DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tollo and Lrrtm1

DIOPT Version :9

Sequence 1:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster
Sequence 2:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus

Alignment Length:	313	Identity:	85/313 - (27%)
Similarity:	141/313 - (45%)	Gaps:	54/313 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 YCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVEFRQLERLDLSLNNIWLIPDGM 171
            ||:..|||:.. ..|..|..|::|     ::::| |:.:..|....||..|.|..|:|..:....
Mouse    51 YCEALNLTEAP-HNLSGLLGLSLR-----YNSLS-ELRAGQFTGLMQLTWLYLDHNHICSVQGDA 108

  Fly   172 VCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSLDLSANKMVSLPTAMLSALGRL 236
            ...|:.::.|..|.|:|.:::|..|...          ..|:|:|||.||:.:|...:...|.:|
Mouse   109 FQKLRRVKELTLSSNQITELANTTFRPM----------PNLRSVDLSYNKLQALAPDLFHGLRKL 163

  Fly   237 THLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAETKQLQEIYLRNNSINVLAPGI 301
            |.|:|..|::.|:..|.|:...||:.:|:..|:|.||....||...:|.|::|.:|.:..:....
Mouse   164 TTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIKVNFAH 228

  Fly   302 FGELAELLVLDLASNEL-----NSQWINAATFVGLKRLMMLDLSANKISRLEAHIFRPLASLQIL 361
            |..|..|..|.|..|::     :..|:        ..|..:|||.|:|..:|.|:|..:..||.|
Mouse   229 FPRLISLHSLCLRRNKVAIVVSSLDWV--------WNLEKMDLSGNEIEYMEPHVFETVPYLQTL 285

  Fly   362 KLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLSLDFN 414
            :|:.                        ||::.||.|.|...|:|..::|..|
Mouse   286 QLDS------------------------NRLTYIEPRILNSWKSLTSITLAGN 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	51/173 (29%)
		leucine-rich repeat	100..123	CDD:275380	6/15 (40%)
		leucine-rich repeat	124..144	CDD:275380	5/19 (26%)
		LRR_8	152..222	CDD:290566	19/69 (28%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	6/22 (27%)
		LRR	210..656	CDD:227223	60/210 (29%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..259	CDD:275380	8/22 (36%)
		leucine-rich repeat	260..283	CDD:275380	8/22 (36%)
		LRR_RI	276..558	CDD:238064	36/144 (25%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	5/29 (17%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	3/9 (33%)
		leucine-rich repeat	430..452	CDD:275380
		leucine-rich repeat	453..500	CDD:275380
		leucine-rich repeat	501..521	CDD:275380
		leucine-rich repeat	525..547	CDD:275380
		leucine-rich repeat	548..573	CDD:275380
		leucine-rich repeat	604..640	CDD:275380
		leucine-rich repeat	641..688	CDD:275380
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Lrrtm1	NP_001349038.1	LRR 1	64..87		7/28 (25%)
		LRR	<75..>315	CDD:227223	76/283 (27%)
		LRR 2	89..111		6/21 (29%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		LRR 3	112..135		7/22 (32%)
		leucine-rich repeat	115..138	CDD:275380	6/32 (19%)
		LRR 4	136..159		8/32 (25%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		LRR 5	161..183		8/21 (38%)
		leucine-rich repeat	163..186	CDD:275380	8/22 (36%)
		LRR 6	184..207		8/22 (36%)
		leucine-rich repeat	187..210	CDD:275380	8/22 (36%)
		LRR 7	209..231		5/21 (24%)
		leucine-rich repeat	211..234	CDD:275380	6/22 (27%)
		LRR 8	233..255		4/21 (19%)
		leucine-rich repeat	235..257	CDD:275380	5/29 (17%)
		LRR 9	256..278		9/21 (43%)
		leucine-rich repeat	258..281	CDD:275380	9/22 (41%)
		LRR 10	280..302		10/45 (22%)
		leucine-rich repeat	282..300	CDD:275380	9/41 (22%)
		leucine-rich repeat	306..318	CDD:275378	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910