DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment robo2 and robo2

DIOPT Version :10

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_031752453.1 Gene:robo2 / 100493913 XenbaseID:XB-GENE-980527 Length:1620 Species:Xenopus tropicalis


Alignment Length:1595 Identity:456/1595 - (28%)
Similarity:690/1595 - (43%) Gaps:374/1595 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 IMPVDRSRRAVFP--LLLLLAGLNGLTQ--VGALKGEN-------------PRIIEHPMDTTVPK 104
            ||.....:||..|  ||:|:..::|:||  :...||::             |||:|||.|..|.|
 Frog     5 IMLSSLRQRAASPEFLLILMLFVSGVTQSKISRTKGKHWKGGSRLRQEDFPPRIVEHPSDVIVSK 69

  Fly   105 NDPFTFNCQAEGNPTPTIQWFKDGRELKTDTG---SHRIMLPAGGLFFLKVIHSRR-ESDAGTYW 165
            .:|.|.||:|||.|||||:|:||...::||..   |||::||:|.||||::||.|: :.|.|:|.
 Frog    70 GEPTTLNCKAEGRPTPTIEWYKDLERVETDKDDPRSHRMLLPSGSLFFLRIIHGRKFKPDEGSYV 134

  Fly   166 CEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGSPEPQISWRKNGQTL 230
            |.|:|..|.|.||||:|:||.|||:|||.|.:..||.||.|::||..|||.|||.|.|:|:    
 Frog   135 CVARNYLGEAMSRNASLEVALLRDDFRLNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKD---- 195

  Fly   231 NLVGNKRIRIVD--------GGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVHVRPFLIR 287
                  ::||.|        ||.|.:...|:||.|.|.||..|:||.|:|..|.|.|..||..:|
 Frog   196 ------KVRIDDKDERISIRGGKLMLSNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLR 254

  Fly   288 GPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTLEDMGEYT 352
            .|.||..:...:|.|:|::.|||.|.|.|::  ...::|..|..:.:|.:|::...:..|.|.:.
 Frog   255 RPINQVVLEDEAVEFRCQVQGDPQPTVRWKK--DDVDLPRGRYDIKDDYTLRIKKASSSDEGTFA 317

  Fly   353 CEADNAVGGITATGILTVH----APPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLYWSVEGNS 413
            |.::|.||.|.|:..|||.    |||:|||||::|:|..|..|.|.|:|.|:|:|.::|..||:.
 Frog   318 CISENRVGKIEASATLTVRVRPVAPPQFVIRPRDQIVAQGRTVTFGCEAKGNPQPAVFWQKEGSQ 382

  Fly   414 SLLLPG---YRDGRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVVSV-DTQF 474
            :||.|.   ..:.|..|:.|.:    |:|....|.|:|..: |.||...||:.::..:.| |...
 Frog   383 NLLFPNQPLQPNSRYSVSPTGD----LTITSIQRSDAGYYI-CQALTVAGSILAKAQLEVTDVLT 442

  Fly   475 ELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDAGALTISD 539
            :.|||||.|||.||||.|....||.|:|.|.|:|.:||..:|....:....|.::.|.|.|.|..
 Frog   443 DRPPPIILQGPANQTLAVDGTAVLKCKTTGDPMPVISWLKEGFKGFIGRDARLSILDQGTLQIKG 507

  Fly   540 LQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMVEKGENSV 604
            | :..|.|.|||||::.:|:::||..|.:.......|.  :..:|:..||.|.|||:.:..:|||
 Frog   508 L-KVTDSGTYTCVATSSSGETTWSAVLEVTESGGAIIS--KNYDLNDLPGSPSKPQVTDVSKNSV 569

  Fly   605 TLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLIRAENSHG 669
            |||| :....|...:..|:||.|.::.::.|..|...|:.|.:|..||.|...|.|::||.|:.|
 Frog   570 TLSW-QPGSPGILPVTSYIIEAFSQSVSNSWQTVANHVKTTLYTVKGLRPNTIYLFMVRAINTEG 633

  Fly   670 LSLPSPMSEPITVGTRYFN---SGLDLSEARASLLSGDV-VELSNASVVDSTSMKLTWQI-INGK 729
            ||.|||:|:|  |.|:..:   .|:|..:.:..|  ||| |.|.|..|:..|::::||.: ...:
 Frog   634 LSDPSPISDP--VRTQDISPPVQGVDHRQVQKEL--GDVIVRLHNPVVLTPTTIQVTWMVDRQSQ 694

  Fly   730 YVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKRDGETN 794
            :::|:.|..||                        ||...:.||...:..|              
 Frog   695 FIQGYRVMYRQ------------------------TSGLQTPSAWQSLEVK-------------- 721

  Fly   795 QSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIARTLED 859
                   .|              ...|..:|.|.:...||..:.|::...:|..|.|:.|||.|:
 Frog   722 -------VP--------------AERSAVLTNLKKGITYEIKVRPYFNEFQGMDSESKSARTTEE 765

