DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cv and TWSG1

DIOPT Version :9

Sequence 1:	NP_001284902.1	Gene:	cv / 44510	FlyBaseID:	FBgn0000394	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_065699.1	Gene:	TWSG1 / 57045	HGNCID:	12429	Length:	223	Species:	Homo sapiens

Alignment Length:	230	Identity:	84/230 - (36%)
Similarity:	125/230 - (54%)	Gaps:	30/230 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LTVGTIVLLAIVCFYGTVESCNEVVCASIVSKCMLTQSCKCE--LKNCSCCKECLKCLGKNYEEC 69
            :.|.|:.:|..:.:.....|||:.:|||.||||::.:.|:|.  ..||||||||:.|||..::||
Human     6 VAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDEC 70

  Fly    70 CSCVELCPKPNDTRNSLSKKSHVEDF-DGVPELFNAVATPDEGDSFGYNWNVFTFQVDFDKYLKG 133
            |.||.:|...|.:....:.||.||:. :.:|.||.|:.   |||: ..|||:.:|
Human    71 CDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALT---EGDT-QLNWNIVSF---------- 121

  Fly   134 PKLEKDGHY-----FLRTNDKNLDEAIQERDNIVTV--------NCTVIYLDQCVSWNKCRTSCQ 185
            |..|:..|:     ||.|.::...:.:....|.|..        .|||:|.|.|:|.::|:.||:
Human   122 PVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCE 186

  Fly   186 TTGASSTRWFHDGCCECVGSTCINYGVNESRCRKC 220
            :.|||..||||:.||||:|..||:||....:|..|
Human   187 SMGASKYRWFHNACCECIGPECIDYGSKTVKCMNC 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cv	NP_001284902.1	Tsg	87..221	CDD:398376	51/148 (34%)
TWSG1	NP_065699.1	Tsg	88..222	CDD:282516	51/148 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149655
Domainoid	1	1.000	89	1.000	Domainoid score	I7865
eggNOG	1	0.900	-	-		E1_28J21
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4278
Isobase	1	0.950	-	0	Normalized mean entropy	S6699
OMA	1	1.010	-	-		QHG47007
OrthoDB	1	1.010	-	-		D1254178at2759
OrthoFinder	1	1.000	-	-		FOG0003932
OrthoInspector	1	1.000	-	-		otm40527
orthoMCL	1	0.900	-	-		OOG6_108753
Panther	1	1.100	-	-	LDO	PTHR12312
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5846
SonicParanoid	1	1.000	-	-		X3232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750