DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and AT5G45220

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_199335.1	Gene:	AT5G45220 / 834558	AraportID:	AT5G45220	Length:	546	Species:	Arabidopsis thaliana

Alignment Length:	442	Identity:	96/442 - (21%)
Similarity:	164/442 - (37%)	Gaps:	107/442 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 LSANKMVSLP---TAML----SALGRLTHLNMA---KNSMSFLADRAFEGLLSLRVVDLSANRLT 271
            ||::..|.||   |..:    |.:|.:.||.||   ||...|:   .|.|.:...|..|| ||:.
plant     4 LSSSSSVELPPQHTVFILYNGSRMGFIYHLIMALEKKNINVFV---GFNGCICEPVERLS-NRIE 64

  Fly   272 SLP-----PELFAETK----QLQEIYLRNNSINVLAPGIFGELAELLVLDLA------------S 315
            |:.     ...:.|:|    :|.:|.......:::|..||.:|....|..|:            |
plant    65 SIIVLVIFTSRYTESKWCLMKLVDINKCAEKDHLVAIPIFYKLDPSTVRGLSGQFGDAFRDLRES 129

  Fly   316 NELNSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLT 380
            ..|..:|..|...:..:..:.:|.|:.|..|:|..:.:.|:.:......:..:|        .|.
plant   130 TGLMEKWKEALKSISDRPGIRVDKSSPKAKRIEIVVKKVLSRIPSEGSHNASVD--------PLE 186

  Fly   381 NLHTLILS---RNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQA 442
            |..|.:.|   .||...|::| |:..|:    .||.|:: |.....::.|            |..
plant   187 NSDTRLTSSGEENRTFGIKER-LKEFKD----KLDLNKM-RSQLGMVIGC------------LLV 233

  Fly   443 VPEALAHVQLLKTLDVGE----NMISQIENTS-----ITQLESLYGLRMTENSLTHIRRGVF--- 495
            :...|.......|..:||    ..||.|:..:     |.:.....|.....::.|....|.:
plant   234 LFFVLKQSAYTSTRLIGEGGAIGAISAIDRIADNVPKIREYVPEEGTEKPRDTYTEFHTGKYGTK 298

  Fly   496 -DRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIRLDGNQLKSIAGLFTELPNL-VWLNISGNRL 558
             :|.||    ::..|      |..|.|.  ....|:||.         .:.|.. |::|..|::|
plant   299 PERSSS----DVKTN------ADLLDRT--FTDTRMDGK---------VKPPKFQVFINFRGDQL 342

  Fly   559 EKFDYSHIPIGLQ------WLDVRANRITQLGNYFE-IE-SELSLSTFDASY 602
            ......::...|:      ::|.:..|...|...|: || |.:::..|.:.|
plant   343 RNNFVGYLVDALRRSEINVFIDNQEQRGEDLNTLFKRIEDSGIAIVVFSSRY 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	23/78 (29%)
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566	2/4 (50%)
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	96/442 (22%)
		leucine-rich repeat	212..235	CDD:275380	7/24 (29%)
		leucine-rich repeat	236..259	CDD:275380	9/25 (36%)
		leucine-rich repeat	260..283	CDD:275380	8/31 (26%)
		LRR_RI	276..558	CDD:238064	62/314 (20%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	6/36 (17%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	2/22 (9%)
		leucine-rich repeat	382..405	CDD:275380	7/25 (28%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	2/21 (10%)
		leucine-rich repeat	453..500	CDD:275380	11/59 (19%)
		leucine-rich repeat	501..521	CDD:275380	3/19 (16%)
		leucine-rich repeat	525..547	CDD:275380	3/21 (14%)
		leucine-rich repeat	548..573	CDD:275380	5/31 (16%)
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
AT5G45220	NP_199335.1	TIR	16..171	CDD:279864	38/158 (24%)
AT5G45220	NP_199335.1	TIR	330..468	CDD:214587	14/65 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010