DRSC/TRiP Functional Genomics Resources

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Protein Alignment robo2 and robo3

DIOPT Version :9

Sequence 1:NP_001259868.1 Gene:robo2 / 44522 FlyBaseID:FBgn0002543 Length:1519 Species:Drosophila melanogaster
Sequence 2:XP_002937567.3 Gene:robo3 / 100493553 XenbaseID:XB-GENE-1032334 Length:1424 Species:Xenopus tropicalis


Alignment Length:1562 Identity:439/1562 - (28%)
Similarity:687/1562 - (43%) Gaps:361/1562 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 PRIIEHPMDTTVPKNDPFTFNCQAEGNPTPTIQWFKDGRELKTDTG---SHRIMLPAGGLFFLKV 152
            |||:|||.|..|.|.:|.|.||:|||.|||.|:|:|||..::||..   |||::||:|.||||::
 Frog    65 PRIVEHPSDHIVSKGEPATLNCKAEGRPTPIIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 129

  Fly   153 IHSRR-ESDAGTYWCEAKNEFGVARSRNATLQVAFLRDEFRLEPANTRVAQGEVALMECGAPRGS 216
            :|.|| :.|.|.|.|.|:|..|.:.||||:|:||.|||:||..|.:..||.||.|:|||..|||.
 Frog   130 VHGRRSKPDEGVYICVARNYLGESVSRNASLEVAILRDDFRQAPNDVVVAAGEPAVMECIPPRGH 194

  Fly   217 PEPQISWRKNGQTLNLVGNKRIRI-VDGGNLAIQEARQSDDGRYQCVVKNVVGTRESATAFLKVH 280
            |||.|||:|:...   :.:|..|| :.||.|.|...|:||.|.|.||..|:||.|:|..|.|.|.
 Frog   195 PEPTISWKKDNMR---ISDKDERITIRGGKLMISNTRKSDAGMYICVATNMVGERDSEPAQLVVF 256

  Fly   281 VRPFLIRGPQNQTAVVGSSVVFQCRIGGDPLPDVLWRRTASGGNMPLRRVHVLEDRSLKLDDVTL 345
            .||..||.|.||..:....|.|.|.:.|||:|...||:  ..|.:|..|..:|.|.:|::..|:.
 Frog   257 ERPTFIRRPINQVVLADDMVDFNCEVQGDPVPTARWRK--EEGELPRGRYEILNDNTLRISRVSA 319

  Fly   346 EDMGEYTCEADNAVGGITATGILTVHA----PPKFVIRPKNQLVEIGDEVLFECQANGHPRPTLY 406
            ||.|.|||..:|:||...|:|.|.||.    ||:.|.||::|:|..|..|.|:|:..|:|.|.::
 Frog   320 EDEGTYTCITENSVGKSEASGSLGVHVGPFFPPQLVTRPRDQIVVQGRTVTFQCETKGNPPPAVF 384

  Fly   407 WSVEGNSSLLLPGYRD---GRMEVTLTPEGRSVLSIARFAREDSGKVVTCNALNAVGSVSSRTVV 468
            |..||:..||.|....   ||..|  :|.|.  |:|......|||..: |.|::..||:.::.::
 Frog   385 WQKEGSQILLFPSQPPQTVGRFSV--SPSGE--LTIIDVQTGDSGYYM-CQAISVAGSILAKALL 444

  Fly   469 SV-DTQFELPPPIIEQGPVNQTLPVKSIVVLPCRTLGTPVPQVSWYLDGIPIDVQEHERRNLSDA 532
            .| |...:..||||.:||.||||.|.|.|.:.|:..|.|:|.:.|..||..| |....|..:.|:
 Frog   445 EVEDATSDRIPPIIRRGPANQTLAVDSTVQMHCQVSGNPLPSIHWLKDGQRI-VGSDPRIGVLDS 508

  Fly   533 GALTISDLQRHEDEGLYTCVASNRNGKSSWSGYLRLDTPTNPNIKFFRAPELSTYPGPPGKPQMV 597
            |.|.|:.|| ..|.|:|||||::..|:::|||::.:....:|  ...:..|.|..||.|.||.:.
 Frog   509 GNLQITHLQ-VTDSGVYTCVATSSTGETTWSGFVEVQEKGSP--IHVQLSEPSLVPGSPSKPLVT 570

  Fly   598 EKGENSVTLSWTRSNKVGGSSLVGYVIEMFGKNETDGWVAVGTRVQNTTFTQTGLLPGVNYFFLI 662
            :..:|||||:|..:.:.|.:.:..|:||.|.::....|..|...|:....|..||.|...|.|:|
 Frog   571 DVTKNSVTLTWQPNLQAGNTQVNSYIIEAFSQSAGSTWQTVADNVKVEKHTVVGLNPNTIYLFII 635

  Fly   663 RAENSHGLSLPSPMSEPI-TVGTRYFNSGLDLSEARASLLSGD-VVELSNASVVDSTSMKLTWQI 725
            ||.||:|||.|||:|||: |........|:|..:.:..|  |: ||:|....::.|:::::||.:
 Frog   636 RAVNSYGLSDPSPISEPVRTQDVSPTRQGVDHRQVQRQL--GEVVVQLQQPIILTSSTVQVTWTV 698

