Protein Alignment Tollo and lrrc15

DIOPT Version :10

• Sequence 1: NP_524757.1
• Gene: Tollo / 44497
• FlyBaseID: FBgn0029114
• Length: 1346
• Species: Drosophila melanogaster
• Sequence 2: NP_001074151.1
• Gene: lrrc15 / 791200
• ZFINID: ZDB-GENE-031113-8
• Length: 564
• Species: Danio rerio
• Alignment Length: 488
• Identity: 131/488 - (26%)
• Similarity: 213/488 - (43%)
• Gaps: 84/488 - (17%)

  Fly     9 YVLIATCVIPIFGAALSKTVLYQAPDECRWSGGGEHDIT-LVCHLRTINSELENTNFSV----IQ 68
            :|:|..|.:        |.|....|:.|      :..:| :||.           .|||    :.
Zfish     6 FVIIGMCAM--------KAVASSCPESC------QCQVTKIVCQ-----------GFSVKEIPLP 45

  Fly    69 PQNTVRLRLECNDALFFQSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHN 133
            ...|:...:..|.::   .||.|..|::..|  .||:...|..|:|:.......:..||.....:
Zfish    46 MPPTINALVISNTSI---QSLKPSDFQTFAE--TLTLFVAKNSNITEVEPHTFDQAFNLNALGFS 105

  Fly   134 GDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSA 198
            |   ||...:..|.|.....|..|.||.|.:.::|..::.||       |:.||
Zfish   106 G---TMLTSLPDNLFQNLTALTTLTLSGNKLEVLPSSLLTPL-------ANVNK----------- 149

  Fly   199 SLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVV 263
                            ||||.|.:.||.......|.:|..|.:.:||:..|....|:||..||.:
Zfish   150 ----------------LDLSKNLLSSLSEDAFRGLDQLEMLMLQRNSIKQLHSSTFQGLSHLRSL 198

  Fly   264 DLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATF 328
            .|..|:||.:|..||.:...|:.::|::|.|..|...:|.::..|..|.|:||.|:  .:.:..|
Zfish   199 FLQQNQLTDIPAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQNLKKLYLSSNRLS--LLPSGIF 261

  Fly   329 VGLKRLMMLDLSANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRIS 393
            :.|..|..:.|..|::|||....|..:| ||.|.|.||.:..|...:|::|||:..|::|||||.
Zfish   262 LSLPNLTHISLYDNRLSRLMPETFGTMA-LQELWLYDNLLTHLEENVFSNLTNIRLLVISRNRIQ 325

  Fly   394 VIEQRTLQGLKNLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDV 458
            .|......|||.|..:||..||::.::.........|.::.:.:|:::.:|     :|||.  .|
Zfish   326 YISPGAFNGLKELKEVSLHTNRLTNIEPGIFRGLPNLANISIENNQIKQIP-----IQLLD--GV 383

  Fly   459 GENMISQIENTSITQL--ESLYGLRMTENSLTH 489
            ....:.:::|.|:..|  :.|..|.:.||.:.|
Zfish   384 SRLSLLEMQNNSLQNLPKDFLNTLSIVENVILH 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR	54..400	CDD:443914	98/349 (28%)
		leucine-rich repeat	100..123	CDD:275380	5/22 (23%)
		leucine-rich repeat	124..144	CDD:275380	5/19 (26%)
		leucine-rich repeat	154..177	CDD:275380	8/22 (36%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		leucine-rich repeat	212..235	CDD:275380	8/22 (36%)
		leucine-rich repeat	236..259	CDD:275380	8/22 (36%)
		LRR	239..634	CDD:443914	79/253 (31%)
		leucine-rich repeat	260..283	CDD:275380	9/22 (41%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	8/24 (33%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	382..405	CDD:275380	9/22 (41%)
		leucine-rich repeat	406..429	CDD:275380	5/22 (23%)
		leucine-rich repeat	430..452	CDD:275380	3/21 (14%)
		leucine-rich repeat	453..500	CDD:275380	10/39 (26%)
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		LRR_8	616..>660	CDD:404697
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR	<794..>920	CDD:443914
		leucine-rich repeat	817..864	CDD:275380
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470	8/43 (19%)
		leucine-rich repeat	53..73	CDD:275380	5/22 (23%)
		LRR	74..418	CDD:443914	111/390 (28%)
		leucine-rich repeat	171..194	CDD:275380	8/22 (36%)
		leucine-rich repeat	195..218	CDD:275380	9/22 (41%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		leucine-rich repeat	243..266	CDD:275380	8/24 (33%)
		leucine-rich repeat	267..289	CDD:275380	7/21 (33%)
		leucine-rich repeat	290..313	CDD:275380	9/22 (41%)
		leucine-rich repeat	314..337	CDD:275380	9/22 (41%)
		leucine-rich repeat	338..361	CDD:275380	5/22 (23%)
		leucine-rich repeat	362..385	CDD:275380	7/29 (24%)
		LRRCT	418..467	CDD:214507