DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tollo and RLP12

DIOPT Version :9

Sequence 1:NP_524757.1 Gene:Tollo / 44497 FlyBaseID:FBgn0029114 Length:1346 Species:Drosophila melanogaster
Sequence 2:NP_177296.2 Gene:RLP12 / 843481 AraportID:AT1G71400 Length:847 Species:Arabidopsis thaliana


Alignment Length:855 Identity:179/855 - (20%)
Similarity:326/855 - (38%) Gaps:219/855 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 LTIRTHNGDW----------STMSLEMASNS-----------FVEFRQLERLDLS--LNNIWLIP 168
            :.||:|. .|          |.:...:||:|           .:|||....::.|  :.|.|..|
plant     1 MMIRSHR-HWVFSSRIIIFLSLLVHSLASSSPHFCRDDQRDALLEFRGEFPINASWHIMNQWRGP 64

  Fly   169 ----------DGMVCPLKSLQHL---------------NASYNKIQ-----DISNFYFSASLSSR 203
                      :|:.|..||.|.:               |:|..|:|     |::|......:.|.
plant    65 WNKSTDCCLWNGVTCNDKSGQVISLDIPNTFLNNYLKTNSSLFKLQYLRHLDLTNCNLYGEIPSS 129

  Fly   204 KARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSAN 268
            ...:...||  ::|..||.|....|.:..|.:|.||.:|.|.::.....:...|..|..::|.:|
plant   130 LGNLSHLTL--VNLYFNKFVGEIPASIGNLNQLRHLILANNVLTGEIPSSLGNLSRLVNLELFSN 192

  Fly   269 RLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKR 333
            ||....|:...:.|||:.:.|.:|::....|...|.|:.|:.|.|..|:|               
plant   193 RLVGKIPDSIGDLKQLRNLSLASNNLIGEIPSSLGNLSNLVHLVLTHNQL--------------- 242

  Fly   334 LMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGI---FADLTNLHTLILSRNRISVI 395
                      :..:.|.|.. |..|:::..|:|   .|.|.|   ||:||.|...:||.|..:..
plant   243 ----------VGEVPASIGN-LIELRVMSFENN---SLSGNIPISFANLTKLSIFVLSSNNFTST 293

  Fly   396 EQRTLQGLKNLLVLSLDFNRISRMDQRSLV-------------------------NCSQLQDLHL 435
            ....:....||....:.:|..|....:||:                         :.::||||.|
plant   294 FPFDMSIFHNLEYFDVSYNSFSGPFPKSLLLIPSLESIYLQENQFTGPIEFANTSSSTKLQDLIL 358

  Fly   436 NDNKLQA-VPEALAHVQLLKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMS 499
            ..|:|.. :||:::.:..|:.||:..|..:.....:|::|.:|..|.:::|:|.........|::
plant   359 GRNRLHGPIPESISRLLNLEELDISHNNFTGAIPPTISKLVNLLHLDLSKNNLEGEVPACLWRLN 423

  Fly   500 SLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKS-IAGLFTELPNLVWLNISGNRLEKFDY 563
            ::.   ||.|...|.|..| |..:.::.:.|:.|..:. |..:..:|.:|.:|::|.|...    
plant   424 TMV---LSHNSFSSFENTS-QEEALIEELDLNSNSFQGPIPYMICKLSSLGFLDLSNNLFS---- 480

  Fly   564 SHIPI-------GLQWLDVRANRITQLGNYFEIESELS-LSTFDASYNLLTEITASSIPN--SVE 618
            ..||.       .::.|::..|..:  |...:|.|:.: |.:.|.|:|.|......|:.|  ::|
plant   481 GSIPSCIRNFSGSIKELNLGDNNFS--GTLPDIFSKATELVSLDVSHNQLEGKFPKSLINCKALE 543

  Fly   619 VLYLNDNQISKIQPYTFFKKPNLTRVDLVRN--------RLTTLEPNALRLSPIAEDR---EIPE 672
            ::.:..|:|..|.|......|:|..::|..|        |..::...:||:..|:.:.   .:|.
plant   544 LVNVESNKIKDIFPSWLESLPSLHVLNLRSNKFYGPLYHRHASIGFQSLRIIDISHNNFSGTLPP 608

  Fly   673 FYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYAS 737
            :|..          :|                              ..::.:..:.|.::.::  
plant   609 YYFS----------NW------------------------------KDMTTLTEEMDQYMTEF-- 631

  Fly   738 HCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGN- 801
                      ::..|         |.||:....:..||   .|:|:     |..|...:...|| 
plant   632 ----------WRYAD---------SYYHEMEMVNKGVD---MSFER-----IRRDFRAIDFSGNK 669

