DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment br and CG6765

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001261582.1	Gene:	CG6765 / 38971	FlyBaseID:	FBgn0035903	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	783	Identity:	159/783 - (20%)
Similarity:	271/783 - (34%)	Gaps:	232/783 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRS-----------IKAHRVVLSACSPYFR 58
            :::.|:|:::.:.:.|:...|..:|.|.||.|.....|           |.||:.:|||.|.:|.
  Fly     4 ENYHLKWDSHLTYLNSSIATLYKNEKFADVVLYSSYNSSGIPSDIPTVGISAHKFILSASSQFFA 68

  Fly    59 ELLKSTPCKHP-----VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQ 118
            .:.::.|..:|     |:|..|::...:..||:::|.||..|....|...|:..|:|::.||.:.
  Fly    69 TMFETAPITNPNGVLYVVLPPDLSHRAIQILVQYMYSGEATVSNDILNEVLRGGEILKIRGLCRT 133

  Fly   119 QAEDTHSHLAQIQNLANSGGRTPLNTHTQSLPHPHH--GSLHDDGGSSTLFSRQGAGS----PPP 177
            .:             :|.||...:.|.|.   |||.  |.|| ...:||::...|..:    |||
  Fly   134 SS-------------SNGGGSGSVVTTTH---HPHSLAGHLH-PREASTMYMSNGTRTALPPPPP 181

  Fly   178 TAVPSLPSHINNQLL-------KRMAMMHRSSAAAAAEETSH----AFKRLRGS----DN----- 222
            ....::.:.:...|.       .|.|:.|...::..:....|    .|:.|..|    |:
  Fly   182 PPQSTMSAQLQGDLYASKPGGSTRFALDHHHLSSHHSHLNHHNPQQQFRGLGASVMPKDSPVIIK 246

  Fly   223 -----------SLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEK 276
                       ::..|..:|...|......|......|:|.|.         .:.::.||
  Fly   247 SPKLAAHTGLLTVASSSKLGISVNKEVAIDPEDKCCFAAPGQL---------ESQSHPPP----- 297

  Fly   277 RNGPTGNGNS---GNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDV-----KSEPMDMVC 333
               ||....:   |.|:..|:||.....|||..::|..:....|..|||..     ::|..:...
  Fly   298 ---PTTTTTTVGGGGGSVGGSGAPPSQPISICTEVGCSSCPLTAGPGADQAETTLRRTEYEEQAL 359

  Fly   334 SNNNANANDEHSNDSTG---EHDANRSSSGDGGKGSLSSGNDEE-IGDGLASHHAAPQFIMSPAE 394
            ...|          ..|   |....|.|:.:..:....:.:.|. :...||:....|     |.:
  Fly   360 RERN----------EVGLVFERRLRRESACERSRDYYEAPHFEHVVSSRLAATPPPP-----PQQ 409

  Fly   395 NKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGS-------------------LLS 440
            ....|......|:       ...|..|:..|.:.:|...|:.|                   .:|
  Fly   410 APPSHPPTLRHPH-------NFLTIKQEPTDWSNNPPNASSASNNNNLEELPLASPKQPLDFKMS 467

  Fly   441 GV-IVPGGSGGTPSNSSSNNNNNNSNNQQQ----KVEQQSSPHQLLQQQHHSTPHTNSPQLKQEQ 500
            .| :......||||..|..:...:.||.:|    ::.|:|.....:..:|..| |...|
  Fly   468 AVKLEVNRDRGTPSEESEEHTLRDYNNFKQLLVCEICQKSFEDTKMLVRHLGT-HAGDP------ 525

  Fly   501 PKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERERERERER 565
                           ..|:||:|..||     |.|.:.:.|...|.  |..:....::|.|..::
  Fly   526 ---------------TGGTERNLLPSS-----ASGSTTSASSNLAL--RSVKTYVPKKRRRVSQQ 568

  Fly   566 ERSLDHE--------------------------------------RDLERPGGTGSPPPPPPSHH 592
            |.::||:                                      :|.|:   .|..|||||:..
  Fly   569 ENNMDHDHVTLLCDLCSTSFDTPAEWVRHMNSQHTEIELAMFNSKKDGEQ---KGQQPPPPPATS 630

  Fly   593 SHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRRASLS 657
            |       |...|:.|:...:...:|..:.|:......:::.|:|...||          .||.|
  Fly   631 S-------SSTVSNSQMQPKYPSSTATRSTHSLMLHKMSNSDAVATTTSP----------GASTS 678

  Fly   658 PSG 660
            |:|
  Fly   679 PNG 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	32/111 (29%)
		BTB	33..118	CDD:197585	29/100 (29%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
CG6765	NP_001261582.1	BTB	24..132	CDD:279045	32/107 (30%)
CG6765	NP_001261582.1	BTB	53..130	CDD:197585	23/76 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010