DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and RLP1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001154318.1	Gene:	RLP1 / 837251	AraportID:	AT1G07390	Length:	1083	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	228/998 - (22%)
Similarity:	358/998 - (35%)	Gaps:	300/998 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 LGNLTDG---SFRGLQELRNLTIRTHNGD---WSTMSLEMASNSFVEFRQLERL----------D 158
            |.||.|.   ...||..|::.|  .|.||   |..:....|.|..|....|:||          .
plant    10 LKNLVDAEEEEEEGLSILKSWT--HHEGDCCRWERVKCSDAINGHVIGLSLDRLVPVAFESQTRS 72

  Fly   159 LSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFY----------------FSASLSSRKA-- 205
            |:|:.:...|        .||.||.|:|...::|:.:                ||.::.....
plant    73 LNLSLLHSFP--------QLQSLNLSWNWFTNLSDHFLGFKSFGTLDKLTTLDFSHNMFDNSIVP 129

  Fly   206 -RVCGSTLQSLDLSANKMVSL-PTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSAN 268
             ....::::||.|.:|.|..: |...||.:..|..||:..||.|||:.:.......|.|:|||.|
plant   130 FLNAATSIRSLHLESNYMEGVFPPQELSNMTNLRVLNLKDNSFSFLSSQGLTDFRDLEVLDLSFN 194

  Fly   269 RLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKR 333
            .:..      :|.         ::|::.         |:|..|||..|.| |.:........|:.
plant   195 GVND------SEA---------SHSLST---------AKLKTLDLNFNPL-SDFSQLKGLESLQE 234

  Fly   334 LMMLDLSANKISR-LEAHIFRPLASLQILKLEDNYIDQLPGGIFAD-------------LTNLHT 384
            |.:|.|..||.:. |..|:.:.|..||.|.|.||....|..|...|             :..:.|
plant   235 LQVLKLRGNKFNHTLSTHVLKDLKMLQELDLSDNGFTNLDHGRDVDESRSEKRFDFREVVQKVET 299

  Fly   385 LILSRN---RISVIEQRTLQ-------GLK---NLLVLSLDFNRISRMDQRSLVNC--SQLQDLH 434
            |.:...   ::|:...:::.       ||:   :|.||....|::|...:..|..|  .:|::|.
plant   300 LWIGLRLSFQMSITHHKSVTVGGNGFLGLEIPTSLQVLDFKRNQLSLTHEGYLGICRLMKLRELD 364

  Fly   435 LNDNKLQAVPEALAHVQLLKTLDVGENMI--------------------------------SQIE 467
            |:.|.|.::|..|.::..|:|||:..|.:                                |.:.
plant   365 LSSNALTSLPYCLGNLTHLRTLDLSNNQLNGNLSSFVSGLPSVLEYLSLLDNNFDGSFLFNSLVN 429

  Fly   468 NTSIT-------------QLES----LYGLRM---TENSLTHIRRGVFDRMSSLQILNLSQNKLK 512
            .|.:|             |.||    |:.|:|   :..||.....|.......|..::||.|||.
plant   430 QTRLTVFKLSSKVGVIQVQTESSWAPLFQLKMLYLSNCSLGSTMLGFLVHQRDLCFVDLSHNKLT 494

  Fly   513 -SIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVW----LNISGNRLEKFDYSHIPIGLQW 572
             :.....::.|::||.|.|.||.|..:     :||.||.    |:||.|.:  :|.....||:.:
plant   495 GTFPTWLVKNNTRLQTILLSGNSLTKL-----QLPILVHGLQVLDISSNMI--YDSIQEDIGMVF 552

  Fly   573 LDVRANRITQLGNYFE--IESEL----SLSTFDASYNLL---TEITASSIPNSVEVLYLNDNQIS 628
            .::|....:  .|:|:  |.|.:    ||...|.|.|.|   ..|...|...|:.||.|::||
plant   553 PNLRFMNFS--SNHFQGTIPSSIGEMKSLQVLDMSSNGLYGQLPIMFLSGCYSLRVLKLSNNQ-- 613

  Fly   629 KIQPYTFFKKPNLT---RVDLVRNRLT-TLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWL 689
             :|...|.|..|||   .:.|..|..| :||...|:      .:.:....|..|.:.....| |:
plant   614 -LQGKIFSKHANLTGLVGLFLDGNNFTGSLEEGLLK------SKNLTLLDISDNRFSGMLPL-WI 670

  Fly   690 QKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCK 754
            .:::|.|..   .|..:|:.....:.|.|..|
plant   671 GRISRLSYL---YMSGNQLKGPFPFLRQSPWV--------------------------------- 699

  Fly   755 MECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDS-TQLYLDGNNFRELQSHAFIGRKRLK 818
                             .|:|.|..|:..::|.::...| .:|.|..|.|..|..........|:
plant   700 -----------------EVMDISHNSFSGSIPRNVNFPSLRELRLQNNEFTGLVPGNLFKAAGLE 747

  Fly   819 VLHLNHS----------------RIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQG------ 861
            ||.|.::                ||.:|.|.:|...:..::.||....|..|:.|:|:|
plant   748 VLDLRNNNFSGKILNTIDQTSKLRILLLRNNSFQTYIPGKICQLSEVGLLDLSHNQFRGPIPSCF 812