  Fly   726 -INGKYVEGFYVYARQLPNPIVNNPAPVTSNTNPLLGSTSTSASASASASALISTKPNIAAAGKR 789
             ...::::|:.|..|                             ..:|...:...|         
 Frog   699 DRQAQFIQGYRVMYR-----------------------------PKSSVWLVQDVK--------- 725

  Fly   790 DGETNQSGGGAPTPLNTKYRMLTILNGGGASSCTITGLVQYTLYEFFIVPFYKSVEGKPSNSRIA 854
                      :|:..||   :|..|..|             |.||..|.|::...:|..|:..:.
 Frog   726 ----------SPSERNT---ILVDLKKG-------------TEYEIKIRPYFDEFQGMDSDVLLI 764

  Fly   855 RTLEDVPSEAPYGMEALLL---NSSAVFLKWKAPELKDRHGVLLNYHVIVRGIDTAHNFSRILTN 916
            ||.|:|||..|..:..:.|   ||:.:.:.|:.|.::.::|::.:|.:.|.|.:|.::.:|    
 Frog   765 RTPEEVPSAPPQAVSVVTLGTNNSTNISISWEPPIVEHQNGIIQDYRIWVLGNETRYHINR---- 825

  Fly   917 VTIDAASPTLVLANLTEGVMYTVGVAAGNNAGVGPYCVPATLRLDPITKRLDPFINQRYPINQDH 981
             |:|....:.|:..|:.||:|.|.|||..:||.|....|.|:::.|.:.::.....:...:. :.
 Frog   826 -TVDGTVHSTVIRGLSPGVLYHVEVAAATSAGFGVKSQPITIQIKPSSDQVPVASGENVSLT-EQ 888

  Fly   982 VNDVLTQPWFIILLGAILAVLMLSFGAMVFVKRKHMMMKQSALNTMRGNHTSDVLKMPSLSARNG 1046
            :.||:.||.||..:|....|:::.|...::.:||    |:..|:    ::|:.....|::|....
 Frog   889 ITDVVKQPAFIAGIGGACWVILMCFSVWIYCRRK----KRKELS----HYTASFAYTPAVSFPES 945

  Fly  1047 NGY------WLDSSTGGMVWRPSPGGDSLEMQKDHIADYAPVC-----GAPGSPAGGGTSSGGSG 1100
            :|:      .|.:|.....|               :||..|..     |.|..|||....     
 Frog   946 SGHITARPGMLATSASNYPW---------------LADSWPATNLLRNGKPKEPAGNCCP----- 990

  Fly  1101 GAGSGASGGDDIHGGHGSERNQQRYVGEYSNIPTDYAEVSSFGKAPSEYGRHGNASP-------- 1157
                            |:....:||..: :.|....|:...||...|:...:....|        
 Frog   991 ----------------GNHNPSERYYND-AGISNYIAQTEKFGTGVSDGPIYSTIDPTTDDMRTF 1038

  Fly  1158 --------APYATSSIL--------SPHQQQQQ-------------QQPRYQQRPVPGYGLQR-- 1191
                    .||||:.::        ||..::.|             |..|.:....|..|.|:  
 Frog  1039 NGAFSQHTTPYATTPVVPYGGQNMHSPELEENQWNVQAGTSGVLYAQPDRTKAENGPKSGKQKAI 1103

  Fly  1192 ----------------PMHPHYQQQQHQQQQA----------------QQTHQQHQALQQHQQLP 1224
                            |..|..:..|:|::..                ::|:.. :.:|:...||
 Frog  1104 GKPVKTPSLNWTEILPPPPPANELSQYQEEDTDVEMSSDTEEWCPPLPERTYLM-ENIQEGCPLP 1167

  Fly  1225 --------PSNIYQQMSTTSEIYPTNTGPSRSVYSEQYYYPKDKQRHIHITENKLSNCHTYEAAP 1281
                    |::.|.|.||.:      ..||          |:|:   :|..|: :...|.:|..|
 Frog  1168 PPRGEASSPAHSYGQQSTAT------LTPS----------PQDE---MHAAED-IPRLHQFEIPP 1212

  Fly  1282 GAK------------------QSSP---ISSQFASVRRQ----QLPPNCSIGRESARFKVLNTDQ 1321
            ..:                  ||:|   .:::.|..:||    .|..|.::..|:...    .:.
 Frog  1213 HPRRLPSGSVPIPRAPSPPLTQSNPSLHTATEGAEAQRQGHRRNLSQNPNLSAENVNL----PNS 1273

  Fly  1322 GKNQ--QNLLDLDGSSMCYNGLADSGCGGSPSPMAMLMSHEDEHALYHTADGDLDDMERLYVKVD 1384
            ||:|  :|:....|........:.||                 |.......|||           
 Frog  1274 GKSQLGENISTPPGQKSRAKKKSKSG-----------------HYRREAKQGDL----------- 1310

