DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tollo and TLR10

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001017388.1	Gene:	TLR10 / 81793	HGNCID:	15634	Length:	811	Species:	Homo sapiens

Alignment Length:	938	Identity:	216/938 - (23%)
Similarity:	356/938 - (37%)	Gaps:	280/938 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 LDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQ 401
            ||||.|.:.:|::..|..::.|::|.|..|.|.||....|.....|..|.||.||:..:....|.
Human    53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLA 117

  Fly   402 GLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVP-EALAHVQLLKTLDVGENMISQ 465
            ||:.|.:...||:.:...::..  |.|.|:.|.|:..|:|... :.:||:. |.|:.:|...:..
Human   118 GLRYLDLSFNDFDTMPICEEAG--NMSHLEILGLSGAKIQKSDFQKIAHLH-LNTVFLGFRTLPH 179

  Fly   466 IENTSI-----TQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNL-SQNKLKSIEAGSLQRNSQ 524
            .|..|:     |:|..:  |.|..|....:|.|: .....|::.|: .:::..|.|   :|||..
Human   180 YEEGSLPILNTTKLHIV--LPMDTNFWVLLRDGI-KTSKILEMTNIDGKSQFVSYE---MQRNLS 238

  Fly   525 LQAIRLDGNQLKSIAGLFTEL---PNLVW---------LNIS-GNRL----EKFDYSHI---PIG 569
            |:..:.....|..:..|:.:|   ...||         .|:: |.:.    ..||||:.   .|.
Human   239 LENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIK 303

  Fly   570 LQWLDVRANRITQLGNYFEIESELSLSTFDASYNLLT--EITASSIPNSVEVLYLNDNQISKIQP 632
            |:.:..|...|.|                |..|.|||  :|...:|.|:.....|..|..:|.|.
Human   304 LEHVHFRVFYIQQ----------------DKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQY 352

  Fly   633 YTF---------FKK----PNLTRVDLVRNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDC 684
            ..|         ||:    |:|..:.|..|:|.||                       :...|..
Human   353 LNFANNILTDELFKRTIQLPHLKTLILNGNKLETL-----------------------SLVSCFA 394

  Fly   685 NLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQ 749
            |           .|..:.:||.|              :|::.|:|:
Human   395 N-----------NTPLEHLDLSQ--------------NLLQHKNDE------------------- 415

  Fly   750 ACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQLYLDGNNFRELQSHAFIGR 814
                        :|    ||...||:.: .||.:              |..:.||.|.
Human   416 ------------NC----SWPETVVNMN-LSYNK--------------LSDSVFRCLP------- 442

  Fly   815 KRLKVLHLNHSRIEVLHNRTFYGLLELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATID 879
            |.:::|.||:::|:.:...|.: |:.|..|.:..|.|..|.|
Human   443 KSIQILDLNNNQIQTVPKETIH-LMALRELNIAFNFLTDLPG----------------------- 483

  Fly   880 TLTFTHLYHLKILRLDHNAITSFAVWNFLPS--YLNELRLASNPWTCSCEFIDKLRDYINRHEYV 942
               .:|...|.:|.::.|.|.|.:: :|:.|  .:..|....||:.|:||    |:::|....|
Human   484 ---CSHFSRLSVLNIEMNFILSPSL-DFVQSCQEVKTLNAGRNPFRCTCE----LKNFIQLETY- 539

  Fly   943 VDKLKMKCDVISGNSTQQMVIYPGSGEPASLPVVQCSQTLPLGLDNNF--NYAEQAGGENASNAT 1005
                                                |:.:.:|..:::  .|.....|....:..
Human   540 ------------------------------------SEVMMVGWSDSYTCEYPLNLRGTRLKDVH 568

  Fly  1006 STKMILNQPPKLDYIPILVAILTAFIFVMIC---ISLVFIFR---QEMRVWCHSRFGVRLFYNAQ 1064
            ..::..|  ..|..:.|:|.:|...:.|..|   ..|.:..|   |..:.| |     |:....|
Human   569 LHELSCN--TALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTW-H-----RVRKTTQ 625