  Fly   802 -NFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNL 865
             |....:|..::  |.|:||:|:.:....:..|....|.:||.|.:..|:|......:...|..|
plant   670 INGNIPESLGYL--KELRVLNLSGNAFTSVIPRFLANLTKLETLDISRNKLSGQIPQDLAALSFL 732

  Fly   866 QELYLQHNAI 875
            ..:...||.:
plant   733 SYMNFSHNLL 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TolloNP_524757.1 LRR_RI <85..281 CDD:238064 47/206 (23%)
leucine-rich repeat 100..123 CDD:275380
leucine-rich repeat 124..144 CDD:275380 5/26 (19%)
LRR_8 152..222 CDD:290566 21/101 (21%)
leucine-rich repeat 154..177 CDD:275380 6/34 (18%)
leucine-rich repeat 178..201 CDD:275380 7/42 (17%)
LRR 210..656 CDD:227223 115/493 (23%)
leucine-rich repeat 212..235 CDD:275380 7/22 (32%)
leucine-rich repeat 236..259 CDD:275380 6/22 (27%)
leucine-rich repeat 260..283 CDD:275380 6/22 (27%)
LRR_RI 276..558 CDD:238064 71/311 (23%)
leucine-rich repeat 284..307 CDD:275380 6/22 (27%)
leucine-rich repeat 308..333 CDD:275380 5/24 (21%)
leucine-rich repeat 334..357 CDD:275380 3/22 (14%)
leucine-rich repeat 358..381 CDD:275380 9/25 (36%)
leucine-rich repeat 382..405 CDD:275380 4/22 (18%)
leucine-rich repeat 406..429 CDD:275380 5/47 (11%)
leucine-rich repeat 430..452 CDD:275380 9/22 (41%)
leucine-rich repeat 453..500 CDD:275380 11/46 (24%)
leucine-rich repeat 501..521 CDD:275380 6/19 (32%)
leucine-rich repeat 525..547 CDD:275380 4/22 (18%)
leucine-rich repeat 548..573 CDD:275380 6/31 (19%)
leucine-rich repeat 604..640 CDD:275380 8/37 (22%)
leucine-rich repeat 641..688 CDD:275380 9/57 (16%)
leucine-rich repeat 689..816 CDD:275380 15/128 (12%)
LRR_8 815..875 CDD:290566 16/59 (27%)
leucine-rich repeat 817..864 CDD:275380 12/46 (26%)
LRR_8 864..921 CDD:290566 3/12 (25%)
leucine-rich repeat 865..888 CDD:275380 3/11 (27%)
leucine-rich repeat 889..910 CDD:275380
TIR 1076..1211 CDD:214587
RLP12NP_177296.2 LRRNT_2 36..80 CDD:285463 8/43 (19%)
LRR_8 112..170 CDD:290566 16/59 (27%)
leucine-rich repeat 112..135 CDD:275380 3/22 (14%)
leucine-rich repeat 136..159 CDD:275380 8/24 (33%)
LRR_8 159..218 CDD:290566 17/58 (29%)
leucine-rich repeat 160..183 CDD:275380 6/22 (27%)
leucine-rich repeat 184..207 CDD:275380 6/22 (27%)
LRR_RI 198..479 CDD:238064 72/313 (23%)
LRR_8 206..266 CDD:290566 19/88 (22%)
leucine-rich repeat 208..231 CDD:275380 6/22 (27%)
leucine-rich repeat 232..255 CDD:275380 8/48 (17%)
leucine-rich repeat 256..279 CDD:275380 9/25 (36%)
leucine-rich repeat 280..352 CDD:275380 10/71 (14%)
leucine-rich repeat 304..322 CDD:275380 3/17 (18%)
LRR_8 351..411 CDD:290566 18/59 (31%)
leucine-rich repeat 353..376 CDD:275380 9/22 (41%)
LRR_RI 374..601 CDD:238064 53/236 (22%)
leucine-rich repeat 377..400 CDD:275380 6/22 (27%)
leucine-rich repeat 401..422 CDD:275380 4/20 (20%)
leucine-rich repeat 445..468 CDD:275380 4/22 (18%)
leucine-rich repeat 469..493 CDD:275380 6/27 (22%)
leucine-rich repeat 494..517 CDD:275380 5/24 (21%)
LRR_8 516..576 CDD:290566 16/59 (27%)
leucine-rich repeat 518..541 CDD:275380 7/22 (32%)
leucine-rich repeat 542..565 CDD:275380 5/22 (23%)
leucine-rich repeat 592..616 CDD:275380 6/63 (10%)
leucine-rich repeat 617..683 CDD:275380 15/96 (16%)
LRR_8 682..742 CDD:290566 16/59 (27%)
LRR_4 682..719 CDD:289563 11/36 (31%)
leucine-rich repeat 684..707 CDD:275380 6/22 (27%)
leucine-rich repeat 708..729 CDD:275380 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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