  Fly   860 VPSEAPYGMEALLL---NSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTNVTIDA 921
            .||..|..:..:.:   ||:::.:.|..|....::|::.:|.:...|     |.:|...|.|:||
 Frog   766 APSAPPQSVTVMTVGNNNSTSISISWDPPPSDHQNGIIQDYRIWCLG-----NETRFHINKTVDA 825

  Fly   922 ASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKRLDPFINQRYPINQDHVNDVL 986
            |..::|:..|..|:.|.|.|||..:||.|....|..::   |..|.:..|.:......:.:.||:
 Frog   826 AIRSVVIGGLFPGIQYRVEVAASTSAGTGVKSAPQHIQ---IGNRNEVVITENNNSITEQITDVV 887

  Fly   987 TQPWFIILLGAILAVLMLSFGAMVFVKRKH----------------------MMMKQSALNTMRG 1029
            .||.||..:|....|:::.|...::.:||.                      .|..:.||.|.:|
 Frog   888 KQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVQSFTFTPADSPDTTMHHKVALGTKKG 952

  Fly  1030 NHTSDVL------------KMPSLSARNGNGY-WLDSSTGGMVWRPS--PGGDSLEMQKDHIADY 1079
            :....|.            ..|.|...|...| ||..|     |..|  |..:|.....| :.::
 Frog   953 SWHKTVTFQRGDGGLMSNGSRPGLLNANDPSYPWLADS-----WPASSMPVNNSNNGPND-LVNF 1011

  Fly  1080 APVCG-----APGSPAGGGTSSGGSGGAGSGASGGDDIHGGHGSERNQQRYVGEYSNIPTDYAEV 1139
            :  ||     .||.  |..|::..|.||                         .||:|  |:...
 Frog  1012 S--CGDVLPTVPGQ--GEKTATMLSDGA-------------------------IYSSI--DFTTK 1045

  Fly  1140 SSFGKAPSEYGRHGNASPAPYATSSIL---SPHQ------QQQQQQPRYQQRPVPGYGLQRPMHP 1195
            ||: ..|.:.     |...||||:.||   |.|:      ..|.:....|:..:.|.|       
 Frog  1046 SSY-NCPGQI-----AQTTPYATTQILHSNSIHELAVDLPDPQWKSSIQQKSDLTGLG------- 1097

  Fly  1196 HYQQQQHQQQQAQQTHQQHQALQQHQQLPPSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDK 1260
            :....|.:...|......::..:......|.|..|..||||....:....|.|       ..||.
 Frog  1098 YCLTDQGKGSNALLYIPDYRMAEGLSNRIPHNQSQDFSTTSSHNSSERSGSLS-------GGKDG 1155

  Fly  1261 QRHIHITENKLSNCHTYEAAPGAKQSSPISSQFASVRRQQLPPNCSIGRESARFKVLNTDQGKNQ 1325
            :|    .:||.|          :|.|....|.:|:|   .|||                      
 Frog  1156 KR----KKNKNS----------SKISKNNGSSWANV---PLPP---------------------- 1181

  Fly  1326 QNLLDLDGSSMCYNGLADSGCG----GSPSPMAMLMSHEDEHALYHTADGDLDDMERLYVKVDEQ 1386
            ..:..|.|:.:.:.||.....|    |...|:.:      :..|:..:|.:|::        ||:
 Frog  1182 PPIQPLPGTEIEHYGLEHQETGYDTNGWCPPLPV------QTYLHQGSDDELEE--------DEE 1232

  Fly  1387 Q---PPQQ-----------QQQLIPLVP------QHPAEGHL-------------QSWRNQSTRS 1418
            :   ||.:           ||....|.|      |...:.||             |||...|   
 Frog  1233 RVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQSWHLHS--- 1294

  Fly  1419 SRKNGQECIKEPSELIYAPGSVASE------------------------RSLLSNSGSGTSSQPA 1459
               |.|..:.....|.|..|:..|:                        |.|....||...    
 Frog  1295 ---NNQPPLAPVPPLGYVSGTFISDLEKDIPDQEEDEIEDESIEITRPLRGLEHTPGSSMD---- 1352

