DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and Robo4

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:NP_001292144.1 Gene:Robo4 / 100911068 RGDID:6494870 Length:1021 Species:Rattus norvegicus


Alignment Length:1326 Identity:271/1326 - (20%)
Similarity:421/1326 - (31%) Gaps:451/1326 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 GERLKIMPVDRSRRAVF----PLLLLLAGLNGLTQVGALKGENPRIIEHPMDTTVPKNDPFTFNC 112
            ||.|: ..||.....:.    ||.|||..:.|    |......|:|:.||.|..:..:.|...:|
  Rat     4 GEELR-AAVDSGGMGLLGTKCPLPLLLLFIMG----GKALDSPPQILVHPQDQLLQGSGPAKMSC 63

  Fly   113 QAEGNPTPTIQWFKDGRELKTDTGSHRIMLPAGGLFFLK-VIHSRRESD-------AGTYWCEAK 169
            :|.|.|.|||:|..:|:.|...|.....:...|.|...: ..|.|.:.|       .|.|.|||.
  Rat    64 RASGQPLPTIRWLLNGQPLSMATPDLHYLQSDGTLLLHRPPTHGRPQDDQNILSAILGVYTCEAS 128

  Fly   170 NEFGVARSRNATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTLNLVG 234
            |..|.|.||.|.|.||.|:::||::|.:|....||..::|||.|.|.|:|.:||.|:|:.|.|..
  Rat   129 NRLGTAVSRGARLSVAVLQEDFRIQPRDTVAVVGESLVLECGPPWGYPKPSVSWWKDGKPLVLQP 193

  Fly   235 NKRIRIVDGGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIRGPQNQTAVVGSS 299
            .|  |.|.|.:|.:..|.::|.|.|.|:..|..|.|||..|                        
  Rat   194 GK--RTVSGDSLMVARAEKNDTGTYMCMATNNAGQRESRAA------------------------ 232

  Fly   300 VVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHV-LEDRSLKLDDVTLEDMGEYTCEADNAVGGIT 363
                 |:.....||              .:.|: |....::|::|||.:                
  Rat   233 -----RVSIQESPD--------------HKEHLELLAVRIQLENVTLLN---------------- 262

  Fly   364 ATGILTVHAPPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLY--WSVEGNSSLLLPGYRDGRME 426
                      |:.|..||                   |.|.::  |.|.|.::            
  Rat   263 ----------PEPVKGPK-------------------PGPAVWLSWKVSGPAA------------ 286

  Fly   427 VTLTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSVDTQFELPPPIIEQGPVNQTLP 491
                 ..:|..::.|..|:.                                             
  Rat   287 -----PAQSYTALFRAQRDP--------------------------------------------- 301

  Fly   492 VKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISDLQRHEDEGLYTCVASNR 556
                     |..|:|..:|  .|||            |.:|   .:..|:..:|.......:|.|
  Rat   302 ---------RDQGSPWTEV--LLDG------------LLNA---KLGGLRWGQDYEFKVRPSSGR 340

  Fly   557 -NGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSVTLSWTRSNKVGGSSLV 620
             .|..|             |:...|.||  ..|..|.:...:..|..||.:||........:..:
  Rat   341 ARGPDS-------------NVLLLRLPE--QVPSAPPQEVTLRPGNGSVFVSWAPPPAENHNGFI 390

  Fly   621 -GYVIEMFGKNE--TDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHGLSLPS-------- 674
             ||.:...|...  ...|..||   :.|.......:|| :|...:.|....|...||        
  Rat   391 RGYQVWSLGNASLPAANWTVVG---EQTQLEIAARMPG-SYCVQVAAVTGAGAGEPSIPVCLLLE 451

  Fly   675 -PMSEPITVGTRYFNSGLDLSEARASLLSGDVVELSNASVVDSTSMKLTWQIINGKYV------- 731
             .|.:.....:::.:  ..|.:.||:|...:|:         ::...|.|.::.|..|       
  Rat   452 QAMEQSARDPSKHVS--WTLEQLRATLKRPEVI---------ASGAVLLWLLLLGIAVCIYRRRK 505

  Fly   732 ------EGFYVYARQLPNPIVNNPAPVTSNTNPLLGST--STSASASASASALISTKPNIAAAGK 788
                  .|.|.|..:  :.|:.:  .:..:.:|.|..|  |||.|...|:|:.:|::..:.....
  Rat   506 AGVHLGPGLYRYTSE--DAILKH--RMDHSDSPWLADTWRSTSGSRDLSSSSSLSSRLGVDPRDP 566

  Fly   789 RDGET-----NQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKP 848
            .||..     :....|.|...:|.                       |.|...|.....|...:|
  Rat   567 LDGRRSLISWDPRSPGVPLLPDTS-----------------------TFYGSLIAEQTSSPPVRP 608

  Fly   849 S-NSRIARTLED--VPSEAPYGMEALLLN---------SSAVFLKWKAPELKDRHGVLLNYHVIV 901
            | .:..||.|..  ..:.:|:.....|.:         |.|....|||.:.::.|..  |...::
  Rat   609 SPQTPAARRLPPKLTGTSSPWASSDSLCSRRGLCSPRMSLAPAEAWKAKKKQELHQA--NSSPLL 671

  Fly   902 RGIDTAHNFSRILTNVTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGP---YCVPATLRLDP- 962
            ||                  :.|..:.|       :.:|..|..|....|   .|.|   |..| 
  Rat   672 RG------------------SHPMEIWA-------WELGSRASKNLSQSPGPNTCSP---REAPG 708