  Fly  1385 EQQPPQQQQQLIPLVPQHPAEGHLQSWRNQSTRSS-----------RKNG----------QECIK 1428
               ||..:.   |...:.|...|....|.:.:.||           |:||          |...:
 Frog  1311 ---PPPPEP---PPADEEPCSPHTNGLRMECSASSLERDTSTSSVERRNGVLQQRGAAGPQFHQR 1369

  Fly  1429 EPSELI-YAPGSVASERSLLSNSGSGTSSQPAGHNVXPLLPGSSLGQSQSKSQSQSQSQSDLQSQ 1492
            :..||| |:..:..| ||.:|::.|.|.|            .||.|.:.|:.|:..:|::..:.:
 Frog  1370 DDEELIPYSKPNFLS-RSQMSSNCSTTGS------------SSSRGSAGSRGQASGRSKTGDRKE 1421

  Fly  1493 EQ 1494
            |:
 Frog  1422 EK 1423

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
robo2NP_001259868.1 Ig1_Robo 90..185 CDD:143317 51/97 (53%)
I-set 91..184 CDD:254352 51/96 (53%)
I-set 190..279 CDD:254352 42/89 (47%)
Ig2_Robo 193..279 CDD:143201 40/86 (47%)
I-set 283..370 CDD:254352 34/86 (40%)
Ig 300..370 CDD:299845 28/69 (41%)
Ig 388..>457 CDD:299845 25/71 (35%)
I-set 479..561 CDD:254352 36/81 (44%)
Ig 496..561 CDD:143165 25/64 (39%)
FN3 588..681 CDD:238020 39/93 (42%)
FN3 <817..856 CDD:238020 8/38 (21%)
fn3 864..952 CDD:278470 26/90 (29%)
robo3XP_002937567.3 IgC_1_Robo 65..163 CDD:409490 51/97 (53%)
Ig strand B 82..86 CDD:409490 1/3 (33%)
Ig strand C 95..99 CDD:409490 1/3 (33%)
Ig strand E 122..126 CDD:409490 2/3 (67%)
Ig strand F 141..146 CDD:409490 2/4 (50%)
Ig strand G 155..158 CDD:409490 2/2 (100%)
Ig 170..255 CDD:416386 41/87 (47%)
Ig strand A 170..173 CDD:409353 1/2 (50%)
Ig strand A' 175..179 CDD:409353 0/3 (0%)
Ig strand B 183..190 CDD:409353 4/6 (67%)
Ig strand C 198..203 CDD:409353 3/4 (75%)
Ig strand C' 205..208 CDD:409353 0/5 (0%)
Ig strand D 214..218 CDD:409353 2/3 (67%)
Ig strand E 220..226 CDD:409353 3/5 (60%)
Ig strand F 233..241 CDD:409353 4/7 (57%)
Ig strand G 244..255 CDD:409353 5/10 (50%)
Ig 262..344 CDD:416386 33/83 (40%)
Ig strand A 262..265 CDD:409353 2/2 (100%)
Ig strand A' 267..271 CDD:409353 2/3 (67%)
Ig strand B 274..283 CDD:409353 3/8 (38%)
Ig strand C 289..294 CDD:409353 1/4 (25%)
Ig strand C' 297..300 CDD:409353 1/2 (50%)
Ig strand D 303..308 CDD:409353 1/4 (25%)
Ig strand E 309..316 CDD:409353 2/6 (33%)
Ig strand F 323..331 CDD:409353 4/7 (57%)
Ig strand G 334..344 CDD:409353 4/9 (44%)
Ig 353..449 CDD:416386 33/100 (33%)
Ig strand A 353..357 CDD:409353 1/3 (33%)
Ig strand A' 359..363 CDD:409353 1/3 (33%)
Ig strand B 369..377 CDD:409353 3/7 (43%)
Ig strand C 380..387 CDD:409353 2/6 (33%)
Ig strand C' 389..392 CDD:409353 1/2 (50%)
Ig strand D 405..410 CDD:409353 2/6 (33%)
Ig strand E 412..419 CDD:409353 3/8 (38%)
Ig strand F 425..434 CDD:409353 3/9 (33%)
Ig strand G 436..447 CDD:409353 2/10 (20%)
Ig 457..543 CDD:416386 38/87 (44%)
Ig strand A 457..460 CDD:409353 2/2 (100%)
Ig strand A' 464..467 CDD:409353 2/2 (100%)
Ig strand B 473..480 CDD:409353 2/6 (33%)
Ig strand C 486..491 CDD:409353 1/4 (25%)
Ig strand C' 493..495 CDD:409353 1/1 (100%)
Ig strand D 502..506 CDD:409353 1/3 (33%)
Ig strand E 509..514 CDD:409353 2/4 (50%)
Ig strand F 522..530 CDD:409353 6/7 (86%)
Ig strand G 533..543 CDD:409353 4/9 (44%)
FN3 561..655 CDD:238020 39/93 (42%)
FN3 687..766 CDD:238020 21/142 (15%)
fn3 774..861 CDD:394996 26/91 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 103 1.000 Domainoid score I6691
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D173520at2759
OrthoFinder 1 1.000 - - FOG0000772
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12231
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X493
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
55.110

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