  Fly  1460 GHNVXPLLPGSSL---GQSQSKSQSQSQSQSDLQS 1491
              |:...:.||.:   |.:..:.::.|..:|.:.|
 Frog  1353 --NLDSSVTGSMVNGWGSASDEDRNYSSHRSSVGS 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 IgC_1_Robo 91..185 CDD:409490 52/97 (54%)
Ig strand A 91..95 CDD:409490 3/3 (100%)
Ig strand A' 98..103 CDD:409490 1/4 (25%)
Ig strand B 107..115 CDD:409490 4/7 (57%)
Ig strand C 121..126 CDD:409490 3/4 (75%)
Ig strand C' 129..131 CDD:409490 0/1 (0%)
Ig strand D 139..142 CDD:409490 1/2 (50%)
Ig strand E 145..151 CDD:409490 4/5 (80%)
Ig strand F 162..170 CDD:409490 4/7 (57%)
Ig strand G 173..185 CDD:409490 7/11 (64%)
IgI_2_Robo 192..279 CDD:409389 39/94 (41%)
Ig strand A 192..195 CDD:409389 2/2 (100%)
Ig strand A' 197..201 CDD:409389 0/3 (0%)
Ig strand B 205..212 CDD:409389 3/6 (50%)
Ig strand C 220..225 CDD:409389 2/4 (50%)
Ig strand C' 227..230 CDD:409389 0/2 (0%)
Ig strand D 237..241 CDD:409389 1/3 (33%)
Ig strand E 244..250 CDD:409389 2/5 (40%)
Ig strand F 257..265 CDD:409389 4/7 (57%)
Ig strand G 268..279 CDD:409389 5/10 (50%)
Ig 286..370 CDD:472250 26/83 (31%)
Ig strand B 300..304 CDD:409353 2/3 (67%)
Ig strand C 313..317 CDD:409353 1/3 (33%)
Ig strand E 336..340 CDD:409353 1/3 (33%)
Ig strand F 350..355 CDD:409353 1/4 (25%)
Ig strand G 363..366 CDD:409353 1/2 (50%)
Ig_3 373..457 CDD:464046 33/86 (38%)
Ig 480..566 CDD:472250 36/85 (42%)
Ig strand B 496..500 CDD:409353 2/3 (67%)
Ig strand C 509..513 CDD:409353 1/3 (33%)
Ig strand E 533..537 CDD:409353 2/3 (67%)
Ig strand F 548..553 CDD:409353 3/4 (75%)
Ig strand G 561..564 CDD:409353 1/2 (50%)
COG3979 586..>800 CDD:443178 63/218 (29%)
FN3 588..681 CDD:238020 39/92 (42%)
fn3 864..952 CDD:394996 26/90 (29%)
robo2XP_031752453.1 IgC_1_Robo 56..154 CDD:409490 55/101 (54%)
Ig strand A 56..60 CDD:409490 1/3 (33%)
Ig strand A' 63..68 CDD:409490 3/4 (75%)
Ig strand B 72..80 CDD:409490 3/7 (43%)
Ig strand C 86..91 CDD:409490 2/4 (50%)
Ig strand C' 94..96 CDD:409490 0/1 (0%)
Ig strand D 107..110 CDD:409490 1/2 (50%)
Ig strand E 113..119 CDD:409490 2/5 (40%)
Ig strand F 131..139 CDD:409490 5/7 (71%)
Ig strand G 142..154 CDD:409490 5/11 (45%)
Ig 161..246 CDD:472250 36/92 (39%)
Ig strand B 175..179 CDD:409389 0/3 (0%)
Ig strand C 189..193 CDD:409389 2/11 (18%)
Ig strand E 211..215 CDD:409389 1/3 (33%)
Ig strand F 225..230 CDD:409389 2/4 (50%)
Ig strand G 239..242 CDD:409389 2/2 (100%)
Ig 253..335 CDD:472250 31/85 (36%)
Ig strand B 267..271 CDD:409390 0/3 (0%)
Ig strand C 280..284 CDD:409390 0/3 (0%)
Ig strand E 301..305 CDD:409390 1/3 (33%)
Ig strand F 315..320 CDD:409390 3/8 (38%)
Ig strand G 328..331 CDD:409390 1/2 (50%)
IgI_4_Robo 344..441 CDD:409391 37/100 (37%)
Ig strand A 344..348 CDD:409391 1/3 (33%)
Ig strand A' 350..354 CDD:409391 1/3 (33%)
Ig strand B 360..368 CDD:409391 3/10 (30%)
Ig strand C 371..378 CDD:409391 2/6 (33%)
Ig strand C' 380..383 CDD:409391 0/2 (0%)
Ig strand D 396..401 CDD:409391 1/4 (25%)
FN3 402..1007 CDD:442628 181/648 (28%)
Ig strand E 403..410 CDD:409391 3/6 (50%)
Ig strand F 416..425 CDD:409391 2/9 (22%)
Ig strand G 427..438 CDD:409391 8/10 (80%)
IgI_5_Robo 448..535 CDD:409544 27/86 (31%)
Ig strand A 448..451 CDD:409544 1/2 (50%)
Ig strand A' 455..458 CDD:409544 1/2 (50%)
Ig strand B 464..471 CDD:409544 1/6 (17%)
Ig strand C 477..482 CDD:409544 1/4 (25%)
Ig strand C' 484..486 CDD:409544 0/1 (0%)
Ig strand D 494..498 CDD:409544 1/3 (33%)
Ig strand E 501..506 CDD:409544 1/4 (25%)
Ig strand F 514..522 CDD:409544 1/7 (14%)
Ig strand G 525..535 CDD:409544 1/9 (11%)
FN3 553..646 CDD:238020 34/95 (36%)

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