DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment br and CG3726

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001284917.1	Gene:	CG3726 / 31525	FlyBaseID:	FBgn0029824	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	165/740 - (22%)
Similarity:	243/740 - (32%)	Gaps:	292/740 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTPC-KH 68
            |.:||||..:.|::.:.|..|.|...|.||||||||:.|:||||||.|||.:|..:|.:... :.
  Fly     4 QQYCLRWKYHHSNLQTMFSQLLDRGCFCDVTLACEGQLIRAHRVVLCACSTFFDAVLSNYASERD 68

  Fly    69 PVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNL 133
            |:|:::||.|.::..|:||:|.||:||...||.|.||||:.|::.||.:....|...
  Fly    69 PIIIMKDVTFAEVKCLIEFMYKGEINVEHSSLPSLLKTADDLKIKGLAEVTWRDDED-------- 125

  Fly   134 ANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRMAMM 198
                                                   |.|||.|.               |..
  Fly   126 ---------------------------------------GPPPPMAA---------------AEF 136

  Fly   199 H---RSSAAAAAEE--TSHAFKRLRGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQQTPADF 258
            |   ||.|.:.|::  ..|..::.:|                   |..|||:..|::
  Fly   137 HSPPRSLAESYAQDLILQHQQQQQQG-------------------PAAPPLNLHSSA-------- 174

  Fly   259 STIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADD 323
            :.::........  ::.:|..|...|..|                   ::..:||
  Fly   175 ALLERDRERERE--RDRERLSPGMEGVLG-------------------RMPVMTP---------- 208

  Fly   324 VKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQF 388
                                    .||       :||..|.||:|.|...| |.....|...|:.
  Fly   209 ------------------------LTG-------ASGSAGVGSVSGGTSLE-GVAPVEHFLGPKR 241

  Fly   389 IMS--PAEN--------KMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVI 443
            ...  |.::        |:...||    |::|:....|.|....:.:..::....|..|
  Fly   242 KRGRPPLDDAYDVFNVRKLAQYAA----NLEPAQRAYLETARHFTEEPPLAAHAASMAS------ 296

  Fly   444 VPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHTNSPQLKQEQPKSGGGSC 508
                    |..:..........:|||  :||    ||||          |....||||
  Fly   297 --------PPAACPPKQRQRLRHQQQ--QQQ----QLLQ----------SESSDQEQP------- 330

  Fly   509 KSSDLHIAAGSERS-LSRSSQGMP------DA------GGHSATPSP-TAAYHKRERERERERER 559
                   |||.:.| |..:....|      ||      ||..:.|:. |.|.....::.|:..||
  Fly   331 -------AAGQDWSNLEPNGSATPKLLSDGDANKQETEGGDESLPAVLTTASSSGTKKLEKIGER 388

  Fly   560 ERERERERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELSAAAAHHA 624
               |||...|.|.|.|....|.....||.        :.|
  Fly   389 ---RERHGKLRHARRLYEKSGEDEVDPPK--------EEP------------------------- 417

  Fly   625 HAHAHAAHAHALARAGSPMEHHHLLHHRRASLSPS------------GAVSSASGAGGRGGGAGG 677
                     ..|.:....:|:.||:.:|..|..|:            |.|::|.|..|.|.|:|.
  Fly   418 ---------DELPQPVEEIENEHLVANRAESPRPTVVIPASFACKYEGGVTAAGGGSGSGTGSGS 473

  Fly   678 PG-----GPGGSLLSSVRAQDVAQA 697
            .|     ...|.|::...|.:||.|
  Fly   474 LGSSYLINEHGMLMAHEFAPNVASA 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	47/96 (49%)
		BTB	33..118	CDD:197585	43/85 (51%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
CG3726	NP_001284917.1	BTB	21..118	CDD:279045	47/96 (49%)
		BTB	32..121	CDD:197585	43/88 (49%)
		HTH_psq	587..622	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020