DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and Tlr9

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_112455.2	Gene:	Tlr9 / 81897	MGIID:	1932389	Length:	1032	Species:	Mus musculus

Alignment Length:	1253	Identity:	283/1253 - (22%)
Similarity:	446/1253 - (35%)	Gaps:	386/1253 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 IQPQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRT 131
            ::|...|    :|| .||.:|.....:..|...:..|::...::.:|.:..|..|..||.|.::
Mouse    37 LKPHGLV----DCN-WLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLK- 95

  Fly   132 HNGDWST-------------MSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNA 183
                |:.             |::|  ..:|:..|.||.|:||.|.|..:|.   .| .||.:|:.
Mouse    96 ----WNCPPTGLSPLHFSCHMTIE--PRTFLAMRTLEELNLSYNGITTVPR---LP-SSLVNLSL 150

  Fly   184 SYNKIQDI-----------------SNFYF----SASLSSRKARVCG-STLQSLDLSANKMVSLP 226
            |:..|..:                 .|.|:    :.::......:.| |.|..|.|..|.:..:|
Mouse   151 SHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVP 215

  Fly   227 TAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSAN----------------RLTSLPP 275
            ..:..:   |.:|.::.|.:..|.......|.||||:|:..|                :...|.|
Mouse   216 RQLPPS---LEYLLVSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHP 277

  Fly   276 ELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLS 340
            |.|.....|:.:.|:::|::.|....|..|..|.||||:.|.|.....:...|..|.||..|:||
Mouse   278 ETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLNLS 342

  Fly   341 AN---KISRLEAHI---FRPLASLQILKLEDNYIDQLPGGIF------------ADLTNLHTLIL 387
            .|   |:|....|:   |:.|.|||.|.:         .|||            |||..||||.|
Mouse   343 FNYRKKVSFARLHLASSFKNLVSLQELNM---------NGIFFRLLNKYTLRWLADLPKLHTLHL 398

  Fly   388 SRNRISVIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQL 452
            ..|.|:..:.......:.|..:.|..||||.....|.....:..|.. .:..|.|.|    |...
Mouse   399 QMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAE-QEELLSADP----HPAP 458

  Fly   453 LKTLDVGENMISQIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAG 517
            |.| ...:|.:.:.:|...|       :.::.|:|..|:..:|..:|.||.|:||.|.:
Mouse   459 LST-PASKNFMDRCKNFKFT-------MDLSRNNLVTIKPEMFVNLSRLQCLSLSHNSI------ 509

  Fly   518 SLQRNSQLQAIRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKF---DYSHIPIGLQWLDVRAN- 578
                   .||:  :|:|       |..|.||..|::|.|:|:.:   .:|.:| .||.||:..|
Mouse   510 -------AQAV--NGSQ-------FLPLTNLQVLDLSHNKLDLYHWKSFSELP-QLQALDLSYNS 557

  Fly   579 ---RITQLGNYFEIESELS-LSTFDASYN-LLTEITASSIPNSVEVLYLNDNQISKIQP----YT 634
               .:..:|:.|...:.|| |.:...::| :.|.:::....|||..|..:.|.:.::..    |.
Mouse   558 QPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYL 622

  Fly   635 FFKK--PNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESR 697
            .|.:  ..|.::||.:|.|..|.|.                           |||.|.|
Mouse   623 HFFQGLSGLLKLDLSQNNLHILRPQ---------------------------NLDNLPK------ 654

  Fly   698 TQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCS 762
             ..:|:.|                      .|::|..:
Mouse   655 -SLKLLSL----------------------RDNYLSFF--------------------------- 669

  Fly   763 CYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRI 827
                 :|||              .|.:|
Mouse   670 -----NWTS--------------LSFLP------------------------------------- 678

  Fly   828 EVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKIL 892
                        .||||.|..||||||..........||:|.:..|:|.::....|.....||.:
Mouse   679 ------------NLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEV 731

  Fly   893 RLDHNAI-TSFAVWNFLPSYLN--ELRLASNPWTCSC--EFIDKLRDYINRHEYVVDKLK----- 947
            .|.||.: |....| |.|..:|  .|.:.|||..|:|  .|:|.|.:       |..|:.
Mouse   732 NLSHNILKTVDRSW-FGPIVMNLTVLDVRSNPLHCACGAAFVDLLLE-------VQTKVPGLANG 788

  Fly   948 MKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILN 1012
            :||    |:        ||..:..|:    .:|.|.|.||...::  ...|
Mouse   789 VKC----GS--------PGQLQGRSI----FAQDLRLCLDEVLSW--DCFG-------------- 821

  Fly  1013 QPPKLDYIPILVAILTAFIF------VMICISLVFIFRQEMRVWCHSRFGVRLFYNAQKDVDKNE 1071
                |..:.:.|.::...:.      |..|..|...:   :.:...||              ::.
Mouse   822 ----LSLLAVAVGMVVPILHHLCGWDVWYCFHLCLAW---LPLLARSR--------------RSA 865

  Fly  1072 REKLFDAFVSYSSKDEL---FVNEELAPMLE--MGEHRYKLCLHQRDFPVGGYLPETIVQAIDSS 1131
            :...:||||.:......   :|..||...||  .|....:|||..||:..|..|.|.:..:|..|
Mouse   866 QTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGS 930

  Fly  1132 RRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVPQKELDPDLRLYLKTNTYLQW 1196
            |:|:.|::.....|...|..|..|.|.:|.||:..:::::|.....:.....||..|...:.|.|
Mouse   931 RKTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFW 995