  Fly   862 ---------LDNLQELYLQHNAIATIDTLTFTHLYHLKI---LRLDHNAITSF-----AVWNFLP 909
                     .|....|      :|..|....|.|.|.:.   |.||......:     .|.:||.
plant   813 SKMSFGAEQNDRTMSL------VADFDFSYITFLPHCQYGSHLNLDDGVRNGYQPKPATVVDFLT 871

  Fly   910 S------------YLNELRLASN 920
            .            |::.|.|:||
plant   872 KSRYEAYQGDILRYMHGLDLSSN 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	52/206 (25%)
		leucine-rich repeat	100..123	CDD:275380	6/15 (40%)
		leucine-rich repeat	124..144	CDD:275380	6/22 (27%)
		LRR_8	152..222	CDD:290566	19/98 (19%)
		leucine-rich repeat	154..177	CDD:275380	6/32 (19%)
		leucine-rich repeat	178..201	CDD:275380	9/38 (24%)
		LRR	210..656	CDD:227223	140/545 (26%)
		leucine-rich repeat	212..235	CDD:275380	8/23 (35%)
		leucine-rich repeat	236..259	CDD:275380	8/22 (36%)
		leucine-rich repeat	260..283	CDD:275380	7/22 (32%)
		LRR_RI	276..558	CDD:238064	86/367 (23%)
		leucine-rich repeat	284..307	CDD:275380	1/22 (5%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	9/35 (26%)
		leucine-rich repeat	382..405	CDD:275380	5/35 (14%)
		leucine-rich repeat	406..429	CDD:275380	7/24 (29%)
		leucine-rich repeat	430..452	CDD:275380	7/21 (33%)
		leucine-rich repeat	453..500	CDD:275380	17/98 (17%)
		leucine-rich repeat	501..521	CDD:275380	6/20 (30%)
		leucine-rich repeat	525..547	CDD:275380	8/21 (38%)
		leucine-rich repeat	548..573	CDD:275380	9/28 (32%)
		leucine-rich repeat	604..640	CDD:275380	12/38 (32%)
		leucine-rich repeat	641..688	CDD:275380	11/50 (22%)
		leucine-rich repeat	689..816	CDD:275380	18/127 (14%)
		LRR_8	815..875	CDD:290566	18/90 (20%)
		leucine-rich repeat	817..864	CDD:275380	16/77 (21%)
		LRR_8	864..921	CDD:290566	17/77 (22%)
		leucine-rich repeat	865..888	CDD:275380	5/22 (23%)
		leucine-rich repeat	889..910	CDD:275380	6/28 (21%)
		TIR	1076..1211	CDD:214587
RLP1	NP_001154318.1	LRR_RI	76..>274	CDD:238064	57/230 (25%)
		leucine-rich repeat	84..112	CDD:275380	7/27 (26%)
		leucine-rich repeat	113..136	CDD:275380	2/22 (9%)
		LRR_8	135..194	CDD:290566	21/58 (36%)
		leucine-rich repeat	137..161	CDD:275380	8/23 (35%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		leucine-rich repeat	186..209	CDD:275380	8/46 (17%)
		LRR_8	209..270	CDD:290566	22/61 (36%)
		leucine-rich repeat	210..231	CDD:275380	7/21 (33%)
		LRR_RI	211..494	CDD:238064	65/283 (23%)
		leucine-rich repeat	232..259	CDD:275380	9/26 (35%)
		leucine-rich repeat	260..333	CDD:275380	14/72 (19%)
		leucine-rich repeat	334..359	CDD:275380	7/24 (29%)
		LRR_8	359..418	CDD:290566	12/58 (21%)
		leucine-rich repeat	360..382	CDD:275380	7/21 (33%)
		leucine-rich repeat	408..429	CDD:275380	1/20 (5%)
		leucine-rich repeat	433..455	CDD:275380	4/21 (19%)
		leucine-rich repeat	459..482	CDD:275380	5/22 (23%)
		leucine-rich repeat	483..507	CDD:275380	7/23 (30%)
		leucine-rich repeat	508..529	CDD:275380	11/25 (44%)
		leucine-rich repeat	530..554	CDD:275380	7/25 (28%)
		leucine-rich repeat	555..578	CDD:275380	5/24 (21%)
		leucine-rich repeat	579..603	CDD:275380	7/23 (30%)
		leucine-rich repeat	604..651	CDD:275380	17/55 (31%)
		LRR_RI	<638..>810	CDD:238064	42/231 (18%)
		leucine-rich repeat	652..675	CDD:275380	4/23 (17%)
		leucine-rich repeat	676..721	CDD:275380	11/97 (11%)
		LRR_8	720..780	CDD:290566	14/59 (24%)
		leucine-rich repeat	722..745	CDD:275380	5/22 (23%)
		leucine-rich repeat	746..769	CDD:275380	4/22 (18%)
		leucine-rich repeat	770..791	CDD:275380	5/20 (25%)
		leucine-rich repeat	794..815	CDD:275380	5/20 (25%)
		leucine-rich repeat	883..909	CDD:275380	5/12 (42%)
		LRR_8	909..968	CDD:290566
		leucine-rich repeat	910..933	CDD:275380
		leucine-rich repeat	934..957	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910