:.|
Worm   830 KRGNGRLPIKWMALEALDSNVYTVESDVW--------------SYGVLLW-----------EIMT 869

  Fly  1027 MRGNHTSDVLKMPSLSARNGNGY-------------------WLD---------SSTGGMVWRPS 1063
            : |......:.||.|.|....||                   |.:         :....:.|..:
Worm   870 L-GGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLT 933

  Fly  1064 PGGDSLEMQK---DHIADYAPVCGAPGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQRY 1125
            ...:::|..:   |...........|.||...                        ..::.:.|.
Worm   934 MTNETIEGSQEFNDQFFSERSTASGPVSPMES------------------------FQKKRKHRP 974

  Fly  1126 VGEYSNIPT--------DYAEVSSFGKAPSEYGRHGNASPAPYATSSILSPH----QQQQQQQPR 1178
            :....|:|:        ||.  |:|...|.....|      .|...::|..|    :..|....:
Worm   975 LSAPVNLPSEPQHTICDDYE--SNFSVEPPNDPNH------LYCNDNMLKNHIITPETSQLYIHK 1031

  Fly  1179 YQQRPV-PGY--------------------GLQRPMHPHYQQQQHQQQQAQQTHQQHQALQQHQQ 1222
            ....|: .||                    .|..|..|.|.:..::.....||||.:
Worm  1032 VLNEPIGNGYVRQDKLARAVSGVANQSLDSALGSPAWPSYDRPSNKASCLDQTHQYY-------- 1088

  Fly  1223 LPPSNIYQQMSTTSEIY--------PTNTGPSR-SVYSEQYYYPKDKQRH 1263
                      :|||:|.        |.....|| |...|:.|:|...|.|
Worm  1089 ----------NTTSKIQYLHFTFDDPDCMTRSRDSAIFEESYHPNYIQSH 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
robo2	NP_001259868.1	Ig1_Robo	90..185	CDD:143317	25/87 (29%)
		I-set	91..184	CDD:254352	25/86 (29%)
		I-set	190..279	CDD:254352	15/91 (16%)
		Ig2_Robo	193..279	CDD:143201	14/85 (16%)
		I-set	283..370	CDD:254352	21/114 (18%)
		Ig	300..370	CDD:299845	19/96 (20%)
		Ig	388..>457	CDD:299845	18/76 (24%)
		I-set	479..561	CDD:254352	19/104 (18%)
		Ig	496..561	CDD:143165	16/87 (18%)
		FN3	588..681	CDD:238020	16/111 (14%)
		FN3	<817..856	CDD:238020	6/38 (16%)
		fn3	864..952	CDD:278470	18/87 (21%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	25/86 (29%)
		Ig	47..126	CDD:299845	25/86 (29%)
		Ig	302..382	CDD:299845	23/92 (25%)
		IG_like	306..384	CDD:214653	24/90 (27%)
		IG_like	401..502	CDD:214653	20/111 (18%)
		Ig3_FGFR	407..503	CDD:143175	18/106 (17%)
		PKc_like	627..933	CDD:304357	63/400 (16%)
		Pkinase_Tyr	640..928	CDD:285015	60/382 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000