  Fly   963 ---ITKRLDPFINQRYPINQDHVNDVLTQPWFIILLGAILAVLMLSF-GAMVFVKRKHMMMKQSA 1023
               ..:.|.|.:::       :.:::..:|         |....||. ||.....:...:.|..|
  Rat   709 AVVAWRALGPQLHR-------NSSELAARP---------LPPTPLSLRGAPSHDPQSQCVEKLQA 757

  Fly  1024 LNTMRGNHTSDVLKMPSLSARNGNGYWLDSSTGGMVWRPSPGGDSL---------EMQKDHIA-- 1077
                   .:||.|....||..|.:.  ..|.....:..||||..:|         |..:|.:.  
  Rat   758 -------PSSDPLPAAPLSVLNSSR--PSSPQASFLSVPSPGSSNLSSSSLSSLEEEDQDSVLTP 813

  Fly  1078 ------------------DYAPVCGAPGSPAGGG-----TSSG----GSGGAGSGASGGD----- 1110
                              ..:|:..||..||..|     ||||    |..|.|.|:..|:     
  Rat   814 EEVALCLELSDGEETPTNSVSPMPRAPSPPATYGYISIPTSSGLADMGRAGGGVGSEVGNLLCPP 878

  Fly  1111 -----------DIHGGHGSERNQQRYVGEYSNIPTDYAEV--SSFGK--APSEYGRHGNASPAPY 1160
                       .:..|.||        ....|:|:..|.:  ||.|.  |.:.:.|....:...:
  Rat   879 RLCPTPTPSEGSLANGWGS--------ASEDNVPSARASLVSSSDGSFLADAHFARALAVAVDSF 935

  Fly  1161 ATSSILSPHQ-------QQQQQQPRYQQRPVPGYGLQRPMHPHYQQQQHQQQQAQQTHQQHQALQ 1218
            ..|  |.|.:       ......||........:.|     |.::.:....:.|:..|.|...  
  Rat   936 GFS--LEPREADCVFTDASSPPSPRDDLSLTRSFSL-----PLWEWRPDWLEDAEINHTQRLG-- 991

  Fly  1219 QHQQLPP----SNIYQQMSTTSEIYP 1240
              :.|||    |.:..|.|..:.:.|
  Rat   992 --RGLPPWPPDSRVSSQRSWLTGVVP 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 34/101 (34%)
Ig strand A 91..95 CDD:409490 2/3 (67%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 2/7 (29%)
Ig strand C 121..126 CDD:409490 3/4 (75%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 0/2 (0%)
Ig strand E 145..151 CDD:409490 2/5 (40%)
Ig strand F 162..170 CDD:409490 5/7 (71%)
Ig strand G 173..185 CDD:409490 6/11 (55%)
IgI_2_Robo 192..279 CDD:409389 34/86 (40%)
Ig strand A 192..195 CDD:409389 1/2 (50%)
Ig strand A' 197..201 CDD:409389 1/3 (33%)
Ig strand B 205..212 CDD:409389 2/6 (33%)
Ig strand C 220..225 CDD:409389 2/4 (50%)
Ig strand C' 227..230 CDD:409389 1/2 (50%)
Ig strand D 237..241 CDD:409389 1/3 (33%)
Ig strand E 244..250 CDD:409389 1/5 (20%)
Ig strand F 257..265 CDD:409389 3/7 (43%)
Ig strand G 268..279 CDD:409389 5/10 (50%)
Ig 286..370 CDD:472250 9/84 (11%)
Ig strand B 300..304 CDD:409353 0/3 (0%)
Ig strand C 313..317 CDD:409353 1/3 (33%)
Ig strand E 336..340 CDD:409353 0/3 (0%)
Ig strand F 350..355 CDD:409353 0/4 (0%)
Ig strand G 363..366 CDD:409353 0/2 (0%)
Ig_3 373..457 CDD:464046 12/85 (14%)
Ig 480..566 CDD:472250 15/86 (17%)
Ig strand B 496..500 CDD:409353 0/3 (0%)
Ig strand C 509..513 CDD:409353 1/3 (33%)
Ig strand E 533..537 CDD:409353 0/3 (0%)
Ig strand F 548..553 CDD:409353 0/4 (0%)
Ig strand G 561..564 CDD:409353 1/2 (50%)
COG3979 586..>800 CDD:443178 47/245 (19%)
FN3 588..681 CDD:238020 22/104 (21%)
fn3 864..952 CDD:394996 17/99 (17%)
Robo4NP_001292144.1 Ig 42..144 CDD:472250 34/101 (34%)
Ig strand B 59..63 CDD:409490 0/3 (0%)
Ig strand C 72..76 CDD:409490 2/3 (67%)
Ig strand E 96..100 CDD:409490 2/3 (67%)
Ig strand F 122..127 CDD:409490 2/4 (50%)
Ig strand G 136..139 CDD:409490 2/2 (100%)
Ig 151..236 CDD:472250 35/115 (30%)
Ig strand B 165..169 CDD:409389 0/3 (0%)
Ig strand C 179..183 CDD:409389 1/3 (33%)
Ig strand E 201..205 CDD:409389 1/3 (33%)
Ig strand F 215..220 CDD:409389 2/4 (50%)
Ig strand G 229..232 CDD:409389 1/2 (50%)
fn3 361..443 CDD:394996 18/85 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..563 5/18 (28%)
PHA03247 <578..861 CDD:223021 67/360 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..634 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 726..810 22/101 (22%)

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