DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment br and Btbd18

DIOPT Version :9

Sequence 1:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	670	Identity:	142/670 - (21%)
Similarity:	207/670 - (30%)	Gaps:	265/670 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AFENLRDDE---AFVDVTLACEGRSIKAHRVVLSACSPYFRELL-KSTPCKHPVILLQ--DVNFM 79
            ||..|...:   .|.|..|..||.::.||..:||||||:|.|.| :..|.:...::|:  .:...
Mouse    20 AFLQLHHQQQSGVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLEMGGLKIQ 84

  Fly    80 DLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQNLAN--------- 135
            .|..||:|:|..|:.|.|:..|..|..|..||||.|...|.|......|......|
Mouse    85 TLRKLVDFLYTSEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPAA 149

  Fly   136 -----------SGGRTPLNTHTQSLP---------------H-----PHHGSLHD---------- 159
                       |..:|||.......|               |     |:..||.|
Mouse   150 APISARVVGPKSRPQTPLPVTQTPSPLGAVRLKSLGEEEGAHKKTNLPNADSLSDTQLKKKARVC 214

  Fly   160 ---DGGSSTLFSRQG----AGSPPPTAVPSLPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRL 217
               :..||....|:|    ..:|.|||:|||...::.|||.|...:.||      :.:.|.:
Mouse   215 LTQESRSSPSSQREGPKETKSNPGPTALPSLYPSVDEQLLPRKIRLSRS------KPSPHVY--- 270

  Fly   218 RGSDNSLPLSGAVGSGSNNNSPDLPPLHARSASPQ------QTPADFSTIKHHNNNNTPPLKEEK 276
                .|.|.|...|..|...:|.......|:.|.:      |.|.:...::     :||
Mouse   271 ----TSTPSSILSGPSSMPTAPGRRLWRQRTVSKEAQGVDKQKPGEVRPLQ-----STP------ 320

  Fly   277 RNGPTGNGNSGNGNGNGNGASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANAN 341
                                               .||.:.:. |::.|..|
Mouse   321 -----------------------------------DPSDVGKP-AENKKQSP------------- 336

  Fly   342 DEHSNDSTGEHDANRSSS---GDGGKGSLSSGNDEEIGDG----------LASHHAAPQFIMSPA 393
                     |..|..|||   |..|:..|     .:|.:|          |.:...:|| |:.|:
Mouse   337 ---------ELRAPTSSSVEEGQVGRVKL-----RKIVNGTCWEVVQEPPLRNTQDSPQ-ILEPS 386

  Fly   394 ENKMFHAAAFNFPNIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSN 458
            :.:            :||                        |:|||.|
Mouse   387 DVE------------EPS------------------------GTLLSSV---------------- 399

  Fly   459 NNNNNSNNQQQ---KVEQ-QSSP-----HQLLQQQHHSTPHTNSPQLKQEQPKSGGGSCKSSDLH 514
                   |:|:   :::. |.||     ..:|....||..|   |.:|.|...|...:.|.|||:
Mouse   400 -------NEQEIPARIQLCQDSPESPRLQDILLSASHSPDH---PMVKSEFGSSPMLTGKESDLN 454

  Fly   515 IAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERERERERERERERERERSLDH---ERDLE 576
            |......:...:..|.|                 .|.|:.|........|.|...|.   ..|:|
Mouse   455 IDCREPYTFDTTLLGQP-----------------CEAEQYRITSAAATSELEEIFDFMLCGSDVE 502

  Fly   577 RPGGT----GSPPPPPPSHH 592
            .|.|:    |:.....||:|
Mouse   503 PPVGSLESPGAEGCRTPSYH 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
br	NP_001162638.2	BTB	22..118	CDD:279045	36/101 (36%)
		BTB	33..118	CDD:197585	33/87 (38%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	40/117 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		45/243 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		7/60 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910