Protein Alignment br and BTBD18

DIOPT Version :9

• Sequence 1: NP_001162638.2
• Gene: br / 44505
• FlyBaseID: FBgn0283451
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001138573.1
• Gene: BTBD18 / 643376
• HGNCID: 37214
• Length: 712
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 113/568 - (19%)
• Similarity: 178/568 - (31%)
• Gaps: 218/568 - (38%)

  Fly    26 RDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELL-KSTPCKHPVILLQ--DVNFMDLHALVEF 87
            :..:.|.||.|..||.::.||..:||||||:|.|.| :..|.:...::|:  .:....|..||:|
Human    28 QQSDVFCDVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDF 92

  Fly    88 IYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLANSGGRTPLNTHTQSLPHP 152
            :|..|:.|.|:..|..|..|..||||.|...|.|
Human    93 LYTSEMEVSQEEAQDVLSAARQLRVSELESLQLE------------------------------- 126

  Fly   153 HHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRL 217
                     |...:.:.||             ..:|.:.|               :.||.|
Human   127 ---------GGKLVKAPQG-------------RRLNRECL---------------QPTSAA---- 150

  Fly   218 RGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKE-EKRNGPT 281
                   |:|..|.:.|::....||        ..|||.....|:         ||. .|..||.
Human   151 -------PISARVVTPSHHPHTPLP--------TNQTPCPLGAIR---------LKSLGKEEGPQ 191

  Fly   282 GNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSN 346
            .|        |...|.|.:|..:..:.....|:|      .:..|.|      ::::....|:.|
Human   192 EN--------NRQNADNLSGTLLLKRKARACPTP------QEKNSSP------SSHSQEPRENKN 236

  Fly   347 DSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPS 411
            |:                                   |....::||             |::.||
Human   237 DT-----------------------------------ALDPTVLSP-------------PSLYPS 253

  Fly   412 A---LLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQ 473
            .   ||....:|.:|     .|..|...|..|.::  .||...|:..........|.|::...::
Human   254 VDKHLLPRKIRLSRS-----KPSPGICTSKPSSIL--SGSSSVPATPGRRLWRQRSVNKETPEDK 311

  Fly   474 ----QSSPHQLLQQQHHSTPHTN-----------SPQLKQEQPKSG--------------GGSCK 509
                ::||.|       |||:.:           ||:::.....|.              .|:|
Human   312 PKPGRASPLQ-------STPNPSGLGKTGGSRKRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTC- 368

  Fly   510 SSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERER 557
               ..:...:....::.|..:||.||....||.|..:...|:|....|
Human   369 ---WEVVQETPLKNTQDSPQIPDPGGDFQEPSGTQPFSSNEQEMSPTR 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	35/94 (37%)
		BTB	33..118	CDD:197585	34/87 (39%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	34/91 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..176		6/26 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..355		35/216 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..410		10/35 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..676
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..712

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910