DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment br and BtbVII

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	1083	Identity:	247/1083 - (22%)
Similarity:	374/1083 - (34%)	Gaps:	345/1083 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPCKHP 69
            |.|||||||:|.:..|...:|..:...||||||.|||.::||::||||||.||:.|..:.||:||
  Fly     4 QQFCLRWNNHQPNFISVCSSLLHNGTLVDVTLAAEGRQLQAHKIVLSACSSYFQALFTTNPCQHP 68

  Fly    70 VILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLA 134
            :::|:||.:.||..:|:|:|:|||||.|:.|...|||||:|::.||.:...:..        ||.
  Fly    69 IVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPA--------NLT 125

  Fly   135 NSGGRTPLNTHTQSLPHPHHGSLHDDGGSST----LFSRQGAGSPPPTAVPSLPSHINNQLLKRM 195
            .|                       |..|||    :....|.|:
  Fly   126 KS-----------------------DSKSSTDGTEMVGGAGVGT--------------------- 146

  Fly   196 AMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSAS------PQQT 254
                                   |:.||   :|::|:||.::..|  .|.:.|.:      .||.
  Fly   147 -----------------------GAGNS---AGSLGAGSGSSVGD--SLWSSSEAQQFQQQQQQQ 183

  Fly   255 PADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSL--TPSPLA 317
            ....:..:||::.....|:::::..........:.:.:.....:|...:.......:  |||||:
  Fly   184 AQQQAQQQHHHHQQQQQLQQQQQQAQQQQQQQQHHHHHHQQQQSGQAQAAQTHHHQMRRTPSPLS 248

  Fly   318 RAGADDVKSEPMDMVCSNNNA----NANDEHSNDSTGEHDANRSSSGDGGKG-SLSSGNDEEI-- 375
             ||.............|||.:    ||.::|::..    ||   .||.|..| ||:..|....
  Fly   249 -AGTSPATRRKRLRKSSNNGSGDRNNAEEQHNSSL----DA---GSGAGNAGLSLAQMNQMTFGA 305

  Fly   376 GDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQLQQSG--------DLAVSPQ- 431
            |.|||.|              ..|||..    :..||...|..|.|.|.        .:.:.|:
  Fly   306 GGGLAGH--------------SLHAAKL----LKESASAELEQQPQDSDLDDGHGHLHMQIKPEV 352

  Fly   432 --GGSTGSL---LSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHT 491
              ||...::   :||       |.|||       .:::.|.|....:.|..|         .||.
  Fly   353 DIGGVNQTMPLDISG-------GTTPS-------EHDAPNSQSSHSEPSPAH---------APHP 394

  Fly   492 NSPQLKQEQPKSGGGSCKSSDLHIAAGS-ERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERER 555
            ..|.|......|||           :|| |||.|....|..:........||.....||.|...|
  Fly   395 PHPPLGAASSSSGG-----------SGSFERSFSIGGVGSVECDPDGTPSSPAVMGTKRNRVLTR 448

  Fly   556 ERERERERERERS------------LDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQ 608
            :...:|:.:...|            ||.:     |.............:|..|.|.|     |||
  Fly   449 QPRVKRDSDSISSTNQISPDTAATTLDFD-----PFNAAGATSATARDYSTTGSHHL-----HHQ 503

  Fly   609 --LHATHHELSAAAAHHAHAHAHA-----AHAHALARAGSP----MEHHHLLHHRRASLSPSGAV 662
              :|..||.|:.......||...|     :..|.|:...|.    .:|...|..|:::|..:|:.
  Fly   504 SAVHHHHHLLTVPPRIERHASEPAPSLAPSTPHLLSVPSSTPYLIKQHSDPLLPRQSALHMAGSG 568

  Fly   663 SSASGAGGRGGGAGGP-----GGP-GGSLLSSVRAQDVAQANRLLLPLPLNACHRCDVCGKLLST 721
            |.:|.|...|.....|     ..| .||..|.|....:...:.:.||..:.|.......|
  Fly   569 SGSSSAMATGSNPFAPLHRQYSHPLSGSNASYVTPAPLHHPHHISLPESIYASGSPPPAG----- 628

  Fly   722 KLTLKRHKEQQHLQPLNNAVC------------NLCHKVFRTL---------------NSLNNH- 758
                    ..|:|.|.....|            |.......|:               ||.:.|
  Fly   629 --------SSQYLVPTRVVACPVVSSETAATPTNASPGSSSTVSAAVSVVTSPNAGLQNSASRHP 685

  Fly   759 --------KSIYHRRQKNHHSYFHHGAGVSQAGSPGSRLHQSLSSLSAAAAAANNSVNVGGGSVG 815
                    ..:.|.|:..|              ||      |:|.......|..|......|
  Fly   686 LSPTFSIGSDVAHERRSPH--------------SP------SISRSQVVERAGKNPAEAANG--- 727

  Fly   816 GAGGNAVAAAAAAAAAAAELLLSPIVGAAAVAGG--------TASSTLQLAAAHQQQQQQ----- 867
              ||:.:..:.:|:.:.....|.|  |.|.::..        ..:..||.:.:..|.|::
  Fly   728 --GGSRLRTSKSASGSITGTHLHP--GQATMSSSFEHLPTLRVKNEELQRSVSSPQTQREIITLE 788

  Fly   868 ----SSPGIVKP--------CMDFLXDQQQLLQ--------------------QLFHVALNNSAA 900
                |...:::|        |.:.:....::|:                    |.:|..|||.||
  Fly   789 NPRSSHCPVIRPGPALGCNFCWNTIDGHGRILRRKTKYHCPECQTNLCIVPCFQEYHERLNNEAA 853

  Fly   901 AAAAAAAA------AAAGGSGGGPGG-----VGAGPESINGGG 932
            ||::.|||      ::..|||....|     |.:...|.:|.|
  Fly   854 AASSGAAAGDNQLSSSTTGSGSSSSGKASPYVSSAGSSSSGAG 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	48/95 (51%)
		BTB	33..118	CDD:197585	46/84 (55%)
		C2H2 Zn finger	712..729	CDD:275368	1/16 (6%)
		C2H2 Zn finger	742..763	CDD:275368	6/56 (11%)
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	48/92 (52%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	46/84 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020