  Fly  1065 KDVDKNEREKLFDAFVSYSSKDELFVNEELAPMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAID 1129
            :.:.:|.|   |.||:|||..|.|:|..||.|.||..:....:||::..|..|..:.|.||..|:
Human   626 EQLKRNVR---FHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIE 687

  Fly  1130 SSRRTIMVVSENFIKSEWCRFEFKSAHQSVLRDRRRRLIVIVLGEVP--------QKELDPDLRL 1186
            .|.::|.|:|.||:::|||.:||..||.::..:....:|:|:|..:|        .|     |:.
Human   688 KSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHK-----LKA 747

  Fly  1187 YLKTNTYLQW-GDK----LFWQKLRFAL 1209
            .|:...||:| .|:    |||..||.|:
Human   748 LLEKKAYLEWPKDRRKCGLFWANLRAAI 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	94/360 (26%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	63/240 (26%)
		leucine-rich repeat	284..307	CDD:275380
		leucine-rich repeat	308..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380	7/19 (37%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	7/22 (32%)
		leucine-rich repeat	453..500	CDD:275380	12/51 (24%)
		leucine-rich repeat	501..521	CDD:275380	4/20 (20%)
		leucine-rich repeat	525..547	CDD:275380	4/24 (17%)
		leucine-rich repeat	548..573	CDD:275380	10/41 (24%)
		leucine-rich repeat	604..640	CDD:275380	13/50 (26%)
		leucine-rich repeat	641..688	CDD:275380	8/46 (17%)
		leucine-rich repeat	689..816	CDD:275380	18/126 (14%)
		LRR_8	815..875	CDD:290566	13/59 (22%)
		leucine-rich repeat	817..864	CDD:275380	12/46 (26%)
		LRR_8	864..921	CDD:290566	9/58 (16%)
		leucine-rich repeat	865..888	CDD:275380	1/22 (5%)
		leucine-rich repeat	889..910	CDD:275380	6/20 (30%)
		TIR	1076..1211	CDD:214587	52/147 (35%)
TLR10	NP_001017388.1	LRR 1	24..46
		LRR 2	49..70		7/16 (44%)
		leucine-rich repeat	50..73	CDD:275378	7/19 (37%)
		LRR_8	72..129	CDD:316378	18/56 (32%)
		LRR 3	73..94		8/20 (40%)
		leucine-rich repeat	74..97	CDD:275378	8/22 (36%)
		LRR 4	97..118		7/20 (35%)
		leucine-rich repeat	98..112	CDD:275378	6/13 (46%)
		leucine-rich repeat	119..143	CDD:275378	5/25 (20%)
		LRR 5	119..139		4/19 (21%)
		LRR 6	143..166		7/22 (32%)
		leucine-rich repeat	144..155	CDD:275378	4/10 (40%)
		LRR	289..>522	CDD:227223	73/381 (19%)
		LRR 7	296..321		6/40 (15%)
		LRR 8	325..348		5/22 (23%)
		LRR 9	349..368		5/18 (28%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
		LRR 10	373..394		7/43 (16%)
		leucine-rich repeat	374..398	CDD:275380	8/57 (14%)
		LRR 11	398..419		7/69 (10%)
		leucine-rich repeat	399..422	CDD:275380	9/71 (13%)
		LRR 12	422..442		7/34 (21%)
		leucine-rich repeat	423..444	CDD:275380	8/42 (19%)
		LRR 13	444..465		5/21 (24%)
		leucine-rich repeat	445..467	CDD:275380	6/22 (27%)
		LRR 14	467..488		7/46 (15%)
		leucine-rich repeat	468..490	CDD:275380	7/47 (15%)
		LRR 15	489..509		6/20 (30%)
		leucine-rich repeat	491..513	CDD:275380	6/22 (27%)
		LRRCT	522..574	CDD:214507	12/92 (13%)
		TIR	633..775	CDD:214587	52/149 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820