  Fly  1197 -----GDKLFWQKLRFAL 1209
                 |...||.:|..||
Mouse   996 PQQPNGQGGFWAQLSTAL 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	52/246 (21%)
		leucine-rich repeat	100..123	CDD:275380	4/22 (18%)
		leucine-rich repeat	124..144	CDD:275380	6/32 (19%)
		LRR_8	152..222	CDD:290566	23/91 (25%)
		leucine-rich repeat	154..177	CDD:275380	9/22 (41%)
		leucine-rich repeat	178..201	CDD:275380	6/43 (14%)
		LRR	210..656	CDD:227223	131/494 (27%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	5/22 (23%)
		leucine-rich repeat	260..283	CDD:275380	9/38 (24%)
		LRR_RI	276..558	CDD:238064	84/299 (28%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	9/24 (38%)
		leucine-rich repeat	334..357	CDD:275380	10/28 (36%)
		leucine-rich repeat	358..381	CDD:275380	9/34 (26%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	7/22 (32%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	9/46 (20%)
		leucine-rich repeat	501..521	CDD:275380	6/19 (32%)
		leucine-rich repeat	525..547	CDD:275380	6/21 (29%)
		leucine-rich repeat	548..573	CDD:275380	9/27 (33%)
		leucine-rich repeat	604..640	CDD:275380	8/41 (20%)
		leucine-rich repeat	641..688	CDD:275380	9/46 (20%)
		leucine-rich repeat	689..816	CDD:275380	11/126 (9%)
		LRR_8	815..875	CDD:290566	15/59 (25%)
		leucine-rich repeat	817..864	CDD:275380	11/46 (24%)
		LRR_8	864..921	CDD:290566	18/59 (31%)
		leucine-rich repeat	865..888	CDD:275380	6/22 (27%)
		leucine-rich repeat	889..910	CDD:275380	8/21 (38%)
		TIR	1076..1211	CDD:214587	43/144 (30%)
Tlr9	NP_112455.2	leucine-rich repeat	43..64	CDD:275380	7/25 (28%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	47..51		2/3 (67%)
		LRR 1	62..85		3/22 (14%)
		LRR_8	63..135	CDD:290566	18/78 (23%)
		leucine-rich repeat	65..88	CDD:275380	4/22 (18%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	72..77		0/4 (0%)
		LRR 2	87..110		4/27 (15%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	95..109		1/18 (6%)
		LRR 3	122..147		12/28 (43%)
		leucine-rich repeat	125..168	CDD:275380	14/46 (30%)
		LRR_8	143..211	CDD:290566	13/67 (19%)
		LRR 4	150..166		2/15 (13%)
		LRR 5	167..190		2/22 (9%)
		leucine-rich repeat	169..200	CDD:275380	3/30 (10%)
		Interaction with CpG-DNA. /evidence=ECO:0000250\|UniProtKB:Q2EEY0	179..181		1/1 (100%)
		LRR_RI	<194..373	CDD:238064	52/190 (27%)
		LRR 6	198..221		6/22 (27%)
		LRR_8	199..254	CDD:290566	16/57 (28%)
		leucine-rich repeat	201..221	CDD:275380	5/19 (26%)
		leucine-rich repeat	222..245	CDD:275380	5/22 (23%)
		LRR 7	223..242		3/18 (17%)
		LRR 8	243..268		7/24 (29%)
		leucine-rich repeat	246..285	CDD:275380	9/38 (24%)
		LRR 9	283..306		5/22 (23%)
		LRR_8	284..344	CDD:290566	20/59 (34%)
		leucine-rich repeat	286..309	CDD:275380	6/22 (27%)
		LRR 10	308..332		8/23 (35%)
		leucine-rich repeat	310..335	CDD:275380	9/24 (38%)
		LRR 11	333..356		9/22 (41%)
		leucine-rich repeat	336..365	CDD:275380	10/28 (36%)
		LRR 12	363..386		8/31 (26%)
		LRR 13	390..413		8/22 (36%)
		leucine-rich repeat	393..411	CDD:275380	7/17 (41%)
		LRR 14	415..440		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..462		8/37 (22%)
		LRR 15	471..495		6/30 (20%)
		leucine-rich repeat	477..498	CDD:275380	5/27 (19%)
		LRR_RI	<490..>641	CDD:238064	45/173 (26%)
		LRR_8	497..556	CDD:290566	25/81 (31%)
		LRR 16	497..520		12/44 (27%)
		leucine-rich repeat	499..523	CDD:275380	12/45 (27%)
		LRR 17	521..544		7/22 (32%)
		leucine-rich repeat	524..547	CDD:275380	7/23 (30%)
		LRR 18	546..573		8/27 (30%)
		leucine-rich repeat	548..577	CDD:275380	8/28 (29%)
		LRR 19	575..599		5/23 (22%)
		leucine-rich repeat	578..600	CDD:275380	3/21 (14%)
		leucine-rich repeat	601..630	CDD:275380	5/28 (18%)
		LRR 20	601..623		4/21 (19%)
		LRR_8	<623..690	CDD:290566	28/217 (13%)
		LRR 21	628..651		9/49 (18%)
		leucine-rich repeat	631..679	CDD:275380	21/198 (11%)
		LRR 22	653..676		8/97 (8%)
		LRR 23	677..700		12/71 (17%)
		leucine-rich repeat	680..703	CDD:275380	11/22 (50%)
		LRR 24	702..724		6/21 (29%)
		leucine-rich repeat	704..752	CDD:275380	15/48 (31%)
		LRR 25	725..748		8/23 (35%)
		LRR 26	750..773		8/22 (36%)
		leucine-rich repeat	753..774	CDD:275380	7/20 (35%)
		TIR_2	870..>974	CDD:304906	32/103 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780