DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment br and CG32121

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001097599.1	Gene:	CG32121 / 317867	FlyBaseID:	FBgn0052121	Length:	648	Species:	Drosophila melanogaster

Alignment Length:	977	Identity:	223/977 - (22%)
Similarity:	326/977 - (33%)	Gaps:	388/977 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC 66
            |..|.|||||:|:|:|:.|....|.|.....|||::.|||.::||||||||||.:|.::.::...
  Fly    25 DSQQQFCLRWHNHQTSLLSTLPILLDQSHLTDVTISAEGRQLRAHRVVLSACSSFFMDIFRALEA 89

  Fly    67 -KHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQI 130
             .||||::...:|..:.:|:.|:|.|||||:::.:...|..||.|.:.|            ||.:
  Fly    90 SNHPVIIIPGASFGAIVSLLTFMYSGEVNVYEEQIPMLLNLAETLGIKG------------LADV 142

  Fly   131 QN-----LANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSL-PSHINN 189
            ||     .|.|||.:.::|..:               .|:.|.|....||.||  |:| |||
  Fly   143 QNNNLPKTARSGGGSYMDTTNE---------------KSSEFERPTTPSPTPT--PTLTPSH--- 187

  Fly   190 QLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQT 254
                             ....||          ||||            |.||     ||:
  Fly   188 -----------------TPTPSH----------SLPL------------PQLP-----SAA---- 204

  Fly   255 PADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKL-------GSLT 312
                        .|||.|                .|..|:..|:|.|.:..:.|       .||.
  Fly   205 ------------LNTPLL----------------ANKLGSVNSSGMGTTPLENLFKSLQFYPSLL 241

  Fly   313 PSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGD 377
            |.||                      |.:....|.:|                           :
  Fly   242 PQPL----------------------NFSQTALNKTT---------------------------E 257

  Fly   378 GLASHHAAPQFIMSPAENKMFHAAAFNFPNI----DPSALLGLNTQLQQSGDLAVSPQGGSTGSL 438
            .||.:....|...|..:........|....:    .|..|    .:|::|  |..:|:..||
  Fly   258 LLAKYQQQCQLYQSGMQEDQLETDCFGSKRLKGDSPPKEL----RRLEKS--LLKNPKSSST--- 313

  Fly   439 LSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHTN---SPQLKQEQ 500
                          :||||:.:....:|....|  .:||..|       .|.|.   ||||...:
  Fly   314 --------------TNSSSSKSPQECSNPNPIV--ATSPVTL-------APPTMAHFSPQLPVVK 355

  Fly   501 PKSGGGSCKSSDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERERERERER 565
                   |.|:....|.|..:..|    ..|..  :||..:||||                  ::
  Fly   356 -------CSSASYPSALGQGQLYS----SKPPL--YSAAVTPTAA------------------QQ 389

  Fly   566 ERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHAHAHAHA 630
            ...:.|.            |.|.||.:.....|      :..|||...::..|||     |.|.|
  Fly   390 AAQMHHH------------PQPGPSPYISAEDH------AKLQLHIEQYQREAAA-----AAAAA 431

  Fly   631 AHAHALARAGSPMEHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPGGSLLSSVRAQDVA 695
            |...||..|.|               .|                         :|||....:|.:
  Fly   432 AGGMALVSAKS---------------EP-------------------------NLLSLSADRDKS 456

  Fly   696 QANRLLLPLPLNA--CHRCDVCGKLLSTKLTLKRHKE-QQHLQPLNNAVCNLCHKVFRTLNSLNN 757
            .|...:.| |.|:  ...|.:|.|.||.:..|:.|.| .|:::    ..||:|..|.|:.::|
  Fly   457 LATAPIKP-PSNSKLYATCFICHKQLSNQYNLRVHLETHQNVR----YACNVCSHVSRSKDAL-- 514

  Fly   758 HKSIYHRRQKNHHSYFHHGAGVSQAGSP--GSRLHQSLSSLSAAAAAANNSVNVGGGSVGGAGGN 820
                     :.|.||.|.|     |.||  .....:.:|.|:|                     .
  Fly   515 ---------RKHVSYRHPG-----APSPCENEARRKRVSKLAA---------------------T 544

  Fly   821 AVAAAAAAAAAAAELLLSPIVGAAAVAGGTASSTLQLAAAHQQQQQQSSPGIVKPCMDFLXDQQQ 885
            .|..:...:.:|:..:.|..||.|      .::||..:.     |:..:|.:      ||.:|.|
  Fly   545 TVPTSTPMSMSASHTVTSGDVGPA------PATTLGCSG-----QEARNPYL------FLPNQFQ 592

  Fly   886 LLQQLFHVALNNSAAAAAAAAAAAAAGGSG--------GGPGGVGAGPESINGGGQEYGGVQGPS 942
            :            ||||||.|.|.::..||        ..|..:.:..|.......|..||:..:
  Fly   593 M------------AAAAAAVAVAESSPASGQPSLDLAHEAPPSIKSEREPPTASNGEATGVEASA 645

  Fly   943 GT 944
            .|
  Fly   646 ST 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	37/96 (39%)
		BTB	33..118	CDD:197585	35/85 (41%)
		C2H2 Zn finger	712..729	CDD:275368	6/16 (38%)
		C2H2 Zn finger	742..763	CDD:275368	6/20 (30%)
CG32121	NP_001097599.1	BTB	48..142	CDD:279045	39/105 (37%)
		BTB	56..149	CDD:197585	39/104 (38%)
		C2H2 Zn finger	474..494	CDD:275370	8/19 (42%)
		C2H2 Zn finger	501..518	CDD:275370	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020