DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment br and CG12236

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_727050.1	Gene:	CG12236 / 31523	FlyBaseID:	FBgn0029822	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	177/799 - (22%)
Similarity:	266/799 - (33%)	Gaps:	298/799 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTP 65
            |..||.:.||||||...:|.:.:|.|.::.||||:|..:||.||||:||||:||.||:|:.|..|
  Fly     1 MATTQQYSLRWNNYLRHLTYSLDNHRLNDDFVDVSLCVDGRRIKAHKVVLSSCSSYFKEIFKENP 65

  Fly    66 CKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLA-- 128
            ..||||:.:.:.|.||::::||:|.|||||.|::|||||:|||:|.|.|||.::.|.....:|
  Fly    66 HPHPVIIFKFIKFEDLNSIIEFMYQGEVNVQQEALQSFLQTAELLAVQGLTAEEKEKPQIPVAPL 130

  Fly   129 ----------------------QIQNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQG 171
                                  |:.|:|.:      .|.||::..|          ::||.....
  Fly   131 ISEHKLIKTIPSTIRAVNEQQQQVSNVAQA------QTATQTIEIP----------AATLLQATN 179

  Fly   172 AGSPPPTAVPSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLPLSGAVGSGSNN 236
            |...|...|.:                  ::|||||::
  Fly   180 ASQVPSQVVAA------------------AAAAAAAQQ--------------------------- 199

  Fly   237 NSPDLPPLHARSASPQQTPADFSTIKHHNNNNTPPLKEEKRNGPTGNGNSGNGNGNGNGASNGNG 301
                   |..:....|......:.|:|....:.||.:::::...................|....
  Fly   200 -------LQVQHQQQQHHHVQTTQIQHIQVQSAPPPQQQQQQQQQQQQQQQQQQQQQQQQSQQQQ 257

  Fly   302 ISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSGDGGKGS 366
            .:..........:.:|...|..||...:..         :|:..|..|.|
  Fly   258 TTPVQTQHLTITNAVALPAASSVKKRKITF---------SDDDDNMYTTE--------------- 298

  Fly   367 LSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAA-FNFPNIDPSALLGLNTQLQQSGDLAVSP 430
               ..|..:.|        .|.|:..||......|. .:.|                  |..|
  Fly   299 ---TVDYAVKD--------EQTIVKTAEMTFLRGAVKMDIP------------------DYIV-- 332

  Fly   431 QGGSTGSLLSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPHTNSPQ 495
              |.....||       .|.||..|     .:.:....|.|.|.||.:::|         |.|..
  Fly   333 --GEVDDRLS-------DGATPQTS-----QDATTAAAQNVAQYSSEYEIL---------TESEM 374

  Fly   496 LKQEQPKSGGGSCKSSDLHIAAGSERSLSRSS--------QGMPDAGGHSATPSPTAAYHKRERE 552
            .::.|       ..:.:..||....|.|..:|        |.|.|:||.|||..|:
  Fly   375 EEKYQ-------ADADNAEIAIEMTRLLGTASGTPGAGSGQVMEDSGGGSATTGPS--------- 423

  Fly   553 RERERERERERERERSLDHERDLERPGGTGSPPPPPPSHHSHFGQHPLSLLPSHHQLHATHHELS 617
                                                                            :
  Fly   424 ----------------------------------------------------------------T 424

  Fly   618 AAAAHHAHAHAHAAHAHALARAGSPMEHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPG 682
            ..:.....:.:.|:..:|..:.||...         |..|.|||.:||.              |.
  Fly   425 TVSVTQVKSDSKASGTNAALKPGSVTV---------ARSSKSGATASAP--------------PA 466

  Fly   683 GSLLSSVRAQDVAQANRLLLPLPLNACHRCDVCGKLLSTKLTLKRHKEQQH--LQPLNNAVCNLC 745
            ||...||:...:|         |||    |..||:.|.:...|:||...:|  :|...:. |.:|
  Fly   467 GSDEESVQYTGLA---------PLN----CSFCGRPLKSVNALRRHIASRHSEIQGKEHE-CFIC 517

  Fly   746 HKVFRTLNSLNNHKSIYHR 764
            .|.|:|..||:.|.|.:||
  Fly   518 MKSFKTKWSLSTHNSRFHR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	53/95 (56%)
		BTB	33..118	CDD:197585	49/84 (58%)
		C2H2 Zn finger	712..729	CDD:275368	6/16 (38%)
		C2H2 Zn finger	742..763	CDD:275368	9/20 (45%)
CG12236	NP_727050.1	BTB	22..116	CDD:279045	51/93 (55%)
		BTB	33..116	CDD:197585	47/82 (57%)
		Herpes_capsid	<376..467	CDD:283714	27/193 (14%)
		C2H2 Zn finger	483..512	CDD:275371	9/28 (32%)
		C2H2 Zn finger	514..535	CDD:275371	9/20 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	1	1.000	-	-		otm40394
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.020