DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment br and ZBTB24

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_055612.2	Gene:	ZBTB24 / 9841	HGNCID:	21143	Length:	697	Species:	Homo sapiens

Alignment Length:	770	Identity:	139/770 - (18%)
Similarity:	223/770 - (28%)	Gaps:	294/770 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELL-KSTPCKHPVILLQDVN 77
            :..::.::||:.|......|:||..|....:||:.:|:|.|.||..:. :.......:.:|:.:.
Human    19 HSDTVLASFEDQRKKGFLCDITLIVENVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMV 83

  Fly    78 FMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLANSGGRTPL 142
            ......|:||||.|.::..:||.:..|.||:.|:|..|.:...:        .||..:|...|.|
Human    84 ADTFGILLEFIYTGYLHASEKSTEQILATAQFLKVYDLVKAYTD--------FQNNHSSPKPTTL 140

  Fly   143 NTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSP----------PPTAVPSLPSHINNQLLKRMAM 197
            ||                           ||:|          ||......|..:|       .:
Human   141 NT---------------------------AGAPVVVISNKKNDPPKRKRGRPKKVN-------TL 171

  Fly   198 MHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIK 262
            ....|..||.||.     :||.:::.......|..|      |...|:.:.|:.::..:: .|.:
Human   172 QEEKSELAAEEEI-----QLRVNNSVQNRQNFVVKG------DSGVLNEQIAAKEKEESE-PTCE 224

  Fly   263 HHNNNNTPPLKEEKRNGPTGNGNSGNGNGN----------------GNGASNGNGISISDKLGSL 311
            .......|..|:|..:..|.:|.:.....:                |:...:|:...|..:
Human   225 PSREEEMPVEKDENYDPKTEDGQASQSRYSKRRIWRSVKLKDYKLVGDQEDHGSAKRICGR---- 285

  Fly   312 TPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDG-------------- 362
                ..|.|..:.:.:....|...|:..|  .|....|||.....:..|.|
Human   286 ----RKRPGGPEARCKDCGKVFKYNHFLA--IHQRSHTGERPFKCNECGKGFAQKHSLQVHTRMH 344

  Fly   363 -----------GKG-----------SLSSGNDEEIGD----------GLASH------HAAPQ-- 387
                       .|.           ||.||......|          .|.||      |:.|:
Human   345 TGERPYTCTVCSKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQNRQLKSHYRVHTGHSLPECK 409

  Fly   388 -------------------------------------------------------------FIMS 391
                                                                         |..|
Human   410 DCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQTHIRIHRGEKPYSCGICGKSFSDS 474

  Fly   392 PAENK--MFHAA--AFNFPNI------------------------DPSALLG-LNT--------- 418
            .|:.:  :.|..  .|:.|..                        |.|::.| .||
Human   475 SAKRRHCILHTGKKPFSCPECNLQFARLDNLKAHLKIHSKEKHASDASSISGSSNTEEVRNILQL 539

  Fly   419 ---QLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGG---TPSNSSSNNNNNNSNNQQQKVEQQSSP 477
               ||..||:..:  |...|.|:.:...:||.|.|   ..:.||.|...:.:.|.....:|   |
Human   540 QPYQLSTSGEQEI--QLLVTDSVHNINFMPGPSQGISIVTAESSQNMTADQAANLTLLTQQ---P 599

  Fly   478 HQL----LQQQHHSTPHTNSPQLKQEQPKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGG-HS 537
            .||    |..|...|.|..|..:.:.|.    |..::..:|:...|:.:|............ |.
Human   600 EQLQNLILSAQQEQTEHIQSLNMIESQM----GPSQTEPVHVITLSKETLEHLHAHQEQTEELHL 660

  Fly   538 ATPSPTAAYHKRERERERERERERERERERSLDHERDLERPGGTGSPPPPPPSHH 592
            ||.:...|.|.:.                              |..|.||||:||
Human   661 ATSTSDPAQHLQL------------------------------TQEPGPPPPTHH 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	29/96 (30%)
		BTB	33..118	CDD:197585	26/85 (31%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
ZBTB24	NP_055612.2	BTB	27..133	CDD:306997	31/113 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..176		12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..254		7/45 (16%)
		C2H2 Zn finger	296..316	CDD:275368	4/21 (19%)
		COG5048	<321..480	CDD:227381	16/158 (10%)
		C2H2 Zn finger	324..344	CDD:275368	2/19 (11%)
		C2H2 Zn finger	352..372	CDD:275368	2/19 (11%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		C2H2 Zn finger	408..428	CDD:275368	0/19 (0%)
		C2H2 Zn finger	436..456	CDD:275368	0/19 (0%)
		C2H2 Zn finger	464..480	CDD:275368	3/15 (20%)
		C2H2 Zn finger	492..512	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	652..697		13/64 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910